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Specificity of glycosaminoglycan-protein interactions.

Kjellén L, Lindahl U.

Curr Opin Struct Biol. 2018 Jun;50:101-108. doi: 10.1016/ Epub 2018 Feb 9. Review.


Proteoglycans and Sulfated Glycosaminoglycans.

Lindahl U, Couchman J, Kimata K, Esko JD.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 17.


A potential role for chondroitin sulfate/dermatan sulfate in arm regeneration in Amphiura filiformis.

Ramachandra R, Namburi RB, Dupont ST, Ortega-Martinez O, van Kuppevelt TH, Lindahl U, Spillmann D.

Glycobiology. 2017 May 1;27(5):438-449. doi: 10.1093/glycob/cwx010.


Enzyme overexpression - an exercise toward understanding regulation of heparan sulfate biosynthesis.

Fang J, Song T, Lindahl U, Li JP.

Sci Rep. 2016 Aug 11;6:31242. doi: 10.1038/srep31242.


Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response.

O'Callaghan P, Li JP, Lannfelt L, Lindahl U, Zhang X.

J Biol Chem. 2015 Jun 12;290(24):14904-14. doi: 10.1074/jbc.M114.634337. Epub 2015 Apr 13.


Apolipoprotein E increases cell association of amyloid-β 40 through heparan sulfate and LRP1 dependent pathways.

O'Callaghan P, Noborn F, Sehlin D, Li JP, Lannfelt L, Lindahl U, Zhang X.

Amyloid. 2014 Jun;21(2):76-87. doi: 10.3109/13506129.2013.879643. Epub 2014 Feb 3.


A personal voyage through the proteoglycan field.

Lindahl U.

Matrix Biol. 2014 Apr;35:3-7. doi: 10.1016/j.matbio.2014.01.001. Epub 2014 Jan 23. Review.


Brittlestars contain highly sulfated chondroitin sulfates/dermatan sulfates that promote fibroblast growth factor 2-induced cell signaling.

Ramachandra R, Namburi RB, Ortega-Martinez O, Shi X, Zaia J, Dupont ST, Thorndyke MC, Lindahl U, Spillmann D.

Glycobiology. 2014 Feb;24(2):195-207. doi: 10.1093/glycob/cwt100. Epub 2013 Nov 18.


Pathophysiology of heparan sulphate: many diseases, few drugs.

Lindahl U, Kjellén L.

J Intern Med. 2013 Jun;273(6):555-71. doi: 10.1111/joim.12061. Epub 2013 Mar 12. Review.


Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-β in murine brain.

Zhang X, Wang B, O'Callaghan P, Hjertström E, Jia J, Gong F, Zcharia E, Nilsson LN, Lannfelt L, Vlodavsky I, Lindahl U, Li JP.

Acta Neuropathol. 2012 Oct;124(4):465-78. doi: 10.1007/s00401-012-0997-1. Epub 2012 Jun 13.


Drosophila heparan sulfate, a novel design.

Kusche-Gullberg M, Nybakken K, Perrimon N, Lindahl U.

J Biol Chem. 2012 Jun 22;287(26):21950-6. doi: 10.1074/jbc.M112.350389. Epub 2012 May 3.


Heparanase affects food intake and regulates energy balance in mice.

Karlsson-Lindahl L, Schmidt L, Haage D, Hansson C, Taube M, Egecioglu E, Tan YX, Admyre T, Jansson JO, Vlodavsky I, Li JP, Lindahl U, Dickson SL.

PLoS One. 2012;7(3):e34313. doi: 10.1371/journal.pone.0034313. Epub 2012 Mar 27. Erratum in: PLoS One. 2012;7(10). doi:10.1371/annotation/c91d94c7-fd12-4a77-ba18-d3ff4f163d72. Egeciouglu, Emil [corrected to Egecioglu, Emil].


Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels.

van der Hoorn J, Lindén D, Lindahl U, Bekkers M, Voskuilen M, Nilsson R, Oscarsson J, Lindstedt E, Princen H.

Br J Pharmacol. 2011 Apr;162(7):1553-63. doi: 10.1111/j.1476-5381.2010.01168.x.


Heparan sulfate domain organization and sulfation modulate FGF-induced cell signaling.

Jastrebova N, Vanwildemeersch M, Lindahl U, Spillmann D.

J Biol Chem. 2010 Aug 27;285(35):26842-51. doi: 10.1074/jbc.M109.093542. Epub 2010 Jun 24.


Proteoglycans and Sulfated Glycosaminoglycans.

Esko JD, Kimata K, Lindahl U.

In: Varki A, Cummings RD, Esko JD, Freeze HH, Stanley P, Bertozzi CR, Hart GW, Etzler ME, editors. Essentials of Glycobiology. 2nd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009. Chapter 16.


Heparan sulfate mediates amyloid-beta internalization and cytotoxicity.

Sandwall E, O'Callaghan P, Zhang X, Lindahl U, Lannfelt L, Li JP.

Glycobiology. 2010 May;20(5):533-41. doi: 10.1093/glycob/cwp205. Epub 2010 Jan 5.


Low molecular weight heparin stimulates myometrial contractility and cervical remodeling in vitro.

Ekman-Ordeberg G, Hellgren M, Akerud A, Andersson E, Dubicke A, Sennstrom M, Byström B, Tzortzatos G, Gomez MF, Edlund M, Lindahl U, Malmström A.

Acta Obstet Gynecol Scand. 2009;88(9):984-9. doi: 10.1080/00016340903176818.


Interactions between heparan sulfate and proteins-design and functional implications.

Lindahl U, Li JP.

Int Rev Cell Mol Biol. 2009;276:105-59. doi: 10.1016/S1937-6448(09)76003-4. Review.


Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases.

Zcharia E, Jia J, Zhang X, Baraz L, Lindahl U, Peretz T, Vlodavsky I, Li JP.

PLoS One. 2009;4(4):e5181. doi: 10.1371/journal.pone.0005181. Epub 2009 Apr 10.


Lack of L-iduronic acid in heparan sulfate affects interaction with growth factors and cell signaling.

Jia J, Maccarana M, Zhang X, Bespalov M, Lindahl U, Li JP.

J Biol Chem. 2009 Jun 5;284(23):15942-50. doi: 10.1074/jbc.M809577200. Epub 2009 Mar 31.


[Artificial polysaccharide in contaminated heparin. Acute hypersensitivity reactions explained--but how could it happen?].

Lindahl U.

Lakartidningen. 2008 Sep 24-30;105(39):2660-1. Swedish. No abstract available.


Heparin/heparan sulfate biosynthesis: processive formation of N-sulfated domains.

Carlsson P, Presto J, Spillmann D, Lindahl U, Kjellén L.

J Biol Chem. 2008 Jul 18;283(29):20008-14. doi: 10.1074/jbc.M801652200. Epub 2008 May 16.


Effects of the synthetic liver X receptor agonist T0901317 on the growth hormone and thyroid hormone axes in male rats.

Davies JS, Kotokorpi P, Lindahl U, Oscarsson J, Wells T, Mode A.

Endocrine. 2008 Apr;33(2):196-204. doi: 10.1007/s12020-008-9067-9. Epub 2008 May 13.


Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells.

O'Callaghan P, Sandwall E, Li JP, Yu H, Ravid R, Guan ZZ, van Kuppevelt TH, Nilsson LN, Ingelsson M, Hyman BT, Kalimo H, Lindahl U, Lannfelt L, Zhang X.

Brain Pathol. 2008 Oct;18(4):548-61. doi: 10.1111/j.1750-3639.2008.00152.x. Epub 2008 Apr 11.


Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate.

Escobar Galvis ML, Jia J, Zhang X, Jastrebova N, Spillmann D, Gottfridsson E, van Kuppevelt TH, Zcharia E, Vlodavsky I, Lindahl U, Li JP.

Nat Chem Biol. 2007 Dec;3(12):773-8. Epub 2007 Oct 21.


Surface-exposed amino acid residues of HPV16 L1 protein mediating interaction with cell surface heparan sulfate.

Knappe M, Bodevin S, Selinka HC, Spillmann D, Streeck RE, Chen XS, Lindahl U, Sapp M.

J Biol Chem. 2007 Sep 21;282(38):27913-22. Epub 2007 Jul 18.


Heparan sulfate-protein interactions--a concept for drug design?

Lindahl U.

Thromb Haemost. 2007 Jul;98(1):109-15. Review.


Characterization of anti-heparan sulfate phage display antibodies AO4B08 and HS4E4.

Kurup S, Wijnhoven TJ, Jenniskens GJ, Kimata K, Habuchi H, Li JP, Lindahl U, van Kuppevelt TH, Spillmann D.

J Biol Chem. 2007 Jul 20;282(29):21032-42. Epub 2007 May 21.


Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development.

Abramsson A, Kurup S, Busse M, Yamada S, Lindblom P, Schallmeiner E, Stenzel D, Sauvaget D, Ledin J, Ringvall M, Landegren U, Kjellén L, Bondjers G, Li JP, Lindahl U, Spillmann D, Betsholtz C, Gerhardt H.

Genes Dev. 2007 Feb 1;21(3):316-31.


Interactions between heparan sulfate and proteins: the concept of specificity.

Kreuger J, Spillmann D, Li JP, Lindahl U.

J Cell Biol. 2006 Jul 31;174(3):323-7. Review.


Heparan sulfate-related oligosaccharides in ternary complex formation with fibroblast growth factors 1 and 2 and their receptors.

Jastrebova N, Vanwildemeersch M, Rapraeger AC, Giménez-Gallego G, Lindahl U, Spillmann D.

J Biol Chem. 2006 Sep 15;281(37):26884-92. Epub 2006 Jun 28.


Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment.

Kurup S, Abramsson A, Li JP, Lindahl U, Kjellen L, Betsholtz C, Gerhardt H, Spillmann D.

Biochem Soc Trans. 2006 Jun;34(Pt 3):454-5. Review.


Heparan sulfate C5-epimerase is essential for heparin biosynthesis in mast cells.

Feyerabend TB, Li JP, Lindahl U, Rodewald HR.

Nat Chem Biol. 2006 Apr;2(4):195-6. Epub 2006 Mar 12.


Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2.

Maccarana M, Olander B, Malmström J, Tiedemann K, Aebersold R, Lindahl U, Li JP, Malmström A.

J Biol Chem. 2006 Apr 28;281(17):11560-8. Epub 2006 Feb 27.


The anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner.

Vanwildemeersch M, Olsson AK, Gottfridsson E, Claesson-Welsh L, Lindahl U, Spillmann D.

J Biol Chem. 2006 Apr 14;281(15):10298-304. Epub 2006 Jan 25.


Substrate specificity and domain functions of extracellular heparan sulfate 6-O-endosulfatases, QSulf1 and QSulf2.

Ai X, Do AT, Kusche-Gullberg M, Lindahl U, Lu K, Emerson CP Jr.

J Biol Chem. 2006 Feb 24;281(8):4969-76. Epub 2005 Dec 23.


3-O-sulfated oligosaccharide structures are recognized by anti-heparan sulfate antibody HS4C3.

Ten Dam GB, Kurup S, van de Westerlo EM, Versteeg EM, Lindahl U, Spillmann D, van Kuppevelt TH.

J Biol Chem. 2006 Feb 24;281(8):4654-62. Epub 2005 Dec 22.


In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis.

Li JP, Galvis ML, Gong F, Zhang X, Zcharia E, Metzger S, Vlodavsky I, Kisilevsky R, Lindahl U.

Proc Natl Acad Sci U S A. 2005 May 3;102(18):6473-7. Epub 2005 Apr 20.


Fibroblast growth factors share binding sites in heparan sulphate.

Kreuger J, Jemth P, Sanders-Lindberg E, Eliahu L, Ron D, Basilico C, Salmivirta M, Lindahl U.

Biochem J. 2005 Jul 1;389(Pt 1):145-50.


Generation of "neoheparin" from E. coli K5 capsular polysaccharide.

Lindahl U, Li JP, Kusche-Gullberg M, Salmivirta M, Alaranta S, Veromaa T, Emeis J, Roberts I, Taylor C, Oreste P, Zoppetti G, Naggi A, Torri G, Casu B.

J Med Chem. 2005 Jan 27;48(2):349-52.


Biosynthesis of hyaluronan: direction of chain elongation.

Bodevin-Authelet S, Kusche-Gullberg M, Pummill PE, DeAngelis PL, Lindahl U.

J Biol Chem. 2005 Mar 11;280(10):8813-8. Epub 2004 Dec 28.


Relative susceptibilities of the glucosamine-glucuronic acid and N-acetylglucosamine-glucuronic acid linkages to heparin lyase III.

Chai W, Leteux C, Westling C, Lindahl U, Feizi T.

Biochemistry. 2004 Jul 6;43(26):8590-9.


Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior.

Zcharia E, Metzger S, Chajek-Shaul T, Aingorn H, Elkin M, Friedmann Y, Weinstein T, Li JP, Lindahl U, Vlodavsky I.

FASEB J. 2004 Feb;18(2):252-63.


Irreversible glucuronyl C5-epimerization in the biosynthesis of heparan sulfate.

Hagner-McWhirter A, Li JP, Oscarson S, Lindahl U.

J Biol Chem. 2004 Apr 9;279(15):14631-8. Epub 2004 Jan 12.


Nitrocellulose filter binding to assess binding of glycosaminoglycans to proteins.

Kreuger J, Lindahl U, Jemth P.

Methods Enzymol. 2003;363:327-39. No abstract available.


QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling.

Ai X, Do AT, Lozynska O, Kusche-Gullberg M, Lindahl U, Emerson CP Jr.

J Cell Biol. 2003 Jul 21;162(2):341-51. Epub 2003 Jul 14.


Processing of macromolecular heparin by heparanase.

Gong F, Jemth P, Escobar Galvis ML, Vlodavsky I, Horner A, Lindahl U, Li JP.

J Biol Chem. 2003 Sep 12;278(37):35152-8. Epub 2003 Jul 1.


Differential tyrosine phosphorylation of fibroblast growth factor (FGF) receptor-1 and receptor proximal signal transduction in response to FGF-2 and heparin.

Lundin L, Rönnstrand L, Cross M, Hellberg C, Lindahl U, Claesson-Welsh L.

Exp Cell Res. 2003 Jul 1;287(1):190-8.


Targeted disruption of a murine glucuronyl C5-epimerase gene results in heparan sulfate lacking L-iduronic acid and in neonatal lethality.

Li JP, Gong F, Hagner-McWhirter A, Forsberg E, Abrink M, Kisilevsky R, Zhang X, Lindahl U.

J Biol Chem. 2003 Aug 1;278(31):28363-6. Epub 2003 Jun 4.


1976-1983, a critical period in the history of heparin: the discovery of the antithrombin binding site.

Petitou M, Casu B, Lindahl U.

Biochimie. 2003 Jan-Feb;85(1-2):83-9. Review.


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