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Items: 1 to 50 of 140

1.

GPER (GPR30): A Nongenomic Receptor (GPCR) for Steroid Hormones with Implications for Cardiovascular Disease and Cancer.

Feldman RD, Limbird LE.

Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:567-584. doi: 10.1146/annurev-pharmtox-010716-104651. Epub 2016 Oct 21. Review.

PMID:
27814026
2.

Aldosterone mediates metastatic spread of renal cancer via the G protein-coupled estrogen receptor (GPER).

Feldman RD, Ding Q, Hussain Y, Limbird LE, Pickering JG, Gros R.

FASEB J. 2016 Jun;30(6):2086-96. doi: 10.1096/fj.15-275552. Epub 2016 Feb 24.

PMID:
26911792
3.

Copernicus Revisited: Overturning Ptolemy's View of the GPER Universe.

Feldman RD, Limbird LE.

Trends Endocrinol Metab. 2015 Nov;26(11):592-594. doi: 10.1016/j.tem.2015.09.002. Epub 2015 Oct 16. Review.

PMID:
26482875
4.

Historical perspective for understanding of adrenergic receptors.

Limbird LE.

Curr Top Membr. 2011;67:1-17. doi: 10.1016/B978-0-12-384921-2.00001-X. Review. No abstract available.

PMID:
21771483
5.

Study of GPCR-protein interactions using gel overlay assays and glutathione-S-transferase-fusion protein pull-downs.

Brady AE, Chen Y, Limbird LE, Wang Q.

Methods Mol Biol. 2011;746:347-55. doi: 10.1007/978-1-61779-126-0_19.

PMID:
21607867
6.

Enhanced hypotensive, bradycardic, and hypnotic responses to alpha2-adrenergic agonists in spinophilin-null mice are accompanied by increased G protein coupling to the alpha2A-adrenergic receptor.

Lu R, Chen Y, Cottingham C, Peng N, Jiao K, Limbird LE, Wyss JM, Wang Q.

Mol Pharmacol. 2010 Aug;78(2):279-86. doi: 10.1124/mol.110.065300. Epub 2010 Apr 29.

7.

Estradiol-mediated ERK phosphorylation and apoptosis in vascular smooth muscle cells requires GPR 30.

Ding Q, Gros R, Limbird LE, Chorazyczewski J, Feldman RD.

Am J Physiol Cell Physiol. 2009 Nov;297(5):C1178-87. doi: 10.1152/ajpcell.00185.2009. Epub 2009 Sep 9.

8.

Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is because of ligand-selective internalization.

Lu R, Li Y, Zhang Y, Chen Y, Shields AD, Winder DG, Angelotti T, Jiao K, Limbird LE, Zhou Y, Wang Q.

J Biol Chem. 2009 May 8;284(19):13233-43. doi: 10.1074/jbc.M807535200. Epub 2009 Mar 10.

9.

Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation.

Mines MA, Goodwin JS, Limbird LE, Cui FF, Fan GH.

J Biol Chem. 2009 Feb 27;284(9):5742-52. doi: 10.1074/jbc.M808507200. Epub 2008 Dec 23.

10.
11.

Centralized oversight of physician-scientist faculty development at Vanderbilt: early outcomes.

Brown AM, Morrow JD, Limbird LE, Byrne DW, Gabbe SG, Balser JR, Brown NJ.

Acad Med. 2008 Oct;83(10):969-75. doi: 10.1097/ACM.0b013e3181850950.

12.

Regulation of alpha2AR trafficking and signaling by interacting proteins.

Wang Q, Limbird LE.

Biochem Pharmacol. 2007 Apr 15;73(8):1135-45. Epub 2006 Dec 28.

13.

Adenylyl cyclase isoform-selective regulation of vascular smooth muscle proliferation and cytoskeletal reorganization.

Gros R, Ding Q, Chorazyczewski J, Pickering JG, Limbird LE, Feldman RD.

Circ Res. 2006 Oct 13;99(8):845-52. Epub 2006 Sep 14.

PMID:
16973907
14.
15.

Proteomic exploration of pancreatic islets in mice null for the alpha2A adrenergic receptor.

Hu X, Friedman D, Hill S, Caprioli R, Nicholson W, Powers AC, Hunter L, Limbird LE.

J Mol Endocrinol. 2005 Aug;35(1):73-88.

PMID:
16087723
16.

Alpha 2-adrenergic agonist enrichment of spinophilin at the cell surface involves beta gamma subunits of Gi proteins and is preferentially induced by the alpha 2A-subtype.

Brady AE, Wang Q, Allen PB, Rizzo M, Greengard P, Limbird LE.

Mol Pharmacol. 2005 May;67(5):1690-6. Epub 2005 Feb 10.

PMID:
15705742
17.

The receptor concept: a continuing evolution.

Limbird LE.

Mol Interv. 2004 Dec;4(6):326-36. Review.

PMID:
15616162
18.
19.
21.

Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors.

Wang Q, Zhao J, Brady AE, Feng J, Allen PB, Lefkowitz RJ, Greengard P, Limbird LE.

Science. 2004 Jun 25;304(5679):1940-4.

22.

"You're always thirty seconds away from a changed life": an interview with Lee Limbird.

Limbird L.

Mol Interv. 2001 Aug;1(3):145-9. No abstract available.

PMID:
14993347
23.

Membrane trafficking of G protein-coupled receptors.

Tan CM, Brady AE, Nickols HH, Wang Q, Limbird LE.

Annu Rev Pharmacol Toxicol. 2004;44:559-609. Review.

PMID:
14744258
25.

Spinophilin stabilizes cell surface expression of alpha 2B-adrenergic receptors.

Brady AE, Wang Q, Colbran RJ, Allen PB, Greengard P, Limbird LE.

J Biol Chem. 2003 Aug 22;278(34):32405-12. Epub 2003 May 8.

26.

Synergies at the synapse.

Límbírd LE.

Br J Pharmacol. 2003 Apr;138(8):1387-8. Review. No abstract available.

27.

Regulated interactions of the alpha 2A adrenergic receptor with spinophilin, 14-3-3zeta, and arrestin 3.

Wang Q, Limbird LE.

J Biol Chem. 2002 Dec 27;277(52):50589-96. Epub 2002 Oct 9.

28.

Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine.

Franowicz JS, Kessler LE, Borja CM, Kobilka BK, Limbird LE, Arnsten AF.

J Neurosci. 2002 Oct 1;22(19):8771-7.

29.

Heterozygous alpha 2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists.

Tan CM, Wilson MH, MacMillan LB, Kobilka BK, Limbird LE.

Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12471-6. Epub 2002 Aug 30.

30.

G protein-coupled receptor interacting proteins: emerging roles in localization and signal transduction.

Brady AE, Limbird LE.

Cell Signal. 2002 Apr;14(4):297-309. Review.

PMID:
11858937
31.
32.
34.

Agonist-regulated Interaction between alpha2-adrenergic receptors and spinophilin.

Richman JG, Brady AE, Wang Q, Hensel JL, Colbran RJ, Limbird LE.

J Biol Chem. 2001 May 4;276(18):15003-8. Epub 2001 Jan 11.

35.

Localization of G-protein-coupled receptors in health and disease.

Edwards SW, Tan CM, Limbird LE.

Trends Pharmacol Sci. 2000 Aug;21(8):304-8. Review.

PMID:
10918636
36.
37.

Measuring contributions to the research mission of medical schools.

Holmes EW, Burks TF, Dzau V, Hindery MA, Jones RF, Kaye CI, Korn D, Limbird LE, Marchase RB, Perlmutter R, Sanfilippo F, Strom BL.

Acad Med. 2000 Mar;75(3):303-13.

PMID:
10724325
38.

5-hydroxytryptamine stimulates phosphorylation of p44/p42 mitogen-activated protein kinase activation in bovine aortic endothelial cell cultures.

McDuffie JE, Motley ED, Limbird LE, Maleque MA.

J Cardiovasc Pharmacol. 2000 Mar;35(3):398-402.

PMID:
10710124
39.

Mechanisms regulating the cell surface residence time of the alpha 2A-adrenergic receptor.

Wilson MH, Limbird LE.

Biochemistry. 2000 Feb 1;39(4):693-700.

PMID:
10651634
41.

Localization and trafficking of alpha2-adrenergic receptor subtypes in cells and tissues.

Saunders C, Limbird LE.

Pharmacol Ther. 1999 Nov;84(2):193-205. Review.

PMID:
10596906
43.
44.

Abnormal regulation of the sympathetic nervous system in alpha2A-adrenergic receptor knockout mice.

Altman JD, Trendelenburg AU, MacMillan L, Bernstein D, Limbird L, Starke K, Kobilka BK, Hein L.

Mol Pharmacol. 1999 Jul;56(1):154-61.

PMID:
10385696
45.

Augmenting beta receptors in the heart: short-term gains offset by long-term pains?

Limbird LE, Vaughan DE.

Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7125-7. No abstract available.

46.
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48.

Nitrous oxide produces antinociceptive response via alpha2B and/or alpha2C adrenoceptor subtypes in mice.

Guo TZ, Davies MF, Kingery WS, Patterson AJ, Limbird LE, Maze M.

Anesthesiology. 1999 Feb;90(2):470-6.

PMID:
9952154
49.

Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy.

Wilson MH, Puranam RS, Ottman R, Gilliam C, Limbird LE, George AL Jr, McNamara JO.

Neurology. 1998 Dec;51(6):1730-1.

PMID:
9855534

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