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Items: 35

1.

The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans.

May PC, Willis BA, Lowe SL, Dean RA, Monk SA, Cocke PJ, Audia JE, Boggs LN, Borders AR, Brier RA, Calligaro DO, Day TA, Ereshefsky L, Erickson JA, Gevorkyan H, Gonzales CR, James DE, Jhee SS, Komjathy SF, Li L, Lindstrom TD, Mathes BM, Martényi F, Sheehan SM, Stout SL, Timm DE, Vaught GM, Watson BM, Winneroski LL, Yang Z, Mergott DJ.

J Neurosci. 2015 Jan 21;35(3):1199-210. doi: 10.1523/JNEUROSCI.4129-14.2015.

2.

Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor.

May PC, Dean RA, Lowe SL, Martenyi F, Sheehan SM, Boggs LN, Monk SA, Mathes BM, Mergott DJ, Watson BM, Stout SL, Timm DE, Smith Labell E, Gonzales CR, Nakano M, Jhee SS, Yen M, Ereshefsky L, Lindstrom TD, Calligaro DO, Cocke PJ, Greg Hall D, Friedrich S, Citron M, Audia JE.

J Neurosci. 2011 Nov 16;31(46):16507-16. doi: 10.1523/JNEUROSCI.3647-11.2011.

3.

High-precision dosimetry for radiotherapy using the optically stimulated luminescence technique and thin Al2O3:C dosimeters.

Yukihara EG, Yoshimura EM, Lindstrom TD, Ahmad S, Taylor KK, Mardirossian G.

Phys Med Biol. 2005 Dec 7;50(23):5619-28. Epub 2005 Nov 16.

PMID:
16306656
4.

Synthesis and biological evaluation of an orally active ghrelin agonist that stimulates food consumption and adiposity in rats.

Lugar CW, Clay MP, Lindstrom TD, Woodson AL, Smiley D, Heiman ML, Dodge JA.

Bioorg Med Chem Lett. 2004 Dec 6;14(23):5873-6.

PMID:
15501059
5.

Substituted 3-imidazo[1,2-a]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino-[6,7,1-hi]indol-7-yl)pyrrole-2,5-diones as highly selective and potent inhibitors of glycogen synthase kinase-3.

Engler TA, Henry JR, Malhotra S, Cunningham B, Furness K, Brozinick J, Burkholder TP, Clay MP, Clayton J, Diefenbacher C, Hawkins E, Iversen PW, Li Y, Lindstrom TD, Marquart AL, McLean J, Mendel D, Misener E, Briere D, O'Toole JC, Porter WJ, Queener S, Reel JK, Owens RA, Brier RA, Eessalu TE, Wagner JR, Campbell RM, Vaughn R.

J Med Chem. 2004 Jul 29;47(16):3934-7.

PMID:
15267232
6.

Synthesis and structure-activity relationships of novel arylpiperazines as potent and selective agonists of the melanocortin subtype-4 receptor.

Richardson TI, Ornstein PL, Briner K, Fisher MJ, Backer RT, Biggers CK, Clay MP, Emmerson PJ, Hertel LW, Hsiung HM, Husain S, Kahl SD, Lee JA, Lindstrom TD, Martinelli MJ, Mayer JP, Mullaney JT, O'Brien TP, Pawlak JM, Revell KD, Shah J, Zgombick JM, Herr RJ, Melekhov A, Sampson PB, King CH.

J Med Chem. 2004 Jan 29;47(3):744-55.

PMID:
14736255
7.

Fused bicyclic Gly-Asp beta-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere.

Fisher MJ, Giese U, Harms CS, Kinnick MD, Lindstrom TD, McCowan JR, Mest HJ, Morin JM Jr, Mullaney JT, Paal M, Rapp A, Rühter G, Ruterbories KJ, Sall DJ, Scarborough RM, Schotten T, Stenzel W, Towner RD, Um SL, Utterback BG, Wyss VL, Jakubowski JA.

Bioorg Med Chem Lett. 2000 Feb 21;10(4):385-9.

PMID:
10714506
8.

Fused bicyclic Gly-Asp beta-turn mimics with specific affinity for GPIIb-IIIa.

Fisher MJ, Arfstan AE, Giese U, Gunn BP, Harms CS, Khau V, Kinnick MD, Lindstrom TD, Martinelli MJ, Mest HJ, Mohr M, Morin JM Jr, Mullaney JT, Nunes A, Paal M, Rapp A, Rühter G, Ruterbories KJ, Sall DJ, Scarborough RM, Schotten T, Sommer B, Stenzel W, Towner RD, Um SL, et al.

J Med Chem. 1999 Nov 18;42(23):4875-89.

PMID:
10579850
9.

Application of oral bioavailability surrogates in the design of orally active inhibitors of rhinovirus replication.

Stratford RE Jr, Clay MP, Heinz BA, Kuhfeld MT, Osborne SJ, Phillips DL, Sweetana SA, Tebbe MJ, Vasudevan V, Zornes LL, Lindstrom TD.

J Pharm Sci. 1999 Aug;88(8):747-53.

PMID:
10430536
10.
11.

In vitro biotransformation and identification of human cytochrome P450 isozyme-dependent metabolism of tazofelone.

Surapaneni SS, Clay MP, Spangle LA, Paschal JW, Lindstrom TD.

Drug Metab Dispos. 1997 Dec;25(12):1383-8.

PMID:
9394028
12.

Benzylamine antioxidants: relationship between structure, peroxyl radical scavenging, lipid peroxidation inhibition, and cytoprotection.

Yu MJ, McCowan JR, Phebus LA, Towner RD, Ho PP, Keith PT, Luttman CA, Saunders RD, Ruterbories KJ, Lindstrom TD, et al.

J Med Chem. 1993 Apr 30;36(9):1262-71.

PMID:
8487263
13.

Chemoimmunoconjugate development for ovarian carcinoma therapy: preclinical studies with vinca alkaloid-monoclonal antibody constructs.

Apelgren LD, Bailey DL, Briggs SL, Barton RL, Guttman-Carlisle D, Koppel GA, Nichols CL, Scott WL, Lindstrom TD, Baker AL, et al.

Bioconjug Chem. 1993 Mar-Apr;4(2):121-6.

PMID:
7873643
14.

Cytochrome P-450 complex formation by dirithromycin and other macrolides in rat and human livers.

Lindstrom TD, Hanssen BR, Wrighton SA.

Antimicrob Agents Chemother. 1993 Feb;37(2):265-9.

15.

Inhibition of granulocyte cAMP-phosphodiesterase by rolipram in vivo is not sufficient to protect the canine myocardium from reperfusion injury.

Simpson PJ, Schelm JA, Smallwood JK, Clay MP, Lindstrom TD.

J Cardiovasc Pharmacol. 1992 Jun;19(6):987-95.

PMID:
1376823
16.

Correlation of anti-inflammatory activity with peak tissue rather than peak plasma levels of BF389.

Bendele AM, Ruterbories KJ, Spaethe SM, Benslay DN, Lindstrom TD, Lee SJ, Naismith RW.

J Pharmacol Exp Ther. 1992 Mar;260(3):1194-8.

PMID:
1545387
17.

Anti-inflammatory activity of BF389, a Di-T-butylphenol, in animal models of arthritis.

Bendele AM, Benslay DN, Hom JT, Spaethe SM, Ruterbories KJ, Lindstrom TD, Lee SJ, Naismith RW.

J Pharmacol Exp Ther. 1992 Jan;260(1):300-5.

PMID:
1309875
18.

Effects of hepatic ischemia-reperfusion injury on the hepatic mixed function oxidase system in rats.

Lindstrom TD, Hanssen BR, Bendele AM.

Mol Pharmacol. 1990 Dec;38(6):829-35.

PMID:
2250663
19.
20.

Pharmacokinetics and disposition of the KS1/4 monoclonal antibody-desacetylvinblastine hydrazide conjugate LY203725 in rats and monkeys.

Lindstrom TD, Althaus WA, Ruterbories KJ, Kau D.

J Pharmacol Exp Ther. 1990 Mar;252(3):1117-24.

PMID:
2319463
21.

Discovery and development of a novel class of nonsteroidal aromatase inhibitors.

Hirsch KS, Jones CD, Lindstrom TD, Stamm NB, Sutton GP, Taylor HM, Weaver DE.

Steroids. 1987 Jul-Sep;50(1-3):201-17.

PMID:
3504060
22.

Inhibition of microsomal biotransformation by a series of nitrogen and oxygen heterocyclic histamine H2-antagonists.

Lindstrom TD, Whitaker GW, Pioch RP.

Biochem Pharmacol. 1987 May 15;36(10):1669-72.

PMID:
2885000
23.
24.
25.

Disposition and metabolism of a new benzothiophene antiestrogen in rats, dogs and monkeys.

Lindstrom TD, Whitaker NG, Whitaker GW.

Xenobiotica. 1984 Nov;14(11):841-7.

PMID:
6506756
26.

Metabolism of the antiarrhythmic agent, indecainide, in rats, dogs, and monkeys.

Lindstrom TD, Lacefield WB, Whitaker GW.

Drug Metab Dispos. 1984 Nov-Dec;12(6):691-7.

PMID:
6150817
27.

The pharmacokinetics of indecainide in mice, rats, dogs, and monkeys.

Lindstrom TD, Whitaker GW.

Drug Metab Dispos. 1984 Nov-Dec;12(6):683-90.

PMID:
6150816
28.

Studies on cytochrome P-450-dependent lipid hydroperoxide reduction.

Lindstrom TD, Aust SD.

Arch Biochem Biophys. 1984 Aug 15;233(1):80-7.

PMID:
6431911
29.
30.

Alpha, beta-ketoalkene reduction. A novel reduction pathway in mammalian tissues.

Lindstrom TD, Whitaker GW.

Drug Metab Dispos. 1984 Jan-Feb;12(1):72-6.

PMID:
6141916
31.
32.

Correlation between the disposition of [14C]clofilium and its cardiac electrophysiological effect.

Lindstrom TD, Murphy PJ, Smallwood JK, Wiest SA, Steinberg MI.

J Pharmacol Exp Ther. 1982 Jun;221(3):584-9.

PMID:
7086672
34.

Effect of phenobarbital and diethyl maleate on carbon tetrachloride toxicity in isolated rat hepatocytes.

Lindstrom TD, Anders MW, Remmer H.

Exp Mol Pathol. 1978 Feb;28(1):48-57. No abstract available.

PMID:
620759
35.

Effect of cycloheximide and actinomycin D on carbon tetrachloride hepatotoxicity.

Lindstrom TD, Anders MW.

Toxicol Appl Pharmacol. 1977 Oct;42(1):167-73. No abstract available.

PMID:
929600

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