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Items: 1 to 50 of 109


In Vivo Imaging of CNS Injury and Disease.

Akassoglou K, Merlini M, Rafalski VA, Real R, Liang L, Jin Y, Dougherty SE, De Paola V, Linden DJ, Misgeld T, Zheng B.

J Neurosci. 2017 Nov 8;37(45):10808-10816. doi: 10.1523/JNEUROSCI.1826-17.2017. Review.


STIM1 Regulates Somatic Ca2+ Signals and Intrinsic Firing Properties of Cerebellar Purkinje Neurons.

Ryu C, Jang DC, Jung D, Kim YG, Shim HG, Ryu HH, Lee YS, Linden DJ, Worley PF, Kim SJ.

J Neurosci. 2017 Sep 13;37(37):8876-8894. doi: 10.1523/JNEUROSCI.3973-16.2017. Epub 2017 Aug 11.


Corrigendum to "Expression of mutant DISC1 in Purkinje cells increases their spontaneous activity and impairs cognitive and social behaviors in mice" [Neurobiol. Dis. 103 (2017) 144-153].

Shevelkin AV, Terrillion CE, Abazyan BN, Kajstura TJ, Jouroukhin YA, Rudow GL, Troncoso JC, Linden DJ, Pletnikov MV.

Neurobiol Dis. 2017 Dec;108:362. doi: 10.1016/j.nbd.2017.07.021. Epub 2017 Aug 8. No abstract available.


Serotonin axons in the neocortex of the adult female mouse regrow after traumatic brain injury.

Kajstura TJ, Dougherty SE, Linden DJ.

J Neurosci Res. 2018 Apr;96(4):512-526. doi: 10.1002/jnr.24059. Epub 2017 May 9.


Expression of mutant DISC1 in Purkinje cells increases their spontaneous activity and impairs cognitive and social behaviors in mice.

Shevelkin AV, Terrillion CE, Abazyan BN, Kajstura TJ, Jouroukhin YA, Rudow GL, Troncoso JC, Linden DJ, Pletnikov MV.

Neurobiol Dis. 2017 Jul;103:144-153. doi: 10.1016/j.nbd.2017.04.008. Epub 2017 Apr 6.


Cerebral vascular structure in the motor cortex of adult mice is stable and is not altered by voluntary exercise.

Cudmore RH, Dougherty SE, Linden DJ.

J Cereb Blood Flow Metab. 2017 Dec;37(12):3725-3743. doi: 10.1177/0271678X16682508. Epub 2017 Jan 6.


Regrowth of Serotonin Axons in the Adult Mouse Brain Following Injury.

Jin Y, Dougherty SE, Wood K, Sun L, Cudmore RH, Abdalla A, Kannan G, Pletnikov M, Hashemi P, Linden DJ.

Neuron. 2016 Aug 17;91(4):748-762. doi: 10.1016/j.neuron.2016.07.024. Epub 2016 Aug 4.


Chronic In Vivo Imaging of Ponto-Cerebellar Mossy Fibers Reveals Morphological Stability during Whisker Sensory Manipulation in the Adult Rat.

Rylkova D, Crank AR, Linden DJ.

eNeuro. 2015 Oct 22;2(6). pii: ENEURO.0075-15.2015. doi: 10.1523/ENEURO.0075-15.2015. eCollection 2015 Nov-Dec.


Visualization of NMDA receptor-dependent AMPA receptor synaptic plasticity in vivo.

Zhang Y, Cudmore RH, Lin DT, Linden DJ, Huganir RL.

Nat Neurosci. 2015 Mar;18(3):402-7. doi: 10.1038/nn.3936. Epub 2015 Feb 2.


DHHC8-dependent PICK1 palmitoylation is required for induction of cerebellar long-term synaptic depression.

Thomas GM, Hayashi T, Huganir RL, Linden DJ.

J Neurosci. 2013 Sep 25;33(39):15401-7. doi: 10.1523/JNEUROSCI.1283-13.2013.


Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model.

Das I, Park JM, Shin JH, Jeon SK, Lorenzi H, Linden DJ, Worley PF, Reeves RH.

Sci Transl Med. 2013 Sep 4;5(201):201ra120. doi: 10.1126/scitranslmed.3005983.


PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression.

Anggono V, Koç-Schmitz Y, Widagdo J, Kormann J, Quan A, Chen CM, Robinson PJ, Choi SY, Linden DJ, Plomann M, Huganir RL.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13976-81. doi: 10.1073/pnas.1312467110. Epub 2013 Aug 5.


A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization.

Park JM, Hu JH, Milshteyn A, Zhang PW, Moore CG, Park S, Datko MC, Domingo RD, Reyes CM, Wang XJ, Etzkorn FA, Xiao B, Szumlinski KK, Kern D, Linden DJ, Worley PF.

Cell. 2013 Aug 1;154(3):637-50. doi: 10.1016/j.cell.2013.07.001.


Characterizing the conductance underlying depolarization-induced slow current in cerebellar Purkinje cells.

Kim YS, Kang E, Makino Y, Park S, Shin JH, Song H, Launay P, Linden DJ.

J Neurophysiol. 2013 Feb;109(4):1174-81. doi: 10.1152/jn.01168.2011. Epub 2012 Nov 28.


Astrocyte inositol triphosphate receptor type 2 and cytosolic phospholipase A2 alpha regulate arteriole responses in mouse neocortical brain slices.

He L, Linden DJ, Sapirstein A.

PLoS One. 2012;7(8):e42194. doi: 10.1371/journal.pone.0042194. Epub 2012 Aug 2.


A late phase of LTD in cultured cerebellar Purkinje cells requires persistent dynamin-mediated endocytosis.

Linden DJ.

J Neurophysiol. 2012 Jan;107(1):448-54. doi: 10.1152/jn.00824.2011. Epub 2011 Nov 2.


Feasibility and effectiveness of early initiation of combination antiretroviral therapy in HIV-infected infants in a government clinic of Kwazulu-Natal, South Africa.

Purchase SE, Van der Linden DJ, McKerrow NH.

J Trop Pediatr. 2012 Apr;58(2):114-9. doi: 10.1093/tropej/fmr053. Epub 2011 Jun 24.


Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism.

Bangash MA, Park JM, Melnikova T, Wang D, Jeon SK, Lee D, Syeda S, Kim J, Kouser M, Schwartz J, Cui Y, Zhao X, Speed HE, Kee SE, Tu JC, Hu JH, Petralia RS, Linden DJ, Powell CM, Savonenko A, Xiao B, Worley PF.

Cell. 2011 May 27;145(5):758-72. doi: 10.1016/j.cell.2011.03.052. Epub 2011 May 12. Retraction in: Cell. 2013 Jan 17;152(1-2):367.


Reevaluating the role of LTD in cerebellar motor learning.

Schonewille M, Gao Z, Boele HJ, Veloz MF, Amerika WE, Simek AA, De Jeu MT, Steinberg JP, Takamiya K, Hoebeek FE, Linden DJ, Huganir RL, De Zeeuw CI.

Neuron. 2011 Apr 14;70(1):43-50. doi: 10.1016/j.neuron.2011.02.044.


Homeostatic scaling requires group I mGluR activation mediated by Homer1a.

Hu JH, Park JM, Park S, Xiao B, Dehoff MH, Kim S, Hayashi T, Schwarz MK, Huganir RL, Seeburg PH, Linden DJ, Worley PF.

Neuron. 2010 Dec 22;68(6):1128-42. doi: 10.1016/j.neuron.2010.11.008.


Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons.

Chang MC, Park JM, Pelkey KA, Grabenstatter HL, Xu D, Linden DJ, Sutula TP, McBain CJ, Worley PF.

Nat Neurosci. 2010 Sep;13(9):1090-7. doi: 10.1038/nn.2621. Epub 2010 Aug 22.


SRF binding to SRE 6.9 in the Arc promoter is essential for LTD in cultured Purkinje cells.

Smith-Hicks C, Xiao B, Deng R, Ji Y, Zhao X, Shepherd JD, Posern G, Kuhl D, Huganir RL, Ginty DD, Worley PF, Linden DJ.

Nat Neurosci. 2010 Sep;13(9):1082-9. doi: 10.1038/nn.2611. Epub 2010 Aug 8.


Calcium influx measured at single presynaptic boutons of cerebellar granule cell ascending axons and parallel fibers.

Zhang W, Linden DJ.

Cerebellum. 2012 Mar;11(1):121-31. doi: 10.1007/s12311-009-0151-3.


Dopamine signaling is required for depolarization-induced slow current in cerebellar Purkinje cells.

Kim YS, Shin JH, Hall FS, Linden DJ.

J Neurosci. 2009 Jul 1;29(26):8530-8. doi: 10.1523/JNEUROSCI.0468-09.2009.


Depolarization-induced slow current in cerebellar Purkinje cells does not require metabotropic glutamate receptor 1.

Shin JH, Kim YS, Worley PF, Linden DJ.

Neuroscience. 2009 Sep 1;162(3):688-93. doi: 10.1016/j.neuroscience.2009.01.044. Epub 2009 Jan 29.


Warm, fuzzy feeling.

Linden DJ.

J Neurophysiol. 2008 Jul;100(1):1. doi: 10.1152/jn.00000.2008. No abstract available.


Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD.

Park S, Park JM, Kim S, Kim JA, Shepherd JD, Smith-Hicks CL, Chowdhury S, Kaufmann W, Kuhl D, Ryazanov AG, Huganir RL, Linden DJ, Worley PF.

Neuron. 2008 Jul 10;59(1):70-83. doi: 10.1016/j.neuron.2008.05.023.


The glutamate receptor-interacting protein family of GluR2-binding proteins is required for long-term synaptic depression expression in cerebellar Purkinje cells.

Takamiya K, Mao L, Huganir RL, Linden DJ.

J Neurosci. 2008 May 28;28(22):5752-5. doi: 10.1523/JNEUROSCI.0654-08.2008.


Transient upregulation of postsynaptic IP3-gated Ca release underlies short-term potentiation of metabotropic glutamate receptor 1 signaling in cerebellar Purkinje cells.

Kim SJ, Jin Y, Kim J, Shin JH, Worley PF, Linden DJ.

J Neurosci. 2008 Apr 23;28(17):4350-5. doi: 10.1523/JNEUROSCI.0284-08.2008.


mGluR1/5-dependent long-term depression requires the regulated ectodomain cleavage of neuronal pentraxin NPR by TACE.

Cho RW, Park JM, Wolff SB, Xu D, Hopf C, Kim JA, Reddy RC, Petralia RS, Perin MS, Linden DJ, Worley PF.

Neuron. 2008 Mar 27;57(6):858-71. doi: 10.1016/j.neuron.2008.01.010.


Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells.

Shin JH, Kim YS, Linden DJ.

Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):746-50. doi: 10.1073/pnas.0709407105. Epub 2008 Jan 3.


Ubiquitous plasticity and memory storage.

Kim SJ, Linden DJ.

Neuron. 2007 Nov 21;56(4):582-92. Review.


Axonal motility and its modulation by activity are branch-type specific in the intact adult cerebellum.

Nishiyama H, Fukaya M, Watanabe M, Linden DJ.

Neuron. 2007 Nov 8;56(3):472-87.


Long-term depression of mGluR1 signaling.

Jin Y, Kim SJ, Kim J, Worley PF, Linden DJ.

Neuron. 2007 Jul 19;55(2):277-87.


Pure spillover transmission between neurons.

Nishiyama H, Linden DJ.

Nat Neurosci. 2007 Jun;10(6):675-7. No abstract available.


Double dissociation between long-term depression and dendritic spine morphology in cerebellar Purkinje cells.

Sdrulla AD, Linden DJ.

Nat Neurosci. 2007 May;10(5):546-8. Epub 2007 Apr 15.


Cytosolic phospholipase A(2) alpha mediates electrophysiologic responses of hippocampal pyramidal neurons to neurotoxic NMDA treatment.

Shen Y, Kishimoto K, Linden DJ, Sapirstein A.

Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):6078-83. Epub 2007 Mar 26.


Long-term depression at the mossy fiber-deep cerebellar nucleus synapse.

Zhang W, Linden DJ.

J Neurosci. 2006 Jun 28;26(26):6935-44.


Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression.

Steinberg JP, Takamiya K, Shen Y, Xia J, Rubio ME, Yu S, Jin W, Thomas GM, Linden DJ, Huganir RL.

Neuron. 2006 Mar 16;49(6):845-60.


Long-term potentiation of neuronal glutamate transporters.

Shen Y, Linden DJ.

Neuron. 2005 Jun 2;46(5):715-22.


SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability.

Ramanan N, Shen Y, Sarsfield S, Lemberger T, Schütz G, Linden DJ, Ginty DD.

Nat Neurosci. 2005 Jun;8(6):759-67. Epub 2005 May 8.


N-ethylmaleimide-sensitive factor is required for the synaptic incorporation and removal of AMPA receptors during cerebellar long-term depression.

Steinberg JP, Huganir RL, Linden DJ.

Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18212-6. Epub 2004 Dec 17.


Adapter protein 14-3-3 is required for a presynaptic form of LTP in the cerebellum.

Simsek-Duran F, Linden DJ, Lonart G.

Nat Neurosci. 2004 Dec;7(12):1296-8. Epub 2004 Nov 14.


A unique PDZ ligand in PKCalpha confers induction of cerebellar long-term synaptic depression.

Leitges M, Kovac J, Plomann M, Linden DJ.

Neuron. 2004 Nov 18;44(4):585-94.


Persistent changes in the intrinsic excitability of rat deep cerebellar nuclear neurones induced by EPSP or IPSP bursts.

Zhang W, Shin JH, Linden DJ.

J Physiol. 2004 Dec 15;561(Pt 3):703-19. Epub 2004 Oct 21.


Differential maturation of climbing fiber innervation in cerebellar vermis.

Nishiyama H, Linden DJ.

J Neurosci. 2004 Apr 21;24(16):3926-32.


Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1.

Kim SJ, Kim YS, Yuan JP, Petralia RS, Worley PF, Linden DJ.

Nature. 2003 Nov 20;426(6964):285-91. Epub 2003 Nov 12.


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