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Lamarck and Panspermia - On the Efficient Spread of Living Systems Throughout the Cosmos.

Steele EJ, Gorczynski RM, Lindley RA, Liu Y, Temple R, Tokoro G, Wickramasinghe DT, Wickramasinghe NC.

Prog Biophys Mol Biol. 2019 Aug 22. pii: S0079-6107(19)30112-9. doi: 10.1016/j.pbiomolbio.2019.08.010. [Epub ahead of print] Review.


Early mobilization and quality of life after stroke: Findings from AVERT.

Cumming TB, Churilov L, Collier J, Donnan G, Ellery F, Dewey H, Langhorne P, Lindley RI, Moodie M, Thrift AG, Bernhardt J; AVERT Trial Collaboration group.

Neurology. 2019 Aug 13;93(7):e717-e728. doi: 10.1212/WNL.0000000000007937. Epub 2019 Jul 26.


Dementia treatment: The need for a paradigm shift.

Lindley RI, Waite L, Cullen J.

Australas J Ageing. 2019 Sep;38(3):149-150. doi: 10.1111/ajag.12698. Epub 2019 Jul 9. No abstract available.


Who will benefit more from low-dose alteplase in acute ischemic stroke?

Wang X, Lee KJ, Moullaali TJ, Kim BJ, Li Q, Bae HJ, Carcel C, Delcourt C, Arima H, Sato S, Robinson TG, Song L, Chen G, Yang J, Chalmers J, Anderson CS, Lindley R, Woodward M; ENCHANTED Investigators.

Int J Stroke. 2019 Jun 21:1747493019858775. doi: 10.1177/1747493019858775. [Epub ahead of print]


Caregiver-Delivered Stroke Rehabilitation in Rural China.

Zhou B, Zhang J, Zhao Y, Li X, Anderson CS, Xie B, Wang N, Zhang Y, Tang X, Prvu Bettger J, Chen S, Gu W, Luo R, Zhao Q, Li X, Sun Z, Lindley RI, Lamb SE, Wu Y, Shi J, Yan LL.

Stroke. 2019 Jul;50(7):1825-1830. doi: 10.1161/STROKEAHA.118.021558. Epub 2019 Jun 10.


Determinants of Early Versus Delayed Neurological Deterioration in Intracerebral Hemorrhage.

You S, Zheng D, Delcourt C, Sato S, Cao Y, Zhang S, Yang J, Wang X, Lindley RI, Robinson T, Anderson CS, Chalmers J.

Stroke. 2019 Jun;50(6):1409-1414. doi: 10.1161/STROKEAHA.118.024403. Epub 2019 Apr 18.


The effect of a multidisciplinary co-management program for the older hip fracture patients in Beijing: a "pre- and post-" retrospective study.

Wu X, Tian M, Zhang J, Yang M, Gong X, Liu Y, Li X, Lindley RI, Anderson M, Peng K, Jagnoor J, Ji J, Wang M, Ivers R, Tian W.

Arch Osteoporos. 2019 Mar 22;14(1):43. doi: 10.1007/s11657-019-0594-1.


Infratentorial Intracerebral Hemorrhage.

Chen R, Wang X, Anderson CS, Robinson T, Lavados PM, Lindley RI, Chalmers J, Delcourt C.

Stroke. 2019 May;50(5):1257-1259. doi: 10.1161/STROKEAHA.118.023766.


Molecular model linking Th2 polarized M2 tumour-associated macrophages with deaminase-mediated cancer progression mutation signatures.

Mamrot J, Balachandran S, Steele EJ, Lindley RA.

Scand J Immunol. 2019 May;89(5):e12760. doi: 10.1111/sji.12760. Epub 2019 Mar 18.


Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial.

Anderson CS, Huang Y, Lindley RI, Chen X, Arima H, Chen G, Li Q, Billot L, Delcourt C, Bath PM, Broderick JP, Demchuk AM, Donnan GA, Durham AC, Lavados PM, Lee TH, Levi C, Martins SO, Olavarria VV, Pandian JD, Parsons MW, Pontes-Neto OM, Ricci S, Sato S, Sharma VK, Silva F, Song L, Thang NH, Wardlaw JM, Wang JG, Wang X, Woodward M, Chalmers J, Robinson TG; ENCHANTED Investigators and Coordinators.

Lancet. 2019 Mar 2;393(10174):877-888. doi: 10.1016/S0140-6736(19)30038-8. Epub 2019 Feb 7.


Incidence, risk factors and economic burden of fall-related injuries in older Chinese people: a systematic review.

Peng K, Tian M, Andersen M, Zhang J, Liu Y, Wang Q, Lindley R, Ivers R.

Inj Prev. 2019 Feb;25(1):4-12. doi: 10.1136/injuryprev-2018-042982.


Returning to Unpaid Work after Stroke: The Psychosocial Outcomes in Stroke Cohort Study.

Carcel C, Farnbach S, Essue BM, Li Q, Glozier N, Jan S, Lindley R, Hackett ML.

Cerebrovasc Dis. 2019;47(1-2):1-7. doi: 10.1159/000496399. Epub 2019 Jan 17.


Canagliflozin and Stroke in Type 2 Diabetes Mellitus.

Zhou Z, Lindley RI, Rådholm K, Jenkins B, Watson J, Perkovic V, Mahaffey KW, de Zeeuw D, Fulcher G, Shaw W, Oh R, Desai M, Matthews DR, Neal B.

Stroke. 2019 Feb;50(2):396-404. doi: 10.1161/STROKEAHA.118.023009.


Effect of IV alteplase on the ischemic brain lesion at 24-48 hours after ischemic stroke.

Mair G, von Kummer R, Morris Z, von Heijne A, Bradey N, Cala L, Peeters A, Farrall AJ, Adami A, Potter G, Sandercock PAG, Lindley RI, Wardlaw JM; IST-3 Collaborative Group.

Neurology. 2018 Nov 27;91(22):e2067-e2077. doi: 10.1212/WNL.0000000000006575. Epub 2018 Oct 26.


Statistical analysis plan for evaluating different intensities of blood pressure control in the ENhanced Control of Hypertension And Thrombolysis strokE stuDy.

Anderson CS, Woodward M, Arima H, Chen X, Lindley RI, Wang X, Chalmers J, Robinson TG.

Int J Stroke. 2019 Jul;14(5):555-558. doi: 10.1177/1747493018806170. Epub 2018 Oct 9.


NIHSS cut point for predicting outcome in supra- vs infratentorial acute ischemic stroke.

Yoshimura S, Lindley RI, Carcel C, Sato S, Delcourt C, Wang X, Chalmers J, Anderson CS; ENCHANTED Investigators.

Neurology. 2018 Oct 30;91(18):e1695-e1701. doi: 10.1212/WNL.0000000000006437. Epub 2018 Sep 28.


Family-led rehabilitation in India (ATTEND)-Findings from the process evaluation of a randomized controlled trial.

Liu H, Lindley R, Alim M, Felix C, Gandhi DB, Verma SJ, Tugnawat DK, Syrigapu A, Ramamurthy RK, Pandian JD, Walker M, Forster A, Hackett ML, Anderson CS, Langhorne P, Murthy GV, Maulik PK, Harvey LA, Jan S.

Int J Stroke. 2019 Jan;14(1):53-60. doi: 10.1177/1747493018790076. Epub 2018 Jul 25.


Treatment with exenatide in acute ischemic stroke trial protocol: A prospective, randomized, open label, blinded end-point study of exenatide vs. standard care in post stroke hyperglycemia.

Muller C, Cheung NW, Dewey H, Churilov L, Middleton S, Thijs V, Ekinci EI, Levi C, Lindley R, Donnan G, Parsons M, Bladin C.

Int J Stroke. 2018 Oct;13(8):857-862. doi: 10.1177/1747493018784436. Epub 2018 Jul 18.


Protocol for process evaluation of CIVIC randomised controlled trial: Community-based InterVentions to prevent serIous Complications following spinal cord injury in Bangladesh.

Hossain MS, Harvey LA, Liu H, Islam MS, Rahman MA, Muldoon S, Biering-Sorensen F, Cameron ID, Chhabra HS, Lindley RI, Jan S.

BMJ Open. 2018 Jul 16;8(7):e024226. doi: 10.1136/bmjopen-2018-024226.


APOBEC and ADAR deaminases may cause many single nucleotide polymorphisms curated in the OMIM database.

Lindley RA, Hall NE.

Mutat Res. 2018 Jul;810:33-38. doi: 10.1016/j.mrfmmm.2018.03.008. Epub 2018 Jun 22.


Clinical Utility of Electronic Alberta Stroke Program Early Computed Tomography Score Software in the ENCHANTED Trial Database.

Nagel S, Wang X, Carcel C, Robinson T, Lindley RI, Chalmers J, Anderson CS; ENCHANTED Investigators.

Stroke. 2018 Jun;49(6):1407-1411. doi: 10.1161/STROKEAHA.117.019863. Epub 2018 May 18.


Resuming anticoagulants after anticoagulation-associated intracranial haemorrhage: systematic review and meta-analysis.

Zhou Z, Yu J, Carcel C, Delcourt C, Shan J, Lindley RI, Neal B, Anderson CS, Hackett ML.

BMJ Open. 2018 May 14;8(5):e019672. doi: 10.1136/bmjopen-2017-019672.


Germline V repertoires: Origin, maintenance, diversification.

Steele EJ, Lindley RA.

Scand J Immunol. 2018 Jun;87(6):e12670. doi: 10.1111/sji.12670.


Comparative effects of low-dose versus standard-dose alteplase in ischemic patients with prior stroke and/or diabetes mellitus: The ENCHANTED trial.

Chen G, Wang X, Robinson TG, Pikkemaat M, Lindley RI, Zhou S, Ping L, Liu W, Liu L, Chalmers J, Anderson CS; ENCHANTED Investigators.

J Neurol Sci. 2018 Apr 15;387:1-5. doi: 10.1016/j.jns.2018.01.014. Epub 2018 Jan 11.


Low- versus Standard-Dose Intravenous Alteplase in the Context of Bridging Therapy for Acute Ischemic Stroke: A Korean ENCHANTED Study.

Kim JS, Kim YJ, Lee KB, Cha JK, Park JM, Hwang Y, Kim EG, Rha JH, Koo J, Kim J, Kim YJ, Seo WK, Kim DE, Robinson TG, Lindley RI, Wang X, Chalmers J, Anderson CS.

J Stroke. 2018 Jan;20(1):131-139. doi: 10.5853/jos.2017.01578. Epub 2018 Jan 31.


Stroke Prevention in the Very Elderly.

Lindley RI.

Stroke. 2018 Mar;49(3):796-802. doi: 10.1161/STROKEAHA.117.017952. Epub 2018 Jan 25. Review. No abstract available.


Pupil Dilation May Affect Retinal Vessel Caliber Measures.

Wang JJ, Shi Y, Xie J, Tan AG, Hogdson LA, Lee S, Wickens M, Cosatto VF, Kairaitis K, Lindley R, Lim LL, Mitchell P, Wheatley JR, Amis TC.

Ophthalmic Epidemiol. 2018 Jun;25(3):234-237. doi: 10.1080/09286586.2017.1409360. Epub 2017 Nov 29.


Frequency, determinants, and effects of early seizures after thrombolysis for acute ischemic stroke: The ENCHANTED trial.

Xu Y, Hackett ML, Chalmers J, Lindley RI, Wang X, Li Q, Robinson T, Arima H, Lavados PM, Anderson CS; ENCHANTED Study Group.

Neurol Clin Pract. 2017 Aug;7(4):324-332. doi: 10.1212/CPJ.0000000000000384.


Effects of alteplase for acute stroke according to criteria defining the European Union and United States marketing authorizations: Individual-patient-data meta-analysis of randomized trials.

Hacke W, Lyden P, Emberson J, Baigent C, Blackwell L, Albers G, Bluhmki E, Brott T, Cohen G, Davis SM, Donnan GA, Grotta JC, Howard G, Kaste M, Koga M, von Kummer R, Lansberg MG, Lindley RI, Olivot JM, Parsons M, Sandercock PA, Toni D, Toyoda K, Wahlgren N, Wardlaw JM, Whiteley WN, Del Zoppo G, Lees KR; Stroke Thrombolysis Trialists’ Collaborators Group.

Int J Stroke. 2018 Feb;13(2):175-189. doi: 10.1177/1747493017744464. Epub 2017 Nov 24. Erratum in: Int J Stroke. 2018 Feb;13(2):NP3.


Clinical stroke research in resource limited settings: Tips and hints.

Pandian JD, Liu H, Gandhi DB, Lindley RI.

Int J Stroke. 2018 Feb;13(2):129-137. doi: 10.1177/1747493017743798. Epub 2017 Nov 17. Review.


Positive impact of the participation in the ENCHANTED trial in reducing Door-to-Needle Time.

Yang J, Wang X, Yu JP, Hang J, Lavados P, Robinson T, Arima H, Lindley RI, Anderson CS, Chalmers J.

Sci Rep. 2017 Oct 26;7(1):14168. doi: 10.1038/s41598-017-14164-8.


Early Cognitive Impairment after Intracerebral Hemorrhage in the INTERACT1 Study.

You S, Wang X, Lindley RI, Robinson T, Anderson CS, Cao Y, Chalmers J.

Cerebrovasc Dis. 2017;44(5-6):320-324. doi: 10.1159/000481443. Epub 2017 Oct 26.


Low-Dose vs Standard-Dose Alteplase for Patients With Acute Ischemic Stroke: Secondary Analysis of the ENCHANTED Randomized Clinical Trial.

Wang X, Robinson TG, Lee TH, Li Q, Arima H, Bath PM, Billot L, Broderick J, Demchuk AM, Donnan G, Kim JS, Lavados P, Lindley RI, Martins SO, Olavarria VV, Pandian JD, Parsons MW, Pontes-Neto OM, Ricci S, Sharma VK, Thang NH, Wang JG, Woodward M, Anderson CS, Chalmers J; Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED) Investigators.

JAMA Neurol. 2017 Nov 1;74(11):1328-1335. doi: 10.1001/jamaneurol.2017.2286. Erratum in: JAMA Neurol. 2018 Mar 1;75(3):384.


Characteristics, management and response to alteplase in China versus non-China participants of the ENCHANTED trial.

Song L, Wang X, Robinson T, Lindley RI, Arima H, Lavados PM, Chen X, Chalmers J, Anderson CS.

Stroke Vasc Neurol. 2017 May 22;2(2):53-58. doi: 10.1136/svn-2017-000085. eCollection 2017 Jun.


The potential health and economic impact of improving stroke care standards for Australia.

Kim J, Andrew NE, Thrift AG, Bernhardt J, Lindley RI, Cadilhac DA.

Int J Stroke. 2017 Oct;12(8):875-885. doi: 10.1177/1747493017700662. Epub 2017 Mar 22.


Blood pressure variability and leukoaraiosis in acute ischemic stroke.

Dickie DA, Aribisala B, Mair G, Berge E, Lindley RI, Sandercock P, von Kummer R, von Heijne A, Peeters A, Cala L, Farrall A, Morris Z, Bradey N, Potter G, Adami A, Wardlaw JM.

Int J Stroke. 2018 Jul;13(5):473-480. doi: 10.1177/1747493017729267. Epub 2017 Sep 5.


Influence of Renal Impairment on Outcome for Thrombolysis-Treated Acute Ischemic Stroke: ENCHANTED (Enhanced Control of Hypertension and Thrombolysis Stroke Study) Post Hoc Analysis.

Carr SJ, Wang X, Olavarria VV, Lavados PM, Rodriguez JA, Kim JS, Lee TH, Lindley RI, Pontes-Neto OM, Ricci S, Sato S, Sharma VK, Woodward M, Chalmers J, Anderson CS, Robinson TG; ENCHANTED Investigators.

Stroke. 2017 Sep;48(9):2605-2609. doi: 10.1161/STROKEAHA.117.017808. Epub 2017 Jul 24.


Low- Versus Standard-Dose Alteplase in Patients on Prior Antiplatelet Therapy: The ENCHANTED Trial (Enhanced Control of Hypertension and Thrombolysis Stroke Study).

Robinson TG, Wang X, Arima H, Bath PM, Billot L, Broderick JP, Demchuk AM, Donnan GA, Kim JS, Lavados PM, Lee TH, Lindley RI, Martins SCO, Olavarria VV, Pandian JD, Parsons MW, Pontes-Neto OM, Ricci S, Sato S, Sharma VK, Nguyen TH, Wang JG, Woodward M, Chalmers J, Anderson CS; ENCHANTED Investigators.

Stroke. 2017 Jul;48(7):1877-1883. doi: 10.1161/STROKEAHA.116.016274. Epub 2017 Jun 15.


Practice Patterns for Neurosurgical Utilization and Outcome in Acute Intracerebral Hemorrhage: Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials 1 and 2 Studies.

Guo R, Blacker DJ, Wang X, Arima H, Lavados PM, Lindley RI, Chalmers J, Anderson CS, Robinson T; INTERACT Investigators.

Neurosurgery. 2017 Dec 1;81(6):980-985. doi: 10.1093/neuros/nyx129.


ADAR deaminase A-to-I editing of DNA and RNA moieties of RNA:DNA hybrids has implications for the mechanism of Ig somatic hypermutation.

Steele EJ, Lindley RA.

DNA Repair (Amst). 2017 Jul;55:1-6. doi: 10.1016/j.dnarep.2017.04.004. Epub 2017 Apr 21. Review.


Cerebral White Matter Hypoperfusion Increases with Small-Vessel Disease Burden. Data From the Third International Stroke Trial.

Arba F, Mair G, Carpenter T, Sakka E, Sandercock PAG, Lindley RI, Inzitari D, Wardlaw JM; IST-3 Trial Collaborators.

J Stroke Cerebrovasc Dis. 2017 Jul;26(7):1506-1513. doi: 10.1016/j.jstrokecerebrovasdis.2017.03.002. Epub 2017 Mar 15.


Intracerebral hemorrhage location and outcome among INTERACT2 participants.

Delcourt C, Sato S, Zhang S, Sandset EC, Zheng D, Chen X, Hackett ML, Arima H, Hata J, Heeley E, Al-Shahi Salman R, Robinson T, Davies L, Lavados PM, Lindley RI, Stapf C, Chalmers J, Anderson CS; INTERACT2 Investigators.

Neurology. 2017 Apr 11;88(15):1408-1414. doi: 10.1212/WNL.0000000000003771. Epub 2017 Feb 24.


Statistical analysis plan for the family-led rehabilitation after stroke in India (ATTEND) trial: A multicenter randomized controlled trial of a new model of stroke rehabilitation compared to usual care.

Billot L, Lindley RI, Harvey LA, Maulik PK, Hackett ML, Murthy GV, Anderson CS, Shamanna BR, Jan S, Walker M, Forster A, Langhorne P, Verma SJ, Felix C, Alim M, Gandhi DB, Pandian JD.

Int J Stroke. 2017 Feb;12(2):208-210. doi: 10.1177/1747493016674956. Epub 2016 Oct 22.


Arterial Obstruction on Computed Tomographic or Magnetic Resonance Angiography and Response to Intravenous Thrombolytics in Ischemic Stroke.

Mair G, von Kummer R, Adami A, White PM, Adams ME, Yan B, Demchuk AM, Farrall AJ, Sellar RJ, Sakka E, Palmer J, Perry D, Lindley RI, Sandercock PA, Wardlaw JM; IST-3 Collaborative Group.

Stroke. 2017 Feb;48(2):353-360. doi: 10.1161/STROKEAHA.116.015164. Epub 2016 Dec 22.


Outcomes following sclerotherapy for mucosal rectal prolapse with oily phenol injection: single-centre review.

Sahay R, Murthi G, Lindley R.

Pediatr Surg Int. 2017 Mar;33(3):363-365. doi: 10.1007/s00383-016-4035-6. Epub 2016 Dec 17.


Protocol-based management of older adults with hip fractures in Delhi, India: a feasibility study.

Yadav L, Tewari A, Jain A, Essue B, Peiris D, Woodward M, Kotwal P, Lindley R, Jan S, Chantler T, Webster P, Norton R, Rath S.

Pilot Feasibility Stud. 2016 Mar 9;2:15. doi: 10.1186/s40814-016-0056-0. eCollection 2016.


Associations with health-related quality of life after intracerebral haemorrhage: pooled analysis of INTERACT studies.

Delcourt C, Zheng D, Chen X, Hackett M, Arima H, Hata J, Heeley E, Al-Shahi Salman R, Woodward M, Huang Y, Robinson T, Lavados PM, Lindley RI, Stapf C, Davies L, Chalmers J, Anderson CS, Sato S; INTERACT Investigators.

J Neurol Neurosurg Psychiatry. 2017 Jan;88(1):70-75. doi: 10.1136/jnnp-2016-314414. Epub 2016 Oct 21.


Effect of Right Insular Involvement on Death and Functional Outcome After Acute Ischemic Stroke in the IST-3 Trial (Third International Stroke Trial).

Sposato LA, Cohen G, Wardlaw JM, Sandercock P, Lindley RI, Hachinski V; IST-3 Expert Reading Panel and the IST-3 Collaborative Group.

Stroke. 2016 Dec;47(12):2959-2965. Epub 2016 Nov 15.


Informal Caregiving: A Growing Need for Inclusion in Stroke Rehabilitation.

Pandian JD, Gandhi DB, Lindley RI, Bettger JP.

Stroke. 2016 Dec;47(12):3057-3062. Epub 2016 Nov 10. Review. No abstract available.


Withdrawal of active treatment after intracerebral haemorrhage in the INTERACT2 study.

Muñoz Venturelli P, Wang X, Zahuranec DB, Lavados PM, Stapf C, Lindley R, Delcourt C, Chalmers J, Anderson CS, Robinson TG, Robinson TG; INTERACT2 Investigators.

Age Ageing. 2017 Mar 1;46(2):329-332. doi: 10.1093/ageing/afw187.

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