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Items: 21

1.

Altered metabolism of LDL in the arterial wall precedes atherosclerosis regression.

Bartels ED, Christoffersen C, Lindholm MW, Nielsen LB.

Circ Res. 2015 Nov 6;117(11):933-42. doi: 10.1161/CIRCRESAHA.115.307182. Epub 2015 Sep 10.

PMID:
26358193
2.

Antisense-mediated reduction of proprotein convertase subtilisin/kexin type 9 (PCSK9): a first-in-human randomized, placebo-controlled trial.

van Poelgeest EP, Hodges MR, Moerland M, Tessier Y, Levin AA, Persson R, Lindholm MW, Dumong Erichsen K, Ørum H, Cohen AF, Burggraaf J.

Br J Clin Pharmacol. 2015 Dec;80(6):1350-61. doi: 10.1111/bcp.12738. Epub 2015 Oct 24.

3.

A Kinetic Model Explains Why Shorter and Less Affine Enzyme-recruiting Oligonucleotides Can Be More Potent.

Pedersen L, Hagedorn PH, Lindholm MW, Lindow M.

Mol Ther Nucleic Acids. 2014 Feb 18;3:e149. doi: 10.1038/mtna.2013.72.

4.

Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR.

Rottiers V, Obad S, Petri A, McGarrah R, Lindholm MW, Black JC, Sinha S, Goody RJ, Lawrence MS, deLemos AS, Hansen HF, Whittaker S, Henry S, Brookes R, Najafi-Shoushtari SH, Chung RT, Whetstine JR, Gerszten RE, Kauppinen S, Näär AM.

Sci Transl Med. 2013 Nov 20;5(212):212ra162. doi: 10.1126/scitranslmed.3006840.

5.

PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates.

Lindholm MW, Elmén J, Fisker N, Hansen HF, Persson R, Møller MR, Rosenbohm C, Ørum H, Straarup EM, Koch T.

Mol Ther. 2012 Feb;20(2):376-81. doi: 10.1038/mt.2011.260. Epub 2011 Nov 22.

6.

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates.

Straarup EM, Fisker N, Hedtjärn M, Lindholm MW, Rosenbohm C, Aarup V, Hansen HF, Ørum H, Hansen JB, Koch T.

Nucleic Acids Res. 2010 Nov;38(20):7100-11. doi: 10.1093/nar/gkq457. Epub 2010 Jul 8.

7.

Oats (Avena sativa) reduce atherogenesis in LDL-receptor-deficient mice.

Andersson KE, Svedberg KA, Lindholm MW, Oste R, Hellstrand P.

Atherosclerosis. 2010 Sep;212(1):93-9. doi: 10.1016/j.atherosclerosis.2010.05.001. Epub 2010 May 11.

PMID:
20553794
8.

Activator protein-1 in carotid plaques is related to cerebrovascular symptoms and cholesteryl ester content.

Gonçalves I, Stollenwerk MM, Lindholm MW, Dias N, Pedro LM, Fernandes JF, Moses J, Fredrikson GN, Nilsson J, Ares MP.

Cardiovasc Pathol. 2011 Jan-Feb;20(1):36-43. doi: 10.1016/j.carpath.2009.09.003.

PMID:
19919900
9.

Effects of oats on plasma cholesterol and lipoproteins in C57BL/6 mice are substrain specific.

Andersson KE, Immerstrand T, Swärd K, Bergenståhl B, Lindholm MW, Oste R, Hellstrand P.

Br J Nutr. 2010 Feb;103(4):513-21. doi: 10.1017/S000711450999211X. Epub 2009 Oct 20.

PMID:
19840420
10.

Interleukin-1beta and tumour necrosis factor-alpha impede neutral lipid turnover in macrophage-derived foam cells.

Persson J, Nilsson J, Lindholm MW.

BMC Immunol. 2008 Nov 25;9:70. doi: 10.1186/1471-2172-9-70.

11.

Perilipin and adipophilin expression in lipid loaded macrophages.

Persson J, Degerman E, Nilsson J, Lindholm MW.

Biochem Biophys Res Commun. 2007 Nov 30;363(4):1020-6. Epub 2007 Sep 29.

PMID:
17927964
12.

Medial Expression of TNF-α and TNF Receptors Precedes the Development of Atherosclerotic Lesions in Apolipoprotein E/LDL Receptor Double Knockout Mice.

Niemann-Jönsson A, Söderberg I, Lindholm MW, Jovinge S, Nilsson J, Fredrikson GN.

Int J Biomed Sci. 2007 Jun;3(2):116-22.

13.

Autoimmune responses against the apo B-100 LDL receptor-binding site protect against arterial accumulation of lipids in LDL receptor deficient mice.

Fredrikson GN, Lindholm MW, Ljungcrantz I, Söderberg I, Shah PK, Nilsson J.

Autoimmunity. 2007 Mar;40(2):122-30.

PMID:
17453711
14.

Estrogen attenuates vascular expression of inflammation associated genes and adhesion of monocytes to endothelial cells.

Gao H, Liang M, Bergdahl A, Hamrén A, Lindholm MW, Dahlman-Wright K, Nilsson BO.

Inflamm Res. 2006 Aug;55(8):349-53.

PMID:
16977382
15.

Simvastatin stimulates macrophage interleukin-1beta secretion through an isoprenylation-dependent mechanism.

Lindholm MW, Nilsson J.

Vascul Pharmacol. 2007 Feb;46(2):91-6. Epub 2006 Jul 25.

PMID:
16942919
16.

Cytokine response to lipoprotein lipid loading in human monocyte-derived macrophages.

Persson J, Nilsson J, Lindholm MW.

Lipids Health Dis. 2006 Jun 26;5:17.

17.

Chromatin modification by lipids and lipoprotein components: an initiating event in atherogenesis?

Zaina S, Døssing KB, Lindholm MW, Lund G.

Curr Opin Lipidol. 2005 Oct;16(5):549-53. Review.

PMID:
16148540
18.

Very low-density lipoprotein induces interleukin-1beta expression in macrophages.

Stollenwerk MM, Lindholm MW, Pörn-Ares MI, Larsson A, Nilsson J, Ares MP.

Biochem Biophys Res Commun. 2005 Sep 23;335(2):603-8.

PMID:
16087165
19.

Low density lipoprotein stimulation of human macrophage proteoglycan secretion.

Lindholm MW, Nilsson J, Moses J.

Biochem Biophys Res Commun. 2005 Mar 11;328(2):455-60.

PMID:
15694369
20.

Nutrition and aberrant DNA methylation patterns in atherosclerosis: more than just hyperhomocysteinemia?

Zaina S, Lindholm MW, Lund G.

J Nutr. 2005 Jan;135(1):5-8. Review.

PMID:
15623824
21.

Elastin and calcium rather than collagen or lipid content are associated with echogenicity of human carotid plaques.

Gonçalves I, Lindholm MW, Pedro LM, Dias N, Fernandes e Fernandes J, Fredrikson GN, Nilsson J, Moses J, Ares MP.

Stroke. 2004 Dec;35(12):2795-800. Epub 2004 Oct 28.

PMID:
15514195

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