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Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism.

Bott AJ, Shen J, Tonelli C, Zhan L, Sivaram N, Jiang YP, Yu X, Bhatt V, Chiles E, Zhong H, Maimouni S, Dai W, Velasquez S, Pan JA, Muthalagu N, Morton J, Anthony TG, Feng H, Lamers WH, Murphy DJ, Guo JY, Jin J, Crawford HC, Zhang L, White E, Lin RZ, Su X, Tuveson DA, Zong WX.

Cell Rep. 2019 Oct 29;29(5):1287-1298.e6. doi: 10.1016/j.celrep.2019.09.056.


CEMIP upregulates BiP to promote breast cancer cell survival in hypoxia.

Banach A, Jiang YP, Roth E, Kuscu C, Cao J, Lin RZ.

Oncotarget. 2019 Jul 2;10(42):4307-4320. doi: 10.18632/oncotarget.27036.


Regulation of heart rate and the pacemaker current by phosphoinositide 3-kinase signaling.

Lin RZ, Lu Z, Anyukhovsky EP, Jiang YP, Wang HZ, Gao J, Rosen MR, Ballou LM, Cohen IS.

J Gen Physiol. 2019 Aug 5;151(8):1051-1058. doi: 10.1085/jgp.201812293. Epub 2019 Jun 19.


Tumor-intrinsic PIK3CA represses tumor immunogenecity in a model of pancreatic cancer.

Sivaram N, McLaughlin PA, Han HV, Petrenko O, Jiang YP, Ballou LM, Pham K, Liu C, van der Velden AW, Lin RZ.

J Clin Invest. 2019 May 21;129(8):3264-3276. doi: 10.1172/JCI123540.


A new role of anterograde motor Kif5b in facilitating large clathrin-coated vesicle mediated endocytosis via regulating clathrin uncoating.

Ni YX, Zhou N, Xue WQ, Rong L, Yung WH, Lin RZ, Kao RY, Duan ZG, Sun HT, Gong HR, Tang XM, Liu MF, Zhang W, Qi S, Chung S, Song YQ, Huang JD.

Cell Discov. 2018 Dec 25;4:65. doi: 10.1038/s41421-018-0067-5. eCollection 2018.


Bioengineering human vascular networks: trends and directions in endothelial and perivascular cell sources.

Wang K, Lin RZ, Melero-Martin JM.

Cell Mol Life Sci. 2019 Feb;76(3):421-439. doi: 10.1007/s00018-018-2939-0. Epub 2018 Oct 12. Review.


Comparison of covalently and physically cross-linked collagen hydrogels on mediating vascular network formation for engineering adipose tissue.

Chuang CH, Lin RZ, Melero-Martin JM, Chen YC.

Artif Cells Nanomed Biotechnol. 2018;46(sup3):S434-S447. doi: 10.1080/21691401.2018.1499660. Epub 2018 Aug 27.


[AMPK regulates mitochondrial oxidative stress in C2C12 myotubes induced by electrical stimulations of different intensities].

Dong HL, Wu HY, Tang Y, Huang YW, Lin RZ, Zhao J, Xu XY.

Nan Fang Yi Ke Da Xue Xue Bao. 2018 Jun 20;38(6):742-747. Chinese.


Phosphoinositide 3-kinases and Diabetic Cardiomyopathy.

Lin RZ.

J Cardiovasc Pharmacol. 2017 Dec;70(6):420-421. doi: 10.1097/FJC.0000000000000547. No abstract available.


Selective Deposition of Multiple Sensing Materials on Si Nanobelt Devices through Plasma-Enhanced Chemical Vapor Deposition and Device-Localized Joule Heating.

Lin RZ, Cheng KY, Pan FM, Sheu JT.

ACS Appl Mater Interfaces. 2017 Nov 22;9(46):39935-39939. doi: 10.1021/acsami.7b13896. Epub 2017 Nov 9.


Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks.

Lin RZ, Lee CN, Moreno-Luna R, Neumeyer J, Piekarski B, Zhou P, Moses MA, Sachdev M, Pu WT, Emani S, Melero-Martin JM.

Nat Biomed Eng. 2017;1. pii: 0081. doi: 10.1038/s41551-017-0081. Epub 2017 Jun 13.


VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis.

Chen J, Fu Y, Day DS, Sun Y, Wang S, Liang X, Gu F, Zhang F, Stevens SM, Zhou P, Li K, Zhang Y, Lin RZ, Smith LEH, Zhang J, Sun K, Melero-Martin JM, Han Z, Park PJ, Zhang B, Pu WT.

Nat Commun. 2017 Aug 29;8(1):383. doi: 10.1038/s41467-017-00405-x.


Phospholipase D2 loss results in increased blood pressure via inhibition of the endothelial nitric oxide synthase pathway.

Nelson RK, Ya-Ping J, Gadbery J, Abedeen D, Sampson N, Lin RZ, Frohman MA.

Sci Rep. 2017 Aug 22;7(1):9112. doi: 10.1038/s41598-017-09852-4.


Acquired long QT syndrome and phosphoinositide 3-kinase.

Cohen IS, Lin RZ, Ballou LM.

Trends Cardiovasc Med. 2017 Oct;27(7):451-459. doi: 10.1016/j.tcm.2017.05.005. Epub 2017 May 17. Review.


Pressure-overload-induced angiotensin-mediated early remodeling in mouse heart.

Kim JH, Jiang YP, Cohen IS, Lin RZ, Mathias RT.

PLoS One. 2017 May 2;12(5):e0176713. doi: 10.1371/journal.pone.0176713. eCollection 2017.


Endothelial colony forming cells and mesenchymal progenitor cells form blood vessels and increase blood flow in ischemic muscle.

Kang KT, Lin RZ, Kuppermann D, Melero-Martin JM, Bischoff J.

Sci Rep. 2017 Apr 10;7(1):770. doi: 10.1038/s41598-017-00809-1.


Activation of Gαq in Cardiomyocytes Increases Vps34 Activity and Stimulates Autophagy.

Liu S, Jiang YP, Ballou LM, Zong WX, Lin RZ.

J Cardiovasc Pharmacol. 2017 Apr;69(4):198-211. doi: 10.1097/FJC.0000000000000461.


Loss of PI3K p110α in the Adipose Tissue Results in Infertility and Delayed Puberty Onset in Male Mice.

Nelson VL, Negrón AL, Reid I, Thomas JA, Yang L, Lin RZ, Acosta-Martínez M.

Biomed Res Int. 2017;2017:3756089. doi: 10.1155/2017/3756089. Epub 2017 Mar 5.


The Phosphoinosotide 3-Kinase Catalytic Subunit p110α is Required for Normal Lens Growth.

Sellitto C, Li L, Vaghefi E, Donaldson PJ, Lin RZ, White TW.

Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3145-51. doi: 10.1167/iovs.16-19607.


[Knockout of Micro-RNA-21 Gene in DLBCL OCI-Ly3 cells by TALEN Technique].

Chen BY, Hu JD, Lin RZ, Chen XJ.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016 Apr;24(2):422-6. doi: 10.7534/j.issn.1009-2137.2016.02.021. Chinese.


Increased Late Sodium Current Contributes to the Electrophysiological Effects of Chronic, but Not Acute, Dofetilide Administration.

Qiu XS, Chauveau S, Anyukhovsky EP, Rahim T, Jiang YP, Harleton E, Feinmark SJ, Lin RZ, Coronel R, Janse MJ, Opthof T, Rosen TS, Cohen IS, Rosen MR.

Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e003655. doi: 10.1161/CIRCEP.115.003655.


TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis.

Pan JA, Sun Y, Jiang YP, Bott AJ, Jaber N, Dou Z, Yang B, Chen JS, Catanzaro JM, Du C, Ding WX, Diaz-Meco MT, Moscat J, Ozato K, Lin RZ, Zong WX.

Mol Cell. 2016 Apr 7;62(1):149-51. doi: 10.1016/j.molcel.2016.03.015. No abstract available.


TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis.

Pan JA, Sun Y, Jiang YP, Bott AJ, Jaber N, Dou Z, Yang B, Chen JS, Catanzaro JM, Du C, Ding WX, Diaz-Meco MT, Moscat J, Ozato K, Lin RZ, Zong WX.

Mol Cell. 2016 Mar 3;61(5):720-733. doi: 10.1016/j.molcel.2016.02.007. Erratum in: Mol Cell. 2016 Apr 7;62(1):149-51.


Mechanism study on stability enhancement of adefovir dipivoxil by cocrystallization: Degradation kinetics and structure-stability correlation.

Lin RZ, Sun PJ, Tao Q, Yao J, Chen JM, Lu TB.

Eur J Pharm Sci. 2016 Mar 31;85:141-8. doi: 10.1016/j.ejps.2015.10.006. Epub 2015 Oct 18.


Bioengineering vascularized tissue constructs using an injectable cell-laden enzymatically crosslinked collagen hydrogel derived from dermal extracellular matrix.

Kuo KC, Lin RZ, Tien HW, Wu PY, Li YC, Melero-Martin JM, Chen YC.

Acta Biomater. 2015 Nov;27:151-166. doi: 10.1016/j.actbio.2015.09.002. Epub 2015 Sep 5.


Clinical, biochemical, neuroimaging and molecular findings of X-linked Adrenoleukodystrophy patients in South China.

Jiang MY, Cai YN, Liang CL, Peng MZ, Sheng HY, Fan LP, Lin RZ, Jiang H, Huang Y, Liu L.

Metab Brain Dis. 2015 Dec;30(6):1439-44. doi: 10.1007/s11011-015-9717-6. Epub 2015 Aug 12.


[Electrophysiological Characteristics of Sensitized Acupoints after Acute Intestinal Mucosal Injury in Rats].

Xu JF, Wu Q, Lin RZ, Shi H, Jing XH, Zhu B, He W, Wang XY, Su YS, Hu L.

Zhen Ci Yan Jiu. 2015 Jun;40(3):180-5. Chinese.


Energy balancing by fat Pik3ca.

Nelson VL, Ballou LM, Lin RZ.

Adipocyte. 2014 Nov 14;4(1):70-4. doi: 10.4161/21623945.2014.955397. eCollection 2015 Jan-Mar.


Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes.

Guo A, Hall D, Zhang C, Peng T, Miller JD, Kutschke W, Grueter CE, Johnson FL, Lin RZ, Song LS.

J Biol Chem. 2015 Jul 17;290(29):17946-55. doi: 10.1074/jbc.M115.652396. Epub 2015 Jun 10.


Differential regulation of Connexin50 and Connexin46 by PI3K signaling.

Martinez JM, Wang HZ, Lin RZ, Brink PR, White TW.

FEBS Lett. 2015 May 22;589(12):1340-5. doi: 10.1016/j.febslet.2015.04.029. Epub 2015 Apr 29.


Enzymatic regulation of functional vascular networks using gelatin hydrogels.

Chuang CH, Lin RZ, Tien HW, Chu YC, Li YC, Melero-Martin JM, Chen YC.

Acta Biomater. 2015 Jun;19:85-99. doi: 10.1016/j.actbio.2015.02.024. Epub 2015 Mar 6.


Complete mitochondrial genome sequence and mutations of the laryngeal cancer model inbred nude rat strain.

Zheng CH, Lin RZ, Qiu EH, Chen YM, Chen XF, Xu ZH, Liang ZY, Hong YM.

Mitochondrial DNA A DNA Mapp Seq Anal. 2016 Nov;27(6):4185-4186. Epub 2015 Jan 29.


Control of cardiac repolarization by phosphoinositide 3-kinase signaling to ion channels.

Ballou LM, Lin RZ, Cohen IS.

Circ Res. 2015 Jan 2;116(1):127-37. doi: 10.1161/CIRCRESAHA.116.303975. Review.


PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice.

Wu CY, Carpenter ES, Takeuchi KK, Halbrook CJ, Peverley LV, Bien H, Hall JC, DelGiorno KE, Pal D, Song Y, Shi C, Lin RZ, Crawford HC.

Gastroenterology. 2014 Dec;147(6):1405-16.e7. doi: 10.1053/j.gastro.2014.08.032. Epub 2014 Aug 27.


Kisspeptin cell-specific PI3K signaling regulates hypothalamic kisspeptin expression and participates in the regulation of female fertility.

Beymer M, Negrón AL, Yu G, Wu S, Mayer C, Lin RZ, Boehm U, Acosta-Martínez M.

Am J Physiol Endocrinol Metab. 2014 Dec 1;307(11):E969-82. doi: 10.1152/ajpendo.00385.2014. Epub 2014 Sep 30.


Epicardium-to-fat transition in injured heart.

Liu Q, Huang X, Oh JH, Lin RZ, Duan S, Yu Y, Yang R, Qiu J, Melero-Martin JM, Pu WT, Zhou B.

Cell Res. 2014 Nov;24(11):1367-9. doi: 10.1038/cr.2014.125. Epub 2014 Sep 26. No abstract available.


Microfluidic capture of endothelial colony-forming cells from human adult peripheral blood: phenotypic and functional validation in vivo.

Lin RZ, Hatch A, Antontsev VG, Murthy SK, Melero-Martin JM.

Tissue Eng Part C Methods. 2015 Mar;21(3):274-83. doi: 10.1089/ten.TEC.2014.0323. Epub 2014 Sep 17.


Human endothelial colony-forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling.

Lin RZ, Moreno-Luna R, Li D, Jaminet SC, Greene AK, Melero-Martin JM.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10137-42. doi: 10.1073/pnas.1405388111. Epub 2014 Jun 30.


Calpain-dependent cleavage of junctophilin-2 and T-tubule remodeling in a mouse model of reversible heart failure.

Wu CY, Chen B, Jiang YP, Jia Z, Martin DW, Liu S, Entcheva E, Song LS, Lin RZ.

J Am Heart Assoc. 2014 Jun 23;3(3):e000527. doi: 10.1161/JAHA.113.000527.


Dose ranging, expanded acute toxicity and safety pharmacology studies for intravenously administered functionalized graphene nanoparticle formulations.

Kanakia S, Toussaint JD, Mullick Chowdhury S, Tembulkar T, Lee S, Jiang YP, Lin RZ, Shroyer KR, Moore W, Sitharaman B.

Biomaterials. 2014 Aug;35(25):7022-31. doi: 10.1016/j.biomaterials.2014.04.066. Epub 2014 May 20.


Galanin-like peptide (GALP) neurone-specific phosphoinositide 3-kinase signalling regulates GALP mRNA levels in the hypothalamus of males and luteinising hormone levels in both sexes.

Aziz R, Beymer M, Negrón AL, Newshan A, Yu G, Rosati B, McKinnon D, Fukuda M, Lin RZ, Mayer C, Boehm U, Acosta-Martínez M.

J Neuroendocrinol. 2014 Jul;26(7):426-38. doi: 10.1111/jne.12163.


Decreased level of cord blood circulating endothelial colony-forming cells in preeclampsia.

Muñoz-Hernandez R, Miranda ML, Stiefel P, Lin RZ, Praena-Fernández JM, Dominguez-Simeon MJ, Villar J, Moreno-Luna R, Melero-Martin JM.

Hypertension. 2014 Jul;64(1):165-71. doi: 10.1161/HYPERTENSIONAHA.113.03058. Epub 2014 Apr 21.


Adipose tissue insulin resistance due to loss of PI3K p110α leads to decreased energy expenditure and obesity.

Nelson VL, Jiang YP, Dickman KG, Ballou LM, Lin RZ.

Am J Physiol Endocrinol Metab. 2014 May 15;306(10):E1205-16. doi: 10.1152/ajpendo.00625.2013. Epub 2014 Apr 1.


Maternal body-mass index and cord blood circulating endothelial colony-forming cells.

Moreno-Luna R, Muñoz-Hernandez R, Lin RZ, Miranda ML, Vallejo-Vaz AJ, Stiefel P, Praena-Fernández JM, Bernal-Bermejo J, Jimenez-Jimenez LM, Villar J, Melero-Martin JM.

J Pediatr. 2014 Mar;164(3):566-571. doi: 10.1016/j.jpeds.2013.10.063. Epub 2013 Dec 5. Erratum in: J Pediatr. 2014 Mar;164(3):678.


AKT activation promotes PTEN hamartoma tumor syndrome-associated cataract development.

Sellitto C, Li L, Gao J, Robinson ML, Lin RZ, Mathias RT, White TW.

J Clin Invest. 2013 Dec;123(12):5401-9. doi: 10.1172/JCI70437. Epub 2013 Nov 25.


Pathological impact of SMN2 mis-splicing in adult SMA mice.

Sahashi K, Ling KK, Hua Y, Wilkinson JE, Nomakuchi T, Rigo F, Hung G, Xu D, Jiang YP, Lin RZ, Ko CP, Bennett CF, Krainer AR.

EMBO Mol Med. 2013 Oct;5(10):1586-601. doi: 10.1002/emmm.201302567. Epub 2013 Sep 9.


Increased persistent sodium current due to decreased PI3K signaling contributes to QT prolongation in the diabetic heart.

Lu Z, Jiang YP, Wu CY, Ballou LM, Liu S, Carpenter ES, Rosen MR, Cohen IS, Lin RZ.

Diabetes. 2013 Dec;62(12):4257-65. doi: 10.2337/db13-0420. Epub 2013 Aug 23.


Transdermal regulation of vascular network bioengineering using a photopolymerizable methacrylated gelatin hydrogel.

Lin RZ, Chen YC, Moreno-Luna R, Khademhosseini A, Melero-Martin JM.

Biomaterials. 2013 Sep;34(28):6785-96. doi: 10.1016/j.biomaterials.2013.05.060. Epub 2013 Jun 14.


Liver-cell patterning lab chip: mimicking the morphology of liver lobule tissue.

Ho CT, Lin RZ, Chen RJ, Chin CK, Gong SE, Chang HY, Peng HL, Hsu L, Yew TR, Chang SF, Liu CH.

Lab Chip. 2013 Sep 21;13(18):3578-87. doi: 10.1039/c3lc50402f.


Human white adipose tissue vasculature contains endothelial colony-forming cells with robust in vivo vasculogenic potential.

Lin RZ, Moreno-Luna R, Muñoz-Hernandez R, Li D, Jaminet SC, Greene AK, Melero-Martin JM.

Angiogenesis. 2013 Oct;16(4):735-44. doi: 10.1007/s10456-013-9350-0. Epub 2013 May 1.

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