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Isobaric tags for relative and absolute quantitation-based proteome analysis of Vietnamese colorectal carcinoma tissues.

Pham TTH, Le KPU, Vo PU, Le KM, Lim TK, Lin Q, Nguyen TTH.

J Cancer Res Ther. 2019 Jan-Mar;15(1):96-103. doi: 10.4103/0973-1482.202889.


Intraoperative and Postoperative Complications after Arthroscopic Coracoclavicular Stabilization.

Lim TK, Oh WK.

Clin Orthop Surg. 2019 Mar;11(1):103-111. doi: 10.4055/cios.2019.11.1.103. Epub 2019 Feb 18.


Quantification of hepatic steatosis in chronic liver disease using novel automated method of second harmonic generation and two-photon excited fluorescence.

Goh GB, Leow WQ, Liang S, Wan WK, Lim TKH, Tan CK, Chang PE.

Sci Rep. 2019 Feb 27;9(1):2975. doi: 10.1038/s41598-019-39783-1.


Sub-clinical abnormalities detected by PET/MRI in household tuberculosis contacts.

Molton JS, Thomas BA, Pang Y, Khor LK, Hallinan J, Naftalin CM, Totman JJ, Townsend DW, Lim TK, Chee CBE, Wang YT, Paton NI.

BMC Infect Dis. 2019 Jan 24;19(1):83. doi: 10.1186/s12879-019-3705-0.


Clonal MET Amplification as a Determinant of Tyrosine Kinase Inhibitor Resistance in Epidermal Growth Factor Receptor-Mutant Non-Small-Cell Lung Cancer.

Lai GGY, Lim TH, Lim J, Liew PJR, Kwang XL, Nahar R, Aung ZW, Takano A, Lee YY, Lau DPX, Tan GS, Tan SH, Tan WL, Ang MK, Toh CK, Tan BS, Devanand A, Too CW, Gogna A, Ong BH, Koh TPT, Kanesvaran R, Ng QS, Jain A, Rajasekaran T, Yuan J, Lim TKH, Lim AST, Hillmer AM, Lim WT, Iyer NG, Tam WL, Zhai W, Tan EH, Tan DSW.

J Clin Oncol. 2019 Jan 24:JCO1800177. doi: 10.1200/JCO.18.00177. [Epub ahead of print]


Procalcitonin and antibiotics in moderate-severe acute exacerbation of chronic obstructive pulmonary disease: to use or not to use.

Chan HP, Lim TK.

Curr Opin Pulm Med. 2019 Mar;25(2):150-157. doi: 10.1097/MCP.0000000000000548.


An integrated automated multispectral imaging technique that simultaneously detects and quantitates viral RNA and immune cell protein markers in fixed sections from Epstein-Barr virus-related tumours.

Wee YTF, Alkaff SMF, Lim JCT, Loh JJH, Hilmy MH, Ong C, Nei WL, Jain A, Lim A, Takano A, Azhar R, Wan WK, Newell E, Yeong J, Lim TKH.

Ann Diagn Pathol. 2018 Dec;37:12-19. doi: 10.1016/j.anndiagpath.2018.09.002. Epub 2018 Sep 11.


Colony Fingerprint-Based Discrimination of Staphylococcus species with Machine Learning Approaches.

Maeda Y, Sugiyama Y, Kogiso A, Lim TK, Harada M, Yoshino T, Matsunaga T, Tanaka T.

Sensors (Basel). 2018 Aug 24;18(9). pii: E2789. doi: 10.3390/s18092789.


The unusual flagellar-targeting mechanism and functions of the trypanosome ortholog of the ciliary GTPase Arl13b.

Zhang Y, Huang Y, Srivathsan A, Lim TK, Lin Q, He CY.

J Cell Sci. 2018 Sep 5;131(17). pii: jcs219071. doi: 10.1242/jcs.219071.


Effectiveness of the eCARE Programme: A Short Message Service (SMS) for Asthma Monitoring.

Prabhakaran L, Yap CW, Neo LP, Gan CC, Tham LM, Wong WM, Abisheganaden J, Lim TK.

Ann Acad Med Singapore. 2018 Jun;47(6):233-236. No abstract available.


Fractionated Stereotactic Radiosurgery for Brain Metastases Using the Novalis Tx® System.

Lim TK, Kim WK, Yoo CJ, Kim EY, Kim MJ, Yee GT.

J Korean Neurosurg Soc. 2018 Jul;61(4):525-529. doi: 10.3340/jkns.2018.0002. Epub 2018 Jul 1.


Multidimensional analyses reveal distinct immune microenvironment in hepatitis B virus-related hepatocellular carcinoma.

Lim CJ, Lee YH, Pan L, Lai L, Chua C, Wasser M, Lim TKH, Yeong J, Toh HC, Lee SY, Chan CY, Goh BK, Chung A, Heikenwälder M, Ng IO, Chow P, Albani S, Chew V.

Gut. 2018 Jul 3. pii: gutjnl-2018-316510. doi: 10.1136/gutjnl-2018-316510. [Epub ahead of print]


Acupuncture and Neural Mechanism in the Management of Low Back Pain-An Update.

Lim TK, Ma Y, Berger F, Litscher G.

Medicines (Basel). 2018 Jun 25;5(3). pii: E63. doi: 10.3390/medicines5030063. Review.


Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates.

Simoni Y, Becht E, Fehlings M, Loh CY, Koo SL, Teng KWW, Yeong JPS, Nahar R, Zhang T, Kared H, Duan K, Ang N, Poidinger M, Lee YY, Larbi A, Khng AJ, Tan E, Fu C, Mathew R, Teo M, Lim WT, Toh CK, Ong BH, Koh T, Hillmer AM, Takano A, Lim TKH, Tan EH, Zhai W, Tan DSW, Tan IB, Newell EW.

Nature. 2018 May;557(7706):575-579. doi: 10.1038/s41586-018-0130-2. Epub 2018 May 16.


Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency.

Simoni Y, Fehlings M, Kløverpris HN, McGovern N, Koo SL, Loh CY, Lim S, Kurioka A, Fergusson JR, Tang CL, Kam MH, Dennis K, Lim TKH, Fui ACY, Hoong CW, Chan JKY, Curotto de Lafaille M, Narayanan S, Baig S, Shabeer M, Toh SES, Tan HKK, Anicete R, Tan EH, Takano A, Klenerman P, Leslie A, Tan DSW, Tan IB, Ginhoux F, Newell EW.

Immunity. 2018 May 15;48(5):1060. doi: 10.1016/j.immuni.2018.04.028. No abstract available.


Anatomic Tunnel Placement Is Not Feasible by Transclavicular-Transcoracoid Drilling Technique for Coracoclavicular Reconstruction: A Cadaveric Study.

Koh KH, Shon MS, Choi NH, Lim TK.

Arthroscopy. 2018 Jul;34(7):2012-2017. doi: 10.1016/j.arthro.2018.01.028. Epub 2018 Apr 10.


Yeast aconitase mitochondrial import is modulated by interactions of its C and N terminal domains and Ssa1/2 (Hsp70).

Ben-Menachem R, Wang K, Marcu O, Yu Z, Lim TK, Lin Q, Schueler-Furman O, Pines O.

Sci Rep. 2018 Apr 12;8(1):5903. doi: 10.1038/s41598-018-24068-w.


Ministry of Health Clinical Practice Guidelines: Chronic Obstructive Pulmonary Disease.

Lim TK, Chee CB, Chow P, Chua GSW, Eng SK, Goh SK, Kng KK, Lim WH, Ng TP, Ong TH, Seah STA, Tan HY, Tee KH, Palanichamy V, Yeung MT.

Singapore Med J. 2018 Feb;59(2):76-86. doi: 10.11622/smedj.2018015.


Year in review 2017: Chronic obstructive pulmonary disease and asthma.

Benton MJ, Lim TK, Ko FWS, Kan-O K, Mak JCW.

Respirology. 2018 May;23(5):538-545. doi: 10.1111/resp.13285. Epub 2018 Mar 4. Review. No abstract available.


Immune activation underlies a sustained clinical response to Yttrium-90 radioembolisation in hepatocellular carcinoma.

Chew V, Lee YH, Pan L, Nasir NJM, Lim CJ, Chua C, Lai L, Hazirah SN, Lim TKH, Goh BKP, Chung A, Lo RHG, Ng D, Filarca RLF, Albani S, Chow PKH.

Gut. 2019 Feb;68(2):335-346. doi: 10.1136/gutjnl-2017-315485. Epub 2018 Feb 13.


Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing.

Nahar R, Zhai W, Zhang T, Takano A, Khng AJ, Lee YY, Liu X, Lim CH, Koh TPT, Aung ZW, Lim TKH, Veeravalli L, Yuan J, Teo ASM, Chan CX, Poh HM, Chua IML, Liew AA, Lau DPX, Kwang XL, Toh CK, Lim WT, Lim B, Tam WL, Tan EH, Hillmer AM, Tan DSW.

Nat Commun. 2018 Jan 15;9(1):216. doi: 10.1038/s41467-017-02584-z.


Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer.

Huang KK, Ramnarayanan K, Zhu F, Srivastava S, Xu C, Tan ALK, Lee M, Tay S, Das K, Xing M, Fatehullah A, Alkaff SMF, Lim TKH, Lee J, Ho KY, Rozen SG, Teh BT, Barker N, Chia CK, Khor C, Ooi CJ, Fock KM, So J, Lim WC, Ling KL, Ang TL, Wong A, Rao J, Rajnakova A, Lim LG, Yap WM, Teh M, Yeoh KG, Tan P.

Cancer Cell. 2018 Jan 8;33(1):137-150.e5. doi: 10.1016/j.ccell.2017.11.018. Epub 2017 Dec 28.


Maternal immune activation in neurodevelopmental disorders.

Solek CM, Farooqi N, Verly M, Lim TK, Ruthazer ES.

Dev Dyn. 2018 Apr;247(4):588-619. doi: 10.1002/dvdy.24612. Epub 2017 Dec 23. Review.


In sepsis, beyond adherence, timeliness matters.

Tan VSR, Phua J, Lim TK.

J Thorac Dis. 2017 Sep;9(9):2808-2811. doi: 10.21037/jtd.2017.08.65. No abstract available.


Clinical Features and Outcomes of Bilateral Decompression Surgery for Immediate Contralateral Hematoma after Craniectomy Following Acute Subdural Hematoma.

Choi YH, Lim TK, Lee SG.

Korean J Neurotrauma. 2017 Oct;13(2):108-112. doi: 10.13004/kjnt.2017.13.2.108. Epub 2017 Oct 31.


Metabolomic prediction of treatment outcome in pancreatic ductal adenocarcinoma patients receiving gemcitabine.

Phua LC, Goh S, Tai DWM, Leow WQ, Alkaff SMF, Chan CY, Kam JH, Lim TKH, Chan ECY.

Cancer Chemother Pharmacol. 2018 Feb;81(2):277-289. doi: 10.1007/s00280-017-3475-6. Epub 2017 Dec 1.


Prolyl isomerization of the CENP-A N-terminus regulates centromeric integrity in fission yeast.

Tan HL, Lim KK, Yang Q, Fan JS, Sayed AMM, Low LS, Ren B, Lim TK, Lin Q, Mok YK, Liou YC, Chen ES.

Nucleic Acids Res. 2018 Feb 16;46(3):1167-1179. doi: 10.1093/nar/gkx1180.


Age and ejection fraction modify the impact of atrial fibrillation on acute heart failure outcomes.

Go YY, Sugimoto T, Bulluck H, Acharyya S, Allen JC, Chia SY, Jaufeerally FR, Sim D, Lim TK, Liew R, Lam CSP.

Eur J Heart Fail. 2018 Apr;20(4):821-822. doi: 10.1002/ejhf.1075. Epub 2017 Nov 16. No abstract available.


Dexmedetomidine-associated hyperthermia: a retrospective cohort study of intensive care unit admissions between 2009 and 2016.

Grayson K, Tobin AE, Lim TK, Reid DE, Ghani M.

Anaesth Intensive Care. 2017 Nov;45(6):727-736.


The APEX trial: Effects of allopurinol on exercise capacity, coronary and peripheral endothelial function, and natriuretic peptides in patients with cardiac syndrome X.

Lim TK, Noman A, Choy AMJ, Khan F, Struthers AD, Lang CC.

Cardiovasc Ther. 2018 Feb;36(1). doi: 10.1111/1755-5922.12311. Epub 2017 Nov 26.


Expanded molecular interrogation for potential actionable targets in non-squamous non-small cell lung cancer.

Lau KW, Seng C, Lim TKH, Tan DSW.

Ann Transl Med. 2017 Sep;5(18):372. doi: 10.21037/atm.2017.08.42. Review.


Comparison between the patients with surgery and without surgery after recommendation of surgical repair for symptomatic rotator cuff tear.

Yoo JC, Lim TK, Kim DH, Koh KH.

J Orthop Sci. 2018 Jan;23(1):64-69. doi: 10.1016/j.jos.2017.09.018. Epub 2017 Oct 8.


Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma.

Tan DSW, Chong FT, Leong HS, Toh SY, Lau DP, Kwang XL, Zhang X, Sundaram GM, Tan GS, Chang MM, Chua BT, Lim WT, Tan EH, Ang MK, Lim TKH, Sampath P, Chowbay B, Skanderup AJ, DasGupta R, Iyer NG.

Nat Med. 2017 Oct;23(10):1167-1175. doi: 10.1038/nm.4401. Epub 2017 Sep 18.


Andrographolide Suppresses MV4-11 Cell Proliferation through the Inhibition of FLT3 Signaling, Fatty Acid Synthesis and Cellular Iron Uptake.

Chen X, Zhang J, Yuan L, Lay Y, Wong YK, Lim TK, Ong CS, Lin Q, Wang J, Hua Z.

Molecules. 2017 Aug 31;22(9). pii: E1444. doi: 10.3390/molecules22091444.


Artesunate Activates the Intrinsic Apoptosis of HCT116 Cells through the Suppression of Fatty Acid Synthesis and the NF-κB Pathway.

Chen X, Wong YK, Lim TK, Lim WH, Lin Q, Wang J, Hua Z.

Molecules. 2017 Aug 8;22(8). pii: E1272. doi: 10.3390/molecules22081272.


Mechanistic Investigation of the Specific Anticancer Property of Artemisinin and Its Combination with Aminolevulinic Acid for Enhanced Anticolorectal Cancer Activity.

Wang J, Zhang J, Shi Y, Xu C, Zhang C, Wong YK, Lee YM, Krishna S, He Y, Lim TK, Sim W, Hua ZC, Shen HM, Lin Q.

ACS Cent Sci. 2017 Jul 26;3(7):743-750. doi: 10.1021/acscentsci.7b00156. Epub 2017 Jun 28.


Pneumonia in the tropics.

Lim TK, Siow WT.

Respirology. 2018 Jan;23(1):28-35. doi: 10.1111/resp.13137. Epub 2017 Aug 1. Review.


Shooting for the bull's eye in septic shock.

See KC, Lim TK.

J Thorac Dis. 2017 Jun;9(6):1463-1465. doi: 10.21037/jtd.2017.05.38. No abstract available.


Evidence for a Role of Nerve Injury in Painful Intervertebral Disc Degeneration: A Cross-Sectional Proteomic Analysis of Human Cerebrospinal Fluid.

Lim TKY, Anderson KM, Hari P, Di Falco M, Reihsen TE, Wilcox GL, Belani KG, LaBoissiere S, Pinto MR, Beebe DS, Kehl LJ, Stone LS.

J Pain. 2017 Oct;18(10):1253-1269. doi: 10.1016/j.jpain.2017.06.002. Epub 2017 Jun 24.


A formalin-fixed paraffin-embedded (FFPE)-based prognostic signature to predict metastasis in clinically low risk stage I/II microsatellite stable colorectal cancer.

Low YS, Blöcker C, McPherson JR, Tang SA, Cheng YY, Wong JYS, Chua C, Lim TKH, Tang CL, Chew MH, Tan P, Tan IB, Rozen SG, Cheah PY.

Cancer Lett. 2017 Sep 10;403:13-20. doi: 10.1016/j.canlet.2017.05.031. Epub 2017 Jun 15.


Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2.

McGovern N, Shin A, Low G, Low D, Duan K, Yao LJ, Msallam R, Low I, Shadan NB, Sumatoh HR, Soon E, Lum J, Mok E, Hubert S, See P, Kunxiang EH, Lee YH, Janela B, Choolani M, Mattar CNZ, Fan Y, Lim TKH, Chan DKH, Tan KK, Tam JKC, Schuster C, Elbe-Bürger A, Wang XN, Bigley V, Collin M, Haniffa M, Schlitzer A, Poidinger M, Albani S, Larbi A, Newell EW, Chan JKY, Ginhoux F.

Nature. 2017 Jun 29;546(7660):662-666. doi: 10.1038/nature22795. Epub 2017 Jun 14.


Role of fluorescence in situ hybridization in diagnosing cholangiocarcinoma in indeterminate biliary strictures.

Liew ZH, Loh TJ, Lim TKH, Lim TH, Khor CJL, Mesenas SJ, Kong CSC, Ong WC, Tan DMY.

J Gastroenterol Hepatol. 2018 Jan;33(1):315-319. doi: 10.1111/jgh.13824.


Is a short arm cast appropriate for stable distal radius fractures in patients older than 55 years? A randomized prospective multicentre study.

Park MJ, Kim JP, Lee HI, Lim TK, Jung HS, Lee JS.

J Hand Surg Eur Vol. 2017 Jun;42(5):487-492. doi: 10.1177/1753193417690464. Epub 2017 Mar 1.


Quantitative proteome profiles help reveal efficient xylose utilization mechanisms in solventogenic Clostridium sp. strain BOH3.

Basu A, Xin F, Lim TK, Lin Q, Yang KL, He J.

Biotechnol Bioeng. 2017 Sep;114(9):1959-1969. doi: 10.1002/bit.26332. Epub 2017 May 25.


Genomic and proteomic characterization of ARID1A chromatin remodeller in ampullary tumors.

Nastase A, Teo JY, Heng HL, Ng CC, Myint SS, Rajasegaran V, Loh JL, Lee SY, Ooi LL, Chung AY, Chow PK, Cheow PC, Wan WK, Azhar R, Khoo A, Xiu SX, Alkaff SM, Cutcutache I, Lim JQ, Ong CK, Herlea V, Dima S, Duda DG, Teh BT, Popescu I, Lim TK.

Am J Cancer Res. 2017 Mar 1;7(3):484-502. eCollection 2017.


Year in review 2016: Chronic obstructive pulmonary disease and asthma.

Lim TK, Ko FW, Benton MJ, Berge MV, Mak J.

Respirology. 2017 May;22(4):820-828. doi: 10.1111/resp.13037. Epub 2017 Mar 28. Review. No abstract available.


Colony fingerprint for discrimination of microbial species based on lensless imaging of microcolonies.

Maeda Y, Dobashi H, Sugiyama Y, Saeki T, Lim TK, Harada M, Matsunaga T, Yoshino T, Tanaka T.

PLoS One. 2017 Apr 3;12(4):e0174723. doi: 10.1371/journal.pone.0174723. eCollection 2017.

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