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Muscularis Propria Macrophages Alter the Proportion of Nitrergic but Not Cholinergic Gastric Myenteric Neurons.

Cipriani G, Terhaar ML, Eisenman ST, Ji S, Linden DR, Wright AM, Sha L, Ordog T, Szurszewski JH, Gibbons SJ, Farrugia G.

Cell Mol Gastroenterol Hepatol. 2019;7(3):689-691.e4. doi: 10.1016/j.jcmgh.2019.01.005. Epub 2019 Jan 31. No abstract available.


Expression of RAD21 immunoreactivity in myenteric neurons of the human and mouse small intestine.

Bianco F, Eisenman ST, Colmenares Aguilar MG, Bonora E, Clavenzani P, Linden DR, De Giorgio R, Farrugia G, Gibbons SJ.

Neurogastroenterol Motil. 2018 Sep;30(9):e13429. doi: 10.1111/nmo.13429. Epub 2018 Aug 1.


A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release.

Alcaino C, Knutson KR, Treichel AJ, Yildiz G, Strege PR, Linden DR, Li JH, Leiter AB, Szurszewski JH, Farrugia G, Beyder A.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7632-E7641. doi: 10.1073/pnas.1804938115. Epub 2018 Jul 23.


Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion.

Bhattarai Y, Williams BB, Battaglioli EJ, Whitaker WR, Till L, Grover M, Linden DR, Akiba Y, Kandimalla KK, Zachos NC, Kaunitz JD, Sonnenburg JL, Fischbach MA, Farrugia G, Kashyap PC.

Cell Host Microbe. 2018 Jun 13;23(6):775-785.e5. doi: 10.1016/j.chom.2018.05.004.


High temporal resolution gastric emptying breath tests in mice.

Miller KE, Bajzer Ž, Hein SS, Phillips JE, Syed S, Wright AM, Cipriani G, Gibbons SJ, Szurszewski JH, Farrugia G, Ordog T, Linden DR.

Neurogastroenterol Motil. 2018 Mar 25:e13333. doi: 10.1111/nmo.13333. [Epub ahead of print]


Change in Populations of Macrophages Promotes Development of Delayed Gastric Emptying in Mice.

Cipriani G, Gibbons SJ, Miller KE, Yang DS, Terhaar ML, Eisenman ST, Ördög T, Linden DR, Gajdos GB, Szurszewski JH, Farrugia G.

Gastroenterology. 2018 Jun;154(8):2122-2136.e12. doi: 10.1053/j.gastro.2018.02.027. Epub 2018 Mar 6.


Extracellular Cl- regulates electrical slow waves and setting of smooth muscle membrane potential by interstitial cells of Cajal in mouse jejunum.

Saravanaperumal SA, Gibbons SJ, Malysz J, Sha L, Linden DR, Szurszewski JH, Farrugia G.

Exp Physiol. 2018 Jan 1;103(1):40-57. doi: 10.1113/EP086367. Epub 2017 Nov 2.


Hyperglycemia Increases Interstitial Cells of Cajal via MAPK1 and MAPK3 Signaling to ETV1 and KIT, Leading to Rapid Gastric Emptying.

Hayashi Y, Toyomasu Y, Saravanaperumal SA, Bardsley MR, Smestad JA, Lorincz A, Eisenman ST, Cipriani G, Nelson Holte MH, Al Khazal FJ, Syed SA, Gajdos GB, Choi KM, Stoltz GJ, Miller KE, Kendrick ML, Rubin BP, Gibbons SJ, Bharucha AE, Linden DR, Maher LJ 3rd, Farrugia G, Ordog T.

Gastroenterology. 2017 Aug;153(2):521-535.e20. doi: 10.1053/j.gastro.2017.04.020. Epub 2017 Apr 21.


Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT3 receptor expression via acetate production.

Bhattarai Y, Schmidt BA, Linden DR, Larson ED, Grover M, Beyder A, Farrugia G, Kashyap PC.

Am J Physiol Gastrointest Liver Physiol. 2017 Jul 1;313(1):G80-G87. doi: 10.1152/ajpgi.00448.2016. Epub 2017 Apr 13.


Constipation-Predominant Irritable Bowel Syndrome Females Have Normal Colonic Barrier and Secretory Function.

Peters SA, Edogawa S, Sundt WJ, Dyer RB, Dalenberg DA, Mazzone A, Singh RJ, Moses N, Smyrk TC, Weber C, Linden DR, MacNaughton WK, Turner JR, Camilleri M, Katzka DA, Farrugia G, Grover M.

Am J Gastroenterol. 2017 Jun;112(6):913-923. doi: 10.1038/ajg.2017.48. Epub 2017 Mar 21.


Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice.

Choi KM, Gibbons SJ, Sha L, Beyder A, Verhulst PJ, Cipriani G, Phillips JE, Bauer AJ, Ordog T, Camp JJ, Ge X, Bharucha AE, Linden DR, Szurszewski JH, Kashyap PC, Farrugia G.

Cell Mol Gastroenterol Hepatol. 2016 Apr 23;2(4):454-467. eCollection 2016 Jul.


Altered gut microbiota in female mice with persistent low body weights following removal of post-weaning chronic dietary restriction.

Chen J, Toyomasu Y, Hayashi Y, Linden DR, Szurszewski JH, Nelson H, Farrugia G, Kashyap PC, Chia N, Ordog T.

Genome Med. 2016 Oct 3;8(1):103.


Measurement of Gastrointestinal and Colonic Motor Functions in Humans and Animals.

Camilleri M, Linden DR.

Cell Mol Gastroenterol Hepatol. 2016 Jul;2(4):412-428.


Desired and side effects of the supplementation with l-glutamine and l-glutathione in enteric glia of diabetic rats.

Panizzon CPDNB, Zanoni JN, Hermes-Uliana C, Trevizan AR, Sehaber CC, Pereira RVF, Linden DR, Neto MHM.

Acta Histochem. 2016 Jul;118(6):625-631. doi: 10.1016/j.acthis.2016.07.008. Epub 2016 Jul 26.


Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces.

Wang F, Knutson K, Alcaino C, Linden DR, Gibbons SJ, Kashyap P, Grover M, Oeckler R, Gottlieb PA, Li HJ, Leiter AB, Farrugia G, Beyder A.

J Physiol. 2017 Jan 1;595(1):79-91. doi: 10.1113/JP272718. Epub 2016 Aug 13.


Differential effects in CGRPergic, nitrergic, and VIPergic myenteric innervation in diabetic rats supplemented with 2% L-glutamine.

Pereira RV, Linden DR, Miranda-Neto MH, Zanoni JN.

An Acad Bras Cienc. 2016;88 Suppl 1:609-22. doi: 10.1590/0001-3765201620150228.


Correlated gene expression encoding serotonin (5-HT) receptor 4 and 5-HT transporter in proximal colonic segments of mice across different colonization states and sexes.

Reigstad CS, Linden DR, Szurszewski JH, Sonnenburg JL, Farrugia G, Kashyap PC.

Neurogastroenterol Motil. 2016 Sep;28(9):1443-8. doi: 10.1111/nmo.12840. Epub 2016 Apr 12.


Outcome of Whole Exome Sequencing for Diagnostic Odyssey Cases of an Individualized Medicine Clinic: The Mayo Clinic Experience.

Lazaridis KN, Schahl KA, Cousin MA, Babovic-Vuksanovic D, Riegert-Johnson DL, Gavrilova RH, McAllister TM, Lindor NM, Abraham RS, Ackerman MJ, Pichurin PN, Deyle DR, Gavrilov DK, Hand JL, Klee EW, Stephens MC, Wick MJ, Atkinson EJ, Linden DR, Ferber MJ, Wieben ED, Farrugia G; Individualized Medicine Clinic Members.

Mayo Clin Proc. 2016 Mar;91(3):297-307. doi: 10.1016/j.mayocp.2015.12.018.


Diabetic Csf1op/op mice lacking macrophages are protected against the development of delayed gastric emptying.

Cipriani G, Gibbons SJ, Verhulst PJ, Choi KM, Eisenman ST, Hein SS, Ordog T, Linden DR, Szurszewski JH, Farrugia G.

Cell Mol Gastroenterol Hepatol. 2016 Jan 1;2(1):40-47.


Walker 256 tumor-bearing rats demonstrate altered interstitial cells of Cajal. Effects on ICC in the Walker 256 tumor model.

Fracaro L, Frez FC, Silva BC, Vicentini GE, de Souza SR, Martins HA, Linden DR, Guarnier FA, Zanoni JN.

Neurogastroenterol Motil. 2016 Jan;28(1):101-15. doi: 10.1111/nmo.12702. Epub 2015 Nov 3.


A novel exon in the human Ca2+-activated Cl- channel Ano1 imparts greater sensitivity to intracellular Ca2.

Strege PR, Bernard CE, Mazzone A, Linden DR, Beyder A, Gibbons SJ, Farrugia G.

Am J Physiol Gastrointest Liver Physiol. 2015 Nov 1;309(9):G743-9. doi: 10.1152/ajpgi.00074.2015. Epub 2015 Sep 10.


A gamma variate model that includes stretched exponential is a better fit for gastric emptying data from mice.

Bajzer Ž, Gibbons SJ, Coleman HD, Linden DR, Farrugia G.

Am J Physiol Gastrointest Liver Physiol. 2015 Aug 1;309(3):G162-70. doi: 10.1152/ajpgi.00280.2014. Epub 2015 Jun 4.


Changes in nitrergic and tachykininergic pathways in rat proximal colon in response to chronic treatment with otilonium bromide.

Cipriani G, Gibbons SJ, Saravanaperumal SA, Malysz J, Sha L, Szurszewski JH, Linden DR, Evangelista S, Faussone-Pellegrini MS, Vannucchi MG, Farrugia G.

Neurogastroenterol Motil. 2015 Jul;27(7):997-1009. doi: 10.1111/nmo.12576. Epub 2015 Apr 30.


Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells.

Reigstad CS, Salmonson CE, Rainey JF 3rd, Szurszewski JH, Linden DR, Sonnenburg JL, Farrugia G, Kashyap PC.

FASEB J. 2015 Apr;29(4):1395-403. doi: 10.1096/fj.14-259598. Epub 2014 Dec 30.


Neuroplasticity and dysfunction after gastrointestinal inflammation.

Brierley SM, Linden DR.

Nat Rev Gastroenterol Hepatol. 2014 Oct;11(10):611-27. doi: 10.1038/nrgastro.2014.103. Epub 2014 Jul 8. Review.


Effects of gestation and lactation on forage intake, digestion, and passage rates of primiparous beef heifers and multiparous beef cows.

Linden DR, Titgemeyer EC, Olson KC, Anderson DE.

J Anim Sci. 2014 May;92(5):2141-51. doi: 10.2527/jas.2013-6813. Epub 2014 Mar 18.


On the fiftieth anniversary. Postinfectious irritable bowel syndrome: mechanisms related to pathogens.

Grover M, Camilleri M, Smith K, Linden DR, Farrugia G.

Neurogastroenterol Motil. 2014 Feb;26(2):156-67. doi: 10.1111/nmo.12304. Review.


Effect of endogenous hydrogen sulfide on the transwall gradient of the mouse colon circular smooth muscle.

Sha L, Linden DR, Farrugia G, Szurszewski JH.

J Physiol. 2014 Mar 1;592(5):1077-89. doi: 10.1113/jphysiol.2013.266841. Epub 2013 Dec 23.


Diabetic neuropathy: an evaluation of the use of quercetin in the cecum of rats.

Ferreira PE, Lopes CR, Alves AM, Alves ÉP, Linden DR, Zanoni JN, Buttow NC.

World J Gastroenterol. 2013 Oct 14;19(38):6416-26. doi: 10.3748/wjg.v19.i38.6416.


Hydrogen sulfide selectively potentiates central preganglionic fast nicotinic synaptic input in mouse superior mesenteric ganglion.

Sha L, Linden DR, Farrugia G, Szurszewski JH.

J Neurosci. 2013 Jul 31;33(31):12638-46. doi: 10.1523/JNEUROSCI.4429-12.2013.


Enhanced excitability of guinea pig ileum myenteric AH neurons during and following recovery from chemical colitis.

Linden DR.

Neurosci Lett. 2013 Jun 17;545:91-5. doi: 10.1016/j.neulet.2013.04.021. Epub 2013 Apr 28.


Hydrogen sulfide signaling in the gastrointestinal tract.

Linden DR.

Antioxid Redox Signal. 2014 Feb 10;20(5):818-30. doi: 10.1089/ars.2013.5312. Epub 2013 May 19. Review.


Assessment of gastric emptying in non-obese diabetic mice using a [13C]-octanoic acid breath test.

Creedon CT, Verhulst PJ, Choi KM, Mason JE, Linden DR, Szurszewski JH, Gibbons SJ, Farrugia G.

J Vis Exp. 2013 Mar 23;(73):e50301. doi: 10.3791/50301.


Colitis is associated with a loss of intestinofugal neurons.

Linden DR.

Am J Physiol Gastrointest Liver Physiol. 2012 Nov 15;303(10):G1096-104. doi: 10.1152/ajpgi.00176.2012. Epub 2012 Sep 20.


Enhanced excitability of guinea pig inferior mesenteric ganglion neurons during and following recovery from chemical colitis.

Linden DR.

Am J Physiol Gastrointest Liver Physiol. 2012 Nov 1;303(9):G1067-75. doi: 10.1152/ajpgi.00226.2012. Epub 2012 Sep 6.


Sulphide quinone reductase contributes to hydrogen sulphide metabolism in murine peripheral tissues but not in the CNS.

Linden DR, Furne J, Stoltz GJ, Abdel-Rehim MS, Levitt MD, Szurszewski JH.

Br J Pharmacol. 2012 Apr;165(7):2178-90. doi: 10.1111/j.1476-5381.2011.01681.x.


Effects of mineral-supplement delivery system on frequency, duration, and timing of supplement use by beef cows grazing topographically rugged, native rangeland in the Kansas Flint Hills.

Aubel NA, Jaeger JR, Drouillard JS, Schlegel MD, Pacheco LA, Linden DR, Bolte JW, Higgins JJ, Olson KC.

J Anim Sci. 2011 Nov;89(11):3699-706. doi: 10.2527/jas.2010-3808. Epub 2011 Jun 10.


Generalized neuromuscular hypoplasia, reduced smooth muscle myosin and altered gut motility in the klotho model of premature aging.

Asuzu DT, Hayashi Y, Izbeki F, Popko LN, Young DL, Bardsley MR, Lorincz A, Kuro-O M, Linden DR, Farrugia G, Ordog T.

Neurogastroenterol Motil. 2011 Jul;23(7):e309-23. doi: 10.1111/j.1365-2982.2011.01730.x. Epub 2011 May 24.


Hydrogen sulfide modulates contractile function in rat jejunum.

Kasparek MS, Linden DR, Farrugia G, Sarr MG.

J Surg Res. 2012 Jun 15;175(2):234-42. doi: 10.1016/j.jss.2011.03.069. Epub 2011 Apr 22.


Hydrogen sulfide is a partially redox-independent activator of the human jejunum Na+ channel, Nav1.5.

Strege PR, Bernard CE, Kraichely RE, Mazzone A, Sha L, Beyder A, Gibbons SJ, Linden DR, Kendrick ML, Sarr MG, Szurszewski JH, Farrugia G.

Am J Physiol Gastrointest Liver Physiol. 2011 Jun;300(6):G1105-14. doi: 10.1152/ajpgi.00556.2010. Epub 2011 Mar 10.


Altered expression of Ano1 variants in human diabetic gastroparesis.

Mazzone A, Bernard CE, Strege PR, Beyder A, Galietta LJ, Pasricha PJ, Rae JL, Parkman HP, Linden DR, Szurszewski JH, Ördög T, Gibbons SJ, Farrugia G.

J Biol Chem. 2011 Apr 15;286(15):13393-403. doi: 10.1074/jbc.M110.196089. Epub 2011 Feb 24.


Getting a handle on cholera and the circuits controlling intestinal motility.

Bertrand PP, Linden DR.

Front Neurosci. 2010 Nov 25;4:197. doi: 10.3389/fnins.2010.00197. eCollection 2010. No abstract available.


Mechanisms of action of the gasotransmitter hydrogen sulfide in modulating contractile activity of longitudinal muscle of rat ileum.

Nagao M, Linden DR, Duenes JA, Sarr MG.

J Gastrointest Surg. 2011 Jan;15(1):12-22. doi: 10.1007/s11605-010-1306-8. Epub 2010 Nov 17.


Loss of Kitlow progenitors, reduced stem cell factor and high oxidative stress underlie gastric dysfunction in progeric mice.

Izbeki F, Asuzu DT, Lorincz A, Bardsley MR, Popko LN, Choi KM, Young DL, Hayashi Y, Linden DR, Kuro-o M, Farrugia G, Ordog T.

J Physiol. 2010 Aug 15;588(Pt 16):3101-17. doi: 10.1113/jphysiol.2010.191023. Epub 2010 Jun 25.


The transwall gradient across the mouse colonic circular muscle layer is carbon monoxide dependent.

Sha L, Farrugia G, Linden DR, Szurszewski JH.

FASEB J. 2010 Oct;24(10):3840-9. doi: 10.1096/fj.10-156232. Epub 2010 Jun 11.


Carbon monoxide reverses diabetic gastroparesis in NOD mice.

Kashyap PC, Choi KM, Dutta N, Linden DR, Szurszewski JH, Gibbons SJ, Farrugia G.

Am J Physiol Gastrointest Liver Physiol. 2010 Jun;298(6):G1013-9. doi: 10.1152/ajpgi.00069.2010. Epub 2010 Apr 8.


Linaclotide - a secretagogue and antihyperalgesic agent - what next?

Bharucha AE, Linden DR.

Neurogastroenterol Motil. 2010 Mar;22(3):227-31. doi: 10.1111/j.1365-2982.2009.01465.x. Review.


CD206-positive M2 macrophages that express heme oxygenase-1 protect against diabetic gastroparesis in mice.

Choi KM, Kashyap PC, Dutta N, Stoltz GJ, Ordog T, Shea Donohue T, Bauer AJ, Linden DR, Szurszewski JH, Gibbons SJ, Farrugia G.

Gastroenterology. 2010 Jun;138(7):2399-409, 2409.e1. doi: 10.1053/j.gastro.2010.02.014. Epub 2010 Feb 20.


Endogenous production of H2S in the gastrointestinal tract: still in search of a physiologic function.

Linden DR, Levitt MD, Farrugia G, Szurszewski JH.

Antioxid Redox Signal. 2010 May 1;12(9):1135-46. doi: 10.1089/ars.2009.2885. Review.


Post-inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses.

Hughes PA, Brierley SM, Martin CM, Brookes SJ, Linden DR, Blackshaw LA.

Gut. 2009 Oct;58(10):1333-41. doi: 10.1136/gut.2008.170811. Epub 2009 Mar 25. Erratum in: Gut.2011 Jan;60(1):140.


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