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Items: 20

1.

Design and Synthesis of Selurampanel, a Novel Orally Active and Competitive AMPA Receptor Antagonist.

Orain D, Tasdelen E, Haessig S, Koller M, Picard A, Dubois C, Lingenhoehl K, Desrayaud S, Floersheim P, Carcache D, Urwyler S, Kallen J, Mattes H.

ChemMedChem. 2017 Feb 3;12(3):197-201. doi: 10.1002/cmdc.201600467. Epub 2016 Nov 15.

PMID:
27863026
2.

AQW051, a novel, potent and selective α7 nicotinic ACh receptor partial agonist: pharmacological characterization and phase I evaluation.

Feuerbach D, Pezous N, Weiss M, Shakeri-Nejad K, Lingenhoehl K, Hoyer D, Hurth K, Bilbe G, Pryce CR, McAllister K, Chaperon F, Kucher K, Johns D, Blaettler T, Lopez Lopez C.

Br J Pharmacol. 2015 Mar;172(5):1292-304. doi: 10.1111/bph.13001. Epub 2015 Jan 12.

3.

Gastrin-releasing peptide signaling plays a limited and subtle role in amygdala physiology and aversive memory.

Chaperon F, Fendt M, Kelly PH, Lingenhoehl K, Mosbacher J, Olpe HR, Schmid P, Sturchler C, McAllister KH, van der Putten PH, Gee CE.

PLoS One. 2012;7(4):e34963. doi: 10.1371/journal.pone.0034963. Epub 2012 Apr 11.

4.

6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists.

Orain D, Ofner S, Koller M, Carcache DA, Froestl W, Allgeier H, Rasetti V, Nozulak J, Mattes H, Soldermann N, Floersheim P, Desrayaud S, Kallen J, Lingenhoehl K, Urwyler S.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):996-9. doi: 10.1016/j.bmcl.2011.12.009. Epub 2011 Dec 8.

PMID:
22197388
5.

Quinazolinedione sulfonamides: a novel class of competitive AMPA receptor antagonists with oral activity.

Koller M, Lingenhoehl K, Schmutz M, Vranesic IT, Kallen J, Auberson YP, Carcache DA, Mattes H, Ofner S, Orain D, Urwyler S.

Bioorg Med Chem Lett. 2011 Jun 1;21(11):3358-61. doi: 10.1016/j.bmcl.2011.04.017. Epub 2011 Apr 8.

PMID:
21531559
6.

The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain.

Feuerbach D, Lingenhoehl K, Olpe HR, Vassout A, Gentsch C, Chaperon F, Nozulak J, Enz A, Bilbe G, McAllister K, Hoyer D.

Neuropharmacology. 2009 Jan;56(1):254-63. doi: 10.1016/j.neuropharm.2008.08.025. Epub 2008 Aug 28.

PMID:
18793655
7.

AMPA receptor antagonists: potential therapeutic applications.

Mattes H, Lingenhoehl K, Kalkman H, Auberson Y, Renaud J, Schmutz M, Orain D.

Recent Pat CNS Drug Discov. 2006 Nov;1(3):247-59. Review.

PMID:
18221206
8.

JN403, in vitro characterization of a novel nicotinic acetylcholine receptor alpha7 selective agonist.

Feuerbach D, Nozulak J, Lingenhoehl K, McAllister K, Hoyer D.

Neurosci Lett. 2007 Apr 6;416(1):61-5. Epub 2007 Jan 25.

PMID:
17314009
9.

Ions and amino acid analysis of Cyperus articulatus L. (Cyperaceae) extracts and the effects of the latter on oocytes expressing some receptors.

Bum EN, Lingenhoehl K, Rakotonirina A, Olpe HR, Schmutz M, Rakotonirina S.

J Ethnopharmacol. 2004 Dec;95(2-3):303-9.

PMID:
15507353
10.

Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity.

Liu L, Wong TP, Pozza MF, Lingenhoehl K, Wang Y, Sheng M, Auberson YP, Wang YT.

Science. 2004 May 14;304(5673):1021-4.

11.

Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines.

Cryan JF, Kelly PH, Chaperon F, Gentsch C, Mombereau C, Lingenhoehl K, Froestl W, Bettler B, Kaupmann K, Spooren WP.

J Pharmacol Exp Ther. 2004 Sep;310(3):952-63. Epub 2004 Apr 27.

PMID:
15113848
12.

N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function.

Urwyler S, Pozza MF, Lingenhoehl K, Mosbacher J, Lampert C, Froestl W, Koller M, Kaupmann K.

J Pharmacol Exp Ther. 2003 Oct;307(1):322-30. Epub 2003 Sep 3.

PMID:
12954816
13.

Electrophysiological studies on the hippocampus and prefrontal cortex assessing the effects of amyloidosis in amyloid precursor protein 23 transgenic mice.

Roder S, Danober L, Pozza MF, Lingenhoehl K, Wiederhold KH, Olpe HR.

Neuroscience. 2003;120(3):705-20.

PMID:
12895511
14.

The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors.

Jensen AA, Mosbacher J, Elg S, Lingenhoehl K, Lohmann T, Johansen TN, Abrahamsen B, Mattsson JP, Lehmann A, Bettler B, Bräuner-Osborne H.

Mol Pharmacol. 2002 Jun;61(6):1377-84.

PMID:
12021399
15.

5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition.

Auberson YP, Allgeier H, Bischoff S, Lingenhoehl K, Moretti R, Schmutz M.

Bioorg Med Chem Lett. 2002 Apr 8;12(7):1099-102.

PMID:
11909726
16.

Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501.

Urwyler S, Mosbacher J, Lingenhoehl K, Heid J, Hofstetter K, Froestl W, Bettler B, Kaupmann K.

Mol Pharmacol. 2001 Nov;60(5):963-71.

PMID:
11641424
17.

Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain.

Walker K, Bowes M, Panesar M, Davis A, Gentry C, Kesingland A, Gasparini F, Spooren W, Stoehr N, Pagano A, Flor PJ, Vranesic I, Lingenhoehl K, Johnson EC, Varney M, Urban L, Kuhn R.

Neuropharmacology. 2001;40(1):1-9.

PMID:
11077065
18.

Immunocytochemical localization of the metabotropic glutamate receptor mGluR4a in the piriform cortex of the rat.

Benítez R, Fernández-Capetillo O, Lázaro E, Mateos JM, Osorio A, Elezgarai I, Bilbao A, Lingenhoehl K, Van Der Putten H, Hampson DR, Kuhn R, Knöpfel T, Grandes P.

J Comp Neurol. 2000 Feb 14;417(3):263-74.

PMID:
10683602
19.

Gamma-hydroxybutyrate is a weak agonist at recombinant GABA(B) receptors.

Lingenhoehl K, Brom R, Heid J, Beck P, Froestl W, Kaupmann K, Bettler B, Mosbacher J.

Neuropharmacology. 1999 Nov;38(11):1667-73.

PMID:
10587082
20.

Developmental expression of the group III metabotropic glutamate receptor mGluR4a in the medial nucleus of the trapezoid body of the rat.

Elezgarai I, Benítez R, Mateos JM, Lázaro E, Osorio A, Azkue JJ, Bilbao A, Lingenhoehl K, Van Der Putten H, Hampson DR, Kuhn R, Knöpfel T, Grandes P.

J Comp Neurol. 1999 Aug 30;411(3):431-40.

PMID:
10413777

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