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Items: 14

1.

Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase.

Shaw AN, Tedesco R, Bambal R, Chai D, Concha NO, Darcy MG, Dhanak D, Duffy KJ, Fitch DM, Gates A, Johnston VK, Keenan RM, Lin-Goerke J, Liu N, Sarisky RT, Wiggall KJ, Zimmerman MN.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4350-3. doi: 10.1016/j.bmcl.2009.05.091. Epub 2009 May 28.

PMID:
19515564
2.

Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors.

Tedesco R, Chai D, Darcy MG, Dhanak D, Fitch DM, Gates A, Johnston VK, Keenan RM, Lin-Goerke J, Sarisky RT, Shaw AN, Valko KL, Wiggall KJ, Zimmerman MN, Duffy KJ.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4354-8. doi: 10.1016/j.bmcl.2009.05.080. Epub 2009 May 27.

PMID:
19505821
3.

Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity.

Burton G, Ku TW, Carr TJ, Kiesow T, Sarisky RT, Lin-Goerke J, Hofmann GA, Slater MJ, Haigh D, Dhanak D, Johnson VK, Parry NR, Thommes P.

Bioorg Med Chem Lett. 2007 Apr 1;17(7):1930-3. Epub 2007 Jan 19.

PMID:
17270443
4.

An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids: potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

Evans KA, Chai D, Graybill TL, Burton G, Sarisky RT, Lin-Goerke J, Johnston VK, Rivero RA.

Bioorg Med Chem Lett. 2006 Apr 15;16(8):2205-8. Epub 2006 Feb 7.

PMID:
16455253
5.

3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.

Tedesco R, Shaw AN, Bambal R, Chai D, Concha NO, Darcy MG, Dhanak D, Fitch DM, Gates A, Gerhardt WG, Halegoua DL, Han C, Hofmann GA, Johnston VK, Kaura AC, Liu N, Keenan RM, Lin-Goerke J, Sarisky RT, Wiggall KJ, Zimmerman MN, Duffy KJ.

J Med Chem. 2006 Feb 9;49(3):971-83.

PMID:
16451063
6.

Identification of small molecule inhibitors of the hepatitis C virus RNA-dependent RNA polymerase from a pyrrolidine combinatorial mixture.

Burton G, Ku TW, Carr TJ, Kiesow T, Sarisky RT, Lin-Goerke J, Baker A, Earnshaw DL, Hofmann GA, Keenan RM, Dhanak D.

Bioorg Med Chem Lett. 2005 Mar 15;15(6):1553-6.

PMID:
15745795
7.

Mapping cooperative activity of the hepatitis C virus RNA-dependent RNA polymerase using genotype 1a-1b chimeras.

Gu B, Gutshall LL, Maley D, Pruss CM, Nguyen TT, Silverman CL, Lin-Goerke J, Khandekar S, Liu C, Baker AE, Casper DJ, Sarisky RT.

Biochem Biophys Res Commun. 2004 Jan 9;313(2):343-50.

PMID:
14684166
8.

Enzymatic activities of the GB virus-B RNA-dependent RNA polymerase.

Ranjith-Kumar CT, Santos JL, Gutshall LL, Johnston VK, Lin-Goerke J, Kim MJ, Porter DJ, Maley D, Greenwood C, Earnshaw DL, Baker A, Gu B, Silverman C, Sarisky RT, Kao C.

Virology. 2003 Aug 1;312(2):270-80.

9.

Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

Dhanak D, Duffy KJ, Johnston VK, Lin-Goerke J, Darcy M, Shaw AN, Gu B, Silverman C, Gates AT, Nonnemacher MR, Earnshaw DL, Casper DJ, Kaura A, Baker A, Greenwood C, Gutshall LL, Maley D, DelVecchio A, Macarron R, Hofmann GA, Alnoah Z, Cheng HY, Chan G, Khandekar S, Keenan RM, Sarisky RT.

J Biol Chem. 2002 Oct 11;277(41):38322-7. Epub 2002 Aug 6.

10.

The RNA helicase and nucleotide triphosphatase activities of the bovine viral diarrhea virus NS3 protein are essential for viral replication.

Gu B, Liu C, Lin-Goerke J, Maley DR, Gutshall LL, Feltenberger CA, Del Vecchio AM.

J Virol. 2000 Feb;74(4):1794-800.

11.

Systematic analysis of hMSH2 and hMLH1 in young colon cancer patients and controls.

Farrington SM, Lin-Goerke J, Ling J, Wang Y, Burczak JD, Robbins DJ, Dunlop MG.

Am J Hum Genet. 1998 Sep;63(3):749-59.

12.

PCR-based random mutagenesis using manganese and reduced dNTP concentration.

Lin-Goerke JL, Robbins DJ, Burczak JD.

Biotechniques. 1997 Sep;23(3):409-12. No abstract available.

13.

Evolution of host cell RNA into efficient template RNA by Q beta replicase: the origin of RNA in untemplated reactions.

Moody MD, Burg JL, DiFrancesco R, Lovern D, Stanick W, Lin-Goerke J, Mahdavi K, Wu Y, Farrell MP.

Biochemistry. 1994 Nov 22;33(46):13836-47.

PMID:
7524666
14.

Structural domains of the extracellular domain of human nerve growth factor receptor detected by partial proteolysis.

Vissavajjhala P, Leszyk JD, Lin-Goerke J, Ross AH.

Arch Biochem Biophys. 1992 Apr;294(1):244-52.

PMID:
1372492

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