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R-spondin 2 Drives Liver Tumor Development in a Yes-Associated Protein-Dependent Manner.

Conboy CB, Vélez-Reyes GL, Tschida BR, Hu H, Kaufmann G, Koes N, Keller B, Alsinet C, Cornellà H, Pinyol R, Abrahante JE, Temiz NA, Linden MA, Amin K, Kuka TP, Keng VW, Llovet JM, Starr TK, Largaespada DA.

Hepatol Commun. 2019 Sep 3;3(11):1496-1509. doi: 10.1002/hep4.1422. eCollection 2019 Nov.


VS38 Identifies Myeloma Cells With Dim CD38 Expression and Plasma Cells Following Daratumumab Therapy, Which Interferes With CD38 Detection for 4 to 6 Months.

Courville EL, Yohe S, Shivers P, Linden MA.

Am J Clin Pathol. 2019 Nov 2. pii: aqz153. doi: 10.1093/ajcp/aqz153. [Epub ahead of print]


Sarcoid-like Histiocytic Proliferations in Patients With Lymphoma Can Be FDG-avid Concerning for Refractory or Recurrent Disease.

Cayci Z, Ozturk K, Ustun C, Omer AK, Dincer E, Sachs Z, Peterson BA, Linden MA.

Clin Lymphoma Myeloma Leuk. 2019 Aug 30. pii: S2152-2650(19)31386-2. doi: 10.1016/j.clml.2019.08.016. [Epub ahead of print] No abstract available.


eNOS deletion impairs mitochondrial quality control and exacerbates Western diet-induced NASH.

Sheldon RD, Meers GM, Morris EM, Linden MA, Cunningham RP, Ibdah JA, Thyfault JP, Laughlin MH, Rector RS.

Am J Physiol Endocrinol Metab. 2019 Oct 1;317(4):E605-E616. doi: 10.1152/ajpendo.00096.2019. Epub 2019 Jul 30.


Analysis of Differentially Expressed MicroRNAs and Circulating Tumor Cells as Predictive Biomarkers of Platinum Chemoresistance in Primary Ovarian Carcinomas: A Prospective Study.

Lou E, Vogel RI, Hoostal S, Wong P, Grad A, Monu M, Łukaszewski T, Deshpande J, Dickson EL, Klein M, Linden MA, Subramanian S, Teoh D, Geller MA.

Oncologist. 2019 Jul 25. pii: theoncologist.2019-0497. doi: 10.1634/theoncologist.2019-0497. [Epub ahead of print]


Exercise-Induced Mitohormesis for the Maintenance of Skeletal Muscle and Healthspan Extension.

Musci RV, Hamilton KL, Linden MA.

Sports (Basel). 2019 Jul 11;7(7). pii: E170. doi: 10.3390/sports7070170. Review.


CD161 Is Expressed in a Subset of T-Cell Prolymphocytic Leukemia Cases and Is Useful for Disease Follow-up.

Gilles SR, Yohe SL, Linden MA, Dolan M, Hirsch B, Grzywacz B.

Am J Clin Pathol. 2019 Sep 9;152(4):471-478. doi: 10.1093/ajcp/aqz060.


Traumatic brain injury and social competence among young male offenders.

Linden MA, O'Rourke C, Lohan M.

Disabil Rehabil. 2019 Jun 22:1-8. doi: 10.1080/09638288.2019.1629699. [Epub ahead of print]


Tumor-Stroma Proportion as a Predictive Biomarker of Resistance to Platinum-Based Chemotherapy in Patients With Ovarian Cancer.

Lou E, Vogel RI, Hoostal S, Klein M, Linden MA, Teoh D, Geller MA.

JAMA Oncol. 2019 Jun 1. doi: 10.1001/jamaoncol.2019.1943. [Epub ahead of print] No abstract available.


The combination of exercise training and sodium-glucose cotransporter-2 inhibition improves glucose tolerance and exercise capacity in a rodent model of type 2 diabetes.

Linden MA, Ross TT, Beebe DA, Gorgoglione MF, Hamilton KL, Miller BF, Braun B, Esler WP.

Metabolism. 2019 Aug;97:68-80. doi: 10.1016/j.metabol.2019.05.009. Epub 2019 May 25.


Identifying patients' support needs following critical illness: a scoping review of the qualitative literature.

King J, O'Neill B, Ramsay P, Linden MA, Darweish Medniuk A, Outtrim J, Blackwood B.

Crit Care. 2019 May 24;23(1):187. doi: 10.1186/s13054-019-2441-6.


Brain Protein Synthesis Rates in the UM-HET3 Mouse Following Treatment with Rapamycin or Rapamycin with Metformin.

Reid JJ, Linden MA, Peelor FF, Miller RA, Hamilton KL, Miller BF.

J Gerontol A Biol Sci Med Sci. 2019 Mar 13. pii: glz069. doi: 10.1093/gerona/glz069. [Epub ahead of print]


Differential Effects of Rapamycin and Metformin in Combination with Rapamycin on Mechanisms of Proteostasis in Cultured Skeletal Myotubes.

Wolff CA, Reid JJ, Musci RV, Linden MA, Konopka AR, Peelor FF, Miller BF, Hamilton KL.

J Gerontol A Biol Sci Med Sci. 2019 Mar 1. pii: glz058. doi: 10.1093/gerona/glz058. [Epub ahead of print]


Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults.

Konopka AR, Laurin JL, Schoenberg HM, Reid JJ, Castor WM, Wolff CA, Musci RV, Safairad OD, Linden MA, Biela LM, Bailey SM, Hamilton KL, Miller BF.

Aging Cell. 2019 Feb;18(1):e12880. doi: 10.1111/acel.12880. Epub 2018 Dec 11.


Traumatic brain injury and abuse among female offenders compared to non-incarcerated controls.

O'Rourke C, Linden MA, Lohan M.

Brain Inj. 2018;32(13-14):1787-1794. doi: 10.1080/02699052.2018.1539872. Epub 2018 Oct 29.


Sleeping Beauty Screen Identifies RREB1 and Other Genetic Drivers in Human B-cell Lymphoma.

Rahrmann EP, Wolf NK, Otto GM, Heltemes-Harris L, Ramsey LB, Shu J, LaRue RS, Linden MA, Rathe SK, Starr TK, Farrar MA, Moriarity BS, Largaespada DA.

Mol Cancer Res. 2019 Feb;17(2):567-582. doi: 10.1158/1541-7786.MCR-18-0582. Epub 2018 Oct 24.


Prognostic value of prior consolidation in acute myeloid leukemia patients undergoing hematopoietic cell transplantation in minimal residual disease-negative first complete remission.

How J, Vij KR, Ebadi M, DeFor TE, Romee R, Dolan MM, Ustun C, Weisdorf DJ, Linden MA, Rashidi A.

Am J Hematol. 2018 Dec;93(12):E381-E383. doi: 10.1002/ajh.25262. Epub 2018 Oct 9. No abstract available.


Core-binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I-CBFit).

Ustun C, Morgan E, Moodie EEM, Pullarkat S, Yeung C, Broesby-Olsen S, Ohgami R, Kim Y, Sperr W, Vestergaard H, Chen D, Kluin PM, Dolan M, Mrózek K, Czuchlewski D, Horny HP, George TI, Kristensen TK, Ku NK, Yi CA, Møller MB, Marcucci G, Baughn L, Schiefer AI, Hilberink JR, Pullarkat V, Shanley R, Kohlschmidt J, Coulombe J, Salhotra A, Soma L, Cho C, Linden MA, Akin C, Gotlib J, Hoermann G, Hornick J, Nakamura R, Deeg J, Bloomfield CD, Weisdorf D, Litzow MR, Valent P, Huls G, Perales MA, Borthakur G.

Cancer Med. 2018 Sep;7(9):4447-4455. doi: 10.1002/cam4.1733. Epub 2018 Aug 16.


Challenges of Conducting Research With Young Offenders With Traumatic Brain Injury.

OʼRourke C, Templeton M, Cohen MH, Linden MA.

J Head Trauma Rehabil. 2018 Nov/Dec;33(6):378-381. doi: 10.1097/HTR.0000000000000392.


Lines of Zahn in the Splenic Vein.

Rashidi A, Gilles S, Linden MA.

Thromb Haemost. 2018 Jun;118(6):957-958. doi: 10.1055/s-0038-1642610. Epub 2018 Apr 21. No abstract available.


An international perspective on educators' perceptions of children with Traumatic Brain Injury.

Kahn LG, Linden MA, McKinlay A, Gomez D, Glang A.

NeuroRehabilitation. 2018;42(3):299-309. doi: 10.3233/NRE-172380.


A systematic review and meta-analysis of educational interventions for children and adolescents with acquired brain injury.

Linden MA, Glang AE, McKinlay A.

NeuroRehabilitation. 2018;42(3):311-323. doi: 10.3233/NRE-172357. Review.


Assessment of Circulating Tumor Cells as a Predictive Biomarker of Histology in Women With Suspected Ovarian Cancer.

Lou E, Vogel RI, Teoh D, Hoostal S, Grad A, Gerber M, Monu M, Lukaszewski T, Deshpande J, Linden MA, Geller MA.

Lab Med. 2018 Mar 21;49(2):134-139. doi: 10.1093/labmed/lmx084.


Fibroblast growth factor 21 increases hepatic oxidative capacity but not physical activity or energy expenditure in hepatic peroxisome proliferator-activated receptor γ coactivator-1α-deficient mice.

Fletcher JA, Linden MA, Sheldon RD, Meers GM, Morris EM, Butterfield A, Perfield JW 2nd, Rector RS, Thyfault JP.

Exp Physiol. 2018 Mar 1;103(3):408-418. doi: 10.1113/EP086629. Epub 2018 Jan 16.


Recommendations for reporting post-transplant relapse in AML.

Rashidi A, Linden MA, Percival ME, Sandmaier BM, Devine S, Weisdorf DJ.

Bone Marrow Transplant. 2018 Feb;53(2):111-113. doi: 10.1038/bmt.2017.227. Epub 2017 Oct 30. No abstract available.


Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors.

Tschida BR, Temiz NA, Kuka TP, Lee LA, Riordan JD, Tierrablanca CA, Hullsiek R, Wagner S, Hudson WA, Linden MA, Amin K, Beckmann PJ, Heuer RA, Sarver AL, Yang JD, Roberts LR, Nadeau JH, Dupuy AJ, Keng VW, Largaespada DA.

Cancer Res. 2017 Dec 1;77(23):6576-6588. doi: 10.1158/0008-5472.CAN-17-2281. Epub 2017 Oct 9.


Importance of conditioning regimen intensity, MRD positivity, and KIR ligand mismatch in UCB transplantation.

Ustun C, Brunstein C, DeFor T, Rashidi A, Yohe S, Bejanyan N, Cooley S, Warlick E, Miller J, Linden MA, Weisdorf D.

Bone Marrow Transplant. 2018 Jan;53(1):97-100. doi: 10.1038/bmt.2017.212. Epub 2017 Oct 9. No abstract available.


Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice.

Riordan JD, Feddersen CR, Tschida BR, Beckmann PJ, Keng VW, Linden MA, Amin K, Stipp CS, Largaespada DA, Dupuy AJ.

Hepatology. 2018 Mar;67(3):924-939. doi: 10.1002/hep.29565. Epub 2018 Jan 26.


High-fat, high-fructose, high-cholesterol feeding causes severe NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine.

Panasevich MR, Meers GM, Linden MA, Booth FW, Perfield JW 2nd, Fritsche KL, Wankhade UD, Chintapalli SV, Shankar K, Ibdah JA, Rector RS.

Am J Physiol Endocrinol Metab. 2018 Jan 1;314(1):E78-E92. doi: 10.1152/ajpendo.00015.2017. Epub 2017 Sep 12.


Obesity and type 2 diabetes, not a diet high in fat, sucrose, and cholesterol, negatively impacts bone outcomes in the hyperphagic Otsuka Long Evans Tokushima Fatty rat.

Ortinau LC, Linden MA, Dirkes R, Rector RS, Hinton PS.

Bone. 2017 Dec;105:200-211. doi: 10.1016/j.bone.2017.09.003. Epub 2017 Sep 9.


Endurance training lowers ribosome density despite increasing ribosome biogenesis markers in rodent skeletal muscle.

Romero MA, Mobley CB, Linden MA, Meers GM, Martin JS, Young KC, Rector RS, Roberts MD.

BMC Res Notes. 2017 Aug 11;10(1):399. doi: 10.1186/s13104-017-2736-0.


Exercise initiated after the onset of insulin resistance improves trabecular microarchitecture and cortical bone biomechanics of the tibia in hyperphagic Otsuka Long Evans Tokushima Fatty rats.

Ortinau LC, Linden MA, Dirkes RK, Rector RS, Hinton PS.

Bone. 2017 Oct;103:188-199. doi: 10.1016/j.bone.2017.07.010. Epub 2017 Jul 12.


History of consolidation is prognostic in acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplantation in minimal residual disease-negative first complete remission.

Rashidi A, Linden MA, DeFor TE, Warlick E, Bejanyan N, Yohe S, Weisdorf DJ, Ustun C.

Am J Hematol. 2017 Oct;92(10):1032-1036. doi: 10.1002/ajh.24834. Epub 2017 Jul 29.


Misconceptions about traumatic brain injury among probation services.

O'Rourke C, Linden MA, Lohan M.

Disabil Rehabil. 2018 May;40(10):1119-1126. doi: 10.1080/09638288.2017.1288274. Epub 2017 Feb 23.


Genomics of clonal evolution in a case of essential thrombocythemia.

Rashidi A, Nelson AC, Linden MA, Weisdorf DJ, Dolan MM, Ustun C.

Leuk Lymphoma. 2018 Feb;59(2):497-500. doi: 10.1080/10428194.2017.1337113. Epub 2017 Jun 11. No abstract available.


Exercise improves femoral whole-bone and tissue-level biomechanical properties in hyperphagic OLETF rats.

Ortinau LC, Linden MA, Rector RS, Hinton PS.

Appl Physiol Nutr Metab. 2017 Aug;42(8):884-892. doi: 10.1139/apnm-2017-0077. Epub 2017 May 1.


The Comparative Diagnostic Features of Canine and Human Lymphoma.

Seelig DM, Avery AC, Ehrhart EJ, Linden MA.

Vet Sci. 2016 Jun;3(2). pii: 11. doi: 10.3390/vetsci3020011. Epub 2016 Jun 9.


Minimal residual disease prior to allogeneic hematopoietic cell transplantation in acute myeloid leukemia: a meta-analysis.

Buckley SA, Wood BL, Othus M, Hourigan CS, Ustun C, Linden MA, DeFor TE, Malagola M, Anthias C, Valkova V, Kanakry CG, Gruhn B, Buccisano F, Devine B, Walter RB.

Haematologica. 2017 May;102(5):865-873. doi: 10.3324/haematol.2016.159343. Epub 2017 Jan 25. Review.


Relapsed Acute Promyelocytic Leukemia Lacks "Classic" Leukemic Promyelocyte Morphology and Can Create Diagnostic Challenges.

Dayton VJ, McKenna RW, Yohe SL, Dolan MM, Courville E, Alvarez H, Linden MA.

Am J Clin Pathol. 2017 Jan 1;147(1):69-76. doi: 10.1093/ajcp/aqw202.


Green Neutrophilic Inclusions are Frequently Associated With Liver Injury and May Portend Short-Term Mortality in Critically Ill Patients.

Courville EL, Crisman S, Linden MA, Yohe S.

Lab Med. 2017 Feb;48(1):18-23. doi: 10.1093/labmed/lmw064. Epub 2016 Dec 29.


Unusual extramedullary hematopoietic neoplasms in lymph nodes.

Dayton VD, Williams SJ, McKenna RW, Linden MA.

Hum Pathol. 2017 Apr;62:13-22. doi: 10.1016/j.humpath.2016.12.014. Epub 2016 Dec 23. Review.


B-cell posttransplant lymphoproliferative disorder isolated to the central nervous system is Epstein-Barr virus positive and lacks p53 and Myc expression by immunohistochemistry.

Sundin A, Grzywacz BJ, Yohe S, Linden MA, Courville EL.

Hum Pathol. 2017 Mar;61:140-147. doi: 10.1016/j.humpath.2016.12.007. Epub 2016 Dec 16.


Phenotypic and functional characterization of a bortezomib-resistant multiple myeloma cell line by flow and mass cytometry.

Baughn LB, Sachs Z, Noble-Orcutt KE, Mitra A, Van Ness BG, Linden MA.

Leuk Lymphoma. 2017 Aug;58(8):1931-1940. doi: 10.1080/10428194.2016.1266621. Epub 2016 Dec 16.


Constitutive activation of alternative nuclear factor kappa B pathway in canine diffuse large B-cell lymphoma contributes to tumor cell survival and is a target of new adjuvant therapies.

Seelig DM, Ito D, Forster CL, Yoon UA, Breen M, Burns LJ, Bachanova V, Lindblad-Toh K, O'Brien TD, Schmechel SC, Rizzardi AE, Modiano JF, Linden MA.

Leuk Lymphoma. 2017 Jul;58(7):1702-1710. doi: 10.1080/10428194.2016.1260122. Epub 2016 Dec 8.


Anaplastic mast cell sarcoma: a unique pathologic entity in mastocytosis.

He F, Horny HP, Boone J, Raza A, Griffith M, Hurley P, Dolan M, Cayci Z, Linden MA, McKenna R, Ustun C.

Leuk Lymphoma. 2017 Jun;58(6):1515-1517. doi: 10.1080/10428194.2016.1250265. Epub 2016 Nov 3. No abstract available.


Loss of UHRF2 expression is associated with human neoplasia, promoter hypermethylation, decreased 5-hydroxymethylcytosine, and high proliferative activity.

Lu H, Bhoopatiraju S, Wang H, Schmitz NP, Wang X, Freeman MJ, Forster CL, Verneris MR, Linden MA, Hallstrom TC.

Oncotarget. 2016 Nov 15;7(46):76047-76061. doi: 10.18632/oncotarget.12583.



Linden MA, Williams SA, Forster C, Croonquist P, Braido J, Danneman S, Beckel M, Callahan M, Seelig D.

J Zoo Wildl Med. 2016 Sep;47(3):948-951. No abstract available.


Encapsulated relapsed FLT3+AML (myeloid sarcoma) and Hürthle cell adenoma presenting in composite: Unlikely partners.

He F, Ha K, Cayci Z, Swenson ME, Caramori L, Amin K, Linden MA, Ustun C.

Am J Hematol. 2016 Dec;91(12):E505-E506. doi: 10.1002/ajh.24558. No abstract available.


Clonal Lymphoproliferations in a Patient With Common Variable Immunodeficiency.

Williams SA, Moench LE, Khan F, Vercellotti G, Linden MA.

Lab Med. 2016 Nov;47(4):318-325. Epub 2016 Sep 10.


A return to ad libitum feeding following caloric restriction promotes hepatic steatosis in hyperphagic OLETF rats.

Linden MA, Fletcher JA, Meers GM, Thyfault JP, Laughlin MH, Rector RS.

Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G387-95. doi: 10.1152/ajpgi.00089.2016. Epub 2016 Jul 21.

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