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[Multiple Sclerosis: Neurorehabilitation and Symptomatic Treatment].

Sailer M, Lindquist S, Sickert A, Lamprecht J.

Rehabilitation (Stuttg). 2019 Oct;58(5):339-350. doi: 10.1055/a-0755-1398. Epub 2019 Oct 23. German.


Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation.

Jaeger AM, Stopfer L, Lee S, Gaglia G, Sandel D, Santagata S, Lin NU, Trepel JB, White F, Jacks T, Lindquist S, Whitesell L.

Clin Cancer Res. 2019 Nov 1;25(21):6392-6405. doi: 10.1158/1078-0432.CCR-19-0596. Epub 2019 Jun 18.


Author Correction: Mitochondrial metabolism promotes adaptation to proteotoxic stress.

Tsvetkov P, Detappe A, Cai K, Keys HR, Brune Z, Ying W, Thiru P, Reidy M, Kugener G, Rossen J, Kocak M, Kory N, Tsherniak A, Santagata S, Whitesell L, Ghobrial IM, Markley JL, Lindquist S, Golub TR.

Nat Chem Biol. 2019 Jul;15(7):757. doi: 10.1038/s41589-019-0315-5.


Mitochondrial metabolism promotes adaptation to proteotoxic stress.

Tsvetkov P, Detappe A, Cai K, Keys HR, Brune Z, Ying W, Thiru P, Reidy M, Kugener G, Rossen J, Kocak M, Kory N, Tsherniak A, Santagata S, Whitesell L, Ghobrial IM, Markley JL, Lindquist S, Golub TR.

Nat Chem Biol. 2019 Jul;15(7):681-689. doi: 10.1038/s41589-019-0291-9. Epub 2019 May 27. Erratum in: Nat Chem Biol. 2019 Jun 4;:.


Cortico-Muscular Coherence Is Reduced Acutely Post-stroke and Increases Bilaterally During Motor Recovery: A Pilot Study.

Krauth R, Schwertner J, Vogt S, Lindquist S, Sailer M, Sickert A, Lamprecht J, Perdikis S, Corbet T, Millán JDR, Hinrichs H, Heinze HJ, Sweeney-Reed CM.

Front Neurol. 2019 Feb 20;10:126. doi: 10.3389/fneur.2019.00126. eCollection 2019.


Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.

Whitesell L, Robbins N, Huang DS, McLellan CA, Shekhar-Guturja T, LeBlanc EV, Nation CS, Hui R, Hutchinson A, Collins C, Chatterjee S, Trilles R, Xie JL, Krysan DJ, Lindquist S, Porco JA Jr, Tatu U, Brown LE, Pizarro J, Cowen LE.

Nat Commun. 2019 Jan 24;10(1):402. doi: 10.1038/s41467-018-08248-w.


Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.

Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV Jr, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D.

Mol Cell. 2019 Mar 7;73(5):1001-1014.e8. doi: 10.1016/j.molcel.2018.11.028. Epub 2018 Dec 4.


An Academic-Practice Partnership at the University of Washington School of Public Health: The Student Epidemic Action Leaders (SEAL) Team.

Simckes M, Melius B, Hawkins V, Lindquist S, Baseman J.

Public Health Rep. 2018 Nov;133(6):749-758. doi: 10.1177/0033354918798805. Epub 2018 Oct 9.


Sporadic Creutzfeldt-Jakob Disease in a Woman Married Into a Gerstmann-Sträussler-Scheinker Family: An Investigation of Prions Transmission via Microchimerism.

Areškeviciute A, Melchior LC, Broholm H, Krarup LH, Lindquist SG, Johansen P, McKenzie N, Green A, Nielsen JE, Laursen H, Lund EL.

J Neuropathol Exp Neurol. 2018 Aug 1;77(8):673-684. doi: 10.1093/jnen/nly043.


Genotype-phenotype correlations, dystonia and disease progression in spinocerebellar ataxia type 14.

Chelban V, Wiethoff S, Fabian-Jessing BK, Haridy NA, Khan A, Efthymiou S, Becker EBE, O'Connor E, Hersheson J, Newland K, Hojland AT, Gregersen PA, Lindquist SG, Petersen MB, Nielsen JE, Nielsen M, Wood NW, Giunti P, Houlden H.

Mov Disord. 2018 Jul;33(7):1119-1129. doi: 10.1002/mds.27334. Epub 2018 Mar 30.


Role of HSP90 in the Regulation of de Novo Purine Biosynthesis.

Pedley AM, Karras GI, Zhang X, Lindquist S, Benkovic SJ.

Biochemistry. 2018 Jun 12;57(23):3217-3221. doi: 10.1021/acs.biochem.8b00140. Epub 2018 Mar 23.


Yeast can accommodate phosphotyrosine: v-Src toxicity in yeast arises from a single disrupted pathway.

Kritzer JA, Freyzon Y, Lindquist S.

FEMS Yeast Res. 2018 May 1;18(3). doi: 10.1093/femsyr/foy027.


Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity.

Kayatekin C, Amasino A, Gaglia G, Flannick J, Bonner JM, Fanning S, Narayan P, Barrasa MI, Pincus D, Landgraf D, Nelson J, Hesse WR, Costanzo M; AMP T2D-GENES Consortium, Myers CL, Boone C, Florez JC, Lindquist S.

Cell. 2018 Mar 22;173(1):62-73.e9. doi: 10.1016/j.cell.2018.02.026. Epub 2018 Mar 8.


An outbreak of Escherichia coli O157:H7 infections following a dairy education school field trip in Washington state, 2015.

Curran KG, Heiman Marshall KE, Singh T, Doobovsky Z, Hensley J, Melius B, Whitlock L, Stevenson L, Leinbach J, Oltean H, Glover WA, Kunesh T, Lindquist S, Williams I, Nichols M.

Epidemiol Infect. 2018 Mar;146(4):442-449. doi: 10.1017/S0950268817002862. Epub 2017 Dec 22.


FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome.

Caraveo G, Soste M, Cappelleti V, Fanning S, van Rossum DB, Whitesell L, Huang Y, Chung CY, Baru V, Zaichick S, Picotti P, Lindquist S.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11313-E11322. doi: 10.1073/pnas.1711926115. Epub 2017 Dec 11.


Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy.

McLellan CA, Vincent BM, Solis NV, Lancaster AK, Sullivan LB, Hartland CL, Youngsaye W, Filler SG, Whitesell L, Lindquist S.

Nat Chem Biol. 2018 Feb;14(2):135-141. doi: 10.1038/nchembio.2534. Epub 2017 Dec 11.


Notes from the Field: Absence of Asymptomatic Mumps Virus Shedding Among Vaccinated College Students During a Mumps Outbreak - Washington, February-June 2017.

Bonwitt J, Kawakami V, Wharton A, Burke RM, Murthy N, Lee A, Dell B, Kay M, Duchin J, Hickman C, McNall RJ, Rota PA, Patel M, Lindquist S, DeBolt C, Routh J.

MMWR Morb Mortal Wkly Rep. 2017 Dec 1;66(47):1307-1308. doi: 10.15585/mmwr.mm6647a5. No abstract available.


Pioneer cells established by the [SWI+] prion can promote dispersal and out-crossing in yeast.

Newby GA, Lindquist S.

PLoS Biol. 2017 Nov 14;15(11):e2003476. doi: 10.1371/journal.pbio.2003476. eCollection 2017 Nov.


A Genetic Tool to Track Protein Aggregates and Control Prion Inheritance.

Newby GA, Kiriakov S, Hallacli E, Kayatekin C, Tsvetkov P, Mancuso CP, Bonner JM, Hesse WR, Chakrabortee S, Manogaran AL, Liebman SW, Lindquist S, Khalil AS.

Cell. 2017 Nov 2;171(4):966-979.e18. doi: 10.1016/j.cell.2017.09.041. Epub 2017 Oct 19.


Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.

Dettmer U, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D.

Hum Mol Genet. 2017 Sep 15;26(18):3466-3481. doi: 10.1093/hmg/ddx227.


TMEM106B and ApoE polymorphisms in CHMP2B-mediated frontotemporal dementia (FTD-3).

Rostgaard N, Roos P, Budtz-Jørgensen E, Johannsen P, Waldemar G, Nørremølle A, Lindquist SG, Gydesen S, Brown JM, Collinge J, Isaacs AM; FReJA collaboration, Nielsen TT, Nielsen JE.

Neurobiol Aging. 2017 Nov;59:221.e1-221.e7. doi: 10.1016/j.neurobiolaging.2017.06.026. Epub 2017 Jul 11.


Acute Flaccid Myelitis Among Children - Washington, September-November 2016.

Bonwitt J, Poel A, DeBolt C, Gonzales E, Lopez A, Routh J, Rietberg K, Linton N, Reggin J, Sejvar J, Lindquist S, Otten C.

MMWR Morb Mortal Wkly Rep. 2017 Aug 11;66(31):826-829. doi: 10.15585/mmwr.mm6631a2.


Association of Previous Cesarean Delivery With Surgical Complications After a Hysterectomy Later in Life.

Lindquist SAI, Shah N, Overgaard C, Torp-Pedersen C, Glavind K, Larsen T, Plough A, Galvin G, Knudsen A.

JAMA Surg. 2017 Dec 1;152(12):1148-1155. doi: 10.1001/jamasurg.2017.2825.


Aggregation and Fibril Structure of AβM01-42 and Aβ1-42.

Silvers R, Colvin MT, Frederick KK, Jacavone AC, Lindquist S, Linse S, Griffin RG.

Biochemistry. 2017 Sep 12;56(36):4850-4859. doi: 10.1021/acs.biochem.7b00729. Epub 2017 Aug 30.


Dihydropyrimidine-Thiones and Clioquinol Synergize To Target β-Amyloid Cellular Pathologies through a Metal-Dependent Mechanism.

Tardiff DF, Brown LE, Yan X, Trilles R, Jui NT, Barrasa MI, Caldwell KA, Caldwell GA, Schaus SE, Lindquist S.

ACS Chem Neurosci. 2017 Sep 20;8(9):2039-2055. doi: 10.1021/acschemneuro.7b00187. Epub 2017 Jul 12.


Purification and characterization of recombinant human bile salt-stimulated lipase expressed in milk of transgenic cloned cows.

Wang Y, Ding F, Wang T, Liu W, Lindquist S, Hernell O, Wang J, Li J, Li L, Zhao Y, Dai Y, Li N.

PLoS One. 2017 May 5;12(5):e0176864. doi: 10.1371/journal.pone.0176864. eCollection 2017.


Combining DNP NMR with segmental and specific labeling to study a yeast prion protein strain that is not parallel in-register.

Frederick KK, Michaelis VK, Caporini MA, Andreas LB, Debelouchina GT, Griffin RG, Lindquist S.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3642-3647. doi: 10.1073/pnas.1619051114. Epub 2017 Mar 22.


HSP90 Shapes the Consequences of Human Genetic Variation.

Karras GI, Yi S, Sahni N, Fischer M, Xie J, Vidal M, D'Andrea AD, Whitesell L, Lindquist S.

Cell. 2017 Feb 23;168(5):856-866.e12. doi: 10.1016/j.cell.2017.01.023. Epub 2017 Feb 16.


In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons.

Chung CY, Khurana V, Yi S, Sahni N, Loh KH, Auluck PK, Baru V, Udeshi ND, Freyzon Y, Carr SA, Hill DE, Vidal M, Ting AY, Lindquist S.

Cell Syst. 2017 Feb 22;4(2):242-250.e4. doi: 10.1016/j.cels.2017.01.002. Epub 2017 Jan 25.


Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways.

Khurana V, Peng J, Chung CY, Auluck PK, Fanning S, Tardiff DF, Bartels T, Koeva M, Eichhorn SW, Benyamini H, Lou Y, Nutter-Upham A, Baru V, Freyzon Y, Tuncbag N, Costanzo M, San Luis BJ, Schöndorf DC, Barrasa MI, Ehsani S, Sanjana N, Zhong Q, Gasser T, Bartel DP, Vidal M, Deleidi M, Boone C, Fraenkel E, Berger B, Lindquist S.

Cell Syst. 2017 Feb 22;4(2):157-170.e14. doi: 10.1016/j.cels.2016.12.011. Epub 2017 Jan 25.


Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers.

Tsvetkov P, Sokol E, Jin D, Brune Z, Thiru P, Ghandi M, Garraway LA, Gupta PB, Santagata S, Whitesell L, Lindquist S.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):382-387. doi: 10.1073/pnas.1619067114. Epub 2016 Dec 27.


Resistance to First-Line Antituberculosis Drugs in Washington State by Region of Birth and Implications for Latent Tuberculosis Treatment Among Foreign-Born Individuals.

Furukawa NW, Haider MZ, Allen SJ, Carlson SL, Lindquist SW.

Am J Trop Med Hyg. 2017 Mar;96(3):543-549. doi: 10.4269/ajtmh.16-0662. Epub 2017 Apr 6.


Long-term functional outcomes after radical cystectomy with ileal bladder substitute: does the definition of continence matter?

Liedberg F, Ahlgren G, Baseckas G, Gudjonsson S, Håkansson U, Lindquist S, Löfgren A, Patschan O, Siller C, Sjödahl G.

Scand J Urol. 2017 Feb;51(1):44-49. doi: 10.1080/21681805.2016.1249943. Epub 2016 Nov 11.


Scarless Gene Tagging with One-Step Transformation and Two-Step Selection in Saccharomyces cerevisiae and Schizosaccharomyces pombe.

Landgraf D, Huh D, Hallacli E, Lindquist S.

PLoS One. 2016 Oct 13;11(10):e0163950. doi: 10.1371/journal.pone.0163950. eCollection 2016.


Intrinsically Disordered Proteins Drive Emergence and Inheritance of Biological Traits.

Chakrabortee S, Byers JS, Jones S, Garcia DM, Bhullar B, Chang A, She R, Lee L, Fremin B, Lindquist S, Jarosz DF.

Cell. 2016 Oct 6;167(2):369-381.e12. doi: 10.1016/j.cell.2016.09.017. Epub 2016 Sep 29.


A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance.

Vincent BM, Langlois JB, Srinivas R, Lancaster AK, Scherz-Shouval R, Whitesell L, Tidor B, Buchwald SL, Lindquist S.

Cell Chem Biol. 2016 Aug 18;23(8):978-991. doi: 10.1016/j.chembiol.2016.06.016. Epub 2016 Aug 11.


A Novel TTBK2 De Novo Mutation in a Danish Family with Early-Onset Spinocerebellar Ataxia.

Lindquist SG, Møller LB, Dali CI, Marner L, Kamsteeg EJ, Nielsen JE, Hjermind LE.

Cerebellum. 2017 Feb;16(1):268-271. doi: 10.1007/s12311-016-0786-9.


Luminidependens (LD) is an Arabidopsis protein with prion behavior.

Chakrabortee S, Kayatekin C, Newby GA, Mendillo ML, Lancaster A, Lindquist S.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):6065-70. doi: 10.1073/pnas.1604478113. Epub 2016 Apr 25.


An inter-species protein-protein interaction network across vast evolutionary distance.

Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Taşan M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barabási AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M.

Mol Syst Biol. 2016 Apr 22;12(4):865. doi: 10.15252/msb.20156484.


Notes from the Field: Outbreak of Multidrug-Resistant Salmonella Infections Linked to Pork--Washington, 2015.

Kawakami VM, Bottichio L, Angelo K, Linton N, Kissler B, Basler C, Lloyd J, Inouye W, Gonzales E, Rietberg K, Melius B, Oltean H, Wise M, Sinatra J, Marsland P, Li Z, Meek R, Kay M, Duchin J, Lindquist S.

MMWR Morb Mortal Wkly Rep. 2016 Apr 15;65(14):379-81. doi: 10.15585/mmwr.mm6514a4.


Public Health-Seattle & King County and Washington State Department of Health Preexposure Prophylaxis Implementation Guidelines, 2015.

Golden MR, Lindquist S, Dombrowski JC.

Sex Transm Dis. 2016 Apr;43(4):264-5. doi: 10.1097/OLQ.0000000000000427. No abstract available.


Microsized BiOCl Square Nanosheets as Ultraviolet Photodetectors and Photocatalysts.

Li M, Zhang J, Gao H, Li F, Lindquist SE, Wu N, Wang R.

ACS Appl Mater Interfaces. 2016 Mar;8(10):6662-8. doi: 10.1021/acsami.6b00042. Epub 2016 Mar 3.


Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis.

Mann PA, McLellan CA, Koseoglu S, Si Q, Kuzmin E, Flattery A, Harris G, Sher X, Murgolo N, Wang H, Devito K, de Pedro N, Genilloud O, Kahn JN, Jiang B, Costanzo M, Boone C, Garlisi CG, Lindquist S, Roemer T.

ACS Infect Dis. 2015 Jan 9;1(1):59-72. doi: 10.1021/id5000212. Epub 2014 Dec 12.


Very low birthweight infants face an increased risk of bloodstream infections following the removal of umbilical catheters.

Lindquist S, Hentz E, Tessin I, Elfvin A.

Acta Paediatr. 2016 Apr;105(4):391-6. doi: 10.1111/apa.13240. Epub 2015 Nov 13.


Sensitivity-enhanced NMR reveals alterations in protein structure by cellular milieus.

Frederick KK, Michaelis VK, Corzilius B, Ong TC, Jacavone AC, Griffin RG, Lindquist S.

Cell. 2015 Oct 22;163(3):620-8. doi: 10.1016/j.cell.2015.09.024. Epub 2015 Oct 8.


Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome.

Tsvetkov P, Mendillo ML, Zhao J, Carette JE, Merrill PH, Cikes D, Varadarajan M, van Diemen FR, Penninger JM, Goldberg AL, Brummelkamp TR, Santagata S, Lindquist S.

Elife. 2015 Sep 1;4. doi: 10.7554/eLife.08467.


Effect of interferon-β1b on CXCR4-dependent chemotaxis in T cells from multiple sclerosis patients.

Wostradowski T, Gudi V, Pul R, Gingele S, Lindquist JA, Stangel M, Lindquist S.

Clin Exp Immunol. 2015 Nov;182(2):162-72. doi: 10.1111/cei.12689. Epub 2015 Aug 31.


Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors.

Bagley AF, Scherz-Shouval R, Galie PA, Zhang AQ, Wyckoff J, Whitesell L, Chen CS, Lindquist S, Bhatia SN.

Cancer Res. 2015 Aug 15;75(16):3255-67. doi: 10.1158/0008-5472.CAN-15-0325. Epub 2015 Jun 29.


Nontoxic antimicrobials that evade drug resistance.

Davis SA, Vincent BM, Endo MM, Whitesell L, Marchillo K, Andes DR, Lindquist S, Burke MD.

Nat Chem Biol. 2015 Jul;11(7):481-7. doi: 10.1038/nchembio.1821. Epub 2015 Jun 1.


The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.

Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA, Patel V, Clish CB, Sullivan WJ Jr, Zhou H, Bopp SE, Schimmel P, Lindquist S, Clardy J, Mota MM, Keller TL, Whitman M, Wiest O, Wirth DF, Mazitschek R.

Sci Transl Med. 2015 May 20;7(288):288ra77. doi: 10.1126/scitranslmed.aaa3575.

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