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Items: 27

1.

Stable Isotope Labeling Highlights Enhanced Fatty Acid and Lipid Metabolism in Human Acute Myeloid Leukemia.

Stuani L, Riols F, Millard P, Sabatier M, Batut A, Saland E, Viars F, Tonini L, Zaghdoudi S, Linares LK, Portais JC, Sarry JE, Bertrand-Michel J.

Int J Mol Sci. 2018 Oct 25;19(11). pii: E3325. doi: 10.3390/ijms19113325.

2.

Calpain-6 controls the fate of sarcoma stem cells by promoting autophagy and preventing senescence.

Andrique C, Morardet L, Linares LK, Cissé MY, Merle C, Chibon F, Provot S, Haÿ E, Ea HK, Cohen-Solal M, Modrowski D.

JCI Insight. 2018 Sep 6;3(17). pii: 121225. doi: 10.1172/jci.insight.121225. [Epub ahead of print]

3.

MDM2 controls gene expression independently of p53 in both normal and cancer cells.

Arena G, Riscal R, Linares LK, Le Cam L.

Cell Death Differ. 2018 Sep;25(9):1533-1535. doi: 10.1038/s41418-018-0156-x. Epub 2018 Jul 23. No abstract available.

PMID:
30038384
4.

Dexamethasone in hyperleukocytic acute myeloid leukemia.

Bertoli S, Picard M, Bérard E, Griessinger E, Larrue C, Mouchel PL, Vergez F, Tavitian S, Yon E, Ruiz J, Delabesse E, Luquet I, Linares LK, Saland E, Carroll M, Danet-Desnoyers G, Sarry A, Huguet F, Sarry JE, Récher C.

Haematologica. 2018 Jun;103(6):988-998. doi: 10.3324/haematol.2017.184267. Epub 2018 Mar 8.

5.

Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53.

Arena G, Cissé MY, Pyrdziak S, Chatre L, Riscal R, Fuentes M, Arnold JJ, Kastner M, Gayte L, Bertrand-Gaday C, Nay K, Angebault-Prouteau C, Murray K, Chabi B, Koechlin-Ramonatxo C, Orsetti B, Vincent C, Casas F, Marine JC, Etienne-Manneville S, Bernex F, Lombès A, Cameron CE, Dubouchaud H, Ricchetti M, Linares LK, Le Cam L.

Mol Cell. 2018 Feb 15;69(4):594-609.e8. doi: 10.1016/j.molcel.2018.01.023.

PMID:
29452639
6.

Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism.

Farge T, Saland E, de Toni F, Aroua N, Hosseini M, Perry R, Bosc C, Sugita M, Stuani L, Fraisse M, Scotland S, Larrue C, Boutzen H, Féliu V, Nicolau-Travers ML, Cassant-Sourdy S, Broin N, David M, Serhan N, Sarry A, Tavitian S, Kaoma T, Vallar L, Iacovoni J, Linares LK, Montersino C, Castellano R, Griessinger E, Collette Y, Duchamp O, Barreira Y, Hirsch P, Palama T, Gales L, Delhommeau F, Garmy-Susini BH, Portais JC, Vergez F, Selak M, Danet-Desnoyers G, Carroll M, Récher C, Sarry JE.

Cancer Discov. 2017 Jul;7(7):716-735. doi: 10.1158/2159-8290.CD-16-0441. Epub 2017 Apr 17.

7.

Chromatin-bound MDM2, a new player in metabolism.

Riscal R, Le Cam L, Linares LK.

Mol Cell Oncol. 2016 Jul 15;3(5):e1210560. eCollection 2016.

8.

FOXO3a and the MAPK p38 are activated by cetuximab to induce cell death and inhibit cell proliferation and their expression predicts cetuximab efficacy in colorectal cancer.

Marzi L, Combes E, Vié N, Ayrolles-Torro A, Tosi D, Desigaud D, Perez-Gracia E, Larbouret C, Montagut C, Iglesias M, Jarlier M, Denis V, Linares LK, Lam EW, Martineau P, Del Rio M, Gongora C.

Br J Cancer. 2016 Nov 8;115(10):1223-1233. doi: 10.1038/bjc.2016.313. Epub 2016 Sep 29.

9.

E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis.

Goguet-Rubio P, Seyran B, Gayte L, Bernex F, Sutter A, Delpech H, Linares LK, Riscal R, Repond C, Rodier G, Kirsh O, Touhami J, Noel J, Vincent C, Pirot N, Pavlovic G, Herault Y, Sitbon M, Pellerin L, Sardet C, Lacroix M, Le Cam L.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):11004-9. doi: 10.1073/pnas.1602751113. Epub 2016 Sep 12.

10.

Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53.

Riscal R, Schrepfer E, Arena G, Cissé MY, Bellvert F, Heuillet M, Rambow F, Bonneil E, Sabourdy F, Vincent C, Ait-Arsa I, Levade T, Thibaut P, Marine JC, Portais JC, Sarry JE, Le Cam L, Linares LK.

Mol Cell. 2016 Jun 16;62(6):890-902. doi: 10.1016/j.molcel.2016.04.033. Epub 2016 Jun 2.

11.

Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia.

Boutzen H, Saland E, Larrue C, de Toni F, Gales L, Castelli FA, Cathebas M, Zaghdoudi S, Stuani L, Kaoma T, Riscal R, Yang G, Hirsch P, David M, De Mas-Mansat V, Delabesse E, Vallar L, Delhommeau F, Jouanin I, Ouerfelli O, Le Cam L, Linares LK, Junot C, Portais JC, Vergez F, Récher C, Sarry JE.

J Exp Med. 2016 Apr 4;213(4):483-97. doi: 10.1084/jem.20150736. Epub 2016 Mar 7.

12.

Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells.

Bach AS, Derocq D, Laurent-Matha V, Montcourrier P, Sebti S, Orsetti B, Theillet C, Gongora C, Pattingre S, Ibing E, Roger P, Linares LK, Reinheckel T, Meurice G, Kaiser FJ, Gespach C, Liaudet-Coopman E.

Oncotarget. 2015 Sep 29;6(29):28084-103. doi: 10.18632/oncotarget.4394.

13.

BAG6/BAT3 modulates autophagy by affecting EP300/p300 intracellular localization.

Sebti S, Prébois C, Pérez-Gracia E, Bauvy C, Desmots F, Pirot N, Gongora C, Bach AS, Hubberstey AV, Palissot V, Berchem G, Codogno P, Linares LK, Liaudet-Coopman E, Pattingre S.

Autophagy. 2014 Jul;10(7):1341-2. doi: 10.4161/auto.28979. Epub 2014 May 15.

14.

BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy.

Sebti S, Prébois C, Pérez-Gracia E, Bauvy C, Desmots F, Pirot N, Gongora C, Bach AS, Hubberstey AV, Palissot V, Berchem G, Codogno P, Linares LK, Liaudet-Coopman E, Pattingre S.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4115-20. doi: 10.1073/pnas.1313618111. Epub 2014 Mar 3.

15.

[Role of the p53 tumor suppressor in metabolism].

Lacroix M, Linares LK, Le Cam L.

Med Sci (Paris). 2013 Dec;29(12):1125-30. doi: 10.1051/medsci/20132912016. Epub 2013 Dec 20. Review. French.

16.

[The Yin and the Yang of senescence: is it possible to age without developing cancer?].

Lacroix M, Linares LK, Le Cam L.

Med Sci (Paris). 2012 Mar;28(3):245-7. doi: 10.1051/medsci/2012283006. Epub 2012 Apr 6. French. No abstract available.

17.

E4F1 deficiency results in oxidative stress-mediated cell death of leukemic cells.

Hatchi E, Rodier G, Lacroix M, Caramel J, Kirsh O, Jacquet C, Schrepfer E, Lagarrigue S, Linares LK, Lledo G, Tondeur S, Dubus P, Sardet C, Le Cam L.

J Exp Med. 2011 Jul 4;208(7):1403-17. doi: 10.1084/jem.20101995. Epub 2011 Jun 27.

18.

Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis.

Lacroix M, Caramel J, Goguet-Rubio P, Linares LK, Estrach S, Hatchi E, Rodier G, Lledo G, de Bettignies C, Thépot A, Deraison C, Chébli K, Hovnanian A, Hainaut P, Dubus P, Sardet C, Le Cam L.

Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21076-81. doi: 10.1073/pnas.1010167107. Epub 2010 Nov 18. Erratum in: Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14716.

19.

Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2.

Linares LK, Kiernan R, Triboulet R, Chable-Bessia C, Latreille D, Cuvier O, Lacroix M, Le Cam L, Coux O, Benkirane M.

Nat Cell Biol. 2007 Mar;9(3):331-8. Epub 2007 Feb 11.

PMID:
17293853
20.

The proteasome regulates HIV-1 transcription by both proteolytic and nonproteolytic mechanisms.

Lassot I, Latreille D, Rousset E, Sourisseau M, Linares LK, Chable-Bessia C, Coux O, Benkirane M, Kiernan RE.

Mol Cell. 2007 Feb 9;25(3):369-83.

21.

E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation.

Le Cam L, Linares LK, Paul C, Julien E, Lacroix M, Hatchi E, Triboulet R, Bossis G, Shmueli A, Rodriguez MS, Coux O, Sardet C.

Cell. 2006 Nov 17;127(4):775-88.

22.

Role of the histone acetyl transferase Tip60 in the p53 pathway.

Legube G, Linares LK, Tyteca S, Caron C, Scheffner M, Chevillard-Briet M, Trouche D.

J Biol Chem. 2004 Oct 22;279(43):44825-33. Epub 2004 Aug 13.

23.

The ubiquitin-protein ligase activity of Hdm2 is inhibited by nucleic acids.

Linares LK, Scheffner M.

FEBS Lett. 2003 Nov 6;554(1-2):73-6.

24.

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

Linares LK, Hengstermann A, Ciechanover A, Müller S, Scheffner M.

Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12009-14. Epub 2003 Sep 24.

25.

A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter.

Brès V, Kiernan RE, Linares LK, Chable-Bessia C, Plechakova O, Tréand C, Emiliani S, Peloponese JM, Jeang KT, Coux O, Scheffner M, Benkirane M.

Nat Cell Biol. 2003 Aug;5(8):754-61.

PMID:
12883554
26.

Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation.

Legube G, Linares LK, Lemercier C, Scheffner M, Khochbin S, Trouche D.

EMBO J. 2002 Apr 2;21(7):1704-12.

27.

Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells.

Hengstermann A, Linares LK, Ciechanover A, Whitaker NJ, Scheffner M.

Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1218-23. Epub 2001 Jan 23.

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