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Items: 1 to 50 of 169


Pharmacokinetics of L-Triiodothyronine in Patients Undergoing Thyroid Hormone Therapy Withdrawal.

Van Tassell B, Wohlford GF 4th, Linderman JD, Smith S, Yavuz S, Pucino F, Celi FS.

Thyroid. 2019 Oct;29(10):1371-1379. doi: 10.1089/thy.2019.0101. Epub 2019 Sep 12.


Short-term cellular memory tunes the signaling responses of the chemokine receptor CXCR4.

Spinosa PC, Humphries BA, Lewin Mejia D, Buschhaus JM, Linderman JJ, Luker GD, Luker KE.

Sci Signal. 2019 Jul 9;12(589). pii: eaaw4204. doi: 10.1126/scisignal.aaw4204.


The Role of Dimensionality in Understanding Granuloma Formation.

Marino S, Hult C, Wolberg P, Linderman JJ, Kirschner DE.

Computation (Basel). 2018 Dec;6(4). pii: 58. doi: 10.3390/computation6040058. Epub 2018 Nov 14.


Data-Driven Model Validation Across Dimensions.

Renardy M, Wessler T, Blemker S, Linderman J, Peirce S, Kirschner D.

Bull Math Biol. 2019 Jun;81(6):1853-1866. doi: 10.1007/s11538-019-00590-4. Epub 2019 Mar 4.


Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations.

Sarathy J, Blanc L, Alvarez-Cabrera N, O'Brien P, Dias-Freedman I, Mina M, Zimmerman M, Kaya F, Ho Liang HP, Prideaux B, Dietzold J, Salgame P, Savic RM, Linderman J, Kirschner D, Pienaar E, Dartois V.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02516-18. doi: 10.1128/AAC.02516-18. Print 2019 May.


A Two-Pulse Cellular Stimulation Test Elucidates Variability and Mechanisms in Signaling Pathways.

Sumit M, Jovic A, Neubig RR, Takayama S, Linderman JJ.

Biophys J. 2019 Mar 5;116(5):962-973. doi: 10.1016/j.bpj.2019.01.022. Epub 2019 Jan 30.


Integrating Non-human Primate, Human, and Mathematical Studies to Determine the Influence of BCG Timing on H56 Vaccine Outcomes.

Joslyn LR, Pienaar E, DiFazio RM, Suliman S, Kagina BM, Flynn JL, Scriba TJ, Linderman JJ, Kirschner DE.

Front Microbiol. 2018 Aug 17;9:1734. doi: 10.3389/fmicb.2018.01734. eCollection 2018.


Dynamic balance of pro- and anti-inflammatory signals controls disease and limits pathology.

Cicchese JM, Evans S, Hult C, Joslyn LR, Wessler T, Millar JA, Marino S, Cilfone NA, Mattila JT, Linderman JJ, Kirschner DE.

Immunol Rev. 2018 Sep;285(1):147-167. doi: 10.1111/imr.12671. Review.


Regulation of Human Adipose Tissue Activation, Gallbladder Size, and Bile Acid Metabolism by a β3-Adrenergic Receptor Agonist.

Baskin AS, Linderman JD, Brychta RJ, McGehee S, Anflick-Chames E, Cero C, Johnson JW, O'Mara AE, Fletcher LA, Leitner BP, Duckworth CJ, Huang S, Cai H, Garraffo HM, Millo CM, Dieckmann W, Tolstikov V, Chen EY, Gao F, Narain NR, Kiebish MA, Walter PJ, Herscovitch P, Chen KY, Cypess AM.

Diabetes. 2018 Oct;67(10):2113-2125. doi: 10.2337/db18-0462. Epub 2018 Jul 6.


Emergence and selection of isoniazid and rifampin resistance in tuberculosis granulomas.

Pienaar E, Linderman JJ, Kirschner DE.

PLoS One. 2018 May 10;13(5):e0196322. doi: 10.1371/journal.pone.0196322. eCollection 2018.


Deletion of TGF-β1 Increases Bacterial Clearance by Cytotoxic T Cells in a Tuberculosis Granuloma Model.

Warsinske HC, Pienaar E, Linderman JJ, Mattila JT, Kirschner DE.

Front Immunol. 2017 Dec 20;8:1843. doi: 10.3389/fimmu.2017.01843. eCollection 2017.


Applying optimization algorithms to tuberculosis antibiotic treatment regimens.

Cicchese JM, Pienaar E, Kirschner DE, Linderman JJ.

Cell Mol Bioeng. 2017 Dec;10(6):523-535. doi: 10.1007/s12195-017-0507-6. Epub 2017 Aug 30.


Improved Tumor Penetration and Single-Cell Targeting of Antibody-Drug Conjugates Increases Anticancer Efficacy and Host Survival.

Cilliers C, Menezes B, Nessler I, Linderman J, Thurber GM.

Cancer Res. 2018 Feb 1;78(3):758-768. doi: 10.1158/0008-5472.CAN-17-1638. Epub 2017 Dec 7.


The CXCL12/CXCR7 signaling axis, isoforms, circadian rhythms, and tumor cellular composition dictate gradients in tissue.

Spinosa PC, Luker KE, Luker GD, Linderman JJ.

PLoS One. 2017 Nov 8;12(11):e0187357. doi: 10.1371/journal.pone.0187357. eCollection 2017.


Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach.

Pienaar E, Sarathy J, Prideaux B, Dietzold J, Dartois V, Kirschner DE, Linderman JJ.

PLoS Comput Biol. 2017 Aug 17;13(8):e1005650. doi: 10.1371/journal.pcbi.1005650. eCollection 2017 Aug.


Body mass index associations between mother and offspring from birth to age 18: the Fels Longitudinal Study.

Swanton S, Choh AC, Lee M, Laubach LL, Linderman JK, Czerwinski SA, Peterson MJ.

Obes Sci Pract. 2017 Apr 26;3(2):127-133. doi: 10.1002/osp4.90. eCollection 2017 Jun.


Identifying mechanisms driving formation of granuloma-associated fibrosis during Mycobacterium tuberculosis infection.

Warsinske HC, DiFazio RM, Linderman JJ, Flynn JL, Kirschner DE.

J Theor Biol. 2017 Sep 21;429:1-17. doi: 10.1016/j.jtbi.2017.06.017. Epub 2017 Jun 20.


A review of computational and mathematical modeling contributions to our understanding of Mycobacterium tuberculosis within-host infection and treatment.

Kirschner D, Pienaar E, Marino S, Linderman JJ.

Curr Opin Syst Biol. 2017 Jun;3:170-185. doi: 10.1016/j.coisb.2017.05.014. Epub 2017 May 22.


Correction: Cell, Isoform, and Environment Factors Shape Gradients and Modulate Chemotaxis.

Chang SL, Cavnar SP, Luker KE, Takayama S, Luker GD, Linderman JJ.

PLoS One. 2017 Mar 14;12(3):e0174189. doi: 10.1371/journal.pone.0174189. eCollection 2017.


Immune Escape via a Transient Gene Expression Program Enables Productive Replication of a Latent Pathogen.

Linderman JA, Kobayashi M, Rayannavar V, Fak JJ, Darnell RB, Chao MV, Wilson AC, Mohr I.

Cell Rep. 2017 Jan 31;18(5):1312-1323. doi: 10.1016/j.celrep.2017.01.017.


New insights into mammalian signaling pathways using microfluidic pulsatile inputs and mathematical modeling.

Sumit M, Takayama S, Linderman JJ.

Integr Biol (Camb). 2017 Jan 23;9(1):6-21. doi: 10.1039/c6ib00178e. Review.


Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning.

Müller AM, Florek M, Kohrt HE, Küpper NJ, Filatenkov A, Linderman JA, Hadeiba H, Negrin RS, Shizuru JA.

J Immunol. 2016 Nov 15;197(10):4151-4162. Epub 2016 Oct 10.


Effects of a New Cooling Technology on Physical Performance in US Air Force Military Personnel.

O'Hara R, Vojta C, Henry A, Caldwell L, Wade M, Swanton S, Linderman JK, Ordway J.

J Spec Oper Med. 2016 summer;16(2):57-61.


Computational Modeling Predicts Simultaneous Targeting of Fibroblasts and Epithelial Cells Is Necessary for Treatment of Pulmonary Fibrosis.

Warsinske HC, Wheaton AK, Kim KK, Linderman JJ, Moore BB, Kirschner DE.

Front Pharmacol. 2016 Jun 23;7:183. doi: 10.3389/fphar.2016.00183. eCollection 2016.


Computational and Empirical Studies Predict Mycobacterium tuberculosis-Specific T Cells as a Biomarker for Infection Outcome.

Marino S, Gideon HP, Gong C, Mankad S, McCrone JT, Lin PL, Linderman JJ, Flynn JL, Kirschner DE.

PLoS Comput Biol. 2016 Apr 11;12(4):e1004804. doi: 10.1371/journal.pcbi.1004804. eCollection 2016 Apr.


Multiscale Model of Mycobacterium tuberculosis Infection Maps Metabolite and Gene Perturbations to Granuloma Sterilization Predictions.

Pienaar E, Matern WM, Linderman JJ, Bader JS, Kirschner DE.

Infect Immun. 2016 Apr 22;84(5):1650-1669. doi: 10.1128/IAI.01438-15. Print 2016 May.


In silico models of M. tuberculosis infection provide a route to new therapies.

Linderman JJ, Kirschner DE.

Drug Discov Today Dis Models. 2015 Spring;15:37-41. Epub 2014 May 9.


Strategic Priming with Multiple Antigens can Yield Memory Cell Phenotypes Optimized for Infection with Mycobacterium tuberculosis: A Computational Study.

Ziraldo C, Gong C, Kirschner DE, Linderman JJ.

Front Microbiol. 2016 Jan 6;6:1477. doi: 10.3389/fmicb.2015.01477. eCollection 2015.


In silico evaluation and exploration of antibiotic tuberculosis treatment regimens.

Pienaar E, Dartois V, Linderman JJ, Kirschner DE.

BMC Syst Biol. 2015 Nov 14;9:79. doi: 10.1186/s12918-015-0221-8.


Identifying Mechanisms of Homeostatic Signaling in Fibroblast Differentiation.

Warsinske HC, Ashley SL, Linderman JJ, Moore BB, Kirschner DE.

Bull Math Biol. 2015 Aug;77(8):1556-82. doi: 10.1007/s11538-015-0096-2. Epub 2015 Sep 18.


Band-pass processing in a GPCR signaling pathway selects for NFAT transcription factor activation.

Sumit M, Neubig RR, Takayama S, Linderman JJ.

Integr Biol (Camb). 2015 Nov;7(11):1378-86. doi: 10.1039/c5ib00181a.


Systems Pharmacology Approach Toward the Design of Inhaled Formulations of Rifampicin and Isoniazid for Treatment of Tuberculosis.

Cilfone NA, Pienaar E, Thurber GM, Kirschner DE, Linderman JJ.

CPT Pharmacometrics Syst Pharmacol. 2015 Mar;4(3):e00022. doi: 10.1002/psp4.22. Epub 2015 Mar 11.


A multi-scale approach to designing therapeutics for tuberculosis.

Linderman JJ, Cilfone NA, Pienaar E, Gong C, Kirschner DE.

Integr Biol (Camb). 2015 May;7(5):591-609. doi: 10.1039/c4ib00295d. Epub 2015 Apr 30.


Cell, isoform, and environment factors shape gradients and modulate chemotaxis.

Chang SL, Cavnar SP, Takayama S, Luker GD, Linderman JJ.

PLoS One. 2015 Apr 24;10(4):e0123450. doi: 10.1371/journal.pone.0123450. eCollection 2015. Erratum in: PLoS One. 2017 Mar 14;12 (3):e0174189.


A population model capturing dynamics of tuberculosis granulomas predicts host infection outcomes.

Gong C, Linderman JJ, Kirschner D.

Math Biosci Eng. 2015 Jun;12(3):625-42. doi: 10.3934/mbe.2015.12.625.


Computational modeling predicts IL-10 control of lesion sterilization by balancing early host immunity-mediated antimicrobial responses with caseation during mycobacterium tuberculosis infection.

Cilfone NA, Ford CB, Marino S, Mattila JT, Gideon HP, Flynn JL, Kirschner DE, Linderman JJ.

J Immunol. 2015 Jan 15;194(2):664-77. doi: 10.4049/jimmunol.1400734. Epub 2014 Dec 15.


A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment.

Pienaar E, Cilfone NA, Lin PL, Dartois V, Mattila JT, Butler JR, Flynn JL, Kirschner DE, Linderman JJ.

J Theor Biol. 2015 Feb 21;367:166-179. doi: 10.1016/j.jtbi.2014.11.021. Epub 2014 Dec 9.


Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection.

Marino S, Cilfone NA, Mattila JT, Linderman JJ, Flynn JL, Kirschner DE.

Infect Immun. 2015 Jan;83(1):324-38. doi: 10.1128/IAI.02494-14. Epub 2014 Nov 3.


Effects of a 12-month moderate weight loss intervention on insulin sensitivity and inflammation status in nondiabetic overweight and obese subjects.

Ho TP, Zhao X, Courville AB, Linderman JD, Smith S, Sebring N, Della Valle DM, Fitzpatrick B, Simchowitz L, Celi FS.

Horm Metab Res. 2015 Apr;47(4):289-96. doi: 10.1055/s-0034-1382011. Epub 2014 Jun 30.


Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans.

Lee P, Smith S, Linderman J, Courville AB, Brychta RJ, Dieckmann W, Werner CD, Chen KY, Celi FS.

Diabetes. 2014 Nov;63(11):3686-98. doi: 10.2337/db14-0513. Epub 2014 Jun 22.


CXCR7 controls competition for recruitment of β-arrestin 2 in cells expressing both CXCR4 and CXCR7.

Coggins NL, Trakimas D, Chang SL, Ehrlich A, Ray P, Luker KE, Linderman JJ, Luker GD.

PLoS One. 2014 Jun 4;9(6):e98328. doi: 10.1371/journal.pone.0098328. eCollection 2014.


A Comprehensive Analysis of CXCL12 Isoforms in Breast Cancer1,2.

Zhao S, Chang SL, Linderman JJ, Feng FY, Luker GD.

Transl Oncol. 2014 May 13. pii: S1936-5233(14)00021-7. doi: 10.1016/j.tranon.2014.04.001. [Epub ahead of print]


Tuneable resolution as a systems biology approach for multi-scale, multi-compartment computational models.

Kirschner DE, Hunt CA, Marino S, Fallahi-Sichani M, Linderman JJ.

Wiley Interdiscip Rev Syst Biol Med. 2014 Jul-Aug;6(4):289-309. doi: 10.1002/wsbm.1270. Epub 2014 May 9. Review.


Microfluidic source-sink model reveals effects of biophysically distinct CXCL12 isoforms in breast cancer chemotaxis.

Cavnar SP, Ray P, Moudgil P, Chang SL, Luker KE, Linderman JJ, Takayama S, Luker GD.

Integr Biol (Camb). 2014 May;6(5):564-76. doi: 10.1039/c4ib00015c.


Using homogeneous primary neuron cultures to study fundamental aspects of HSV-1 latency and reactivation.

Kim JY, Shiflett LA, Linderman JA, Mohr I, Wilson AC.

Methods Mol Biol. 2014;1144:167-79. doi: 10.1007/978-1-4939-0428-0_11.


Harnessing the heterogeneity of T cell differentiation fate to fine-tune generation of effector and memory T cells.

Gong C, Linderman JJ, Kirschner D.

Front Immunol. 2014 Feb 19;5:57. doi: 10.3389/fimmu.2014.00057. eCollection 2014.


Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans.

Lee P, Linderman JD, Smith S, Brychta RJ, Wang J, Idelson C, Perron RM, Werner CD, Phan GQ, Kammula US, Kebebew E, Pacak K, Chen KY, Celi FS.

Cell Metab. 2014 Feb 4;19(2):302-9. doi: 10.1016/j.cmet.2013.12.017.


Fibroblast growth factor 21 (FGF21) and bone: is there a relationship in humans?

Lee P, Linderman J, Smith S, Brychta RJ, Perron R, Idelson C, Werner CD, Chen KY, Celi FS.

Osteoporos Int. 2013 Dec;24(12):3053-7. doi: 10.1007/s00198-013-2464-9. Epub 2013 Aug 3.


Moderate weight loss is sufficient to affect thyroid hormone homeostasis and inhibit its peripheral conversion.

Agnihothri RV, Courville AB, Linderman JD, Smith S, Brychta R, Remaley A, Chen KY, Simchowitz L, Celi FS.

Thyroid. 2014 Jan;24(1):19-26. doi: 10.1089/thy.2013.0055.

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