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Dynamic evaluation of the immune infiltrate and immune function genes as predictive markers for neoadjuvant chemotherapy in hormone receptor positive, HER2 negative breast cancer.

Matikas A, Lövrot J, Ramberg A, Eriksson M, Lindsten T, Lekberg T, Hedenfalk I, Loman N, Bergh J, Hatschek T, Erlandsson A, Foukakis T.

Oncoimmunology. 2018 Jul 26;7(9):e1466017. doi: 10.1080/2162402X.2018.1466017. eCollection 2018.


Effect of macrophages on breast cancer cell proliferation, and on expression of hormone receptors, uPAR and HER-2.

Lindsten T, Hedbrant A, Ramberg A, Wijkander J, Solterbeck A, Eriksson M, Delbro D, Erlandsson A.

Int J Oncol. 2017 Jul;51(1):104-114. doi: 10.3892/ijo.2017.3996. Epub 2017 May 11.


The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis.

Joo JH, Wang B, Frankel E, Ge L, Xu L, Iyengar R, Li-Harms X, Wright C, Shaw TI, Lindsten T, Green DR, Peng J, Hendershot LM, Kilic F, Sze JY, Audhya A, Kundu M.

Mol Cell. 2016 Jun 16;62(6):982. doi: 10.1016/j.molcel.2016.05.030. Epub 2016 Jun 16. No abstract available.


The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis.

Joo JH, Wang B, Frankel E, Ge L, Xu L, Iyengar R, Li-Harms X, Wright C, Shaw TI, Lindsten T, Green DR, Peng J, Hendershot LM, Kilic F, Sze JY, Audhya A, Kundu M.

Mol Cell. 2016 May 19;62(4):491-506. doi: 10.1016/j.molcel.2016.04.020. Erratum in: Mol Cell. 2016 Jun 16;62(6):982.


GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.

Ye J, Palm W, Peng M, King B, Lindsten T, Li MO, Koumenis C, Thompson CB.

Genes Dev. 2015 Nov 15;29(22):2331-6. doi: 10.1101/gad.269324.115. Epub 2015 Nov 5.


In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA.

La Rocca G, Olejniczak SH, González AJ, Briskin D, Vidigal JA, Spraggon L, DeMatteo RG, Radler MR, Lindsten T, Ventura A, Tuschl T, Leslie CS, Thompson CB.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):767-72. doi: 10.1073/pnas.1424217112. Epub 2015 Jan 7.


Serine catabolism regulates mitochondrial redox control during hypoxia.

Ye J, Fan J, Venneti S, Wan YW, Pawel BR, Zhang J, Finley LW, Lu C, Lindsten T, Cross JR, Qing G, Liu Z, Simon MC, Rabinowitz JD, Thompson CB.

Cancer Discov. 2014 Dec;4(12):1406-17. doi: 10.1158/2159-8290.CD-14-0250. Epub 2014 Sep 3.


Analysis of a lung defect in autophagy-deficient mouse strains.

Cheong H, Wu J, Gonzales LK, Guttentag SH, Thompson CB, Lindsten T.

Autophagy. 2014 Jan;10(1):45-56. doi: 10.4161/auto.26505. Epub 2013 Nov 11.


Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia.

Karar J, Cerniglia GJ, Lindsten T, Koumenis C, Maity A.

Cancer Biol Ther. 2012 Sep;13(11):1102-11. doi: 10.4161/cbt.21144. Epub 2012 Aug 16.


Therapeutic targets in cancer cell metabolism and autophagy.

Cheong H, Lu C, Lindsten T, Thompson CB.

Nat Biotechnol. 2012 Jul 10;30(7):671-8. doi: 10.1038/nbt.2285. Review.


Bax regulates primary necrosis through mitochondrial dynamics.

Whelan RS, Konstantinidis K, Wei AC, Chen Y, Reyna DE, Jha S, Yang Y, Calvert JW, Lindsten T, Thompson CB, Crow MT, Gavathiotis E, Dorn GW 2nd, O'Rourke B, Kitsis RN.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6566-71. doi: 10.1073/pnas.1201608109. Epub 2012 Apr 9.


Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.

Tai X, Van Laethem F, Pobezinsky L, Guinter T, Sharrow SO, Adams A, Granger L, Kruhlak M, Lindsten T, Thompson CB, Feigenbaum L, Singer A.

Blood. 2012 May 31;119(22):5155-63. doi: 10.1182/blood-2011-11-388918. Epub 2012 Mar 7.


The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation.

Gordon SM, Chaix J, Rupp LJ, Wu J, Madera S, Sun JC, Lindsten T, Reiner SL.

Immunity. 2012 Jan 27;36(1):55-67. doi: 10.1016/j.immuni.2011.11.016. Epub 2012 Jan 18.


Autophagy and ammonia.

Cheong H, Lindsten T, Thompson CB.

Autophagy. 2012 Jan;8(1):122-3. doi: 10.4161/auto.8.1.18078. Epub 2012 Jan 1.


Ammonia-induced autophagy is independent of ULK1/ULK2 kinases.

Cheong H, Lindsten T, Wu J, Lu C, Thompson CB.

Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11121-6. doi: 10.1073/pnas.1107969108. Epub 2011 Jun 20. Erratum in: Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17856.


Cutting edge: Lymphoproliferation caused by Fas deficiency is dependent on the transcription factor eomesodermin.

Kinjyo I, Gordon SM, Intlekofer AM, Dowdell K, Mooney EC, Caricchio R, Grupp SA, Teachey DT, Rao VK, Lindsten T, Reiner SL.

J Immunol. 2010 Dec 15;185(12):7151-5. doi: 10.4049/jimmunol.1003193. Epub 2010 Nov 12.


Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche.

Banerjee A, Gordon SM, Intlekofer AM, Paley MA, Mooney EC, Lindsten T, Wherry EJ, Reiner SL.

J Immunol. 2010 Nov 1;185(9):4988-92. doi: 10.4049/jimmunol.1002042. Epub 2010 Oct 8.


CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL. Immunity. 1995. 3: 87-98.

Boise LH, Minn AJ, Noel PJ, June CH, Accavitti MA, Lindsten T, Thompson CB.

J Immunol. 2010 Oct 1;185(7):3788-99. No abstract available.


Maintenance of the relative proportion of oligodendrocytes to axons even in the absence of BAX and BAK.

Kawai K, Itoh T, Itoh A, Horiuchi M, Wakayama K, Bannerman P, Garbern JY, Pleasure D, Lindsten T.

Eur J Neurosci. 2009 Dec 3;30(11):2030-41. doi: 10.1111/j.1460-9568.2009.06988.x. Epub 2009 Nov 25.


Differing in vitro survival dependency of mouse and rat NG2+ oligodendroglial progenitor cells.

Horiuchi M, Lindsten T, Pleasure D, Itoh T.

J Neurosci Res. 2010 Apr;88(5):957-70. doi: 10.1002/jnr.22262.


Alpha4 is an essential regulator of PP2A phosphatase activity.

Kong M, Ditsworth D, Lindsten T, Thompson CB.

Mol Cell. 2009 Oct 9;36(1):51-60. doi: 10.1016/j.molcel.2009.09.025.


Rapid pathogen-induced apoptosis: a mechanism used by dendritic cells to limit intracellular replication of Legionella pneumophila.

Nogueira CV, Lindsten T, Jamieson AM, Case CL, Shin S, Thompson CB, Roy CR.

PLoS Pathog. 2009 Jun;5(6):e1000478. doi: 10.1371/journal.ppat.1000478. Epub 2009 Jun 12.


Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin.

Intlekofer AM, Banerjee A, Takemoto N, Gordon SM, Dejong CS, Shin H, Hunter CA, Wherry EJ, Lindsten T, Reiner SL.

Science. 2008 Jul 18;321(5887):408-11. doi: 10.1126/science.1159806.


The role of cell death in sexually dimorphic muscle development: male-specific muscles are retained in female bax/bak knockout mice.

Jacob DA, Ray T, Bengston CL, Lindsten T, Wu J, Thompson CB, Forger NG.

Dev Neurobiol. 2008 Sep 15;68(11):1303-14. doi: 10.1002/dneu.20658.


Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation.

Kundu M, Lindsten T, Yang CY, Wu J, Zhao F, Zhang J, Selak MA, Ney PA, Thompson CB.

Blood. 2008 Aug 15;112(4):1493-502. doi: 10.1182/blood-2008-02-137398. Epub 2008 Jun 6.


The PP2A-associated protein alpha4 plays a critical role in the regulation of cell spreading and migration.

Kong M, Bui TV, Ditsworth D, Gruber JJ, Goncharov D, Krymskaya VP, Lindsten T, Thompson CB.

J Biol Chem. 2007 Oct 5;282(40):29712-20. Epub 2007 Aug 10.


The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis.

Jones RG, Bui T, White C, Madesh M, Krawczyk CM, Lindsten T, Hawkins BJ, Kubek S, Frauwirth KA, Wang YL, Conway SJ, Roderick HL, Bootman MD, Shen H, Foskett JK, Thompson CB.

Immunity. 2007 Aug;27(2):268-80. Epub 2007 Aug 9.


How do cancer cells acquire the fuel needed to support cell growth?

Thompson CB, Bauer DE, Lum JJ, Hatzivassiliou G, Zong WX, Zhao F, Ditsworth D, Buzzai M, Lindsten T.

Cold Spring Harb Symp Quant Biol. 2005;70:357-62.


Cell death in the absence of Bax and Bak.

Lindsten T, Thompson CB.

Cell Death Differ. 2006 Aug;13(8):1272-6. Epub 2006 May 5. No abstract available.


Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin.

Intlekofer AM, Takemoto N, Wherry EJ, Longworth SA, Northrup JT, Palanivel VR, Mullen AC, Gasink CR, Kaech SM, Miller JD, Gapin L, Ryan K, Russ AP, Lindsten T, Orange JS, Goldrath AW, Ahmed R, Reiner SL.

Nat Immunol. 2005 Dec;6(12):1236-44. Epub 2005 Nov 6. Erratum in: Nat Immunol. 2006 Jan;7(1):113.


Persistent fetal ocular vasculature in mice deficient in bax and bak.

Hahn P, Lindsten T, Tolentino M, Thompson CB, Bennett J, Dunaief JL.

Arch Ophthalmol. 2005 Jun;123(6):797-802.


Growth factor regulation of autophagy and cell survival in the absence of apoptosis.

Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T, Thompson CB.

Cell. 2005 Jan 28;120(2):237-48.


Defining the role of the Bcl-2 family of proteins in the nervous system.

Lindsten T, Zong WX, Thompson CB.

Neuroscientist. 2005 Feb;11(1):10-5. Review.


Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation.

Hammerman PS, Fox CJ, Cinalli RM, Xu A, Wagner JD, Lindsten T, Thompson CB.

Cancer Res. 2004 Nov 15;64(22):8341-8.


The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis.

Kong M, Fox CJ, Mu J, Solt L, Xu A, Cinalli RM, Birnbaum MJ, Lindsten T, Thompson CB.

Science. 2004 Oct 22;306(5696):695-8.


Deficiency of Bax and Bak protects photoreceptors from light damage in vivo.

Hahn P, Lindsten T, Lyubarsky A, Ying GS, Pugh EN Jr, Thompson CB, Dunaief JL.

Cell Death Differ. 2004 Nov;11(11):1192-7.


The proapoptotic activities of Bax and Bak limit the size of the neural stem cell pool.

Lindsten T, Golden JA, Zong WX, Minarcik J, Harris MH, Thompson CB.

J Neurosci. 2003 Dec 3;23(35):11112-9.


Control of effector CD8+ T cell function by the transcription factor Eomesodermin.

Pearce EL, Mullen AC, Martins GA, Krawczyk CM, Hutchins AS, Zediak VP, Banica M, DiCioccio CB, Gross DA, Mao CA, Shen H, Cereb N, Yang SY, Lindsten T, Rossant J, Hunter CA, Reiner SL.

Science. 2003 Nov 7;302(5647):1041-3.


Caspase regulation of genotoxin-induced neural precursor cell death.

D'Sa C, Klocke BJ, Cecconi F, Lindsten T, Thompson CB, Korsmeyer SJ, Flavell RA, Roth KA.

J Neurosci Res. 2003 Nov 1;74(3):435-45.


Proapoptotic bcl-2 family members, Bax and Bak, are essential for developmental photoreceptor apoptosis.

Hahn P, Lindsten T, Ying GS, Bennett J, Milam AH, Thompson CB, Dunaief JL.

Invest Ophthalmol Vis Sci. 2003 Aug;44(8):3598-605.


Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis.

Zong WX, Li C, Hatzivassiliou G, Lindsten T, Yu QC, Yuan J, Thompson CB.

J Cell Biol. 2003 Jul 7;162(1):59-69.


The proapoptotic proteins Bax and Bak are not involved in Wallerian degeneration.

Whitmore AV, Lindsten T, Raff MC, Thompson CB.

Cell Death Differ. 2003 Feb;10(2):260-1. No abstract available.


BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal development.

Fannjiang Y, Kim CH, Huganir RL, Zou S, Lindsten T, Thompson CB, Mito T, Traystman RJ, Larsen T, Griffin DE, Mandir AS, Dawson TM, Dike S, Sappington AL, Kerr DA, Jonas EA, Kaczmarek LK, Hardwick JM.

Dev Cell. 2003 Apr;4(4):575-85.


Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.

Rathmell JC, Lindsten T, Zong WX, Cinalli RM, Thompson CB.

Nat Immunol. 2002 Oct;3(10):932-9. Epub 2002 Sep 3.


BAX and BAK mediate p53-independent suppression of tumorigenesis.

Degenhardt K, Chen G, Lindsten T, White E.

Cancer Cell. 2002 Sep;2(3):193-203.


Bax and Bak independently promote cytochrome C release from mitochondria.

Degenhardt K, Sundararajan R, Lindsten T, Thompson C, White E.

J Biol Chem. 2002 Apr 19;277(16):14127-34. Epub 2002 Feb 8.


BCLW mediates survival of postmitotic Sertoli cells by regulating BAX activity.

Ross AJ, Amy SP, Mahar PL, Lindsten T, Knudson CM, Thompson CB, Korsmeyer SJ, MacGregor GR.

Dev Biol. 2001 Nov 15;239(2):295-308.


BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis.

Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lindsten T, Korsmeyer SJ.

Mol Cell. 2001 Sep;8(3):705-11.


BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak.

Zong WX, Lindsten T, Ross AJ, MacGregor GR, Thompson CB.

Genes Dev. 2001 Jun 15;15(12):1481-6.

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