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Automation of chromatographic peak review and order to result data transfer in a clinical mass spectrometry laboratory.

Vicente FB, Lin DC, Haymond S.

Clin Chim Acta. 2019 Aug 14. pii: S0009-8981(19)31992-8. doi: 10.1016/j.cca.2019.08.004. [Epub ahead of print]


Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in oesophageal adenocarcinoma.

Chen L, Huang M, Plummer J, Pan J, Jiang YY, Yang Q, Silva TC, Gull N, Chen S, Ding LW, An O, Yang H, Cheng Y, Said JW, Doan N, Dinjens WN, Waters KM, Tuli R, Gayther SA, Klempner SJ, Berman BP, Meltzer SJ, Lin DC, Koeffler HP.

Gut. 2019 Aug 13. pii: gutjnl-2019-318325. doi: 10.1136/gutjnl-2019-318325. [Epub ahead of print]


Biological Significance of Tumor Heterogeneity in Esophageal Squamous Cell Carcinoma.

Lin L, Lin DC.

Cancers (Basel). 2019 Aug 12;11(8). pii: E1156. doi: 10.3390/cancers11081156. Review.


SOX7 regulates MAPK/ERK-BIM mediated apoptosis in cancer cells.

Sun QY, Ding LW, Johnson K, Zhou S, Tyner JW, Yang H, Doan NB, Said JW, Xiao JF, Loh XY, Ran XB, Venkatachalam N, Lao Z, Chen Y, Xu L, Fan LF, Chien W, Lin DC, Koeffler HP.

Oncogene. 2019 Aug;38(34):6196-6210. doi: 10.1038/s41388-019-0865-8. Epub 2019 Jul 22.


Tendons from kangaroo rats are exceptionally strong and tough.

Javidi M, McGowan CP, Schiele NR, Lin DC.

Sci Rep. 2019 Jun 3;9(1):8196. doi: 10.1038/s41598-019-44671-9.


The Contributions of Individual Muscle-Tendon Units to the Plantarflexor Group Force-Length Properties.

Javidi M, McGowan CP, Lin DC.

Ann Biomed Eng. 2019 May 20. doi: 10.1007/s10439-019-02288-z. [Epub ahead of print]


LNK suppresses interferon signaling in melanoma.

Ding LW, Sun QY, Edwards JJ, Fernández LT, Ran XB, Zhou SQ, Scolyer RA, Wilmott JS, Thompson JF, Doan N, Said JW, Venkatachalam N, Xiao JF, Loh XY, Pein M, Xu L, Mullins DW, Yang H, Lin DC, Koeffler HP.

Nat Commun. 2019 May 20;10(1):2230. doi: 10.1038/s41467-019-09711-y.


Metabolomic Patterns in Adolescents With Mild to Moderate CKD.

Brooks ER, Lin DC, Langman CB, Thompson JW, St John-Williams L, Furth SL, Warady B, Haymond S.

Kidney Int Rep. 2019 Jan 28;4(5):720-723. doi: 10.1016/j.ekir.2019.01.009. eCollection 2019 May. No abstract available.


SEanalysis: a web tool for super-enhancer associated regulatory analysis.

Qian FC, Li XC, Guo JC, Zhao JM, Li YY, Tang ZD, Zhou LW, Zhang J, Bai XF, Jiang Y, Pan Q, Wang QY, Li EM, Li CQ, Xu LY, Lin DC.

Nucleic Acids Res. 2019 Jul 2;47(W1):W248-W255. doi: 10.1093/nar/gkz302.


Increased caveolin-1 expression enhances the receptor-operated Ca2+ entry in the aorta of two-kidney, one-clip hypertensive rats.

Yan FR, Zhu ZL, Mu YP, Zhuang XL, Lin DC, Wu ZJ, Gui LX, Lin MJ.

Exp Physiol. 2019 Jun;104(6):932-945. doi: 10.1113/EP086924. Epub 2019 Apr 19.


Mutational and transcriptomic profiling of acute leukemia of ambiguous lineage reveals obscure but clinically important lineage bias.

Lao ZT, Ding LW, An O, Hattori N, Sun QY, Tan KT, Mayakonda A, Chuan WG, Madan V, Lin DC, Yang H, Koeffler HP.

Haematologica. 2019 May;104(5):e200-e203. doi: 10.3324/haematol.2018.202911. Epub 2018 Dec 4. No abstract available.


Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1.

Lin L, Huang M, Shi X, Mayakonda A, Hu K, Jiang YY, Guo X, Chen L, Pang B, Doan N, Said JW, Xie J, Gery S, Cheng X, Lin Z, Li J, Berman BP, Yin D, Lin DC, Koeffler HP.

Nucleic Acids Res. 2019 Feb 20;47(3):1255-1267. doi: 10.1093/nar/gky1207.


Midnight salivary cortisol for the diagnosis of Cushing's syndrome in a Chinese population.

Lin DC, Tsai PS, Lin YC.

Singapore Med J. 2019 Jul;60(7):359-363. doi: 10.11622/smedj.2018154. Epub 2018 Nov 29.


Super-Enhancer-Associated Long Noncoding RNA HCCL5 Is Activated by ZEB1 and Promotes the Malignancy of Hepatocellular Carcinoma.

Peng L, Jiang B, Yuan X, Qiu Y, Peng J, Huang Y, Zhang C, Zhang Y, Lin Z, Li J, Yao W, Deng W, Zhang Y, Meng M, Pan X, Li C, Yin D, Bi X, Li G, Lin DC.

Cancer Res. 2019 Feb 1;79(3):572-584. doi: 10.1158/0008-5472.CAN-18-0367. Epub 2018 Nov 27.


Mutations in glucokinase and other genes detected in neonatal and type 1B diabetes patient using whole exome sequencing may lead to disease-causing changes in protein activity.

Lin DC, Huang CY, Ting WH, Lo FS, Lin CL, Yang HW, Chang TY, Lin CH, Tzeng YW, Yang WS, Juang YL, Lee YJ.

Biochim Biophys Acta Mol Basis Dis. 2019 Feb 1;1865(2):428-433. doi: 10.1016/j.bbadis.2018.11.013. Epub 2018 Nov 20.


Jumping mechanics of desert kangaroo rats.

Schwaner MJ, Lin DC, McGowan CP.

J Exp Biol. 2018 Nov 12;221(Pt 22). pii: jeb186700. doi: 10.1242/jeb.186700.


A quantitative image analysis using MRI for diagnosis of biliary atresia.

Lin DC, Wu KY, Sun FJ, Huang CC, Wu TH, Shih SL, Tsai PS.

Clin Imaging. 2019 Jan - Feb;53:186-190. doi: 10.1016/j.clinimag.2018.10.001. Epub 2018 Oct 12.


ELMER v.2: an R/Bioconductor package to reconstruct gene regulatory networks from DNA methylation and transcriptome profiles.

Silva TC, Coetzee SG, Gull N, Yao L, Hazelett DJ, Noushmehr H, Lin DC, Berman BP.

Bioinformatics. 2019 Jun 1;35(11):1974-1977. doi: 10.1093/bioinformatics/bty902.


Maftools: efficient and comprehensive analysis of somatic variants in cancer.

Mayakonda A, Lin DC, Assenov Y, Plass C, Koeffler HP.

Genome Res. 2018 Nov;28(11):1747-1756. doi: 10.1101/gr.239244.118. Epub 2018 Oct 19.


Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Tan KT, Ding LW, Sun QY, Lao ZT, Chien W, Ren X, Xiao JF, Loh XY, Xu L, Lill M, Mayakonda A, Lin DC, Yang H, Koeffler HP.

BMC Cancer. 2018 Oct 1;18(1):940. doi: 10.1186/s12885-018-4840-5.


Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression.

Jiang Y, Jiang YY, Xie JJ, Mayakonda A, Hazawa M, Chen L, Xiao JF, Li CQ, Huang ML, Ding LW, Sun QY, Xu L, Kanojia D, Jeitany M, Deng JW, Liao LD, Soukiasian HJ, Berman BP, Hao JJ, Xu LY, Li EM, Wang MR, Bi XG, Lin DC, Koeffler HP.

Nat Commun. 2018 Sep 6;9(1):3619. doi: 10.1038/s41467-018-06081-9.


Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates.

Brown SP, Dransfield P, Vimolratana M, Zhu L, Luo J, Zhang J, Jiao X, Pattaropong V, Wong S, Zhuang R, Swaminath G, Houze JB, Lin DC.

ACS Med Chem Lett. 2018 Jun 6;9(7):757-760. doi: 10.1021/acsmedchemlett.8b00213. eCollection 2018 Jul 12.


Effect of Subject-Specific Vertebral Position and Head and Neck Size on Calculation of Spine Musculoskeletal Moments.

Vasavada AN, Hughes E, Nevins DD, Monda SM, Lin DC.

Ann Biomed Eng. 2018 Nov;46(11):1844-1856. doi: 10.1007/s10439-018-2084-9. Epub 2018 Jul 9.


ARID1A and CEBPα cooperatively inhibit UCA1 transcription in breast cancer.

Guo X, Zhang Y, Mayakonda A, Madan V, Ding LW, Lin LH, Zia S, Gery S, Tyner JW, Zhou W, Yin D, Lin DC, Koeffler HP.

Oncogene. 2018 Nov;37(45):5939-5951. doi: 10.1038/s41388-018-0371-4. Epub 2018 Jul 6.


The c-MYC-BMI1 axis is essential for SETDB1-mediated breast tumourigenesis.

Xiao JF, Sun QY, Ding LW, Chien W, Liu XY, Mayakonda A, Jiang YY, Loh XY, Ran XB, Doan NB, Castor B, Chia D, Said JW, Tan KT, Yang H, Fu XY, Lin DC, Koeffler HP.

J Pathol. 2018 Sep;246(1):89-102. doi: 10.1002/path.5126. Epub 2018 Aug 3.


Transient Receptor Potential Melastatin-8 Activation Induces Relaxation of Pulmonary Artery by Inhibition of Store-Operated Calcium Entry in Normoxic and Chronic Hypoxic Pulmonary Hypertensive Rats.

Mu YP, Lin DC, Zheng SY, Jiao HX, Sham JSK, Lin MJ.

J Pharmacol Exp Ther. 2018 Jun;365(3):544-555. doi: 10.1124/jpet.117.247320. Epub 2018 Apr 5.


Clonality and clonal evolution analysis of paediatric ALL based on B-cell receptor/T-cell receptor rearrangement.

Ding LW, Tan KT, Sun QY, Lao ZT, Yang H, Jiang N, Chien W, Xiao JF, Loh XY, Huang ML, Lill M, Lin DC, Yeoh AEJ, Koeffler HP.

Br J Haematol. 2019 Mar;184(5):829-833. doi: 10.1111/bjh.15179. Epub 2018 Mar 13. No abstract available.


Super-Enhancer-Driven Long Non-Coding RNA LINC01503, Regulated by TP63, Is Over-Expressed and Oncogenic in Squamous Cell Carcinoma.

Xie JJ, Jiang YY, Jiang Y, Li CQ, Lim MC, An O, Mayakonda A, Ding LW, Long L, Sun C, Lin LH, Chen L, Wu JY, Wu ZY, Cao Q, Fang WK, Yang W, Soukiasian H, Meltzer SJ, Yang H, Fullwood M, Xu LY, Li EM, Lin DC, Koeffler HP.

Gastroenterology. 2018 Jun;154(8):2137-2151.e1. doi: 10.1053/j.gastro.2018.02.018. Epub 2018 Feb 15.


SLC52A3 expression is activated by NF-κB p65/Rel-B and serves as a prognostic biomarker in esophageal cancer.

Long L, Pang XX, Lei F, Zhang JS, Wang W, Liao LD, Xu XE, He JZ, Wu JY, Wu ZY, Wang LD, Lin DC, Li EM, Xu LY.

Cell Mol Life Sci. 2018 Jul;75(14):2643-2661. doi: 10.1007/s00018-018-2757-4. Epub 2018 Feb 10.


Independent and combined effects of environmental factors and miR-126, miR-143, and miR-145 on the risk of coronary heart disease.

Lin DC, Lin JB, Chen Z, Chen R, Wan CY, Lin SW, Ruan QS, Li HY, Wu SY.

J Geriatr Cardiol. 2017 Nov;14(11):688-695. doi: 10.11909/j.issn.1671-5411.2017.11.004.


Genomic lesions drive the metastasis of esophageal squamous cell carcinoma.

Lin DC, Koeffler HP.

J Thorac Dis. 2017 Oct;9(10):3523-3524. doi: 10.21037/jtd.2017.09.58. No abstract available.


Non-malignant epithelial cells preferentially proliferate from nasopharyngeal carcinoma biopsy cultured under conditionally reprogrammed conditions.

Yu F, Lu Y, Tao L, Jiang YY, Lin DC, Wang L, Petersson F, Yoshiyama H, Koeffler PH, Goh BC, Loh KS.

Sci Rep. 2017 Dec 12;7(1):17359. doi: 10.1038/s41598-017-17628-z.


ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation.

Hazawa M, Lin DC, Kobayashi A, Jiang YY, Xu L, Dewi FRP, Mohamed MS, Hartono, Nakada M, Meguro-Horike M, Horike SI, Koeffler HP, Wong RW.

EMBO Rep. 2018 Jan;19(1):73-88. doi: 10.15252/embr.201744523. Epub 2017 Dec 7.


Circadian clock cryptochrome proteins regulate autoimmunity.

Cao Q, Zhao X, Bai J, Gery S, Sun H, Lin DC, Chen Q, Chen Z, Mack L, Yang H, Deng R, Shi X, Chong LW, Cho H, Xie J, Li QZ, Müschen M, Atkins AR, Liddle C, Yu RT, Alkan S, Said JW, Zheng Y, Downes M, Evans RM, Koeffler HP.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12548-12553. doi: 10.1073/pnas.1619119114. Epub 2017 Nov 6.


Technology-embedded health education on nutrition for middle-aged and older adults living in the community.

Chiu CJ, Kuo SE, Lin DC.

Glob Health Promot. 2017 Nov 1:1757975917732351. doi: 10.1177/1757975917732351. [Epub ahead of print]


Candidate recommendations for protein electrophoresis reporting from the Canadian Society of Clinical Chemists Monoclonal Gammopathy Working Group.

Booth RA, McCudden CR, Balion CM, Blasutig IM, Bouhtiauy I, Rodriguez-Capote K, Catomeris P, Chan PC, Chen Y, Collier C, Hauff K, Kalra J, Li D, Lin DC, Lou AH, Meng QH, Morrison T, Pasic MD, Qureshi M, Randell E, Sohn KY, Thakur V, Thomas D, Thoni A, Tomalty C, Yang L, Zamkanei M.

Clin Biochem. 2018 Jan;51:10-20. doi: 10.1016/j.clinbiochem.2017.10.013. Epub 2017 Oct 20.


Correction: Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia.

Sun H, Lin DC, Guo X, Masouleh BK, Gery S, Cao Q, Alkan S, Ikezoe T, Akiba C, Paquette R, Chien W, Müller-Tidow C, Jing Y, Agelopoulos K, Müschen M, Koeffler HP.

Oncotarget. 2017 Sep 8;8(38):64651. doi: 10.18632/oncotarget.20707. eCollection 2017 Sep 8.


Synoptic reporting for protein electrophoresis and immunofixation.

McCudden CR, Booth RA, Lin DCC, McCurdy A, Rupani N, Kew A.

Clin Biochem. 2018 Jan;51:21-28. doi: 10.1016/j.clinbiochem.2017.09.020. Epub 2017 Sep 28. Review. No abstract available.


Degalactotigonin, a Natural Compound from Solanum nigrum L., Inhibits Growth and Metastasis of Osteosarcoma through GSK3β Inactivation-Mediated Repression of the Hedgehog/Gli1 Pathway.

Zhao Z, Jia Q, Wu MS, Xie X, Wang Y, Song G, Zou CY, Tang Q, Lu J, Huang G, Wang J, Lin DC, Koeffler HP, Yin JQ, Shen J.

Clin Cancer Res. 2018 Jan 1;24(1):130-144. doi: 10.1158/1078-0432.CCR-17-0692. Epub 2017 Sep 26.


Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma.

Yuan J, Jiang YY, Mayakonda A, Huang M, Ding LW, Lin H, Yu F, Lu Y, Loh TKS, Chow M, Savage S, Tyner JW, Lin DC, Koeffler HP.

Cancer Res. 2017 Dec 1;77(23):6614-6626. doi: 10.1158/0008-5472.CAN-17-1143. Epub 2017 Sep 26.


Concordance analysis of paired cancer antigen (CA) 15-3 and 27.29 testing.

Lin DC, Genzen JR.

Breast Cancer Res Treat. 2018 Jan;167(1):269-276. doi: 10.1007/s10549-017-4513-0. Epub 2017 Sep 19.


The Role of Leisure Activities in the Relationship Between Marital Transition in Later Midlife and Psychological Well-Being Trajectories.

Hu YH, Chiu CJ, Wong JD, Lin DC, Wray LA.

Int J Aging Hum Dev. 2018 Jun;86(4):327-346. doi: 10.1177/0091415017729683. Epub 2017 Sep 14.


Targeting the vulnerability to NAD+ depletion in B-cell acute lymphoblastic leukemia.

Takao S, Chien W, Madan V, Lin DC, Ding LW, Sun QY, Mayakonda A, Sudo M, Xu L, Chen Y, Jiang YY, Gery S, Lill M, Park E, Senapedis W, Baloglu E, Müschen M, Koeffler HP.

Leukemia. 2018 Mar;32(3):616-625. doi: 10.1038/leu.2017.281. Epub 2017 Sep 14.


Identification of distinct mutational patterns and new driver genes in oesophageal squamous cell carcinomas and adenocarcinomas.

Lin DC, Dinh HQ, Xie JJ, Mayakonda A, Silva TC, Jiang YY, Ding LW, He JZ, Xu XE, Hao JJ, Wang MR, Li C, Xu LY, Li EM, Berman BP, Phillip Koeffler H.

Gut. 2018 Oct;67(10):1769-1779. doi: 10.1136/gutjnl-2017-314607. Epub 2017 Aug 31.


Skeletal muscle contractile properties in a novel murine model for limb girdle muscular dystrophy 2i.

Rehwaldt JD, Rodgers BD, Lin DC.

J Appl Physiol (1985). 2017 Dec 1;123(6):1698-1707. doi: 10.1152/japplphysiol.00744.2016. Epub 2017 Aug 31.


Valosin-Containing Protein/p97 as a Novel Therapeutic Target in Acute Lymphoblastic Leukemia.

Gugliotta G, Sudo M, Cao Q, Lin DC, Sun H, Takao S, Le Moigne R, Rolfe M, Gery S, Müschen M, Cavo M, Koeffler HP.

Neoplasia. 2017 Oct;19(10):750-761. doi: 10.1016/j.neo.2017.08.001. Epub 2017 Aug 29.


Prenatal diagnosis of congenital lobar fluid overload.

Tsai PS, Chen CP, Lin DC, Liu YP.

Taiwan J Obstet Gynecol. 2017 Aug;56(4):425-431. doi: 10.1016/j.tjog.2017.05.001. Review.


Genomic and Epigenomic Aberrations in Esophageal Squamous Cell Carcinoma and Implications for Patients.

Lin DC, Wang MR, Koeffler HP.

Gastroenterology. 2018 Jan;154(2):374-389. doi: 10.1053/j.gastro.2017.06.066. Epub 2017 Jul 27. Review.


Lipoxin A4 Suppresses Estrogen-Induced Epithelial-Mesenchymal Transition via ALXR-Dependent Manner in Endometriosis.

Wu RF, Huang ZX, Ran J, Dai SJ, Lin DC, Ng TW, Chen QX, Chen QH.

Reprod Sci. 2018 Apr;25(4):566-578. doi: 10.1177/1933719117718271. Epub 2017 Jul 10.


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