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Preclinical imaging using single track location shear wave elastography: monitoring the progression of murine pancreatic tumor liver metastasis in vivo.

Ahmed R, Ye J, Gerber SA, Linehan DC, Doyley MM.

IEEE Trans Med Imaging. 2020 Feb 3. doi: 10.1109/TMI.2020.2971422. [Epub ahead of print]


Purity Independent Subtyping of Tumors (PurIST), A Clinically Robust, Single-sample Classifier for Tumor Subtyping in Pancreatic Cancer.

Rashid NU, Peng XL, Jin C, Moffitt RA, Volmar KE, Belt BA, Panni RZ, Nywening TM, Herrera SG, Moore KJ, Hennessey SG, Morrison AB, Kawalerski R, Nayyar A, Chang AE, Schmidt B, Kim HJ, Linehan DC, Yeh JJ.

Clin Cancer Res. 2020 Jan 1;26(1):82-92. doi: 10.1158/1078-0432.CCR-19-1467. Epub 2019 Nov 21.


Assessing the Magnitude of Immunogenic Cell Death Following Chemotherapy and Irradiation Reveals a New Strategy to Treat Pancreatic Cancer.

Ye J, Mills BN, Zhao T, Han BJ, Murphy JD, Patel AP, Johnston CJ, Lord EM, Belt BA, Linehan DC, Gerber SA.

Cancer Immunol Res. 2020 Jan;8(1):94-107. doi: 10.1158/2326-6066.CIR-19-0373. Epub 2019 Nov 12.


Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment.

Mills BN, Connolly KA, Ye J, Murphy JD, Uccello TP, Han BJ, Zhao T, Drage MG, Murthy A, Qiu H, Patel A, Figueroa NM, Johnston CJ, Prieto PA, Egilmez NK, Belt BA, Lord EM, Linehan DC, Gerber SA.

Cell Rep. 2019 Oct 8;29(2):406-421.e5. doi: 10.1016/j.celrep.2019.08.095.


Narcotic Free Cervical Endocrine Surgery: A Shift in Paradigm.

Ruffolo LI, Jackson KM, Juviler P, Kaur R, Chennell T, Glover DM, Linehan DC, Moalem J.

Ann Surg. 2019 Jul 6. doi: 10.1097/SLA.0000000000003443. [Epub ahead of print]


Phase 1b study of a small molecule antagonist of human chemokine (C-C motif) receptor 2 (PF-04136309) in combination with nab-paclitaxel/gemcitabine in first-line treatment of metastatic pancreatic ductal adenocarcinoma.

Noel M, O'Reilly EM, Wolpin BM, Ryan DP, Bullock AJ, Britten CD, Linehan DC, Belt BA, Gamelin EC, Ganguly B, Yin D, Joh T, Jacobs IA, Taylor CT, Lowery MA.

Invest New Drugs. 2019 Jul 12. doi: 10.1007/s10637-019-00830-3. [Epub ahead of print]


Recruitment of CCR2+ tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer.

Grossman JG, Nywening TM, Belt BA, Panni RZ, Krasnick BA, DeNardo DG, Hawkins WG, Goedegebuure SP, Linehan DC, Fields RC.

Oncoimmunology. 2018 Aug 1;7(9):e1470729. doi: 10.1080/2162402X.2018.1470729. eCollection 2018.


Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer.

Yurgelun MB, Chittenden AB, Morales-Oyarvide V, Rubinson DA, Dunne RF, Kozak MM, Qian ZR, Welch MW, Brais LK, Da Silva A, Bui JL, Yuan C, Li T, Li W, Masuda A, Gu M, Bullock AJ, Chang DT, Clancy TE, Linehan DC, Findeis-Hosey JJ, Doyle LA, Thorner AR, Ducar MD, Wollison BM, Khalaf N, Perez K, Syngal S, Aguirre AJ, Hahn WC, Meyerson ML, Fuchs CS, Ogino S, Hornick JL, Hezel AF, Koong AC, Nowak JA, Wolpin BM.

Genet Med. 2019 Jan;21(1):213-223. doi: 10.1038/s41436-018-0009-5. Epub 2018 Jul 2.


Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance.

Meyer MA, Baer JM, Knolhoff BL, Nywening TM, Panni RZ, Su X, Weilbaecher KN, Hawkins WG, Ma C, Fields RC, Linehan DC, Challen GA, Faccio R, Aft RL, DeNardo DG.

Nat Commun. 2018 Mar 28;9(1):1250. doi: 10.1038/s41467-018-03600-6.


Have Recent Modifications of Operating Room Attire Policies Decreased Surgical Site Infections? An American College of Surgeons NSQIP Review of 6,517 Patients.

Farach SM, Kelly KN, Farkas RL, Ruan DT, Matroniano A, Linehan DC, Moalem J.

J Am Coll Surg. 2018 May;226(5):804-813. doi: 10.1016/j.jamcollsurg.2018.01.005. Epub 2018 Feb 28.


Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma.

Nywening TM, Belt BA, Cullinan DR, Panni RZ, Han BJ, Sanford DE, Jacobs RC, Ye J, Patel AA, Gillanders WE, Fields RC, DeNardo DG, Hawkins WG, Goedegebuure P, Linehan DC.

Gut. 2018 Jun;67(6):1112-1123. doi: 10.1136/gutjnl-2017-313738. Epub 2017 Dec 1.


Comment: Fancier and More Expensive Do Mean Better: An Argument for Computed Tomography Staging of Patients With Colorectal Liver Metastases.

Fowler KJ, Linehan DC, Menias CO.

Ann Surg Oncol. 2017 Dec;24(Suppl 3):605-606. doi: 10.1245/s10434-017-6167-x. Epub 2017 Nov 22. No abstract available.


Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma.

Qian ZR, Rubinson DA, Nowak JA, Morales-Oyarvide V, Dunne RF, Kozak MM, Welch MW, Brais LK, Da Silva A, Li T, Li W, Masuda A, Yang J, Shi Y, Gu M, Masugi Y, Bui J, Zellers CL, Yuan C, Babic A, Khalaf N, Aguirre A, Ng K, Miksad RA, Bullock AJ, Chang DT, Tseng JF, Clancy TE, Linehan DC, Findeis-Hosey JJ, Doyle LA, Thorner AR, Ducar M, Wollison B, Laing A, Hahn WC, Meyerson M, Fuchs CS, Ogino S, Hornick JL, Hezel AF, Koong AC, Wolpin BM.

JAMA Oncol. 2018 Mar 8;4(3):e173420. doi: 10.1001/jamaoncol.2017.3420. Epub 2018 Mar 8. Erratum in: JAMA Oncol. 2019 Apr 1;5(4):579.


Lymph node metastases in resected pancreatic ductal adenocarcinoma: predictors of disease recurrence and survival.

Morales-Oyarvide V, Rubinson DA, Dunne RF, Kozak MM, Bui JL, Yuan C, Qian ZR, Babic A, Da Silva A, Nowak JA, Khalaf N, Brais LK, Welch MW, Zellers CL, Ng K, Chang DT, Miksad RA, Bullock AJ, Tseng JF, Swanson RS, Clancy TE, Linehan DC, Findeis-Hosey JJ, Doyle LA, Hornick JL, Ogino S, Fuchs CS, Hezel AF, Koong AC, Wolpin BM.

Br J Cancer. 2017 Dec 5;117(12):1874-1882. doi: 10.1038/bjc.2017.349. Epub 2017 Oct 5.


Research priorities in cancer cachexia: The University of Rochester Cancer Center NCI Community Oncology Research Program Research Base Symposium on Cancer Cachexia and Sarcopenia.

Dunne RF, Mustian KM, Garcia JM, Dale W, Hayward R, Roussel B, Buschmann MM, Caan BJ, Cole CL, Fleming FJ, Chakkalakal JV, Linehan DC, Hezel AF, Mohile SG.

Curr Opin Support Palliat Care. 2017 Dec;11(4):278-286. doi: 10.1097/SPC.0000000000000301. Review.


Staging for Intrahepatic Cholangiocarcinoma: Are We Getting Close to Understanding the True Tumor Biology?

Tomiyama K, Hernandez-Alejandro R, Linehan DC.

JAMA Surg. 2017 May 17;152(5):e170108. doi: 10.1001/jamasurg.2017.0108. Epub 2017 May 17. No abstract available.


Interferon-based chemoradiation followed by gemcitabine for resected pancreatic adenocarcinoma: long-term follow-up.

Ohman KA, Liu J, Linehan DC, Tan MC, Tan BR, Fields RC, Strasberg SM, Hawkins WG.

HPB (Oxford). 2017 May;19(5):449-457. doi: 10.1016/j.hpb.2017.01.012. Epub 2017 Feb 3.


Hepatectomy for Early Hepatocellular Carcinoma: Not If, but When and How?

Hernandez-Alejandro R, Levstik MA, Linehan DC.

JAMA Surg. 2017 Mar 15;152(3):e165042. doi: 10.1001/jamasurg.2016.5042. Epub 2017 Mar 15. No abstract available.


Increasing the efficacy of radiotherapy by modulating the CCR2/CCR5 chemokine axes.

Connolly KA, Belt BA, Figueroa NM, Murthy A, Patel A, Kim M, Lord EM, Linehan DC, Gerber SA.

Oncotarget. 2016 Dec 27;7(52):86522-86535. doi: 10.18632/oncotarget.13287.


Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial.

Nywening TM, Wang-Gillam A, Sanford DE, Belt BA, Panni RZ, Cusworth BM, Toriola AT, Nieman RK, Worley LA, Yano M, Fowler KJ, Lockhart AC, Suresh R, Tan BR, Lim KH, Fields RC, Strasberg SM, Hawkins WG, DeNardo DG, Goedegebuure SP, Linehan DC.

Lancet Oncol. 2016 May;17(5):651-62. doi: 10.1016/S1470-2045(16)00078-4. Epub 2016 Apr 4.


Colorectal liver metastases: disappearing lesions in the era of Eovist hepatobiliary magnetic resonance imaging.

Owen JW, Fowler KJ, Doyle MB, Saad NE, Linehan DC, Chapman WC.

HPB (Oxford). 2016 Mar;18(3):296-303. doi: 10.1016/j.hpb.2015.10.009. Epub 2016 Mar 14.


Interaction of Postoperative Morbidity and Receipt of Adjuvant Therapy on Long-Term Survival After Resection for Gastric Adenocarcinoma: Results From the U.S. Gastric Cancer Collaborative.

Jin LX, Sanford DE, Squires MH 3rd, Moses LE, Yan Y, Poultsides GA, Votanopoulos KI, Weber SM, Bloomston M, Pawlik TM, Hawkins WG, Linehan DC, Schmidt C, Worhunsky DJ, Acher AW, Cardona K, Cho CS, Kooby DA, Levine EA, Winslow E, Saunders N, Spolverato G, Colditz GA, Maithel SK, Fields RC.

Ann Surg Oncol. 2016 Aug;23(8):2398-408. doi: 10.1245/s10434-016-5121-7. Epub 2016 Mar 22.


Wound Infections After Pancreaticoduodenectomy.

Schoeniger LO, Linehan DC.

JAMA Surg. 2016 May 1;151(5):440. doi: 10.1001/jamasurg.2015.4659. No abstract available.


Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients.

Sausen M, Phallen J, Adleff V, Jones S, Leary RJ, Barrett MT, Anagnostou V, Parpart-Li S, Murphy D, Kay Li Q, Hruban CA, Scharpf R, White JR, O'Dwyer PJ, Allen PJ, Eshleman JR, Thompson CB, Klimstra DS, Linehan DC, Maitra A, Hruban RH, Diaz LA Jr, Von Hoff DD, Johansen JS, Drebin JA, Velculescu VE.

Nat Commun. 2015 Jul 7;6:7686. doi: 10.1038/ncomms8686.


Factors Associated With Recurrence and Survival in Lymph Node-negative Gastric Adenocarcinoma: A 7-Institution Study of the US Gastric Cancer Collaborative.

Jin LX, Moses LE, Squires MH 3rd, Poultsides GA, Votanopoulos K, Weber SM, Bloomston M, Pawlik TM, Hawkins WG, Linehan DC, Strasberg SM, Schmidt C, Worhunsky DJ, Acher AW, Cardona K, Cho CS, Kooby DA, Levine E, Winslow ER, Saunders ND, Spolverato G, Maithel SK, Fields RC.

Ann Surg. 2015 Dec;262(6):999-1005. doi: 10.1097/SLA.0000000000001084.


Severe nutritional risk predicts decreased long-term survival in geriatric patients undergoing pancreaticoduodenectomy for benign disease.

Sanford DE, Sanford AM, Fields RC, Hawkins WG, Strasberg SM, Linehan DC.

J Am Coll Surg. 2014 Dec;219(6):1149-56. doi: 10.1016/j.jamcollsurg.2014.06.017. Epub 2014 Jun 30.


Association of discharge home with home health care and 30-day readmission after pancreatectomy.

Sanford DE, Olsen MA, Bommarito KM, Shah M, Fields RC, Hawkins WG, Jaques DP, Linehan DC.

J Am Coll Surg. 2014 Nov;219(5):875-86.e1. doi: 10.1016/j.jamcollsurg.2014.07.008. Epub 2014 Jul 18.


CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models.

Zhu Y, Knolhoff BL, Meyer MA, Nywening TM, West BL, Luo J, Wang-Gillam A, Goedegebuure SP, Linehan DC, DeNardo DG.

Cancer Res. 2014 Sep 15;74(18):5057-69. doi: 10.1158/0008-5472.CAN-13-3723. Epub 2014 Jul 31.


Histological features and severity of oxaliplatin-induced liver injury and clinical associations.

Nalbantoglu IL, Tan BR Jr, Linehan DC, Gao F, Brunt EM.

J Dig Dis. 2014 Oct;15(10):553-60. doi: 10.1111/1751-2980.12177.


Variations in definition and method of retrieval of complications influence outcomes statistics after pancreatoduodenectomy: comparison of NSQIP with non-NSQIP methods.

Sanford DE, Woolsey CA, Hall BL, Linehan DC, Hawkins WG, Fields RC, Strasberg SM.

J Am Coll Surg. 2014 Sep;219(3):407-15. doi: 10.1016/j.jamcollsurg.2014.01.064. Epub 2014 Apr 18.


Natural history of preoperative subcentimeter pulmonary nodules in patients with resectable pancreatic adenocarcinoma: a retrospective cohort study.

Chang ST, Nguyen DC, Raptis C, Menias CO, Zhou G, Wang-Gillam A, Linehan DC, Hawkins WG, Strasberg SM, Fields RC.

Ann Surg. 2015 May;261(5):970-5. doi: 10.1097/SLA.0000000000000719.


Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer.

Panni RZ, Sanford DE, Belt BA, Mitchem JB, Worley LA, Goetz BD, Mukherjee P, Wang-Gillam A, Link DC, Denardo DG, Goedegebuure SP, Linehan DC.

Cancer Immunol Immunother. 2014 May;63(5):513-28. doi: 10.1007/s00262-014-1527-x. Epub 2014 Mar 21.


Induction Chemotherapy Followed by Concurrent Full-dose Gemcitabine and Intensity-modulated Radiation Therapy for Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma.

Badiyan SN, Olsen JR, Lee AY, Yano M, Menias CO, Khwaja S, Wang-Gillam A, Strasberg SM, Hawkins WG, Linehan DC, Myerson RJ, Parikh PJ.

Am J Clin Oncol. 2016 Feb;39(1):1-7. doi: 10.1097/COC.0000000000000003.


Regional lymphadenectomy is indicated in the surgical treatment of pancreatic neuroendocrine tumors (PNETs).

Hashim YM, Trinkaus KM, Linehan DC, Strasberg SS, Fields RC, Cao D, Hawkins WG.

Ann Surg. 2014 Feb;259(2):197-203. doi: 10.1097/SLA.0000000000000348.


A new operative approach for type I choledochal cysts.

Jin LX, Fields RC, Hawkins WG, Linehan DC, Strasberg SM.

J Gastrointest Surg. 2014 May;18(5):1049-53. doi: 10.1007/s11605-013-2405-0. Epub 2013 Nov 13.


Down-regulation of PLCγ2-β-catenin pathway promotes activation and expansion of myeloid-derived suppressor cells in cancer.

Capietto AH, Kim S, Sanford DE, Linehan DC, Hikida M, Kumosaki T, Novack DV, Faccio R.

J Exp Med. 2013 Oct 21;210(11):2257-71. doi: 10.1084/jem.20130281. Epub 2013 Oct 14.


A Study of Zoledronic Acid as Neo-Adjuvant, Perioperative Therapy in Patients with Resectable Pancreatic Ductal Adenocarcinoma.

Sanford DE, Porembka MR, Panni RZ, Mitchem JB, Belt BA, Plambeck-Suess SM, Lin G, Denardo DG, Fields RC, Hawkins WG, Strasberg SM, Lockhart AC, Wang-Gillam A, Goedegebuure SP, Linehan DC.

J Cancer Ther. 2013 May;4(3):797-803.


Targeting tumor-infiltrating macrophages to combat cancer.

Panni RZ, Linehan DC, DeNardo DG.

Immunotherapy. 2013 Oct;5(10):1075-87. doi: 10.2217/imt.13.102. Review.


Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis.

Sanford DE, Belt BA, Panni RZ, Mayer A, Deshpande AD, Carpenter D, Mitchem JB, Plambeck-Suess SM, Worley LA, Goetz BD, Wang-Gillam A, Eberlein TJ, Denardo DG, Goedegebuure SP, Linehan DC.

Clin Cancer Res. 2013 Jul 1;19(13):3404-15. doi: 10.1158/1078-0432.CCR-13-0525. Epub 2013 May 7.


Jaundice: an important, poorly recognized risk factor for diminished survival in patients with adenocarcinoma of the head of the pancreas.

Strasberg SM, Gao F, Sanford D, Linehan DC, Hawkins WG, Fields R, Carpenter DH, Brunt EM, Phillips C.

HPB (Oxford). 2014 Feb;16(2):150-6. doi: 10.1111/hpb.12094. Epub 2013 Apr 22.


Cost benefit analysis of mesh reinforcement of stapled left pancreatectomy.

Idrees K, Edler JR, Linehan DC, Strasberg SM, Jacques D, Hamilton NA, Fields RC, Lambert D, Kymes S, Hawkins WG.

HPB (Oxford). 2013 Nov;15(11):893-8. doi: 10.1111/hpb.12055. Epub 2013 Feb 20.


Tumor-infiltrating macrophages, cancer stem cells and therapeutic responses.

Panni RZ, Linehan DC, Denardo DG.

Oncotarget. 2012 Dec;3(12):1497-8. No abstract available.


Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses.

Mitchem JB, Brennan DJ, Knolhoff BL, Belt BA, Zhu Y, Sanford DE, Belaygorod L, Carpenter D, Collins L, Piwnica-Worms D, Hewitt S, Udupi GM, Gallagher WM, Wegner C, West BL, Wang-Gillam A, Goedegebuure P, Linehan DC, DeNardo DG.

Cancer Res. 2013 Feb 1;73(3):1128-41. doi: 10.1158/0008-5472.CAN-12-2731. Epub 2012 Dec 5.


Colorectal liver metastases: state of the art imaging.

Fowler KJ, Linehan DC, Menias CO.

Ann Surg Oncol. 2013 Apr;20(4):1185-93. doi: 10.1245/s10434-012-2730-7. Epub 2012 Nov 1. Review.


Microscopic margins and patterns of treatment failure in resected pancreatic adenocarcinoma.

Gnerlich JL, Luka SR, Deshpande AD, Dubray BJ, Weir JS, Carpenter DH, Brunt EM, Strasberg SM, Hawkins WG, Linehan DC.

Arch Surg. 2012 Aug;147(8):753-60. doi: 10.1001/archsurg.2012.1126.


Mesh reinforcement of pancreatic transection decreases incidence of pancreatic occlusion failure for left pancreatectomy: a single-blinded, randomized controlled trial.

Hamilton NA, Porembka MR, Johnston FM, Gao F, Strasberg SM, Linehan DC, Hawkins WG.

Ann Surg. 2012 Jun;255(6):1037-42. doi: 10.1097/SLA.0b013e31825659ef.


Ki-67 predicts disease recurrence and poor prognosis in pancreatic neuroendocrine neoplasms.

Hamilton NA, Liu TC, Cavatiao A, Mawad K, Chen L, Strasberg SS, Linehan DC, Cao D, Hawkins WG.

Surgery. 2012 Jul;152(1):107-13. doi: 10.1016/j.surg.2012.02.011. Epub 2012 Apr 11.


Resection of tumors of the neck of the pancreas with venous invasion: the "Whipple at the Splenic Artery (WATSA)" procedure.

Strasberg SM, Sanchez LA, Hawkins WG, Fields RC, Linehan DC.

J Gastrointest Surg. 2012 May;16(5):1048-54. doi: 10.1007/s11605-012-1841-6. Epub 2012 Mar 8.


The right way to do a Whipple procedure: comment on "Stenting and the rate of pancreatic fistula following pancreaticoduodenectomy".

Linehan DC.

Arch Surg. 2012 Jan;147(1):41. doi: 10.1001/archsurg.2011.1016. No abstract available.


Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth.

Porembka MR, Mitchem JB, Belt BA, Hsieh CS, Lee HM, Herndon J, Gillanders WE, Linehan DC, Goedegebuure P.

Cancer Immunol Immunother. 2012 Sep;61(9):1373-85. doi: 10.1007/s00262-011-1178-0. Epub 2012 Jan 4.

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