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An Optimised Protocol Harnessing Laser Capture Microdissection for Transcriptomic Analysis on Matched Primary and Metastatic Colorectal Tumours.

Ong CJ, Tan QX, Lim HJ, Shannon NB, Lim WK, Hendrikson J, Ng WH, Tan JWS, Koh KKN, Wasudevan SD, Ng CCY, Rajasegaran V, Lim TKH, Ong CK, Kon OL, Teh BT, Tan GHC, Chia CS, Soo KC, Teo MCC.

Sci Rep. 2020 Jan 20;10(1):682. doi: 10.1038/s41598-019-55146-2.


Digital phenotyping by consumer wearables identifies sleep-associated markers of cardiovascular disease risk and biological aging.

Teo JX, Davila S, Yang C, Hii AA, Pua CJ, Yap J, Tan SY, Sahlén A, Chin CW, Teh BT, Rozen SG, Cook SA, Yeo KK, Tan P, Lim WK.

Commun Biol. 2019 Oct 4;2(1):361. doi: 10.1038/s42003-019-0605-1.


Novel surface plasmon resonance biosensor that uses full-length Det7 phage tail protein for rapid and selective detection of Salmonella enterica serovar Typhimurium.

Hyeon SH, Lim WK, Shin HJ.

Biotechnol Appl Biochem. 2020 Jan 8. doi: 10.1002/bab.1883. [Epub ahead of print]


Prevalence of sarcopenia as a comorbid disease: A systematic review and meta-analysis.

Pacifico J, Geerlings MAJ, Reijnierse EM, Phassouliotis C, Lim WK, Maier AB.

Exp Gerontol. 2019 Dec 28;131:110801. doi: 10.1016/j.exger.2019.110801. [Epub ahead of print] Review.


Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4Rα antibody, is required to broadly inhibit type 2 inflammation.

Le Floc'h A, Allinne J, Nagashima K, Scott G, Birchard D, Asrat S, Bai Y, Lim WK, Martin J, Huang T, Potocky TB, Kim JH, Rafique A, Papadopoulos NJ, Stahl N, Yancopoulos GD, Murphy AJ, Sleeman MA, Orengo JM.

Allergy. 2019 Dec 14. doi: 10.1111/all.14151. [Epub ahead of print]


Harnessing technology and molecular analysis to understand the development of cardiovascular diseases in Asia: a prospective cohort study (SingHEART).

Yap J, Lim WK, Sahlén A, Chin CW, Chew KMY, Davila S, Allen J, Goh V, Tan SY, Tan P, Lam CSP, Cook SA, Yeo KK.

BMC Cardiovasc Disord. 2019 Nov 21;19(1):259. doi: 10.1186/s12872-019-1248-3.


Subacute combined degeneration of the spinal cord masking motor neuron disease: a case report.

Loveland P, Wong A, Vivekanandam V, Lim WK.

J Med Case Rep. 2019 Nov 18;13(1):336. doi: 10.1186/s13256-019-2256-8.


Gα-13 induces CXC motif chemokine ligand 5 expression in prostate cancer cells by transactivating NF-κB.

Lim WK, Chai X, Ghosh S, Ray D, Wang M, Rasheed SAK, Casey PJ.

J Biol Chem. 2019 Nov 29;294(48):18192-18206. doi: 10.1074/jbc.RA119.010018. Epub 2019 Oct 21.


Digital phenotyping by consumer wearables identifies sleep-associated markers of cardiovascular disease risk and biological aging.

Teo JX, Davila S, Yang C, Hii AA, Pua CJ, Yap J, Tan SY, Sahlén A, Chin CW, Teh BT, Rozen SG, Cook SA, Yeo KK, Tan P, Lim WK.

Commun Biol. 2019 Oct 4;2:361. doi: 10.1038/s42003-019-0605-1. eCollection 2019.


IL-33 blockade affects mediators of persistence and exacerbation in a model of chronic airway inflammation.

Allinne J, Scott G, Lim WK, Birchard D, Erjefält JS, Sandén C, Ben LH, Agrawal A, Kaur N, Kim JH, Kamat V, Fury W, Huang T, Stahl N, Yancopoulos GD, Murphy AJ, Sleeman MA, Orengo JM.

J Allergy Clin Immunol. 2019 Dec;144(6):1624-1637.e10. doi: 10.1016/j.jaci.2019.08.039. Epub 2019 Sep 25.


Integrated paired-end enhancer profiling and whole-genome sequencing reveals recurrent CCNE1 and IGF2 enhancer hijacking in primary gastric adenocarcinoma.

Ooi WF, Nargund AM, Lim KJ, Zhang S, Xing M, Mandoli A, Lim JQ, Ho SWT, Guo Y, Yao X, Lin SJ, Nandi T, Xu C, Ong X, Lee M, Tan AL, Lam YN, Teo JX, Kaneda A, White KP, Lim WK, Rozen SG, Teh BT, Li S, Skanderup AJ, Tan P.

Gut. 2019 Sep 21. pii: gutjnl-2018-317612. doi: 10.1136/gutjnl-2018-317612. [Epub ahead of print]


Introducing Goals of Patient Care in Residential Aged Care Facilities to Decrease Hospitalization: A Cluster Randomized Controlled Trial.

Martin RS, Hayes BJ, Hutchinson A, Tacey M, Yates P, Lim WK.

J Am Med Dir Assoc. 2019 Oct;20(10):1318-1324.e2. doi: 10.1016/j.jamda.2019.06.017. Epub 2019 Aug 14.


Germline Pathogenic Variants in Homologous Recombination and DNA Repair Genes in an Asian Cohort of Young-Onset Colorectal Cancer.

Toh MR, Chiang JB, Chong ST, Chan SH, Ishak NDB, Courtney E, Lee WH, Syed Abdillah Al SMFB, Carson Allen J Jr, Lim KH, Davila S, Tan P, Lim WK, Tan IBH, Ngeow J.

JNCI Cancer Spectr. 2018 Dec 10;2(4):pky054. doi: 10.1093/jncics/pky054. eCollection 2018 Oct.


Implementation of genomics in medical practice to deliver precision medicine for an Asian population.

Bylstra Y, Davila S, Lim WK, Wu R, Teo JX, Kam S, Lysaght T, Rozen S, Teh BT, Yeo KK, Cook SA, Tan P, Jamuar SS.

NPJ Genom Med. 2019 Jun 7;4:12. doi: 10.1038/s41525-019-0085-8. eCollection 2019. Review.


Obesity in older adults: Effect of degree of weight loss on cardiovascular markers and medications.

Haywood CJ, Prendergast LA, Lim R, Lappas M, Lim WK, Proietto J.

Clin Obes. 2019 Aug;9(4):e12316. doi: 10.1111/cob.12316. Epub 2019 Jun 17.


Contributors to frailty in critical illness: Multi-dimensional analysis of the Clinical Frailty Scale.

Darvall JN, Greentree K, Braat MS, Story DA, Lim WK.

J Crit Care. 2019 Aug;52:193-199. doi: 10.1016/j.jcrc.2019.04.032. Epub 2019 May 2.


Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta-analysis.

Yeung SSY, Reijnierse EM, Pham VK, Trappenburg MC, Lim WK, Meskers CGM, Maier AB.

J Cachexia Sarcopenia Muscle. 2019 Jun;10(3):485-500. doi: 10.1002/jcsm.12411. Epub 2019 Apr 16. Review.


Extensive intracranial haemorrhage as a complication of acute lymphoblastic leukaemia with hyperleukocytosis.

Lim WK, Fong CY, Li L, Foo JC, Yap TY.

J Clin Neurosci. 2019 Jun;64:11-14. doi: 10.1016/j.jocn.2019.03.056. Epub 2019 Apr 2.


Improving awareness, knowledge, and attitude among Malaysian parents of children with epilepsy using an Interactive Animated Epilepsy Education Programme (IAEEP).

Fong CY, Hong SY, Ong LC, Lim WK, Lua PL.

Epilepsy Behav. 2019 May;94:52-58. doi: 10.1016/j.yebeh.2019.02.008. Epub 2019 Mar 16.


Orthostatic hypotension and cognition in older adults: A systematic review and meta-analysis.

Iseli R, Nguyen VTV, Sharmin S, Reijnierse EM, Lim WK, Maier AB.

Exp Gerontol. 2019 Jun;120:40-49. doi: 10.1016/j.exger.2019.02.017. Epub 2019 Feb 28. Review.


Protocol for a prospective observational study to develop a frailty index for use in perioperative and critical care.

Darvall JN, Braat S, Story DA, Greentree K, Bose T, Loth J, Lim WK.

BMJ Open. 2019 Jan 9;9(1):e024682. doi: 10.1136/bmjopen-2018-024682.


Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder.

Chen CW, Wang HL, Huang CW, Huang CY, Lim WK, Tu IC, Koorapati A, Hsieh ST, Kan HW, Tzeng SR, Liao JC, Chong WM, Naroditzky I, Kidron D, Eran A, Nijim Y, Sela E, Feldman HB, Kalfon L, Raveh-Barak H, Falik-Zaccai TC, Elpeleg O, Mandel H, Chang ZF.

Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):566-574. doi: 10.1073/pnas.1818629116. Epub 2018 Dec 26.


Lower Skeletal Muscle Mass at Admission Independently Predicts Falls and Mortality 3 Months Post-discharge in Hospitalized Older Patients.

Reijnierse EM, Verlaan S, Pham VK, Lim WK, Meskers CGM, Maier AB.

J Gerontol A Biol Sci Med Sci. 2019 Sep 15;74(10):1650-1656. doi: 10.1093/gerona/gly281.


Improving the utility of multisource feedback for medical consultants in a tertiary hospital: a study of the psychometric properties of a survey tool.

Corbett H, Pearson K, Karimi L, Lim WK.

Aust Health Rev. 2018 Nov 22. doi: 10.1071/AH17219. [Epub ahead of print]


Clinical relevance of screening checklists for detecting cancer predisposition syndromes in Asian childhood tumours.

Chan SH, Chew W, Ishak NDB, Lim WK, Li ST, Tan SH, Teo JX, Shaw T, Chang K, Chen Y, Iyer P, Tan EEK, Seng MS, Chan MY, Tan AM, Low SYY, Soh SY, Loh AHP, Ngeow J.

NPJ Genom Med. 2018 Nov 15;3:30. doi: 10.1038/s41525-018-0070-7. eCollection 2018.


Hospital-Associated Complications of Older People: A Proposed Multicomponent Outcome for Acute Care.

Mudge AM, McRae P, Hubbard RE, Peel NM, Lim WK, Barnett AG, Inouye SK.

J Am Geriatr Soc. 2019 Feb;67(2):352-356. doi: 10.1111/jgs.15662. Epub 2018 Nov 13.


Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) - Report 2: Pattern of Uveitis Investigations in Singapore.

Low R, Chen EJ, Bin Ismail MA, Mi H, Ling HS, Lim WK, Teoh SC, Agrawal R.

Ocul Immunol Inflamm. 2018 Oct 18:1-8. doi: 10.1080/09273948.2018.1535080. [Epub ahead of print]


Frailty indexes in perioperative and critical care: A systematic review.

Darvall JN, Gregorevic KJ, Story DA, Hubbard RE, Lim WK.

Arch Gerontol Geriatr. 2018 Nov - Dec;79:88-96. doi: 10.1016/j.archger.2018.08.006. Epub 2018 Aug 19.


A frail future.

Darvall JN, Gregorevic KJ, Story DA, Hubbard RE, Lim WK.

Anaesthesia. 2018 Aug;73(8):1041-1042. doi: 10.1111/anae.14371. No abstract available.


Do health assets have a protective effect for hospitalized frail older adults?

Gregorevic KJ, Peel NM, Lim WK, Hubbard RE.

QJM. 2018 Nov 1;111(11):785-789. doi: 10.1093/qjmed/hcy172.


Correction: Population genomics in South East Asia captures unexpectedly high carrier frequency for treatable inherited disorders.

Bylstra Y, Kuan JL, Lim WK, Bhalshankar JD, Teo JX, Davila S, Teh BT, Rozen S, Tan EC, Liew WKM, Yeo KK, Tan P; SinGapore Incidental Finding (SGIF) study group, Saw SM, Cheng CY, Cook S, Foo R, Jamuar SS.

Genet Med. 2018 Dec;20(12):1692. doi: 10.1038/s41436-018-0142-1.


Population genomics in South East Asia captures unexpectedly high carrier frequency for treatable inherited disorders.

Bylstra Y, Kuan JL, Lim WK, Bhalshankar JD, Teo JX, Davila S, Teh BT, Rozen S, Tan EC, Liew WKM, Yeo KK, Tan P; SinGapore Incidental Finding (SGIF) study group, Saw SM, Cheng CY, Cook S, Foo R, Jamuar SS.

Genet Med. 2019 Jan;21(1):207-212. doi: 10.1038/s41436-018-0008-6. Epub 2018 Jul 2. Erratum in: Genet Med. 2018 Dec;20(12):1692.


Rapid label-free detection of E. coli using a novel SPR biosensor containing a fragment of tail protein from phage lambda.

Shin HJ, Lim WK.

Prep Biochem Biotechnol. 2018;48(6):498-505. doi: 10.1080/10826068.2018.1466154. Epub 2018 Jun 22.


Using technology to support care in gestational diabetes mellitus: Quantitative outcomes of an exploratory randomised control trial of adjunct telemedicine for gestational diabetes mellitus (TeleGDM).

Rasekaba TM, Furler J, Young D, Liew D, Gray K, Blackberry I, Lim WK.

Diabetes Res Clin Pract. 2018 Aug;142:276-285. doi: 10.1016/j.diabres.2018.05.049. Epub 2018 Jun 7.


Validation of the health assets index in the Australian inpatient setting: a multicentre prospective cohort protocol study.

Gregorevic K, Hubbard RE, Peel NM, Lim WK.

BMJ Open. 2018 May 10;8(5):e021135. doi: 10.1136/bmjopen-2017-021135.


A physician targeted intervention improves prescribing in chronic heart failure in general medical units.

Chua CC, Hutchinson A, Tacey M, Parikh S, Lim WK, Aboltins C.

BMC Health Serv Res. 2018 Mar 23;18(1):206. doi: 10.1186/s12913-018-3009-x.


Beyond fitness tracking: The use of consumer-grade wearable data from normal volunteers in cardiovascular and lipidomics research.

Lim WK, Davila S, Teo JX, Yang C, Pua CJ, Blöcker C, Lim JQ, Ching J, Yap JJL, Tan SY, Sahlén A, Chin CW, Teh BT, Rozen SG, Cook SA, Yeo KK, Tan P.

PLoS Biol. 2018 Feb 27;16(2):e2004285. doi: 10.1371/journal.pbio.2004285. eCollection 2018 Feb.


Ocular Autoimmune Systemic Inflammatory Infectious Study - Report 3: Posterior and Panuveitis.

Lee JH, Mi H, Lim R, Ho SL, Lim WK, Teoh SC, Agrawal R.

Ocul Immunol Inflamm. 2019;27(1):89-98. doi: 10.1080/09273948.2017.1358377. Epub 2017 Oct 9.


The draft genome of tropical fruit durian (Durio zibethinus).

Teh BT, Lim K, Yong CH, Ng CCY, Rao SR, Rajasegaran V, Lim WK, Ong CK, Chan K, Cheng VKY, Soh PS, Swarup S, Rozen SG, Nagarajan N, Tan P.

Nat Genet. 2017 Nov;49(11):1633-1641. doi: 10.1038/ng.3972. Epub 2017 Oct 9.


Germline Mutations in Cancer Predisposition Genes are Frequent in Sporadic Sarcomas.

Chan SH, Lim WK, Ishak NDB, Li ST, Goh WL, Tan GS, Lim KH, Teo M, Young CNC, Malik S, Tan MH, Teh JYH, Chin FKC, Kesavan S, Selvarajan S, Tan P, Teh BT, Soo KC, Farid M, Quek R, Ngeow J.

Sci Rep. 2017 Sep 6;7(1):10660. doi: 10.1038/s41598-017-10333-x.


Reliability of an Online Geriatric Assessment Procedure Using the interRAI Acute Care Assessment System.

Martin-Khan MG, Edwards H, Wootton R, Counsell SR, Varghese P, Lim WK, Darzins P, Dakin L, Klein K, Gray LC.

J Am Geriatr Soc. 2017 Sep;65(9):2029-2036. doi: 10.1111/jgs.14895. Epub 2017 Aug 21.


Provision of sudden unexpected death in epilepsy (SUDEP) information among Malaysian parents of children with epilepsy.

Fong CY, Lim WK, Kong AN, Lua PL, Ong LC.

Epilepsy Behav. 2017 Oct;75:6-12. doi: 10.1016/j.yebeh.2017.06.037. Epub 2017 Aug 12.


Recognizing the Continuous Nature of Expression Heterogeneity and Clinical Outcomes in Clear Cell Renal Cell Carcinoma.

Wei X, Choudhury Y, Lim WK, Anema J, Kahnoski RJ, Lane B, Ludlow J, Takahashi M, Kanayama HO, Belldegrun A, Kim HL, Rogers C, Nicol D, Teh BT, Tan MH.

Sci Rep. 2017 Aug 4;7(1):7342. doi: 10.1038/s41598-017-07191-y.


Epithelium-on photorefractive intrastromal cross-linking (PiXL) for reduction of low myopia.

Lim WK, Soh ZD, Choi HKY, Theng JTS.

Clin Ophthalmol. 2017 Jun 27;11:1205-1211. doi: 10.2147/OPTH.S137712. eCollection 2017.


Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma.

Jusakul A, Cutcutache I, Yong CH, Lim JQ, Huang MN, Padmanabhan N, Nellore V, Kongpetch S, Ng AWT, Ng LM, Choo SP, Myint SS, Thanan R, Nagarajan S, Lim WK, Ng CCY, Boot A, Liu M, Ong CK, Rajasegaran V, Lie S, Lim AST, Lim TH, Tan J, Loh JL, McPherson JR, Khuntikeo N, Bhudhisawasdi V, Yongvanit P, Wongkham S, Totoki Y, Nakamura H, Arai Y, Yamasaki S, Chow PK, Chung AYF, Ooi LLPJ, Lim KH, Dima S, Duda DG, Popescu I, Broet P, Hsieh SY, Yu MC, Scarpa A, Lai J, Luo DX, Carvalho AL, Vettore AL, Rhee H, Park YN, Alexandrov LB, Gordân R, Rozen SG, Shibata T, Pairojkul C, Teh BT, Tan P.

Cancer Discov. 2017 Oct;7(10):1116-1135. doi: 10.1158/2159-8290.CD-17-0368. Epub 2017 Jun 30.


Very Low Calorie Diets for Weight Loss in Obese Older Adults-A Randomized Trial.

Haywood CJ, Prendergast LA, Purcell K, Le Fevre L, Lim WK, Galea M, Proietto J.

J Gerontol A Biol Sci Med Sci. 2017 Dec 12;73(1):59-65. doi: 10.1093/gerona/glx012.


Implementation of 'Goals of Patient Care' medical treatment orders in residential aged care facilities: protocol for a randomised controlled trial.

Martin RS, Hayes BJ, Hutchinson A, Yates P, Lim WK.

BMJ Open. 2017 Mar 10;7(3):e013909. doi: 10.1136/bmjopen-2016-013909.


Medical student-led patient education prior to hospital discharge improves 1-month adherence rates.

Leung CH, Chong C, Lim WK.

Intern Med J. 2017 Mar;47(3):328-332. doi: 10.1111/imj.13365.


Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2.

Ler LD, Ghosh S, Chai X, Thike AA, Heng HL, Siew EY, Dey S, Koh LK, Lim JQ, Lim WK, Myint SS, Loh JL, Ong P, Sam XX, Huang D, Lim T, Tan PH, Nagarajan S, Cheng CW, Ho H, Ng LG, Yuen J, Lin PH, Chuang CK, Chang YH, Weng WH, Rozen SG, Tan P, Creasy CL, Pang ST, McCabe MT, Poon SL, Teh BT.

Sci Transl Med. 2017 Feb 22;9(378). pii: eaai8312. doi: 10.1126/scitranslmed.aai8312.


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