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Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15.

Mofers A, Perego P, Selvaraju K, Gatti L, Gullbo J, Linder S, D'Arcy P.

PLoS One. 2019 Oct 22;14(10):e0223807. doi: 10.1371/journal.pone.0223807. eCollection 2019.


A Technology Enabled Concussion Care Pathway Reduces Costs and Enhances Care.

Alberts JL, Modic MT, Udeh BL, Zimmerman N, Cherian K, Lu X, Gray R, Figler R, Russman A, Linder SM.

Phys Ther. 2019 Oct 4. pii: pzz141. doi: 10.1093/ptj/pzz141. [Epub ahead of print]


ERCP-related perforations: a population-based study of incidence, mortality, and risk factors.

Langerth A, Isaksson B, Karlson BM, Urdzik J, Linder S.

Surg Endosc. 2019 Sep 26. doi: 10.1007/s00464-019-06966-w. [Epub ahead of print]


A novel tumor spheroid model identifies selective enhancement of radiation by an inhibitor of oxidative phosphorylation.

Karlsson H, Senkowski W, Fryknäs M, Mansoori S, Linder S, Gullbo J, Larsson R, Nygren P.

Oncotarget. 2019 Sep 3;10(51):5372-5382. doi: 10.18632/oncotarget.27166. eCollection 2019 Sep 3.


Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP.

Sammel M, Peters F, Lokau J, Scharfenberg F, Werny L, Linder S, Garbers C, Rose-John S, Becker-Pauly C.

Int J Mol Sci. 2019 Jul 26;20(15). pii: E3677. doi: 10.3390/ijms20153677.


SNX3 drives maturation of Borrelia phagosomes by forming a hub for PI(3)P, Rab5a, and galectin-9.

Klose M, Salloum JE, Gonschior H, Linder S.

J Cell Biol. 2019 Sep 2;218(9):3039-3059. doi: 10.1083/jcb.201812106. Epub 2019 Jul 23.


Forced, Not Voluntary, Aerobic Exercise Enhances Motor Recovery in Persons With Chronic Stroke.

Linder SM, Rosenfeldt AB, Davidson S, Zimmerman N, Penko A, Lee J, Clark C, Alberts JL.

Neurorehabil Neural Repair. 2019 Aug;33(8):681-690. doi: 10.1177/1545968319862557. Epub 2019 Jul 17.


Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system.

Selvaraju K, Mofers A, Pellegrini P, Salomonsson J, Ahlner A, Morad V, Hillert EK, Espinosa B, Arnér ESJ, Jensen L, Malmström J, Turkina MV, D'Arcy P, Walters MA, Sunnerhagen M, Linder S.

Sci Rep. 2019 Jul 8;9(1):9841. doi: 10.1038/s41598-019-46168-x.


Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment.

Zhang X, Espinosa B, Saei AA, D'Arcy P, Zubarev RA, Linder S.

Oxid Med Cell Longev. 2019 Jun 10;2019:1659468. doi: 10.1155/2019/1659468. eCollection 2019.


Detection and Characterization of Silver Nanostructures in Consumer Products.

Lim JH, Bairi VG, Linder SW, Fong A.

J Nanosci Nanotechnol. 2019 Dec 1;19(12):8078-8087. doi: 10.1166/jnn.2019.16754.


Antiproliferative Effects of the Natural Oxadiazine Nocuolin A Are Associated With Impairment of Mitochondrial Oxidative Phosphorylation.

Sousa ML, Preto M, Vasconcelos V, Linder S, Urbatzka R.

Front Oncol. 2019 Apr 3;9:224. doi: 10.3389/fonc.2019.00224. eCollection 2019.


Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug.

Zhang X, Selvaraju K, Saei AA, D'Arcy P, Zubarev RA, Arnér ES, Linder S.

Biochimie. 2019 Jul;162:46-54. doi: 10.1016/j.biochi.2019.03.015. Epub 2019 Apr 1.


A technology-enabled electronic incident report to document and facilitate management of sport concussion: A cohort study of youth and young adults.

Linder SM, Cruickshank J, Zimmerman NM, Figler R, Alberts JL.

Medicine (Baltimore). 2019 Apr;98(14):e14948. doi: 10.1097/MD.0000000000014948.


A Mobile Device Dual-Task Paradigm for the Assessment of mTBI.

Linder SM, Koop MM, Ozinga S, Goldfarb Z, Alberts JL.

Mil Med. 2019 Mar 1;184(Suppl 1):174-180. doi: 10.1093/milmed/usy334.


The utility of a system dynamics approach for understanding cumulative health risk from exposure to environmental hazards.

Prochaska JD, Kim H, Buschmann RN, Jupiter D, Croisant S, Linder SH, Sexton K.

Environ Res. 2019 May;172:462-469. doi: 10.1016/j.envres.2019.02.039. Epub 2019 Feb 27.


Estimating Bacterial Concentrations in Fibrous Substrates Through a Combination of Scanning Electron Microscopy and ImageJ.

Bera T, Xu J, Alusta P, Fong A, Linder SW, Torosian SD.

Anal Chem. 2019 Apr 2;91(7):4405-4412. doi: 10.1021/acs.analchem.8b04862. Epub 2019 Mar 15.


Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation.

Hillert EK, Brnjic S, Zhang X, Mazurkiewicz M, Saei AA, Mofers A, Selvaraju K, Zubarev R, Linder S, D'Arcy P.

Cancer Lett. 2019 Apr 28;448:70-83. doi: 10.1016/j.canlet.2019.02.003. Epub 2019 Feb 13.


Development and Implementation of a Multi-Disciplinary Technology Enhanced Care Pathway for Youth and Adults with Concussion.

Alberts JL, Modic MT, Udeh B, Dey T, Cherian K, Lu X, Figler R, Russman A, Linder SM.

J Vis Exp. 2019 Jan 20;(143). doi: 10.3791/58962.


Targeting Mitochondria for Treatment of Chemoresistant Ovarian Cancer.

Emmings E, Mullany S, Chang Z, Landen CN Jr, Linder S, Bazzaro M.

Int J Mol Sci. 2019 Jan 8;20(1). pii: E229. doi: 10.3390/ijms20010229. Review.


Optimized ChIP-seq method facilitates transcription factor profiling in human tumors.

Singh AA, Schuurman K, Nevedomskaya E, Stelloo S, Linder S, Droog M, Kim Y, Sanders J, van der Poel H, Bergman AM, Wessels LF, Zwart W.

Life Sci Alliance. 2018 Dec 28;2(1):e201800115. doi: 10.26508/lsa.201800115. eCollection 2019 Feb.


Methods for Evaluating the Combined Effects of Chemical and Nonchemical Exposures for Cumulative Environmental Health Risk Assessment.

Payne-Sturges DC, Scammell MK, Levy JI, Cory-Slechta DA, Symanski E, Carr Shmool JL, Laumbach R, Linder S, Clougherty JE.

Int J Environ Res Public Health. 2018 Dec 10;15(12). pii: E2797. doi: 10.3390/ijerph15122797.


Combined Aerobic Exercise and Task Practice Improve Health-Related Quality of Life Poststroke: A Preliminary Analysis.

Rosenfeldt AB, Linder SM, Davidson S, Clark C, Zimmerman NM, Lee JJ, Alberts JL.

Arch Phys Med Rehabil. 2019 May;100(5):923-930. doi: 10.1016/j.apmr.2018.11.011. Epub 2018 Dec 10.


Treatment of de Garengeot's hernia: a meta-analysis.

Linder S, Linder G, Månsson C.

Hernia. 2019 Feb;23(1):131-141. doi: 10.1007/s10029-018-1862-5. Epub 2018 Dec 7. Review.


Reducing the Cost of Medicaid: A Multistate Simulation.

Linder SH, Aguillard K, French K, Garson A.

Health Serv Insights. 2018 Nov 27;11:1178632918813311. doi: 10.1177/1178632918813311. eCollection 2018.


Enzalutamide therapy for advanced prostate cancer: efficacy, resistance and beyond

Linder S, van der Poel HG, Bergman AM, Zwart W, Prekovic S.

Endocr Relat Cancer. 2018 Oct 31;26(1):R31-R52. doi: 10.1530/ERC-18-0289.


Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells.

Cabron AS, El Azzouzi K, Boss M, Arnold P, Schwarz J, Rosas M, Dobert JP, Pavlenko E, Schumacher N, Renné T, Taylor PR, Linder S, Rose-John S, Zunke F.

J Immunol. 2018 Nov 15;201(10):3106-3118. doi: 10.4049/jimmunol.1701556. Epub 2018 Oct 24.


Molecular underpinnings of enzalutamide resistance

Prekovic S, van den Broeck T, Linder S, van Royen ME, Houtsmuller AB, Handle F, Joniau S, Zwart W, Claessens F.

Endocr Relat Cancer. 2018 Nov 1;25(11):R545–R557. doi: 10.1530/ERC-17-0136.


A Population-Based Approach to Mapping Vulnerability to Diabetes.

Linder S, Marko D, Tian Y, Wisniewski T.

Int J Environ Res Public Health. 2018 Oct 2;15(10). pii: E2167. doi: 10.3390/ijerph15102167.


A drug screening assay on cancer cells chronically adapted to acidosis.

Pellegrini P, Serviss JT, Lundbäck T, Bancaro N, Mazurkiewicz M, Kolosenko I, Yu D, Haraldsson M, D'Arcy P, Linder S, De Milito A.

Cancer Cell Int. 2018 Sep 25;18:147. doi: 10.1186/s12935-018-0645-5. eCollection 2018.


The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage.

Zhang X, Pellegrini P, Saei AA, Hillert EK, Mazurkiewicz M, Olofsson MH, Zubarev RA, D'Arcy P, Linder S.

Biochem Pharmacol. 2018 Oct;156:291-301. doi: 10.1016/j.bcp.2018.08.039. Epub 2018 Aug 25.


MT1-MMP targeting to endolysosomes is mediated by upregulation of flotillins.

Planchon D, Rios Morris E, Genest M, Comunale F, Vacher S, Bièche I, Denisov EV, Tashireva LA, Perelmuter VM, Linder S, Chavrier P, Bodin S, Gauthier-Rouvière C.

J Cell Sci. 2018 Sep 5;131(17). pii: jcs218925. doi: 10.1242/jcs.218925.


Normative Performance on the Balance Error Scoring System by Youth, High School, and Collegiate Athletes.

Ozinga SJ, Linder SM, Koop MM, Dey T, Figler R, Russman AN, So R, Rosenthal AH, Cruickshank J, Alberts JL.

J Athl Train. 2018 Jul;53(7):636-645. doi: 10.4085/1062-6050-129-17. Epub 2018 Aug 15.


Clinical relevance of cytoskeleton associated proteins for ovarian cancer.

Schiewek J, Schumacher U, Lange T, Joosse SA, Wikman H, Pantel K, Mikhaylova M, Kneussel M, Linder S, Schmalfeldt B, Oliveira-Ferrer L, Windhorst S.

J Cancer Res Clin Oncol. 2018 Nov;144(11):2195-2205. doi: 10.1007/s00432-018-2710-9. Epub 2018 Aug 9.


[Perspectives for the Electroencephalogram in Psychiatry].

Kirsten A, Linder S, Olbrich S.

Praxis (Bern 1994). 2018 Jul;107(15):837-843. doi: 10.1024/1661-8157/a003028. Review. German.


The combined effect of ambient ozone exposure and toxic air releases on hospitalization for asthma among children in Harris County, Texas.

Nnoli NC, Linder SH, Smith MA, Gemeinhardt GL, Zhang K.

Int J Environ Health Res. 2018 Aug;28(4):358-378. doi: 10.1080/09603123.2018.1479515. Epub 2018 Jul 2.


Novel analytical methods to assess the chemical and physical properties of liposomes.

Kothalawala N, Mudalige TK, Sisco P, Linder SW.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 1;1091:14-20. doi: 10.1016/j.jchromb.2018.05.028. Epub 2018 May 19.


Cleveland Clinic Postural Stability Index Norms for the Balance Error Scoring System.

Linder SM, Ozinga SJ, Koop MM, Dey T, Figler R, Cruickshank J, Alberts JL.

Med Sci Sports Exerc. 2018 Oct;50(10):1998-2006. doi: 10.1249/MSS.0000000000001660.


Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division.

Maia ARR, Linder S, Song JY, Vaarting C, Boon U, Pritchard CEJ, Velds A, Huijbers IJ, van Tellingen O, Jonkers J, Medema RH.

Br J Cancer. 2018 Jun;118(12):1586-1595. doi: 10.1038/s41416-018-0081-2. Epub 2018 May 8.


Improved lower extremity pedaling mechanics in individuals with stroke under maximal workloads.

Linder SM, Rosenfeldt AB, Bazyk AS, Koop MM, Ozinga S, Alberts JL.

Top Stroke Rehabil. 2018 May;25(4):248-255. doi: 10.1080/10749357.2018.1437935. Epub 2018 Feb 15.


Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.

Stafford WC, Peng X, Olofsson MH, Zhang X, Luci DK, Lu L, Cheng Q, Trésaugues L, Dexheimer TS, Coussens NP, Augsten M, Ahlzén HM, Orwar O, Östman A, Stone-Elander S, Maloney DJ, Jadhav A, Simeonov A, Linder S, Arnér ESJ.

Sci Transl Med. 2018 Feb 14;10(428). pii: eaaf7444. doi: 10.1126/scitranslmed.aaf7444.


Lymphocyte-specific protein 1 regulates mechanosensory oscillation of podosomes and actin isoform-based actomyosin symmetry breaking.

Cervero P, Wiesner C, Bouissou A, Poincloux R, Linder S.

Nat Commun. 2018 Feb 6;9(1):515. doi: 10.1038/s41467-018-02904-x.


Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group.

Perego P, Hempel G, Linder S, Bradshaw TD, Larsen AK, Peters GJ, Phillips RM; EORTC PAMM Group.

Cancer Chemother Pharmacol. 2018 Mar;81(3):427-441. doi: 10.1007/s00280-017-3502-7. Epub 2017 Dec 28. Review.


The Essential Elements of a Risk Governance Framework for Current and Future Nanotechnologies.

Stone V, Führ M, Feindt PH, Bouwmeester H, Linkov I, Sabella S, Murphy F, Bizer K, Tran L, Ågerstrand M, Fito C, Andersen T, Anderson D, Bergamaschi E, Cherrie JW, Cowan S, Dalemcourt JF, Faure M, Gabbert S, Gajewicz A, Fernandes TF, Hristozov D, Johnston HJ, Lansdown TC, Linder S, Marvin HJP, Mullins M, Purnhagen K, Puzyn T, Sanchez Jimenez A, Scott-Fordsmand JJ, Streftaris G, van Tongeren M, Voelcker NH, Voyiatzis G, Yannopoulos SN, Poortvliet PM.

Risk Anal. 2018 Jul;38(7):1321-1331. doi: 10.1111/risa.12954. Epub 2017 Dec 14.


Innovating patient care delivery: DSRIP's interrupted time series analysis paradigm.

Shenoy AG, Begley CE, Revere L, Linder SH, Daiger SP.

Healthc (Amst). 2019 Mar;7(1):44-50. doi: 10.1016/j.hjdsi.2017.11.004. Epub 2017 Dec 8.


Physiological acclimation dampens initial effects of elevated temperature and atmospheric CO2 concentration in mature boreal Norway spruce.

Lamba S, Hall M, Räntfors M, Chaudhary N, Linder S, Way D, Uddling J, Wallin G.

Plant Cell Environ. 2018 Feb;41(2):300-313. doi: 10.1111/pce.13079. Epub 2017 Dec 11.


Cytotoxicity of portoamides in human cancer cells and analysis of the molecular mechanisms of action.

Ribeiro T, Lemos F, Preto M, Azevedo J, Sousa ML, Leão PN, Campos A, Linder S, Vitorino R, Vasconcelos V, Urbatzka R.

PLoS One. 2017 Dec 7;12(12):e0188817. doi: 10.1371/journal.pone.0188817. eCollection 2017.


Fentanyl Rising: EMS strategies for combatting the increasing use and abuse of highly potent opioids.

Linder SH, Huang LC, Hodge K.

JEMS. 2016 Nov;41(11):49-51. No abstract available.


MYC is downregulated by a mitochondrial checkpoint mechanism.

Zhang X, Mofers A, Hydbring P, Olofsson MH, Guo J, Linder S, D'Arcy P.

Oncotarget. 2017 Oct 6;8(52):90225-90237. doi: 10.18632/oncotarget.21653. eCollection 2017 Oct 27.


Proteasome-associated deubiquitinases and cancer.

Mofers A, Pellegrini P, Linder S, D'Arcy P.

Cancer Metastasis Rev. 2017 Dec;36(4):635-653. doi: 10.1007/s10555-017-9697-6. Review.

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