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Items: 21

1.

Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 During Replication Stress.

Oravcová M, Gadaleta MC, Nie M, Reubens MC, Limbo O, Russell P, Boddy MN.

Mol Cell Biol. 2018 Oct 22. pii: MCB.00271-18. doi: 10.1128/MCB.00271-18. [Epub ahead of print]

PMID:
30348841
2.

Mre11 complex links sister chromatids to promote repair of a collapsed replication fork.

Zhu M, Zhao H, Limbo O, Russell P.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):8793-8798. doi: 10.1073/pnas.1808189115. Epub 2018 Aug 13.

PMID:
30104346
3.

Mre11-Rad50-dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1.

Limbo O, Yamada Y, Russell P.

Mol Biol Cell. 2018 Jun 1;29(11):1389-1399. doi: 10.1091/mbc.E17-07-0470. Epub 2018 Apr 5.

4.

RNase H eliminates R-loops that disrupt DNA replication but is nonessential for efficient DSB repair.

Zhao H, Zhu M, Limbo O, Russell P.

EMBO Rep. 2018 May;19(5). pii: e45335. doi: 10.15252/embr.201745335. Epub 2018 Apr 5.

PMID:
29622660
5.

Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in the polynucleotide kinase/phosphatase mutant of fission yeast.

Sanchez A, Gadaleta MC, Limbo O, Russell P.

PLoS Genet. 2017 Sep 18;13(9):e1007013. doi: 10.1371/journal.pgen.1007013. eCollection 2017 Sep.

6.

ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling.

Deshpande RA, Williams GJ, Limbo O, Williams RS, Kuhnlein J, Lee JH, Classen S, Guenther G, Russell P, Tainer JA, Paull TT.

EMBO J. 2016 Apr 1;35(7):791. doi: 10.15252/embj.201694047. No abstract available.

7.

Critical Function of γH2A in S-Phase.

Mejia-Ramirez E, Limbo O, Langerak P, Russell P.

PLoS Genet. 2015 Sep 14;11(9):e1005517. doi: 10.1371/journal.pgen.1005517. eCollection 2015 Sep.

8.

Tolerance of deregulated G1/S transcription depends on critical G1/S regulon genes to prevent catastrophic genome instability.

Caetano C, Limbo O, Farmer S, Klier S, Dovey C, Russell P, de Bruin RA.

Cell Rep. 2014 Dec 24;9(6):2279-89. doi: 10.1016/j.celrep.2014.11.039. Epub 2014 Dec 18.

9.

Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif.

Wang L, Limbo O, Fei J, Chen L, Kim B, Luo J, Chong J, Conaway RC, Conaway JW, Ranish JA, Kadonaga JT, Russell P, Wang D.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18566-71. doi: 10.1073/pnas.1420227112. Epub 2014 Dec 15.

10.

ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling.

Deshpande RA, Williams GJ, Limbo O, Williams RS, Kuhnlein J, Lee JH, Classen S, Guenther G, Russell P, Tainer JA, Paull TT.

EMBO J. 2014 Mar 3;33(5):482-500. doi: 10.1002/embj.201386100. Epub 2014 Feb 3. Erratum in: EMBO J. 2016 Apr 1;35(7):791.

11.

Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair.

Limbo O, Moiani D, Kertokalio A, Wyman C, Tainer JA, Russell P.

Nucleic Acids Res. 2012 Dec;40(22):11435-49. doi: 10.1093/nar/gks954. Epub 2012 Oct 17.

12.

Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.

Langerak P, Mejia-Ramirez E, Limbo O, Russell P.

PLoS Genet. 2011 Sep;7(9):e1002271. doi: 10.1371/journal.pgen.1002271. Epub 2011 Sep 8.

13.

ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.

Williams GJ, Williams RS, Williams JS, Moncalian G, Arvai AS, Limbo O, Guenther G, SilDas S, Hammel M, Russell P, Tainer JA.

Nat Struct Mol Biol. 2011 Apr;18(4):423-31. doi: 10.1038/nsmb.2038. Epub 2011 Mar 27. Erratum in: Nat Struct Mol Biol. 2012 Mar;19(3):364. Nat Struct Mol Biol. 2011 Sep;18(9):1084.

14.

Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks.

Limbo O, Porter-Goff ME, Rhind N, Russell P.

Mol Cell Biol. 2011 Feb;31(3):573-83. doi: 10.1128/MCB.00994-10. Epub 2010 Nov 22.

15.

Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance.

Mendoza-Cózatl DG, Zhai Z, Jobe TO, Akmakjian GZ, Song WY, Limbo O, Russell MR, Kozlovskyy VI, Martinoia E, Vatamaniuk OK, Russell P, Schroeder JI.

J Biol Chem. 2010 Dec 24;285(52):40416-26. doi: 10.1074/jbc.M110.155408. Epub 2010 Oct 11.

16.

Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast.

Cavero S, Limbo O, Russell P.

PLoS Genet. 2010 Sep 23;6(9):e1001138. doi: 10.1371/journal.pgen.1001138.

17.

BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint.

Sofueva S, Du LL, Limbo O, Williams JS, Russell P.

Mol Cell Biol. 2010 Oct;30(19):4732-43. doi: 10.1128/MCB.00413-10. Epub 2010 Aug 2.

18.

Phosphorylation-regulated binding of Ctp1 to Nbs1 is critical for repair of DNA double-strand breaks.

Dodson GE, Limbo O, Nieto D, Russell P.

Cell Cycle. 2010 Apr 15;9(8):1516-22. Epub 2010 Apr 15. Review.

19.

Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair.

Williams RS, Dodson GE, Limbo O, Yamada Y, Williams JS, Guenther G, Classen S, Glover JN, Iwasaki H, Russell P, Tainer JA.

Cell. 2009 Oct 2;139(1):87-99. doi: 10.1016/j.cell.2009.07.033.

20.

Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair.

Williams RS, Moncalian G, Williams JS, Yamada Y, Limbo O, Shin DS, Groocock LM, Cahill D, Hitomi C, Guenther G, Moiani D, Carney JP, Russell P, Tainer JA.

Cell. 2008 Oct 3;135(1):97-109. doi: 10.1016/j.cell.2008.08.017.

21.

Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination.

Limbo O, Chahwan C, Yamada Y, de Bruin RA, Wittenberg C, Russell P.

Mol Cell. 2007 Oct 12;28(1):134-46.

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