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Items: 24


Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer.

Reina-Campos M, Linares JF, Duran A, Cordes T, L'Hermitte A, Badur MG, Bhangoo MS, Thorson PK, Richards A, Rooslid T, Garcia-Olmo DC, Nam-Cha SY, Salinas-Sanchez AS, Eng K, Beltran H, Scott DA, Metallo CM, Moscat J, Diaz-Meco MT.

Cancer Cell. 2019 Mar 18;35(3):385-400.e9. doi: 10.1016/j.ccell.2019.01.018. Epub 2019 Feb 28.


Mechanistic insight into the regulation of SQSTM1/p62.

Zhang Y, Mun SR, Linares JF, Towers CG, Thorburn A, Diaz-Meco MT, Kwon YT, Kutateladze TG.

Autophagy. 2019 Apr;15(4):735-737. doi: 10.1080/15548627.2019.1569935. Epub 2019 Jan 22.


ZZ-dependent regulation of p62/SQSTM1 in autophagy.

Zhang Y, Mun SR, Linares JF, Ahn J, Towers CG, Ji CH, Fitzwalter BE, Holden MR, Mi W, Shi X, Moscat J, Thorburn A, Diaz-Meco MT, Kwon YT, Kutateladze TG.

Nat Commun. 2018 Oct 22;9(1):4373. doi: 10.1038/s41467-018-06878-8.


ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma.

Linares JF, Cordes T, Duran A, Reina-Campos M, Valencia T, Ahn CS, Castilla EA, Moscat J, Metallo CM, Diaz-Meco MT.

Cell Metab. 2017 Dec 5;26(6):817-829.e6. doi: 10.1016/j.cmet.2017.09.001. Epub 2017 Oct 5.


Correction for Linares et al., "Phosphorylation of p62 by cdk1 Controls the Timely Transit of Cells through Mitosis and Tumor Cell Proliferation".

Linares JF, Amanchy R, Greis K, Diaz-Meco MT, Moscat J.

Mol Cell Biol. 2017 Jul 14;37(15). pii: e00252-17. doi: 10.1128/MCB.00252-17. Print 2017 Aug 1. No abstract available.


p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells.

Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M.

Cancer Cell. 2016 Jun 13;29(6):935-948. doi: 10.1016/j.ccell.2016.04.006. Epub 2016 May 19.


Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade.

Linares JF, Duran A, Reina-Campos M, Aza-Blanc P, Campos A, Moscat J, Diaz-Meco MT.

Cell Rep. 2015 Aug 25;12(8):1339-52. doi: 10.1016/j.celrep.2015.07.045. Epub 2015 Aug 13.


Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ.

Llado V, Nakanishi Y, Duran A, Reina-Campos M, Shelton PM, Linares JF, Yajima T, Campos A, Aza-Blanc P, Leitges M, Diaz-Meco MT, Moscat J.

Cell Rep. 2015 Feb 10;10(5):740-754. doi: 10.1016/j.celrep.2015.01.007. Epub 2015 Feb 5.


A macrophage NBR1-MEKK3 complex triggers JNK-mediated adipose tissue inflammation in obesity.

Hernandez ED, Lee SJ, Kim JY, Duran A, Linares JF, Yajima T, Müller TD, Tschöp MH, Smith SR, Diaz-Meco MT, Moscat J.

Cell Metab. 2014 Sep 2;20(3):499-511. doi: 10.1016/j.cmet.2014.06.008. Epub 2014 Jul 17.


K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells.

Linares JF, Duran A, Yajima T, Pasparakis M, Moscat J, Diaz-Meco MT.

Mol Cell. 2013 Aug 8;51(3):283-96. doi: 10.1016/j.molcel.2013.06.020. Epub 2013 Aug 1.


Overproduction of the multidrug efflux pump MexEF-OprN does not impair Pseudomonas aeruginosa fitness in competition tests, but produces specific changes in bacterial regulatory networks.

Olivares J, Alvarez-Ortega C, Linares JF, Rojo F, Köhler T, Martínez JL.

Environ Microbiol. 2012 Aug;14(8):1968-81. doi: 10.1111/j.1462-2920.2012.02727.x. Epub 2012 Mar 15.


p62 is a key regulator of nutrient sensing in the mTORC1 pathway.

Duran A, Amanchy R, Linares JF, Joshi J, Abu-Baker S, Porollo A, Hansen M, Moscat J, Diaz-Meco MT.

Mol Cell. 2011 Oct 7;44(1):134-46. doi: 10.1016/j.molcel.2011.06.038.


Phosphorylation of p62 by cdk1 controls the timely transit of cells through mitosis and tumor cell proliferation.

Linares JF, Amanchy R, Greis K, Diaz-Meco MT, Moscat J.

Mol Cell Biol. 2011 Jan;31(1):105-17. doi: 10.1128/MCB.00620-10. Epub 2010 Oct 25. Erratum in: Mol Cell Biol. 2011 Feb;31(3):599. Mol Cell Biol. 2011 May;31(10):2171. Greis, Kenneth [added]. Mol Cell Biol. 2017 Jul 14;37(15):.


The global regulator Crc modulates metabolism, susceptibility to antibiotics and virulence in Pseudomonas aeruginosa.

Linares JF, Moreno R, Fajardo A, Martínez-Solano L, Escalante R, Rojo F, Martínez JL.

Environ Microbiol. 2010 Dec;12(12):3196-212. doi: 10.1111/j.1462-2920.2010.02292.x.


PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance.

Lee SJ, Kim JY, Nogueiras R, Linares JF, Perez-Tilve D, Jung DY, Ko HJ, Hofmann SM, Drew A, Leitges M, Kim JK, Tschöp MH, Diaz-Meco MT, Moscat J.

Cell Metab. 2010 Jul 7;12(1):65-77. doi: 10.1016/j.cmet.2010.05.003.


Towards an ecological approach to antibiotics and antibiotic resistance genes.

Fajardo A, Linares JF, Martínez JL.

Clin Microbiol Infect. 2009 Jan;15 Suppl 1:14-6. doi: 10.1111/j.1469-0691.2008.02688.x. Review.


A global view of antibiotic resistance.

Martinez JL, Fajardo A, Garmendia L, Hernandez A, Linares JF, Martínez-Solano L, Sánchez MB.

FEMS Microbiol Rev. 2009 Jan;33(1):44-65. doi: 10.1111/j.1574-6976.2008.00142.x. Epub 2008 Nov 13. Review.


Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo.

Galvez AS, Duran A, Linares JF, Pathrose P, Castilla EA, Abu-Baker S, Leitges M, Diaz-Meco MT, Moscat J.

Mol Cell Biol. 2009 Jan;29(1):104-15. doi: 10.1128/MCB.01294-08. Epub 2008 Oct 27.


Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis.

Joshi J, Fernandez-Marcos PJ, Galvez A, Amanchy R, Linares JF, Duran A, Pathrose P, Leitges M, Cañamero M, Collado M, Salas C, Serrano M, Moscat J, Diaz-Meco MT.

EMBO J. 2008 Aug 20;27(16):2181-93. doi: 10.1038/emboj.2008.149. Epub 2008 Jul 24.


The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis.

Duran A, Linares JF, Galvez AS, Wikenheiser K, Flores JM, Diaz-Meco MT, Moscat J.

Cancer Cell. 2008 Apr;13(4):343-54. doi: 10.1016/j.ccr.2008.02.001.


Antibiotics as intermicrobial signaling agents instead of weapons.

Linares JF, Gustafsson I, Baquero F, Martinez JL.

Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19484-9. Epub 2006 Dec 5.


Fitness of in vitro selected Pseudomonas aeruginosa nalB and nfxB multidrug resistant mutants.

Sánchez P, Linares JF, Ruiz-Díez B, Campanario E, Navas A, Baquero F, Martínez JL.

J Antimicrob Chemother. 2002 Nov;50(5):657-64.


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