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Items: 15

1.

Multi-column ultra-high performance liquid chromatography screening with chaotropic agents and computer-assisted separation modeling enables process development of new drug substances.

Haidar Ahmad IA, Chen W, Halsey HM, Klapars A, Limanto J, Pirrone GF, Nowak T, Bennett R, Hartman R, Makarov AA, Mangion I, Regalado EL.

Analyst. 2019 Apr 23;144(9):2872-2880. doi: 10.1039/c8an02499e.

PMID:
30830135
2.

Highly Diastereoselective Synthesis of a HCV NS5B Nucleoside Polymerase Inhibitor.

Zhong YL, Cleator E, Liu Z, Yin J, Morris WJ, Alam M, Bishop B, Dumas AM, Edwards J, Goodyear A, Mullens P, Song ZJ, Shevlin M, Thaisrivongs DA, Li H, Sherer EC, Cohen RD, Yin J, Tan L, Yasuda N, Limanto J, Davies A, Campos KR.

J Org Chem. 2019 Apr 19;84(8):4780-4795. doi: 10.1021/acs.joc.8b02500. Epub 2018 Dec 10.

PMID:
30475616
3.

Supercritical fluid chromatography-photodiode array detection-electrospray ionization mass spectrometry as a framework for impurity fate mapping in the development and manufacture of drug substances.

Pirrone GF, Mathew RM, Makarov AA, Bernardoni F, Klapars A, Hartman R, Limanto J, Regalado EL.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Mar 30;1080:42-49. doi: 10.1016/j.jchromb.2018.02.006. Epub 2018 Feb 8.

PMID:
29477066
4.

A multifunctional catalyst that stereoselectively assembles prodrugs.

DiRocco DA, Ji Y, Sherer EC, Klapars A, Reibarkh M, Dropinski J, Mathew R, Maligres P, Hyde AM, Limanto J, Brunskill A, Ruck RT, Campeau LC, Davies IW.

Science. 2017 Apr 28;356(6336):426-430. doi: 10.1126/science.aam7936.

PMID:
28450641
5.

Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction.

Hyde AM, Liu Z, Kosjek B, Tan L, Klapars A, Ashley ER, Zhong YL, Alvizo O, Agard NJ, Liu G, Gu X, Yasuda N, Limanto J, Huffman MA, Tschaen DM.

Org Lett. 2016 Nov 18;18(22):5888-5891. Epub 2016 Nov 1.

PMID:
27802043
6.

Promotion of a Ti-Mediated Mannich Reaction by a Proton Source.

Limanto J, Yoshikawa N, Reamer RA, Tan L, Brunskill A, Reibarkh M.

J Org Chem. 2016 Jan 15;81(2):723-8. doi: 10.1021/acs.joc.5b02452. Epub 2015 Dec 21.

PMID:
26656787
7.

A highly efficient asymmetric synthesis of vernakalant.

Limanto J, Ashley ER, Yin J, Beutner GL, Grau BT, Kassim AM, Kim MM, Klapars A, Liu Z, Strotman HR, Truppo MD.

Org Lett. 2014 May 16;16(10):2716-9. doi: 10.1021/ol501002a. Epub 2014 May 1.

PMID:
24786635
8.

Practical and cost-effective manufacturing route for the synthesis of a β-lactamase inhibitor.

Miller SP, Zhong YL, Liu Z, Simeone M, Yasuda N, Limanto J, Chen Z, Lynch J, Capodanno V.

Org Lett. 2014 Jan 3;16(1):174-7. doi: 10.1021/ol4031606. Epub 2013 Dec 13.

PMID:
24329136
9.

Dynamic kinetic resolution: asymmetric transfer hydrogenation of alpha-alkyl-substituted beta-ketoamides.

Limanto J, Krska SW, Dorner BT, Vazquez E, Yoshikawa N, Tan L.

Org Lett. 2010 Feb 5;12(3):512-5. doi: 10.1021/ol902715d.

PMID:
20028132
10.

Synthesis of a tertiary carbinamide via a novel Rh-catalyzed asymmetric hydrogenation.

Limanto J, Shultz CS, Dorner B, Desmond RA, Devine PN, Krska SW.

J Org Chem. 2008 Feb 15;73(4):1639-42. doi: 10.1021/jo702429u. Epub 2008 Jan 11.

PMID:
18186647
11.

Palladium-catalyzed regioselective arylation of imidazo[1,2-b][1,2,4]triazine: synthesis of an alpha 2/3-selective GABA agonist.

Gauthier DR Jr, Limanto J, Devine PN, Desmond RA, Szumigala RH Jr, Foster BS, Volante RP.

J Org Chem. 2005 Jul 22;70(15):5938-45.

PMID:
16018689
12.

An efficient chemoenzymatic approach to (S)-gamma-fluoroleucine ethyl ester.

Limanto J, Shafiee A, Devine PN, Upadhyay V, Desmond RA, Foster BR, Gauthier DR Jr, Reamer RA, Volante RP.

J Org Chem. 2005 Mar 18;70(6):2372-5.

PMID:
15760235
13.
14.

A regioselective approach to 5-substituted-3-amino-1,2,4-triazines.

Limanto J, Desmond RA, Gauthier DR Jr, Devine PN, Reamer RA, Volante RP.

Org Lett. 2003 Jun 26;5(13):2271-4.

PMID:
12816426
15.

Intramolecular cycloadditions of cyclobutadiene with olefins.

Limanto J, Tallarico JA, Porter JR, Khuong KS, Houk KN, Snapper ML.

J Am Chem Soc. 2002 Dec 11;124(49):14748-58.

PMID:
12465988

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