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BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors.

Kotov JA, Kotov DI, Linehan JL, Bardwell VJ, Gearhart MD, Jenkins MK.

J Exp Med. 2019 Jun 3;216(6):1450-1464. doi: 10.1084/jem.20182376. Epub 2019 May 3.


Evaluating the impacts of amino acids in the second and outer coordination spheres of Rh-bis(diphosphine) complexes for CO2 hydrogenation.

Walsh AP, Laureanti JA, Katipamula S, Chambers GM, Priyadarshani N, Lense S, Bays JT, Linehan JC, Shaw WJ.

Faraday Discuss. 2019 Jul 4;215(0):123-140. doi: 10.1039/c8fd00164b.


Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone.

Purro SA, Farrow MA, Linehan J, Nazari T, Thomas DX, Chen Z, Mengel D, Saito T, Saido T, Rudge P, Brandner S, Walsh DM, Collinge J.

Nature. 2018 Dec;564(7736):415-419. doi: 10.1038/s41586-018-0790-y. Epub 2018 Dec 13.


Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury.

Harrison OJ, Linehan JL, Shih HY, Bouladoux N, Han SJ, Smelkinson M, Sen SK, Byrd AL, Enamorado M, Yao C, Tamoutounour S, Van Laethem F, Hurabielle C, Collins N, Paun A, Salcedo R, O'Shea JJ, Belkaid Y.

Science. 2019 Jan 4;363(6422). pii: eaat6280. doi: 10.1126/science.aat6280. Epub 2018 Dec 6.


Making a Splash in Homogeneous CO2 Hydrogenation: Elucidating the Impact of Solvent on Catalytic Mechanisms.

Wiedner ES, Linehan JC.

Chemistry. 2018 Nov 16;24(64):16964-16971. doi: 10.1002/chem.201801759. Epub 2018 Jul 27. Review.


Does rectal diclofenac reduce post-ERCP pancreatitis? A district general hospital experience.

Sheiybani G, Brydon P, Toolan M, Linehan J, Farrant M, Colleypriest B.

Frontline Gastroenterol. 2018 Jan;9(1):73-77. doi: 10.1136/flgastro-2017-100832. Epub 2017 Aug 10.


Experimental sheep BSE prions generate the vCJD phenotype when serially passaged in transgenic mice expressing human prion protein.

Joiner S, Asante EA, Linehan JM, Brock L, Brandner S, Bellworthy SJ, Simmons MM, Hope J, Collinge J, Wadsworth JDF.

J Neurol Sci. 2018 Mar 15;386:4-11. doi: 10.1016/j.jns.2017.12.038. Epub 2017 Dec 29.


Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair.

Linehan JL, Harrison OJ, Han SJ, Byrd AL, Vujkovic-Cvijin I, Villarino AV, Sen SK, Shaik J, Smelkinson M, Tamoutounour S, Collins N, Bouladoux N, Dzutsev A, Rosshart SP, Arbuckle JH, Wang CR, Kristie TM, Rehermann B, Trinchieri G, Brenchley JM, O'Shea JJ, Belkaid Y.

Cell. 2018 Feb 8;172(4):784-796.e18. doi: 10.1016/j.cell.2017.12.033. Epub 2018 Jan 18.


Two-stage classifiers that minimize PCA3 and the PSA proteolytic activity testing in the prediction of prostate cancer recurrence after radical prostatectomy.

Jeske DR, Linehan JA, Wilson TG, Kawachi MH, Wittig K, Lamparska K, Amparo C, Mejia R, Lai F, Georganopoulou D, Smith SS.

Can J Urol. 2017 Dec;24(6):9089-9097.


Changing the Mechanism for CO2 Hydrogenation Using Solvent-Dependent Thermodynamics.

Burgess SA, Appel AM, Linehan JC, Wiedner ES.

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):15002-15005. doi: 10.1002/anie.201709319. Epub 2017 Oct 23.


A Bimetallic Nickel-Gallium Complex Catalyzes CO2 Hydrogenation via the Intermediacy of an Anionic d10 Nickel Hydride.

Cammarota RC, Vollmer MV, Xie J, Ye J, Linehan JC, Burgess SA, Appel AM, Gagliardi L, Lu CC.

J Am Chem Soc. 2017 Oct 11;139(40):14244-14250. doi: 10.1021/jacs.7b07911. Epub 2017 Sep 28.


Detection of an Iridium-Dihydrogen Complex: A Proposed Intermediate in Ionic Hydrogenation.

Goldberg JM, Goldberg KI, Heinekey DM, Burgess SA, Lao DB, Linehan JC.

J Am Chem Soc. 2017 Sep 13;139(36):12638-12646. doi: 10.1021/jacs.7b06480. Epub 2017 Sep 1.


Methods for Molecular Diagnosis of Human Prion Disease.

Wadsworth JDF, Adamson G, Joiner S, Brock L, Powell C, Linehan JM, Beck JA, Brandner S, Mead S, Collinge J.

Methods Mol Biol. 2017;1658:311-346. doi: 10.1007/978-1-4939-7244-9_22.


Emerging Utility of Urinary Cell-free Nucleic Acid Biomarkers for Prostate, Bladder, and Renal Cancers.

Lin SY, Linehan JA, Wilson TG, Hoon DSB.

Eur Urol Focus. 2017 Apr;3(2-3):265-272. doi: 10.1016/j.euf.2017.03.009. Epub 2017 Mar 31. Review.


Hypothermic Cooling Measured by Thermal Magnetic Resonance Imaging; Feasibility and Implications for Virtual Imaging in the Urogenital Pelvis.

Skarecky D, Yu H, Linehan J, Morales B, Su MY, Fwu P, Ahlering T.

Urology. 2017 Oct;108:220-224. doi: 10.1016/j.urology.2017.07.006. Epub 2017 Jul 18.


Hydrogenation of CO2 at Room Temperature and Low Pressure with a Cobalt Tetraphosphine Catalyst.

Burgess SA, Grubel K, Appel AM, Wiedner ES, Linehan JC.

Inorg Chem. 2017 Jul 17;56(14):8580-8589. doi: 10.1021/acs.inorgchem.7b01391. Epub 2017 Jun 28.


Triphosphine-Ligated Copper Hydrides for CO2 Hydrogenation: Structure, Reactivity, and Thermodynamic Studies.

Zall CM, Linehan JC, Appel AM.

J Am Chem Soc. 2016 Aug 10;138(31):9968-77. doi: 10.1021/jacs.6b05349. Epub 2016 Aug 1.


Solvent influence on the thermodynamics for hydride transfer from bis(diphosphine) complexes of nickel.

Connelly Robinson SJ, Zall CM, Miller DL, Linehan JC, Appel AM.

Dalton Trans. 2016 Jun 14;45(24):10017-23. doi: 10.1039/c6dt00309e.


CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors.

Kalekar LA, Schmiel SE, Nandiwada SL, Lam WY, Barsness LO, Zhang N, Stritesky GL, Malhotra D, Pauken KE, Linehan JL, O'Sullivan MG, Fife BT, Hogquist KA, Jenkins MK, Mueller DL.

Nat Immunol. 2016 Mar;17(3):304-14. doi: 10.1038/ni.3331. Epub 2016 Feb 1.


Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns.

Malhotra D, Linehan JL, Dileepan T, Lee YJ, Purtha WE, Lu JV, Nelson RW, Fife BT, Orr HT, Anderson MS, Hogquist KA, Jenkins MK.

Nat Immunol. 2016 Feb;17(2):187-95. doi: 10.1038/ni.3327. Epub 2016 Jan 4.


Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome system.

McKinnon C, Goold R, Andre R, Devoy A, Ortega Z, Moonga J, Linehan JM, Brandner S, Lucas JJ, Collinge J, Tabrizi SJ.

Acta Neuropathol. 2016 Mar;131(3):411-25. doi: 10.1007/s00401-015-1508-y. Epub 2015 Dec 8.


A systematic investigation of production of synthetic prions from recombinant prion protein.

Schmidt C, Fizet J, Properzi F, Batchelor M, Sandberg MK, Edgeworth JA, Afran L, Ho S, Badhan A, Klier S, Linehan JM, Brandner S, Hosszu LL, Tattum MH, Jat P, Clarke AR, Klöhn PC, Wadsworth JD, Jackson GS, Collinge J.

Open Biol. 2015 Dec;5(12):150165. doi: 10.1098/rsob.150165.


Dementia in older people admitted to hospital: a regional multi-hospital observational study of prevalence, associations and case recognition.

Timmons S, Manning E, Barrett A, Brady NM, Browne V, O'Shea E, Molloy DW, O'Regan NA, Trawley S, Cahill S, O'Sullivan K, Woods N, Meagher D, Ni Chorcorain AM, Linehan JG.

Age Ageing. 2015 Nov;44(6):993-9. doi: 10.1093/ageing/afv131. Epub 2015 Sep 28.


Generation of Th17 cells in response to intranasal infection requires TGF-β1 from dendritic cells and IL-6 from CD301b+ dendritic cells.

Linehan JL, Dileepan T, Kashem SW, Kaplan DH, Cleary P, Jenkins MK.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12782-7. doi: 10.1073/pnas.1513532112. Epub 2015 Sep 28.


Erratum: Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy.

Jaunmuktane Z, Mead S, Ellis M, Wadsworth JD, Nicoll AJ, Kenny J, Launchbury F, Linehan J, Richard-Loendt A, Walker AS, Rudge P, Collinge J, Brandner S.

Nature. 2015 Oct 22;526(7574):595. doi: 10.1038/nature15704. Epub 2015 Sep 16. No abstract available.


Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy.

Jaunmuktane Z, Mead S, Ellis M, Wadsworth JD, Nicoll AJ, Kenny J, Launchbury F, Linehan J, Richard-Loendt A, Walker AS, Rudge P, Collinge J, Brandner S.

Nature. 2015 Sep 10;525(7568):247-50. doi: 10.1038/nature15369. Erratum in: Nature. 2015 Oct 22;526(7574):595.


Photoswitching a molecular catalyst to regulate CO2 hydrogenation.

Priyadarshani N, Ginovska B, Bays JT, Linehan JC, Shaw WJ.

Dalton Trans. 2015 Sep 7;44(33):14854-64. doi: 10.1039/c5dt01649e.


Transmission Properties of Human PrP 102L Prions Challenge the Relevance of Mouse Models of GSS.

Asante EA, Grimshaw A, Smidak M, Jakubcova T, Tomlinson A, Jeelani A, Hamdan S, Powell C, Joiner S, Linehan JM, Brandner S, Wadsworth JD, Collinge J.

PLoS Pathog. 2015 Jul 2;11(7):e1004953. doi: 10.1371/journal.ppat.1004953. eCollection 2015 Jul.


A naturally occurring variant of the human prion protein completely prevents prion disease.

Asante EA, Smidak M, Grimshaw A, Houghton R, Tomlinson A, Jeelani A, Jakubcova T, Hamdan S, Richard-Londt A, Linehan JM, Brandner S, Alpers M, Whitfield J, Mead S, Wadsworth JD, Collinge J.

Nature. 2015 Jun 25;522(7557):478-81. doi: 10.1038/nature14510. Epub 2015 Jun 10.


A novel and rapid method for obtaining high titre intact prion strains from mammalian brain.

Wenborn A, Terry C, Gros N, Joiner S, D'Castro L, Panico S, Sells J, Cronier S, Linehan JM, Brandner S, Saibil HR, Collinge J, Wadsworth JD.

Sci Rep. 2015 May 7;5:10062. doi: 10.1038/srep10062.


Commensal-dendritic-cell interaction specifies a unique protective skin immune signature.

Naik S, Bouladoux N, Linehan JL, Han SJ, Harrison OJ, Wilhelm C, Conlan S, Himmelfarb S, Byrd AL, Deming C, Quinones M, Brenchley JM, Kong HH, Tussiwand R, Murphy KM, Merad M, Segre JA, Belkaid Y.

Nature. 2015 Apr 2;520(7545):104-8. doi: 10.1038/nature14052. Epub 2015 Jan 5.


Homogeneous hydrogenation of CO₂ to methyl formate utilizing switchable ionic liquids.

Yadav M, Linehan JC, Karkamkar AJ, van der Eide E, Heldebrant DJ.

Inorg Chem. 2014 Sep 15;53(18):9849-54. doi: 10.1021/ic501378w. Epub 2014 Aug 29.


N-terminal domain of prion protein directs its oligomeric association.

Trevitt CR, Hosszu LL, Batchelor M, Panico S, Terry C, Nicoll AJ, Risse E, Taylor WA, Sandberg MK, Al-Doujaily H, Linehan JM, Saibil HR, Scott DJ, Collinge J, Waltho JP, Clarke AR.

J Biol Chem. 2014 Sep 12;289(37):25497-508. doi: 10.1074/jbc.M114.566588. Epub 2014 Jul 29.


Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked.

Sandberg MK, Al-Doujaily H, Sharps B, De Oliveira MW, Schmidt C, Richard-Londt A, Lyall S, Linehan JM, Brandner S, Wadsworth JD, Clarke AR, Collinge J.

Nat Commun. 2014 Jul 9;5:4347. doi: 10.1038/ncomms5347.


Beyond the active site: the impact of the outer coordination sphere on electrocatalysts for hydrogen production and oxidation.

Ginovska-Pangovska B, Dutta A, Reback ML, Linehan JC, Shaw WJ.

Acc Chem Res. 2014 Aug 19;47(8):2621-30. doi: 10.1021/ar5001742. Epub 2014 Jun 19.


Removing T-cell epitopes with computational protein design.

King C, Garza EN, Mazor R, Linehan JL, Pastan I, Pepper M, Baker D.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8577-82. doi: 10.1073/pnas.1321126111. Epub 2014 May 19.


Peripheral administration of a humanized anti-PrP antibody blocks Alzheimer's disease Aβ synaptotoxicity.

Klyubin I, Nicoll AJ, Khalili-Shirazi A, Farmer M, Canning S, Mably A, Linehan J, Brown A, Wakeling M, Brandner S, Walsh DM, Rowan MJ, Collinge J.

J Neurosci. 2014 Apr 30;34(18):6140-5. doi: 10.1523/JNEUROSCI.3526-13.2014.


Focused specificity of intestinal TH17 cells towards commensal bacterial antigens.

Yang Y, Torchinsky MB, Gobert M, Xiong H, Xu M, Linehan JL, Alonzo F, Ng C, Chen A, Lin X, Sczesnak A, Liao JJ, Torres VJ, Jenkins MK, Lafaille JJ, Littman DR.

Nature. 2014 Jun 5;510(7503):152-6. doi: 10.1038/nature13279. Epub 2014 Apr 13.


Intermediate-term oncologic outcomes of robot-assisted radical cystectomy for urothelial carcinoma.

Yuh B, Torrey RR, Ruel NH, Wittig K, Tobis S, Linehan J, Lau CS, Chan KG, Yamzon J, Wilson TG.

J Endourol. 2014 Aug;28(8):939-45. doi: 10.1089/end.2014.0073. Epub 2014 Apr 16.


Variant Creutzfeldt-Jakob disease with extremely low lymphoreticular deposition of prion protein.

Mead S, Wadsworth JD, Porter MC, Linehan JM, Pietkiewicz W, Jackson GS, Brandner S, Collinge J.

JAMA Neurol. 2014 Mar;71(3):340-3. doi: 10.1001/jamaneurol.2013.5378.


Filamentous white matter prion protein deposition is a distinctive feature of multiple inherited prion diseases.

Reiniger L, Mirabile I, Lukic A, Wadsworth JD, Linehan JM, Groves M, Lowe J, Druyeh R, Rudge P, Collinge J, Mead S, Brandner S.

Acta Neuropathol Commun. 2013 May 9;1:8. doi: 10.1186/2051-5960-1-8.


A novel prion disease associated with diarrhea and autonomic neuropathy.

Mead S, Gandhi S, Beck J, Caine D, Gallujipali D, Carswell C, Hyare H, Joiner S, Ayling H, Lashley T, Linehan JM, Al-Doujaily H, Sharps B, Revesz T, Sandberg MK, Reilly MM, Koltzenburg M, Forbes A, Rudge P, Brandner S, Warren JD, Wadsworth JDF, Wood NW, Holton JL, Collinge J.

N Engl J Med. 2013 Nov 14;369(20):1904-14. doi: 10.1056/NEJMoa1214747. Erratum in: N Engl J Med. 2014 Jan 9;370(2):188. Gallujipali, Dillip [corrected to Gajulapalli, Dilip].


Atypical scrapie prions from sheep and lack of disease in transgenic mice overexpressing human prion protein.

Wadsworth JD, Joiner S, Linehan JM, Balkema-Buschmann A, Spiropoulos J, Simmons MM, Griffiths PC, Groschup MH, Hope J, Brandner S, Asante EA, Collinge J.

Emerg Infect Dis. 2013 Nov;19(11):1731-9. doi: 10.3201/eid1911.121341.


Prevalent abnormal prion protein in human appendixes after bovine spongiform encephalopathy epizootic: large scale survey.

Gill ON, Spencer Y, Richard-Loendt A, Kelly C, Dabaghian R, Boyes L, Linehan J, Simmons M, Webb P, Bellerby P, Andrews N, Hilton DA, Ironside JW, Beck J, Poulter M, Mead S, Brandner S.

BMJ. 2013 Oct 15;347:f5675. doi: 10.1136/bmj.f5675.


Cutting edge: type 1 diabetes occurs despite robust anergy among endogenous insulin-specific CD4 T cells in NOD mice.

Pauken KE, Linehan JL, Spanier JA, Sahli NL, Kalekar LA, Binstadt BA, Moon JJ, Mueller DL, Jenkins MK, Fife BT.

J Immunol. 2013 Nov 15;191(10):4913-7. doi: 10.4049/jimmunol.1301927. Epub 2013 Oct 11.


Early and late complications of robot-assisted radical cystectomy: a standardized analysis by urinary diversion type.

Nazmy M, Yuh B, Kawachi M, Lau CS, Linehan J, Ruel NH, Torrey RR, Yamzon J, Wilson TG, Chan KG.

J Urol. 2014 Mar;191(3):681-7. doi: 10.1016/j.juro.2013.10.022. Epub 2013 Oct 4.


Inherited prion disease A117V is not simply a proteinopathy but produces prions transmissible to transgenic mice expressing homologous prion protein.

Asante EA, Linehan JM, Smidak M, Tomlinson A, Grimshaw A, Jeelani A, Jakubcova T, Hamdan S, Powell C, Brandner S, Wadsworth JD, Collinge J.

PLoS Pathog. 2013;9(9):e1003643. doi: 10.1371/journal.ppat.1003643. Epub 2013 Sep 26.


Molecular dynamics study of the proposed proton transport pathways in [FeFe]-hydrogenase.

Ginovska-Pangovska B, Ho MH, Linehan JC, Cheng Y, Dupuis M, Raugei S, Shaw WJ.

Biochim Biophys Acta. 2014 Jan;1837(1):131-8. doi: 10.1016/j.bbabio.2013.08.004. Epub 2013 Aug 24.


Fresh frozen cadaver workshops for advanced vascular surgical training.

Jansen S, Cowie M, Linehan J, Hamdorf JM.

ANZ J Surg. 2014 Nov;84(11):877-80. doi: 10.1111/ans.12361. Epub 2013 Aug 16.


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