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Items: 1 to 50 of 137


The Design Principles of Biochemical Timers: Circuits that Discriminate between Transient and Sustained Stimulation.

Gerardin J, Reddy NR, Lim WA.

Cell Syst. 2019 Sep 25;9(3):297-308.e2. doi: 10.1016/j.cels.2019.07.008. Epub 2019 Sep 11.


Molecular cloning and oxidative-stress responses of a novel manganese superoxide dismutase (MnSOD) gene in the dinoflagellate Prorocentrum minimum.

Wang H, Kim H, Lim WA, Ki JS.

Mol Biol Rep. 2019 Aug 12. doi: 10.1007/s11033-019-05029-6. [Epub ahead of print]


High-throughput multicolor optogenetics in microwell plates.

Bugaj LJ, Lim WA.

Nat Protoc. 2019 Jul;14(7):2205-2228. doi: 10.1038/s41596-019-0178-y. Epub 2019 Jun 24.


Engineering cell-cell communication networks: programming multicellular behaviors.

Toda S, Frankel NW, Lim WA.

Curr Opin Chem Biol. 2019 May 28;52:31-38. doi: 10.1016/j.cbpa.2019.04.020. [Epub ahead of print] Review.


Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway.

Bugaj LJ, Sabnis AJ, Mitchell A, Garbarino JE, Toettcher JE, Bivona TG, Lim WA.

Science. 2018 Aug 31;361(6405). pii: eaao3048. doi: 10.1126/science.aao3048.


Significant and conservative long-range transport of dissolved organic nutrients in the Changjiang diluted water.

Kwon HK, Kim G, Hwang J, Lim WA, Park JW, Kim TH.

Sci Rep. 2018 Aug 24;8(1):12768. doi: 10.1038/s41598-018-31105-1.


Programming self-organizing multicellular structures with synthetic cell-cell signaling.

Toda S, Blauch LR, Tang SKY, Morsut L, Lim WA.

Science. 2018 Jul 13;361(6398):156-162. doi: 10.1126/science.aat0271. Epub 2018 May 31.


Building a Stable Relationship: Ensuring Homeostasis among Cell Types within a Tissue.

Frankel NW, Lim WA.

Cell. 2018 Feb 8;172(4):638-640. doi: 10.1016/j.cell.2018.01.024.


CpMCA, a novel metacaspase gene from the harmful dinoflagellate Cochlodinium polykrikoides and its expression during cell death.

Wang H, Park BS, Lim WA, Ki JS.

Gene. 2018 Apr 20;651:70-78. doi: 10.1016/j.gene.2018.02.002. Epub 2018 Feb 3.


Design of Tunable Oscillatory Dynamics in a Synthetic NF-κB Signaling Circuit.

Zhang ZB, Wang QY, Ke YX, Liu SY, Ju JQ, Lim WA, Tang C, Wei P.

Cell Syst. 2017 Nov 22;5(5):460-470.e5. doi: 10.1016/j.cels.2017.09.016. Epub 2017 Oct 25.


Which species, Alexandrium catenella (Group I) or A. pacificum (Group IV), is really responsible for past paralytic shellfish poisoning outbreaks in Jinhae-Masan Bay, Korea?

Shin HH, Li Z, Kim ES, Park JW, Lim WA.

Harmful Algae. 2017 Sep;68:31-39. doi: 10.1016/j.hal.2017.07.006. Epub 2017 Jul 26.


Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control.

Wilson MZ, Ravindran PT, Lim WA, Toettcher JE.

Mol Cell. 2017 Sep 7;67(5):757-769.e5. doi: 10.1016/j.molcel.2017.07.016. Epub 2017 Aug 17.


Formation and germination of temporary cysts of Cochlodinium polykrikoides Margalef (Dinophyceae) and their ecological role in dense blooms.

Shin HH, Li Z, Yoon YH, Oh SJ, Lim WA.

Harmful Algae. 2017 Jun;66:57-64. doi: 10.1016/j.hal.2017.05.002. Epub 2017 May 15.


Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities.

Roybal KT, Lim WA.

Annu Rev Immunol. 2017 Apr 26;35:229-253. doi: 10.1146/annurev-immunol-051116-052302. Review.


CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells.

Rupp LJ, Schumann K, Roybal KT, Gate RE, Ye CJ, Lim WA, Marson A.

Sci Rep. 2017 Apr 7;7(1):737. doi: 10.1038/s41598-017-00462-8.


The Principles of Engineering Immune Cells to Treat Cancer.

Lim WA, June CH.

Cell. 2017 Feb 9;168(4):724-740. doi: 10.1016/j.cell.2017.01.016. Review.


Interrogating cellular perception and decision making with optogenetic tools.

Bugaj LJ, O'Donoghue GP, Lim WA.

J Cell Biol. 2017 Jan 2;216(1):25-28. doi: 10.1083/jcb.201612094. Epub 2016 Dec 21.


Engineering Therapeutic T Cells: From Synthetic Biology to Clinical Trials.

Esensten JH, Bluestone JA, Lim WA.

Annu Rev Pathol. 2017 Jan 24;12:305-330. doi: 10.1146/annurev-pathol-052016-100304. Epub 2016 Dec 5. Review.


Engineering dynamical control of cell fate switching using synthetic phospho-regulons.

Gordley RM, Williams RE, Bashor CJ, Toettcher JE, Yan S, Lim WA.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13528-13533. Epub 2016 Nov 7.


Complex transcriptional modulation with orthogonal and inducible dCas9 regulators.

Gao Y, Xiong X, Wong S, Charles EJ, Lim WA, Qi LS.

Nat Methods. 2016 Dec;13(12):1043-1049. doi: 10.1038/nmeth.4042. Epub 2016 Oct 24.


Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors.

Roybal KT, Williams JZ, Morsut L, Rupp LJ, Kolinko I, Choe JH, Walker WJ, McNally KA, Lim WA.

Cell. 2016 Oct 6;167(2):419-432.e16. doi: 10.1016/j.cell.2016.09.011. Epub 2016 Sep 29.


Modular engineering of cellular signaling proteins and networks.

Gordley RM, Bugaj LJ, Lim WA.

Curr Opin Struct Biol. 2016 Aug;39:106-114. doi: 10.1016/ Epub 2016 Jul 15. Review.


Genome-wide analysis of transcription and photosynthesis inhibition in the harmful dinoflagellate Prorocentrum minimum in response to the biocide copper sulfate.

Guo R, Lim WA, Ki JS.

Harmful Algae. 2016 Jul;57(Pt A):27-38. doi: 10.1016/j.hal.2016.05.004. Epub 2016 Jun 9.


CRISPR/Cas9 for Human Genome Engineering and Disease Research.

Xiong X, Chen M, Lim WA, Zhao D, Qi LS.

Annu Rev Genomics Hum Genet. 2016 Aug 31;17:131-54. doi: 10.1146/annurev-genom-083115-022258. Epub 2016 May 23. Review.


Nucleosome breathing and remodeling constrain CRISPR-Cas9 function.

Isaac RS, Jiang F, Doudna JA, Lim WA, Narlikar GJ, Almeida R.

Elife. 2016 Apr 28;5. pii: e13450. doi: 10.7554/eLife.13450.


Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits.

Roybal KT, Rupp LJ, Morsut L, Walker WJ, McNally KA, Park JS, Lim WA.

Cell. 2016 Feb 11;164(4):770-9. doi: 10.1016/j.cell.2016.01.011. Epub 2016 Jan 28.


Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors.

Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, Thomson M, Lim WA.

Cell. 2016 Feb 11;164(4):780-91. doi: 10.1016/j.cell.2016.01.012. Epub 2016 Jan 28.


Expanding the CRISPR imaging toolset with Staphylococcus aureus Cas9 for simultaneous imaging of multiple genomic loci.

Chen B, Hu J, Almeida R, Liu H, Balakrishnan S, Covill-Cooke C, Lim WA, Huang B.

Nucleic Acids Res. 2016 May 5;44(8):e75. doi: 10.1093/nar/gkv1533. Epub 2016 Jan 5.


Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation.

Dominguez AA, Lim WA, Qi LS.

Nat Rev Mol Cell Biol. 2016 Jan;17(1):5-15. doi: 10.1038/nrm.2015.2. Epub 2015 Dec 16. Review.


Oscillatory stress stimulation uncovers an Achilles' heel of the yeast MAPK signaling network.

Mitchell A, Wei P, Lim WA.

Science. 2015 Dec 11;350(6266):1379-83. doi: 10.1126/science.aab0892. Epub 2015 Nov 19.


Remote control of therapeutic T cells through a small molecule-gated chimeric receptor.

Wu CY, Roybal KT, Puchner EM, Onuffer J, Lim WA.

Science. 2015 Oct 16;350(6258):aab4077. doi: 10.1126/science.aab4077. Epub 2015 Sep 24.


Outcomes are favorable in Asian patients undergoing deltoid-on open rotator cuff repair without acromioplasty.

Lim WA, Bin Abd Razak HR, Lim LW, Dhanaraj ID, Sedeek Mosaid SM, Tan HC.

J Orthop. 2015 Feb 12;12(3):126-9. doi: 10.1016/j.jor.2015.01.019. eCollection 2015 Sep.


Synthetic biology approaches to engineer T cells.

Wu CY, Rupp LJ, Roybal KT, Lim WA.

Curr Opin Immunol. 2015 Aug;35:123-30. doi: 10.1016/j.coi.2015.06.015. Epub 2015 Jul 25. Review.


Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds.

Zalatan JG, Lee ME, Almeida R, Gilbert LA, Whitehead EH, La Russa M, Tsai JC, Weissman JS, Dueber JE, Qi LS, Lim WA.

Cell. 2015 Jan 15;160(1-2):339-50. doi: 10.1016/j.cell.2014.11.052. Epub 2014 Dec 18.


Specific gene repression by CRISPRi system transferred through bacterial conjugation.

Ji W, Lee D, Wong E, Dadlani P, Dinh D, Huang V, Kearns K, Teng S, Chen S, Haliburton J, Heimberg G, Heineike B, Ramasubramanian A, Stevens T, Helmke KJ, Zepeda V, Qi LS, Lim WA.

ACS Synth Biol. 2014 Dec 19;3(12):929-31. doi: 10.1021/sb500036q. Epub 2014 Dec 6.


Sending mixed messages for cell population control.

Youk H, Lim WA.

Cell. 2014 Aug 28;158(5):973-975. doi: 10.1016/j.cell.2014.08.013.


Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal.

Park JS, Rhau B, Hermann A, McNally KA, Zhou C, Gong D, Weiner OD, Conklin BR, Onuffer J, Lim WA.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5896-901. doi: 10.1073/pnas.1402087111. Epub 2014 Apr 7.


Secreting and sensing the same molecule allows cells to achieve versatile social behaviors.

Youk H, Lim WA.

Science. 2014 Feb 7;343(6171):1242782. doi: 10.1126/science.1242782.


Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module.

Toettcher JE, Weiner OD, Lim WA.

Cell. 2013 Dec 5;155(6):1422-34. doi: 10.1016/j.cell.2013.11.004.


CRISPR interference (CRISPRi) for sequence-specific control of gene expression.

Larson MH, Gilbert LA, Wang X, Lim WA, Weissman JS, Qi LS.

Nat Protoc. 2013 Nov;8(11):2180-96. doi: 10.1038/nprot.2013.132. Epub 2013 Oct 17.


Actin dynamics rapidly reset chemoattractant receptor sensitivity following adaptation in neutrophils.

Dandekar SN, Park JS, Peng GE, Onuffer JJ, Lim WA, Weiner OD.

Philos Trans R Soc Lond B Biol Sci. 2013 Sep 23;368(1629):20130008. doi: 10.1098/rstb.2013.0008. Print 2013.


Counting molecules in single organelles with superresolution microscopy allows tracking of the endosome maturation trajectory.

Puchner EM, Walter JM, Kasper R, Huang B, Lim WA.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16015-20. doi: 10.1073/pnas.1309676110. Epub 2013 Sep 16.


Exploitation of latent allostery enables the evolution of new modes of MAP kinase regulation.

Coyle SM, Flores J, Lim WA.

Cell. 2013 Aug 15;154(4):875-87. doi: 10.1016/j.cell.2013.07.019.


CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes.

Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH, Doudna JA, Lim WA, Weissman JS, Qi LS.

Cell. 2013 Jul 18;154(2):442-51. doi: 10.1016/j.cell.2013.06.044. Epub 2013 Jul 11.


Improved blue, green, and red fluorescent protein tagging vectors for S. cerevisiae.

Lee S, Lim WA, Thorn KS.

PLoS One. 2013 Jul 2;8(7):e67902. doi: 10.1371/journal.pone.0067902. Print 2013.


Signalling change: signal transduction through the decades.

Hynes NE, Ingham PW, Lim WA, Marshall CJ, Massagué J, Pawson T.

Nat Rev Mol Cell Biol. 2013 Jun;14(6):393-8. doi: 10.1038/nrm3581. Epub 2013 May 2. Review.


Cell-based therapeutics: the next pillar of medicine.

Fischbach MA, Bluestone JA, Lim WA.

Sci Transl Med. 2013 Apr 3;5(179):179ps7. doi: 10.1126/scitranslmed.3005568.


Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.

Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA.

Cell. 2013 Feb 28;152(5):1173-83. doi: 10.1016/j.cell.2013.02.022.


Bridging cross-cultural gaps in scientific exchange through innovative team challenge workshops.

Lee CM, Gong S, Tang C, Lim WA.

Quant Biol. 2013 Mar;1(1):3-8. No abstract available.

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