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Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2 T-type voltage-gated calcium channels and Ca2+ influx.

Jimenez H, Wang M, Zimmerman JW, Pennison MJ, Sharma S, Surratt T, Xu ZX, Brezovich I, Absher D, Myers RM, DeYoung B, Caudell DL, Chen D, Lo HW, Lin HK, Godwin DW, Olivier M, Ghanekar A, Chen K, Miller LD, Gong Y, Capstick M, D'Agostino RB Jr, Munden R, Merle P, Barbault A, Blackstock AW, Bonkovsky HL, Yang GY, Jin G, Liu L, Zhang W, Watabe K, Blackman CF, Pasche BC.

EBioMedicine. 2019 May 24. pii: S2352-3964(19)30342-1. doi: 10.1016/j.ebiom.2019.05.034. [Epub ahead of print]


Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS.

Zhang W, Wang G, Xu ZG, Tu H, Hu F, Dai J, Chang Y, Chen Y, Lu Y, Zeng H, Cai Z, Han F, Xu C, Jin G, Sun L, Pan BS, Lai SW, Hsu CC, Xu J, Chen ZZ, Li HY, Seth P, Hu J, Zhang X, Li H, Lin HK.

Cell. 2019 May 20. pii: S0092-8674(19)30501-X. doi: 10.1016/j.cell.2019.05.003. [Epub ahead of print]


[Research rules of famous veteran traditional Chinese medicine practitioners in treating infertility].

Qi XJ, Zhang ZP, Zhang HZ, Li JM, Huang RL, Li QL, Lin HK, Lu YQ, Chen GM, Deng GP.

Zhongguo Zhong Yao Za Zhi. 2019 Apr;44(7):1491-1496. doi: 10.19540/j.cnki.cjcmm.20181213.003. Chinese.


Comparison of patient reported symptom burden on an enhanced recovery after surgery (ERAS) care pathway in patients with ovarian cancer undergoing primary vs. interval tumor reductive surgery.

Meyer LA, Shi Q, Lasala J, Iniesta MD, Lin HK, Nick AM, Williams L, Sun C, Wang XS, Lu KH, Ramirez PT.

Gynecol Oncol. 2019 Mar;152(3):501-508. doi: 10.1016/j.ygyno.2018.10.044.


SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis.

Wang G, Long J, Gao Y, Zhang W, Han F, Xu C, Sun L, Yang SC, Lan J, Hou Z, Cai Z, Jin G, Hsu CC, Wang YH, Hu J, Chen TY, Li H, Lee MG, Lin HK.

Nat Cell Biol. 2019 Feb;21(2):214-225. doi: 10.1038/s41556-018-0266-1. Epub 2019 Jan 28.


Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression.

Zhu GF, Xu YW, Li J, Niu HL, Ma WX, Xu J, Zhou PR, Liu X, Ye DL, Liu XR, Yan T, Zhai WK, Xu ZJ, Liu C, Wang L, Wang H, Luo JM, Liu L, Li XQ, Guo S, Jiang HP, Shen P, Lin HK, Yu DH, Ding YQ, Zhang QL.

Nat Commun. 2019 Jan 10;10(1):112. doi: 10.1038/s41467-018-07998-x.


CRNC12: Maxilla Reconstruction with 12 Telescopic Fixed Dental Prosthesis.

Lin SY, Liou DY, Lin HK.

J Indian Prosthodont Soc. 2018 Oct;18(Suppl 1):S50. doi: 10.4103/0972-4052.244583. No abstract available.


CRNC9: Full Mouth Rehabilitation in a Deep Bite Case with Posterior Implant-Supported Fixed Dental Prosthesis.

Huang YC, Lin HK.

J Indian Prosthodont Soc. 2018 Oct;18(Suppl 1):S49. doi: 10.4103/0972-4052.244580. No abstract available.


Immunomodulatory response of layered small intestinal submucosa in a rat bladder regeneration model.

Xia D, Yang Q, Fung KM, Towner RA, Smith N, Saunders D, Greenwood-Van Meerveld B, Kropp BP, Madihally SV, Lin HK.

J Biomed Mater Res B Appl Biomater. 2018 Dec 6. doi: 10.1002/jbm.b.34289. [Epub ahead of print]


The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance.

Han F, Li CF, Cai Z, Zhang X, Jin G, Zhang WN, Xu C, Wang CY, Morrow J, Zhang S, Xu D, Wang G, Lin HK.

Nat Commun. 2018 Nov 9;9(1):4728. doi: 10.1038/s41467-018-07188-9.


[Minimally invasive retrograde insertion of elastic intramedullary nails for displaced clavicle fractures in children].

Lin HK, Zhou ZP, Lai CS, Liu Z.

Zhongguo Gu Shang. 2018 Sep 25;31(9):808-811. doi: 10.3969/j.issn.1003-0034.2018.09.006. Chinese.


A prospective analysis of symptom burden for patients with chronic myeloid leukemia in chronic phase treated with frontline second- and third-generation tyrosine kinase inhibitors.

Zulbaran-Rojas A, Lin HK, Shi Q, Williams LA, George B, Garcia-Manero G, Jabbour E, O'Brien S, Ravandi F, Wierda W, Estrov Z, Borthakur G, Kadia T, Cleeland C, Cortes JE, Kantarjian H.

Cancer Med. 2018 Nov;7(11):5457-5469. doi: 10.1002/cam4.1808. Epub 2018 Oct 14.


Abnormal gametogenesis induced by p53 deficiency promotes tumor progression and drug resistance.

Liu C, Cai Z, Jin G, Peng D, Pan BS, Zhang X, Han F, Xu X, Lin HK.

Cell Discov. 2018 Oct 2;4:54. doi: 10.1038/s41421-018-0054-x. eCollection 2018.


A new mechanism for LKB1 activation.

Lee SW, Lin HK.

Mol Cell Oncol. 2018 Apr 10;5(3):e1035691. doi: 10.1080/23723556.2015.1035691. eCollection 2018.


Numerical simulation of nanopost-guided self-organization dendritic architectures using phase-field model.

Hsu YR, Lin MC, Lin HK, Chang YH, Lu CC, Hsu HY.

PLoS One. 2018 Jul 2;13(7):e0199620. doi: 10.1371/journal.pone.0199620. eCollection 2018.


Facile construction of fused benzimidazole-isoquinolinones that induce cell-cycle arrest and apoptosis in colorectal cancer cells.

He LJ, Yang DL, Li SQ, Zhang YJ, Tang Y, Lei J, Frett B, Lin HK, Li HY, Chen ZZ, Xu ZG.

Bioorg Med Chem. 2018 Aug 7;26(14):3899-3908. doi: 10.1016/j.bmc.2018.06.010. Epub 2018 Jun 12.


Doping ZnO Electron Transport Layers with MoS2 Nanosheets Enhances the Efficiency of Polymer Solar Cells.

Huang YJ, Chen HC, Lin HK, Wei KH.

ACS Appl Mater Interfaces. 2018 Jun 13;10(23):20196-20204. doi: 10.1021/acsami.8b06413. Epub 2018 May 30.


Functionalized Spiroindolines with Anticancer Activity through a Metal-Free Post-Ugi Diastereoselective One-Pot Cascade Reaction.

Xu ZG, Li SQ, Meng JP, Tang DY, He LJ, Lei J, Lin HK, Li HY, Chen ZZ.

Chemistry. 2018 May 7;24(26):6732-6736. doi: 10.1002/chem.201801081. Epub 2018 Apr 20.


Caveolin-1 down-regulation is required for Wnt5a-Frizzled 2 signalling in Ha-RasV12 -induced cell transformation.

Lin HK, Lin HH, Chiou YW, Wu CL, Chiu WT, Tang MJ.

J Cell Mol Med. 2018 May;22(5):2631-2643. doi: 10.1111/jcmm.13531. Epub 2018 Mar 4.


Sulfur Radical Transfer and Coupling Reaction to Benzoxazine Groups: A New Reaction Route for Preparation of Polymeric Materials Using Elemental Sulfur as a Feedstock.

Lin HK, Liu YL.

Macromol Rapid Commun. 2018 Apr;39(8):e1700832. doi: 10.1002/marc.201700832. Epub 2018 Feb 16.


Up-regulation of golgi α-mannosidase IA and down-regulation of golgi α-mannosidase IC activates unfolded protein response during hepatocarcinogenesis.

Tu HC, Hsiao YC, Yang WY, Tsai SL, Lin HK, Liao CY, Lu JW, Chou YT, Wang HD, Yuh CH.

Hepatol Commun. 2017 Apr 19;1(3):230-247. doi: 10.1002/hep4.1032. eCollection 2017 May.


Identification of a noncanonical function for ribose-5-phosphate isomerase A promotes colorectal cancer formation by stabilizing and activating β-catenin via a novel C-terminal domain.

Chou YT, Jiang JK, Yang MH, Lu JW, Lin HK, Wang HD, Yuh CH.

PLoS Biol. 2018 Jan 16;16(1):e2003714. doi: 10.1371/journal.pbio.2003714. eCollection 2018 Jan.


Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells.

Jin G, Xu C, Zhang X, Long J, Rezaeian AH, Liu C, Furth ME, Kridel S, Pasche B, Bian XW, Lin HK.

Nat Immunol. 2018 Jan;19(1):29-40. doi: 10.1038/s41590-017-0002-1. Epub 2017 Nov 21.


Danshen improves survival of patients with advanced lung cancer and targeting the relationship between macrophages and lung cancer cells.

Wu CY, Cherng JY, Yang YH, Lin CL, Kuan FC, Lin YY, Lin YS, Shu LH, Cheng YC, Liu HT, Lu MC, Lung J, Chen PC, Lin HK, Lee KD, Tsai YH.

Oncotarget. 2017 Jun 28;8(53):90925-90947. doi: 10.18632/oncotarget.18767. eCollection 2017 Oct 31.


Transition from androgenic to neurosteroidal action of 5α-androstane-3α, 17β-diol through the type A γ-aminobutyric acid receptor in prostate cancer progression.

Xia D, Lai DV, Wu W, Webb ZD, Yang Q, Zhao L, Yu Z, Thorpe JE, Disch BC, Ihnat MA, Jayaraman M, Dhanasekaran DN, Stratton KL, Cookson MS, Fung KM, Lin HK.

J Steroid Biochem Mol Biol. 2018 Apr;178:89-98. doi: 10.1016/j.jsbmb.2017.11.006. Epub 2017 Nov 21.


Validation and Application of the MD Anderson Symptom Inventory for Traditional Chinese Medicine (MDASI-TCM).

Li Z, Shi Q, Liu M, Jia L, He B, Yang Y, Liu J, Lin H, Lin HK, Li P, Wang XS.

J Natl Cancer Inst Monogr. 2017 Nov 1;2017(52). doi: 10.1093/jncimonographs/lgx010.


Dual Roles of Glutathione in Ecdysone Biosynthesis and Antioxidant Function During Larval Development in Drosophila.

Enya S, Yamamoto C, Mizuno H, Esaki T, Lin HK, Iga M, Morohashi K, Hirano Y, Kataoka H, Masujima T, Shimada-Niwa Y, Niwa R.

Genetics. 2017 Dec;207(4):1519-1532. doi: 10.1534/genetics.117.300391. Epub 2017 Oct 11.


Cell Penetrating Peptide Derived from Human Eosinophil Cationic Protein Decreases Airway Allergic Inflammation.

Fu LS, Wu YR, Fang SL, Tsai JJ, Lin HK, Chen YJ, Chen TY, Chang MD.

Sci Rep. 2017 Sep 27;7(1):12352. doi: 10.1038/s41598-017-12390-8.


Reduced urothelial regeneration in rat bladders augmented with permeable porcine small intestinal submucosa assessed by magnetic resonance imaging.

Yang Q, Xia D, Towner RA, Smith N, Saunders D, Fung KM, Aston CE, Greenwood-Van Meerveld B, Hurst RE, Madihally SV, Kropp BP, Lin HK.

J Biomed Mater Res B Appl Biomater. 2018 Jul;106(5):1778-1787. doi: 10.1002/jbm.b.33985. Epub 2017 Sep 13.


Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core.

Lin HK, Boatz JC, Krabbendam IE, Kodali R, Hou Z, Wetzel R, Dolga AM, Poirier MA, van der Wel PCA.

Nat Commun. 2017 May 24;8:15462. doi: 10.1038/ncomms15462.


Phosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer.

Geng Q, Liu J, Gong Z, Chen S, Chen S, Li X, Lu Y, Zhu X, Lin HK, Xu D.

Mol Cancer. 2017 Apr 26;16(1):83. doi: 10.1186/s12943-017-0649-0.


Reactive Hybrid of Polyhedral Oligomeric Silsesquioxane (POSS) and Sulfur as a Building Block for Self-Healing Materials.

Lin HK, Liu YL.

Macromol Rapid Commun. 2017 May;38(10). doi: 10.1002/marc.201700051. Epub 2017 Mar 30.


Skp2 deficiency restricts the progression and stem cell features of castration-resistant prostate cancer by destabilizing Twist.

Ruan D, He J, Li CF, Lee HJ, Liu J, Lin HK, Chan CH.

Oncogene. 2017 Jul 27;36(30):4299-4310. doi: 10.1038/onc.2017.64. Epub 2017 Mar 27.


Overexpression of exogenous kidney-specific Ngal attenuates progressive cyst development and prolongs lifespan in a murine model of polycystic kidney disease.

Wang E, Chiou YY, Jeng WY, Lin HK, Lin HH, Chin HJ, Leo Wang CK, Yu SS, Tsai SC, Chiang CY, Cheng PH, Lin HJ, Jiang ST, Chiu ST, Hsieh-Li HM.

Kidney Int. 2017 Feb;91(2):412-422. doi: 10.1016/j.kint.2016.09.005. Epub 2016 Oct 27.


H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis.

Zhang X, Li B, Rezaeian AH, Xu X, Chou PC, Jin G, Han F, Pan BS, Wang CY, Long J, Zhang A, Huang CY, Tsai FJ, Tsai CH, Logothetis C, Lin HK.

Nat Commun. 2017 Mar 16;8:14799. doi: 10.1038/ncomms14799.


DNA damage players are linked to HIF-1α/hypoxia signaling.

Rezaeian AH, Wang YH, Lin HK.

Cell Cycle. 2017 Apr 18;16(8):725-726. doi: 10.1080/15384101.2017.1302208. Epub 2017 Mar 10. No abstract available.


Characterization of the GNMT-HectH9-PREX2 tripartite relationship in the pathogenesis of hepatocellular carcinoma.

Li CH, Yen CH, Chen YF, Lee KJ, Fang CC, Zhang X, Lai CC, Huang SF, Lin HK, Arthur Chen YM.

Int J Cancer. 2017 May 15;140(10):2284-2297. doi: 10.1002/ijc.30652.


Lymphotoxin-β Interacts with Methylated EGFR to Mediate Acquired Resistance to Cetuximab in Head and Neck Cancer.

Hsu DS, Hwang WL, Yuh CH, Chu CH, Ho YH, Chen PB, Lin HS, Lin HK, Wu SP, Lin CY, Hsu WH, Lan HY, Wang HJ, Tai SK, Hung MC, Yang MH.

Clin Cancer Res. 2017 Aug 1;23(15):4388-4401. doi: 10.1158/1078-0432.CCR-16-1955. Epub 2017 Feb 14.


Elevated transglutaminase-2 expression in the epidermis of psoriatic skin and its role in the skin lesion development.

Su CC, Su TR, Lai JC, Tsay GJ, Lin HK.

J Dermatol. 2017 Jun;44(6):699-702. doi: 10.1111/1346-8138.13742. Epub 2017 Feb 2.


Marginal Bone Level Evaluation after Functional Loading Around Two Different Dental Implant Designs.

Ho KN, Salamanca E, Lin HK, Lee SY, Chang WJ.

Biomed Res Int. 2016;2016:1472090. doi: 10.1155/2016/1472090. Epub 2016 Nov 24.


NBR2-GLUT1 axis regulates cancer cell sensitivity to biguanides.

Zhang X, Lin HK.

Cell Cycle. 2017 Feb;16(3):249-250. doi: 10.1080/15384101.2016.1263498. Epub 2016 Dec 8. No abstract available.


A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis.

Rezaeian AH, Li CF, Wu CY, Zhang X, Delacerda J, You MJ, Han F, Cai Z, Jeong YS, Jin G, Phan L, Chou PC, Lee MH, Hung MC, Sarbassov D, Lin HK.

Nat Cell Biol. 2017 Jan;19(1):38-51. doi: 10.1038/ncb3445. Epub 2016 Dec 5.


SENP1 regulates PTEN stability to dictate prostate cancer development.

Bawa-Khalfe T, Yang FM, Ritho J, Lin HK, Cheng J, Yeh ET.

Oncotarget. 2017 Mar 14;8(11):17651-17664. doi: 10.18632/oncotarget.13283.


TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression.

Zhang X, Li CF, Zhang L, Wu CY, Han L, Jin G, Rezaeian AH, Han F, Liu C, Xu C, Xu X, Huang CY, Tsai FJ, Tsai CH, Watabe K, Lin HK.

Mol Cell. 2016 Nov 17;64(4):803-814. doi: 10.1016/j.molcel.2016.10.002. Epub 2016 Nov 3.


Block Copolymer-Tuned Fullerene Electron Transport Layer Enhances the Efficiency of Perovskite Photovoltaics.

Lin HK, Su YW, Chen HC, Huang YJ, Wei KH.

ACS Appl Mater Interfaces. 2016 Sep 21;8(37):24603-11. doi: 10.1021/acsami.6b07690. Epub 2016 Sep 7.


Cancer Chemopreventive Effects of Boswellia sacra Gum Resin Hydrodistillates on Invasive Urothelial Cell Carcinoma: Report of a Case.

Xia D, Lou W, Fung KM, Wolley CL, Suhail MM, Lin HK.

Integr Cancer Ther. 2017 Dec;16(4):605-611. doi: 10.1177/1534735416664174. Epub 2016 Aug 16.


Secreted Protein Acidic and Rich in Cysteine (SPARC) Mediates Metastatic Dormancy of Prostate Cancer in Bone.

Sharma S, Xing F, Liu Y, Wu K, Said N, Pochampally R, Shiozawa Y, Lin HK, Balaji KC, Watabe K.

J Biol Chem. 2016 Sep 9;291(37):19351-63. doi: 10.1074/jbc.M116.737379. Epub 2016 Jul 15.


Intensity Modulated Proton Therapy Versus Intensity Modulated Photon Radiation Therapy for Oropharyngeal Cancer: First Comparative Results of Patient-Reported Outcomes.

Sio TT, Lin HK, Shi Q, Gunn GB, Cleeland CS, Lee JJ, Hernandez M, Blanchard P, Thaker NG, Phan J, Rosenthal DI, Garden AS, Morrison WH, Fuller CD, Mendoza TR, Mohan R, Wang XS, Frank SJ.

Int J Radiat Oncol Biol Phys. 2016 Jul 15;95(4):1107-14. doi: 10.1016/j.ijrobp.2016.02.044. Epub 2016 Feb 18.


LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress.

Liu X, Xiao ZD, Han L, Zhang J, Lee SW, Wang W, Lee H, Zhuang L, Chen J, Lin HK, Wang J, Liang H, Gan B.

Nat Cell Biol. 2016 Apr;18(4):431-42. doi: 10.1038/ncb3328. Epub 2016 Mar 21.


Discovering Peptide Inhibitors of Human Squalene Synthase Through Screening the Phage-Displayed Cyclic Peptide c7c Library.

Shiuan D, Chen YH, Lin HK, Huang KJ, Tai DF, Chang DK.

Appl Biochem Biotechnol. 2016 Jun;179(4):597-609. doi: 10.1007/s12010-016-2016-9. Epub 2016 Feb 27.


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