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Items: 1 to 50 of 114


Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species.

Montay-Gruel P, Acharya MM, Petersson K, Alikhani L, Yakkala C, Allen BD, Ollivier J, Petit B, Jorge PG, Syage AR, Nguyen TA, Baddour AAD, Lu C, Singh P, Moeckli R, Bochud F, Germond JF, Froidevaux P, Bailat C, Bourhis J, Vozenin MC, Limoli CL.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):10943-10951. doi: 10.1073/pnas.1901777116. Epub 2019 May 16.


An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses.

Spitz DR, Buettner GR, Petronek MS, St-Aubin JJ, Flynn RT, Waldron TJ, Limoli CL.

Radiother Oncol. 2019 Apr 19. pii: S0167-8140(19)30150-1. doi: 10.1016/j.radonc.2019.03.028. [Epub ahead of print]


Biological Benefits of Ultra-high Dose Rate FLASH Radiotherapy: Sleeping Beauty Awoken.

Vozenin MC, Hendry JH, Limoli CL.

Clin Oncol (R Coll Radiol). 2019 Jul;31(7):407-415. doi: 10.1016/j.clon.2019.04.001. Epub 2019 Apr 19.


miRNA-based therapeutic potential of stem cell-derived extracellular vesicles: a safe cell-free treatment to ameliorate radiation-induced brain injury.

Leavitt RJ, Limoli CL, Baulch JE.

Int J Radiat Biol. 2019 Apr;95(4):427-435. doi: 10.1080/09553002.2018.1522012. Epub 2018 Sep 25.


Alterations in synaptic density and myelination in response to exposure to high-energy charged particles.

Dickstein DL, Talty R, Bresnahan E, Varghese M, Perry B, Janssen WGM, Sowa A, Giedzinski E, Apodaca L, Baulch J, Acharya M, Parihar V, Limoli CL.

J Comp Neurol. 2018 Dec 1;526(17):2845-2855. doi: 10.1002/cne.24530. Epub 2018 Nov 8.


Exposure to Ionizing Radiation Causes Endoplasmic Reticulum Stress in the Mouse Hippocampus.

Hinzman CP, Baulch JE, Mehta KY, Gill K, Limoli CL, Cheema AK.

Radiat Res. 2018 Nov;190(5):483-493. doi: 10.1667/RR15061.1. Epub 2018 Aug 7.


Stochastic Modeling of Radiation-induced Dendritic Damage on in silico Mouse Hippocampal Neurons.

Cacao E, Parihar VK, Limoli CL, Cucinotta FA.

Sci Rep. 2018 Apr 3;8(1):5494. doi: 10.1038/s41598-018-23855-9.


Persistent nature of alterations in cognition and neuronal circuit excitability after exposure to simulated cosmic radiation in mice.

Parihar VK, Maroso M, Syage A, Allen BD, Angulo MC, Soltesz I, Limoli CL.

Exp Neurol. 2018 Jul;305:44-55. doi: 10.1016/j.expneurol.2018.03.009. Epub 2018 Mar 11.


Stem Cell Therapies for the Resolution of Radiation Injury to the Brain.

Smith SM, Limoli CL.

Curr Stem Cell Rep. 2017 Dec;3(4):342-347. doi: 10.1007/s40778-017-0105-5. Epub 2017 Oct 11.


Space-brain: The negative effects of space exposure on the central nervous system.

Jandial R, Hoshide R, Waters JD, Limoli CL.

Surg Neurol Int. 2018 Jan 16;9:9. doi: 10.4103/sni.sni_250_17. eCollection 2018. Review.


Remediation of Radiation-Induced Cognitive Dysfunction through Oral Administration of the Neuroprotective Compound NSI-189.

Allen BD, Acharya MM, Lu C, Giedzinski E, Chmielewski NN, Quach D, Hefferan M, Johe KK, Limoli CL.

Radiat Res. 2018 Apr;189(4):345-353. doi: 10.1667/RR14879.1. Epub 2018 Jan 19.


Corrigendum: Adenosine Kinase Inhibition Protects against Cranial Radiation-Induced Cognitive Dysfunction.

Acharya MM, Baulch JE, Lusardi TA, Allen BD, Chmielewski NN, Baddour AAD, Limoli CL, Boison D.

Front Mol Neurosci. 2017 Jul 10;10:218. doi: 10.3389/fnmol.2017.00218. eCollection 2017.


Deep-Space Deal Breaker.

Limoli CL.

Sci Am. 2017 Jan 17;316(2):54-59. doi: 10.1038/scientificamerican0217-54. No abstract available.


Lessons learned from an unstable genomic landscape.

Limoli CL.

Int J Radiat Biol. 2017 Oct;93(10):1177-1181. doi: 10.1080/09553002.2016.1277800. Epub 2017 Jan 26.


Neurophysiology of space travel: energetic solar particles cause cell type-specific plasticity of neurotransmission.

Lee SH, Dudok B, Parihar VK, Jung KM, Zöldi M, Kang YJ, Maroso M, Alexander AL, Nelson GA, Piomelli D, Katona I, Limoli CL, Soltesz I.

Brain Struct Funct. 2017 Jul;222(5):2345-2357. doi: 10.1007/s00429-016-1345-3. Epub 2016 Nov 30.


Cosmic radiation exposure and persistent cognitive dysfunction.

Parihar VK, Allen BD, Caressi C, Kwok S, Chu E, Tran KK, Chmielewski NN, Giedzinski E, Acharya MM, Britten RA, Baulch JE, Limoli CL.

Sci Rep. 2016 Oct 10;6:34774. doi: 10.1038/srep34774.


Elimination of microglia improves cognitive function following cranial irradiation.

Acharya MM, Green KN, Allen BD, Najafi AR, Syage A, Minasyan H, Le MT, Kawashita T, Giedzinski E, Parihar VK, West BL, Baulch JE, Limoli CL.

Sci Rep. 2016 Aug 12;6:31545. doi: 10.1038/srep31545.


Apollo Lunar Astronauts Show Higher Cardiovascular Disease Mortality: Possible Deep Space Radiation Effects on the Vascular Endothelium.

Delp MD, Charvat JM, Limoli CL, Globus RK, Ghosh P.

Sci Rep. 2016 Jul 28;6:29901. doi: 10.1038/srep29901.


Adenosine Kinase Inhibition Protects against Cranial Radiation-Induced Cognitive Dysfunction.

Acharya MM, Baulch JE, Lusardi TA, Allen BD, Chmielewski NN, Baddour AA, Limoli CL, Boison D.

Front Mol Neurosci. 2016 Jun 3;9:42. doi: 10.3389/fnmol.2016.00042. eCollection 2016. Erratum in: Front Mol Neurosci. 2017 Jul 10;10 :218.


Understanding and targeting dynamic stress responses of the brain: What we have learned and how to improve neurocognitive outcome following neurotoxic insult.

Limoli CL.

Environ Mol Mutagen. 2016 Jun;57(5):319-21. doi: 10.1002/em.22022. Epub 2016 May 21. No abstract available.


3D surface analysis of hippocampal microvasculature in the irradiated brain.

Craver BM, Acharya MM, Allen BD, Benke SN, Hultgren NW, Baulch JE, Limoli CL.

Environ Mol Mutagen. 2016 Jun;57(5):341-9. doi: 10.1002/em.22015. Epub 2016 May 13.


Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain.

Baulch JE, Acharya MM, Allen BD, Ru N, Chmielewski NN, Martirosian V, Giedzinski E, Syage A, Park AL, Benke SN, Parihar VK, Limoli CL.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4836-41. doi: 10.1073/pnas.1521668113. Epub 2016 Apr 4.


Contrasting the effects of proton irradiation on dendritic complexity of subiculum neurons in wild type and MCAT mice.

Chmielewski NN, Caressi C, Giedzinski E, Parihar VK, Limoli CL.

Environ Mol Mutagen. 2016 Jun;57(5):364-71. doi: 10.1002/em.22006. Epub 2016 Mar 20.


Dried plum diet protects from bone loss caused by ionizing radiation.

Schreurs AS, Shirazi-Fard Y, Shahnazari M, Alwood JS, Truong TA, Tahimic CG, Limoli CL, Turner ND, Halloran B, Globus RK.

Sci Rep. 2016 Feb 11;6:21343. doi: 10.1038/srep21343.


Irradiation of primary human gliomas triggers dynamic and aggressive survival responses involving microvesicle signaling.

Baulch JE, Geidzinski E, Tran KK, Yu L, Zhou YH, Limoli CL.

Environ Mol Mutagen. 2016 Jun;57(5):405-15. doi: 10.1002/em.21988. Epub 2015 Nov 25.


Irradiation of Neurons with High-Energy Charged Particles: An In Silico Modeling Approach.

Alp M, Parihar VK, Limoli CL, Cucinotta FA.

PLoS Comput Biol. 2015 Aug 7;11(8):e1004428. doi: 10.1371/journal.pcbi.1004428. eCollection 2015 Aug.


What happens to your brain on the way to Mars.

Parihar VK, Allen B, Tran KK, Macaraeg TG, Chu EM, Kwok SF, Chmielewski NN, Craver BM, Baulch JE, Acharya MM, Cucinotta FA, Limoli CL.

Sci Adv. 2015 May 1;1(4). pii: e1400256.


Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release.

Lee SH, Ledri M, Tóth B, Marchionni I, Henstridge CM, Dudok B, Kenesei K, Barna L, Szabó SI, Renkecz T, Oberoi M, Watanabe M, Limoli CL, Horvai G, Soltesz I, Katona I.

J Neurosci. 2015 Jul 8;35(27):10039-57. doi: 10.1523/JNEUROSCI.4112-14.2015.


Consequences of low dose ionizing radiation exposure on the hippocampal microenvironment.

Acharya MM, Patel NH, Craver BM, Tran KK, Giedzinski E, Tseng BP, Parihar VK, Limoli CL.

PLoS One. 2015 Jun 4;10(6):e0128316. doi: 10.1371/journal.pone.0128316. eCollection 2015.


Persistent oxidative stress in human neural stem cells exposed to low fluences of charged particles.

Baulch JE, Craver BM, Tran KK, Yu L, Chmielewski N, Allen BD, Limoli CL.

Redox Biol. 2015 Aug;5:24-32. doi: 10.1016/j.redox.2015.03.001. Epub 2015 Mar 11.


Stem cell transplantation reverses chemotherapy-induced cognitive dysfunction.

Acharya MM, Martirosian V, Chmielewski NN, Hanna N, Tran KK, Liao AC, Christie LA, Parihar VK, Limoli CL.

Cancer Res. 2015 Feb 15;75(4):676-86. doi: 10.1158/0008-5472.CAN-14-2237.


Defining the optimal window for cranial transplantation of human induced pluripotent stem cell-derived cells to ameliorate radiation-induced cognitive impairment.

Acharya MM, Martirosian V, Christie LA, Riparip L, Strnadel J, Parihar VK, Limoli CL.

Stem Cells Transl Med. 2015 Jan;4(1):74-83. doi: 10.5966/sctm.2014-0063. Epub 2014 Nov 12.


Human neural stem cell transplantation provides long-term restoration of neuronal plasticity in the irradiated hippocampus.

Acharya MM, Rosi S, Jopson T, Limoli CL.

Cell Transplant. 2015;24(4):691-702. doi: 10.3727/096368914X684600. Epub 2014 Oct 6.


Targeted overexpression of mitochondrial catalase prevents radiation-induced cognitive dysfunction.

Parihar VK, Allen BD, Tran KK, Chmielewski NN, Craver BM, Martirosian V, Morganti JM, Rosi S, Vlkolinsky R, Acharya MM, Nelson GA, Allen AR, Limoli CL.

Antioxid Redox Signal. 2015 Jan 1;22(1):78-91. doi: 10.1089/ars.2014.5929.


Defining functional changes in the brain caused by targeted stereotaxic radiosurgery.

Parihar VK, Acharya MM, Roa DE, Bosch O, Christie LA, Limoli CL.

Transl Cancer Res. 2014 Apr 1;3(2):124-137.


Long-term cognitive effects of human stem cell transplantation in the irradiated brain.

Acharya MM, Martirosian V, Christie LA, Limoli CL.

Int J Radiat Biol. 2014 Sep;90(9):816-20. doi: 10.3109/09553002.2014.927934. Epub 2014 Jun 25.


Linking differential radiation responses to glioma heterogeneity.

Ke C, Tran K, Chen Y, Di Donato AT, Yu L, Hu Y, Linskey ME, Wang PH, Limoli CL, Zhou YH.

Oncotarget. 2014 Mar 30;5(6):1657-65.


Persistent changes in neuronal structure and synaptic plasticity caused by proton irradiation.

Parihar VK, Pasha J, Tran KK, Craver BM, Acharya MM, Limoli CL.

Brain Struct Funct. 2015 Mar;220(2):1161-71. doi: 10.1007/s00429-014-0709-9. Epub 2014 Jan 21.


Tumor-specific chromosome mis-segregation controls cancer plasticity by maintaining tumor heterogeneity.

Hu Y, Ru N, Xiao H, Chaturbedi A, Hoa NT, Tian XJ, Zhang H, Ke C, Yan F, Nelson J, Li Z, Gramer R, Yu L, Siegel E, Zhang X, Jia Z, Jadus MR, Limoli CL, Linskey ME, Xing J, Zhou YH.

PLoS One. 2013 Nov 25;8(11):e80898. doi: 10.1371/journal.pone.0080898. eCollection 2013.


Stem cell therapies for the treatment of radiation-induced normal tissue side effects.

Benderitter M, Caviggioli F, Chapel A, Coppes RP, Guha C, Klinger M, Malard O, Stewart F, Tamarat R, van Luijk P, Limoli CL.

Antioxid Redox Signal. 2014 Jul 10;21(2):338-55. doi: 10.1089/ars.2013.5652. Epub 2014 Feb 3. Review.


Characterizing low dose and dose rate effects in rodent and human neural stem cells exposed to proton and gamma irradiation.

Tseng BP, Lan ML, Tran KK, Acharya MM, Giedzinski E, Limoli CL.

Redox Biol. 2013 Jan 19;1:153-62. doi: 10.1016/j.redox.2013.01.008. eCollection 2013.


Transplantation of human fetal-derived neural stem cells improves cognitive function following cranial irradiation.

Acharya MM, Christie LA, Hazel TG, Johe KK, Limoli CL.

Cell Transplant. 2014;23(10):1255-66. doi: 10.3727/096368913X670200. Epub 2013 Jul 17.


Cranial irradiation compromises neuronal architecture in the hippocampus.

Parihar VK, Limoli CL.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12822-7. doi: 10.1073/pnas.1307301110. Epub 2013 Jul 15.


Functional consequences of radiation-induced oxidative stress in cultured neural stem cells and the brain exposed to charged particle irradiation.

Tseng BP, Giedzinski E, Izadi A, Suarez T, Lan ML, Tran KK, Acharya MM, Nelson GA, Raber J, Parihar VK, Limoli CL.

Antioxid Redox Signal. 2014 Mar 20;20(9):1410-22. doi: 10.1089/ars.2012.5134. Epub 2013 Aug 12.


Mitochondrial-targeted human catalase affords neuroprotection from proton irradiation.

Liao AC, Craver BM, Tseng BP, Tran KK, Parihar VK, Acharya MM, Limoli CL.

Radiat Res. 2013 Jul;180(1):1-6. doi: 10.1667/RR3339.1. Epub 2013 May 14.


Enhanced hippocampus-dependent memory and reduced anxiety in mice over-expressing human catalase in mitochondria.

Olsen RH, Johnson LA, Zuloaga DG, Limoli CL, Raber J.

J Neurochem. 2013 Apr;125(2):303-13. doi: 10.1111/jnc.12187. Epub 2013 Mar 6.


Characterizing the radioresponse of pluripotent and multipotent human stem cells.

Lan ML, Acharya MM, Tran KK, Bahari-Kashani J, Patel NH, Strnadel J, Giedzinski E, Limoli CL.

PLoS One. 2012;7(12):e50048. doi: 10.1371/journal.pone.0050048. Epub 2012 Dec 14.


Low-dose, ionizing radiation and age-related changes in skeletal microarchitecture.

Alwood JS, Kumar A, Tran LH, Wang A, Limoli CL, Globus RK.

J Aging Res. 2012;2012:481983. doi: 10.1155/2012/481983. Epub 2012 Apr 18.


Comparing the functional consequences of human stem cell transplantation in the irradiated rat brain.

Acharya MM, Christie LA, Lan ML, Limoli CL.

Cell Transplant. 2013;22(1):55-64. doi: 10.3727/096368912X640565. Epub 2012 Apr 26.


Impaired cognitive function and hippocampal neurogenesis following cancer chemotherapy.

Christie LA, Acharya MM, Parihar VK, Nguyen A, Martirosian V, Limoli CL.

Clin Cancer Res. 2012 Apr 1;18(7):1954-65. doi: 10.1158/1078-0432.CCR-11-2000. Epub 2012 Feb 14.

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