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Items: 31


De novo Mutations From Whole Exome Sequencing in Neurodevelopmental and Psychiatric Disorders: From Discovery to Application.

Wang W, Corominas R, Lin GN.

Front Genet. 2019 Apr 3;10:258. doi: 10.3389/fgene.2019.00258. eCollection 2019. Review.


When loss-of-function is loss of function: assessing mutational signatures and impact of loss-of-function genetic variants.

Pagel KA, Pejaver V, Lin GN, Nam HJ, Mort M, Cooper DN, Sebat J, Iakoucheva LM, Mooney SD, Radivojac P.

Bioinformatics. 2017 Jul 15;33(14):i389-i398. doi: 10.1093/bioinformatics/btx272.


Comprehensive Analyses of Tissue-Specific Networks with Implications to Psychiatric Diseases.

Lin GN, Corominas R, Nam HJ, Urresti J, Iakoucheva LM.

Methods Mol Biol. 2017;1613:371-402. doi: 10.1007/978-1-4939-7027-8_15.


Chemotherapy Near the End of Life for Chinese Patients with Solid Malignancies.

Sheng J, Zhang YX, He XB, Fang WF, Yang YP, Lin GN, Wu X, Li N, Zhang J, Zhai LZ, Zhao YY, Huang Y, Zhou NN, Zhao HY, Zhang L.

Oncologist. 2017 Jan;22(1):53-60. doi: 10.1634/theoncologist.2016-0013. Epub 2016 Oct 27.


Frequency and Complexity of De Novo Structural Mutation in Autism.

Brandler WM, Antaki D, Gujral M, Noor A, Rosanio G, Chapman TR, Barrera DJ, Lin GN, Malhotra D, Watts AC, Wong LC, Estabillo JA, Gadomski TE, Hong O, Fajardo KV, Bhandari A, Owen R, Baughn M, Yuan J, Solomon T, Moyzis AG, Maile MS, Sanders SJ, Reiner GE, Vaux KK, Strom CM, Zhang K, Muotri AR, Akshoomoff N, Leal SM, Pierce K, Courchesne E, Iakoucheva LM, Corsello C, Sebat J.

Am J Hum Genet. 2016 Apr 7;98(4):667-79. doi: 10.1016/j.ajhg.2016.02.018. Epub 2016 Mar 24.


Hepatitis B Virus Infection Is Associated with Poor Prognosis in Patients with Advanced Non Small Cell Lung Cancer.

Peng JW, Liu DY, Lin GN, Xiao JJ, Xia ZJ.

Asian Pac J Cancer Prev. 2015;16(13):5285-8.


Spatiotemporal 16p11.2 protein network implicates cortical late mid-fetal brain development and KCTD13-Cul3-RhoA pathway in psychiatric diseases.

Lin GN, Corominas R, Lemmens I, Yang X, Tavernier J, Hill DE, Vidal M, Sebat J, Iakoucheva LM.

Neuron. 2015 Feb 18;85(4):742-54. doi: 10.1016/j.neuron.2015.01.010.


A proteome-scale map of the human interactome network.

Rolland T, Taşan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabási AL, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP, Vidal M.

Cell. 2014 Nov 20;159(5):1212-1226. doi: 10.1016/j.cell.2014.10.050.


Elevated neutrophil-to-lymphocyte ratio predicts poor outcome in patients with advanced non-small-cell lung cancer receiving first-line gefitinib or erlotinib treatment.

Lin GN, Peng JW, Liu PP, Liu DY, Xiao JJ, Chen XQ.

Asia Pac J Clin Oncol. 2017 Oct;13(5):e189-e194. doi: 10.1111/ajco.12273. Epub 2014 Oct 31.


Increased lymphocyte to monocyte ratio is associated with better prognosis in patients with newly diagnosed metastatic nasopharyngeal carcinoma receiving chemotherapy.

Lin GN, Peng JW, Liu DY, Xiao JJ, Chen YQ, Chen XQ.

Tumour Biol. 2014 Nov;35(11):10849-54. doi: 10.1007/s13277-014-2362-6. Epub 2014 Aug 1.


Prognostic impact of circulating monocytes and lymphocyte-to-monocyte ratio on previously untreated metastatic non-small cell lung cancer patients receiving platinum-based doublet.

Lin GN, Peng JW, Xiao JJ, Liu DY, Xia ZJ.

Med Oncol. 2014 Jul;31(7):70. doi: 10.1007/s12032-014-0070-0. Epub 2014 Jun 14.


Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

Corominas R, Yang X, Lin GN, Kang S, Shen Y, Ghamsari L, Broly M, Rodriguez M, Tam S, Trigg SA, Fan C, Yi S, Tasan M, Lemmens I, Kuang X, Zhao N, Malhotra D, Michaelson JJ, Vacic V, Calderwood MA, Roth FP, Tavernier J, Horvath S, Salehi-Ashtiani K, Korkin D, Sebat J, Hill DE, Hao T, Vidal M, Iakoucheva LM.

Nat Commun. 2014 Apr 11;5:3650. doi: 10.1038/ncomms4650.


Whole-genome sequencing in autism identifies hot spots for de novo germline mutation.

Michaelson JJ, Shi Y, Gujral M, Zheng H, Malhotra D, Jin X, Jian M, Liu G, Greer D, Bhandari A, Wu W, Corominas R, Peoples A, Koren A, Gore A, Kang S, Lin GN, Estabillo J, Gadomski T, Singh B, Zhang K, Akshoomoff N, Corsello C, McCarroll S, Iakoucheva LM, Li Y, Wang J, Sebat J.

Cell. 2012 Dec 21;151(7):1431-42. doi: 10.1016/j.cell.2012.11.019.


Hepatitis B virus reactivation in hepatocellular carcinoma patients undergoing transcatheter arterial chemoembolization therapy.

Peng JW, Lin GN, Xiao JJ, Jiang XM.

Asia Pac J Clin Oncol. 2012 Dec;8(4):356-61. doi: 10.1111/j.1743-7563.2012.01534.x. Epub 2012 May 15.


Polytomy identification in microbial phylogenetic reconstruction.

Lin GN, Zhang C, Xu D.

BMC Syst Biol. 2011;5 Suppl 3:S2. doi: 10.1186/1752-0509-5-S3-S2. Epub 2011 Dec 23.


Induction therapy using the MRC UKALLXII/ECOG E2993 protocol in Chinese adults with acute lymphoblastic leukemia.

Wang H, Chen XQ, Geng QR, Liu PP, Lin GN, Xia ZJ, Lu Y.

Int J Hematol. 2011 Aug;94(2):163-168. doi: 10.1007/s12185-011-0891-y. Epub 2011 Jul 6.


Expression of ezrin correlates with poor prognosis of nasopharyngeal carcinoma.

Wang L, Lin GN, Jiang XL, Lu Y.

Tumour Biol. 2011 Aug;32(4):707-12. doi: 10.1007/s13277-011-0171-8. Epub 2011 Apr 6.


The effect of prophylactic lamivudine on hepatitis B virus reactivation in HBsAg-positive patients with diffuse large B-cell lymphoma undergoing prolonged rituximab therapy.

Chen XQ, Peng JW, Lin GN, Li M, Xia ZJ.

Med Oncol. 2012 Jun;29(2):1237-41. doi: 10.1007/s12032-011-9974-0. Epub 2011 May 10.


The GDC1 gene encodes a novel ankyrin domain-containing protein that is essential for grana formation in Arabidopsis.

Cui YL, Jia QS, Yin QQ, Lin GN, Kong MM, Yang ZN.

Plant Physiol. 2011 Jan;155(1):130-41. doi: 10.1104/pp.110.165589. Epub 2010 Nov 19.


SeqRate: sequence-based protein folding type classification and rates prediction.

Lin GN, Wang Z, Xu D, Cheng J.

BMC Bioinformatics. 2010 Apr 29;11 Suppl 3:S1. doi: 10.1186/1471-2105-11-S3-S1.


ComPhy: prokaryotic composite distance phylogenies inferred from whole-genome gene sets.

Lin GN, Cai Z, Lin G, Chakraborty S, Xu D.

BMC Bioinformatics. 2009 Jan 30;10 Suppl 1:S5. doi: 10.1186/1471-2105-10-S1-S5.


A critical assessment of Mus musculus gene function prediction using integrated genomic evidence.

Peña-Castillo L, Tasan M, Myers CL, Lee H, Joshi T, Zhang C, Guan Y, Leone M, Pagnani A, Kim WK, Krumpelman C, Tian W, Obozinski G, Qi Y, Mostafavi S, Lin GN, Berriz GF, Gibbons FD, Lanckriet G, Qiu J, Grant C, Barutcuoglu Z, Hill DP, Warde-Farley D, Grouios C, Ray D, Blake JA, Deng M, Jordan MI, Noble WS, Morris Q, Klein-Seetharaman J, Bar-Joseph Z, Chen T, Sun F, Troyanskaya OG, Marcotte EM, Xu D, Hughes TR, Roth FP.

Genome Biol. 2008;9 Suppl 1:S2. doi: 10.1186/gb-2008-9-s1-s2. Epub 2008 Jun 27.


GeneFAS: A tool for prediction of gene function using multiple sources of data.

Joshi T, Zhang C, Lin GN, Song Z, Xu D.

Methods Mol Biol. 2008;439:369-86. doi: 10.1007/978-1-59745-188-8_25.


An integrated probabilistic approach for gene function prediction using multiple sources of high-throughput data.

Zhang C, Joshi T, Lin GN, Xu D.

Int J Comput Biol Drug Des. 2008;1(3):254-74.


NFU-Enabled FASTA: moving bioinformatics applications onto wide area networks.

Baker EJ, Lin GN, Liu H, Kosuri R.

Source Code Biol Med. 2007 Nov 26;2:8. doi: 10.1186/1751-0473-2-8.


Comparisons among two fertile and three male-sterile mitochondrial genomes of maize.

Allen JO, Fauron CM, Minx P, Roark L, Oddiraju S, Lin GN, Meyer L, Sun H, Kim K, Wang C, Du F, Xu D, Gibson M, Cifrese J, Clifton SW, Newton KJ.

Genetics. 2007 Oct;177(2):1173-92. Epub 2007 Jul 29.


Radiolocalized sentinel lymph node biopsy in squamous cell carcinoma of the oral cavity and analysis of various parameters.

Yen CY, Lee SY, Hsieh JF, Wang DZ, Lin GN, Tsai CM, Liu SY.

Ann Surg Oncol. 2006 Aug;13(8):1130-5. Epub 2006 Jun 21.


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