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Items: 1 to 50 of 183

1.

NS5 from Dengue virus serotype 2 can adopt a conformation analogous to its ZIKV and JEV homologues.

El Sahili A, Soh TS, Schiltz J, Gharbi-Ayachi A, Seh CC, Shi PY, Lim SP, Lescar J.

J Virol. 2019 Oct 9. pii: JVI.01294-19. doi: 10.1128/JVI.01294-19. [Epub ahead of print]

PMID:
31597763
2.

Development and validation of a real-time multiplex PCR assay for the detection of dermatophytes and Fusarium spp.

Koo SH, Teoh YL, Koh WL, Ochi H, Tan SK, Sim DMF, Jiang B, Tan AL, Tan TY, Lim SPR.

J Med Microbiol. 2019 Sep 17. doi: 10.1099/jmm.0.001082. [Epub ahead of print]

PMID:
31526456
3.

Dengue drug discovery: Progress, challenges and outlook.

Lim SP.

Antiviral Res. 2019 Mar;163:156-178. doi: 10.1016/j.antiviral.2018.12.016. Epub 2018 Dec 29. Review.

PMID:
30597183
4.

Purification of the Recombinant Green Fluorescent Protein Using Aqueous Two-Phase System Composed of Recyclable CO2-Based Alkyl Carbamate Ionic Liquid.

Song CP, Liew PE, Teh Z, Lim SP, Show PL, Ooi CW.

Front Chem. 2018 Oct 31;6:529. doi: 10.3389/fchem.2018.00529. eCollection 2018.

5.

Sleeve Gastrectomy and Roux-En-Y Gastric Bypass Lead to Comparable Changes in Body Composition in a Multiethnic Asian Population.

Kim G, Tan CS, Tan KW, Lim SPY, So JBY, Shabbir A.

J Gastrointest Surg. 2019 Mar;23(3):445-450. doi: 10.1007/s11605-018-3920-9. Epub 2018 Sep 5.

PMID:
30187324
6.

Discovery of Potent Non-nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from Fragment Screening and Structure-Guided Design.

Lim SP, Noble CG, Nilar S, Shi PY, Yokokawa F.

Adv Exp Med Biol. 2018;1062:187-198. doi: 10.1007/978-981-10-8727-1_14. Review.

PMID:
29845534
7.

The Dengue Virus Replication Complex: From RNA Replication to Protein-Protein Interactions to Evasion of Innate Immunity.

Lescar J, Soh S, Lee LT, Vasudevan SG, Kang C, Lim SP.

Adv Exp Med Biol. 2018;1062:115-129. doi: 10.1007/978-981-10-8727-1_9. Review.

PMID:
29845529
8.

Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase.

Wang G, Lim SP, Chen YL, Hunziker J, Rao R, Gu F, Seh CC, Ghafar NA, Xu H, Chan K, Lin X, Saunders OL, Fenaux M, Zhong W, Shi PY, Yokokawa F.

Bioorg Med Chem Lett. 2018 Jul 15;28(13):2324-2327. doi: 10.1016/j.bmcl.2018.04.069. Epub 2018 May 3.

PMID:
29801997
9.

miR-181c-BRK1 axis plays a key role in actin cytoskeleton-dependent T cell function.

Lim SP, Ioannou N, Ramsay AG, Darling D, Gäken J, Mufti GJ.

J Leukoc Biol. 2018 May;103(5):855-866. doi: 10.1002/JLB.1A0817-325RR. Epub 2018 Apr 14.

PMID:
29656550
10.

Salivary cariogenic bacteria counts are associated with obesity in student women at a Malaysian university.

Yeo WZ, Lim SP, Say YH.

Asia Pac J Clin Nutr. 2018;27(1):99-106. doi: 10.6133/apjcn.032017.14.

11.

Gold-silver@TiO2 nanocomposite-modified plasmonic photoanodes for higher efficiency dye-sensitized solar cells.

Lim SP, Lim YS, Pandikumar A, Lim HN, Ng YH, Ramaraj R, Bien DC, Abou-Zied OK, Huang NM.

Phys Chem Chem Phys. 2017 Jan 4;19(2):1395-1407. doi: 10.1039/c6cp05950c.

PMID:
27976767
12.

How adults with cardiac conditions in Singapore understand the Patient Activation Measure (PAM-13) items: a cognitive interviewing study.

Ngooi BX, Packer TL, Warner G, Kephart G, Koh KWL, Wong RCC, Lim SP.

Disabil Rehabil. 2018 Mar;40(5):587-596. doi: 10.1080/09638288.2016.1261413. Epub 2016 Dec 15.

PMID:
27973921
13.

Validation of the Patient Activation Measure (PAM-13) among adults with cardiac conditions in Singapore.

Ngooi BX, Packer TL, Kephart G, Warner G, Koh KW, Wong RC, Lim SP.

Qual Life Res. 2017 Apr;26(4):1071-1080. doi: 10.1007/s11136-016-1412-5. Epub 2016 Sep 19.

PMID:
27645458
14.

Antiviral Nucleotide Incorporation by Recombinant Human Mitochondrial RNA Polymerase Is Predictive of Increased In Vivo Mitochondrial Toxicity Risk.

Fenaux M, Lin X, Yokokawa F, Sweeney Z, Saunders O, Xie L, Lim SP, Uteng M, Uehara K, Warne R, Gang W, Jones C, Yendluri S, Gu H, Mansfield K, Boisclair J, Heimbach T, Catoire A, Bracken K, Weaver M, Moser H, Zhong W.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7077-7085. Print 2016 Dec.

15.

Long-Term Follow-Up of Outcomes With F-18-Fluorodeoxyglucose Positron Emission Tomography Imaging-Assisted Management of Patients With Severe Left Ventricular Dysfunction Secondary to Coronary Disease.

Mc Ardle B, Shukla T, Nichol G, deKemp RA, Bernick J, Guo A, Lim SP, Davies RA, Haddad H, Duchesne L, Hendry P, Masters R, Ross H, Freeman M, Gulenchyn K, Racine N, Humen D, Benard F, Ruddy TD, Chow BJ, Mielniczuk L, DaSilva JN, Garrard L, Wells GA, Beanlands RS; PARR-2 Investigators.

Circ Cardiovasc Imaging. 2016 Sep;9(9). pii: e004331. doi: 10.1161/CIRCIMAGING.115.004331.

PMID:
27609816
16.

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling.

Lim SP, Noble CG, Seh CC, Soh TS, El Sahili A, Chan GK, Lescar J, Arora R, Benson T, Nilar S, Manjunatha U, Wan KF, Dong H, Xie X, Shi PY, Yokokawa F.

PLoS Pathog. 2016 Aug 8;12(8):e1005737. doi: 10.1371/journal.ppat.1005737. eCollection 2016 Aug.

17.

A rare case of occupational contact urticaria syndrome caused by meranti wood dust.

Koh WL, Ang CC, Lim SP.

Contact Dermatitis. 2016 Jul;75(1):56-8. doi: 10.1111/cod.12558. No abstract available.

PMID:
27264292
18.

Imaging of cardiac sarcoidosis.

Erthal F, Juneau D, Lim SP, Dwivedi G, Nery PB, Birnie D, Beanlands RS.

Q J Nucl Med Mol Imaging. 2016 Sep;60(3):252-63. Epub 2016 May 26. Review.

19.

Outcomes of the Tower Crane Technique with a 15-mm Trocar in Primary Spontaneous Pneumothorax.

Chong Y, Cho HJ, Kang SK, Na MH, Yu JH, Lim SP, Kang MW.

Korean J Thorac Cardiovasc Surg. 2016 Apr;49(2):80-4. doi: 10.5090/kjtcs.2016.49.2.80. Epub 2016 Apr 5.

20.

Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design.

Yokokawa F, Nilar S, Noble CG, Lim SP, Rao R, Tania S, Wang G, Lee G, Hunziker J, Karuna R, Manjunatha U, Shi PY, Smith PW.

J Med Chem. 2016 Apr 28;59(8):3935-52. doi: 10.1021/acs.jmedchem.6b00143. Epub 2016 Apr 8.

PMID:
26984786
21.

Tramadol-induced peripheral oedema.

Yeo PM, Koh WL, Lim SP.

Clin Exp Dermatol. 2016 Jul;41(5):557-8. doi: 10.1111/ced.12822. Epub 2016 Mar 1. No abstract available.

PMID:
26932660
22.

A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening.

Noble CG, Lim SP, Arora R, Yokokawa F, Nilar S, Seh CC, Wright SK, Benson TE, Smith PW, Shi PY.

J Biol Chem. 2016 Apr 15;291(16):8541-8. doi: 10.1074/jbc.M115.710731. Epub 2016 Feb 12.

23.

Metagenomics study of endophytic bacteria in Aloe vera using next-generation technology.

Akinsanya MA, Goh JK, Lim SP, Ting AS.

Genom Data. 2015 Sep 10;6:159-63. doi: 10.1016/j.gdata.2015.09.004. eCollection 2015 Dec.

24.

Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5).

Zhao Y, Soh TS, Lim SP, Chung KY, Swaminathan K, Vasudevan SG, Shi PY, Lescar J, Luo D.

Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14834-9. doi: 10.1073/pnas.1514978112. Epub 2015 Nov 17.

25.

Diversity, antimicrobial and antioxidant activities of culturable bacterial endophyte communities in Aloe vera.

Akinsanya MA, Goh JK, Lim SP, Ting AS.

FEMS Microbiol Lett. 2015 Dec;362(23):fnv184. doi: 10.1093/femsle/fnv184. Epub 2015 Oct 9.

PMID:
26454221
26.

Dramatic hyperpigmentation of keloids after intralesional triamcinolone acetonide injection.

Koh WL, Lim SP.

Dermatol Online J. 2015 May 18;21(5). pii: 13030/qt4dg9h1qr. No abstract available.

PMID:
26295862
27.

Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication.

Zhao Y, Soh TS, Chan KW, Fung SS, Swaminathan K, Lim SP, Shi PY, Huber T, Lescar J, Luo D, Vasudevan SG.

J Virol. 2015 Oct;89(20):10717-21. doi: 10.1128/JVI.01239-15. Epub 2015 Aug 12.

28.

Boosting Photovoltaic Performance of Dye-Sensitized Solar Cells Using Silver Nanoparticle-Decorated N,S-Co-Doped-TiO2 Photoanode.

Lim SP, Pandikumar A, Lim HN, Ramaraj R, Huang NM.

Sci Rep. 2015 Jul 6;5:11922. doi: 10.1038/srep11922.

29.

The dengue virus NS5 protein as a target for drug discovery.

Lim SP, Noble CG, Shi PY.

Antiviral Res. 2015 Jul;119:57-67. doi: 10.1016/j.antiviral.2015.04.010. Epub 2015 Apr 24. Review.

PMID:
25912817
30.

Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening.

Niyomrattanakit P, Wan KF, Chung KY, Abas SN, Seh CC, Dong H, Lim CC, Chao AT, Lee CB, Nilar S, Lescar J, Shi PY, Beer D, Lim SP.

Antiviral Res. 2015 Jul;119:36-46. doi: 10.1016/j.antiviral.2015.04.007. Epub 2015 Apr 18.

PMID:
25896272
31.

Investigation of the relationship between facial injuries and traumatic brain injuries using a realistic subject-specific finite element head model.

Tse KM, Tan LB, Lee SJ, Lim SP, Lee HP.

Accid Anal Prev. 2015 Jun;79:13-32. doi: 10.1016/j.aap.2015.03.012. Epub 2015 Mar 17.

PMID:
25795050
32.

A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication.

Zhao Y, Soh TS, Zheng J, Chan KW, Phoo WW, Lee CC, Tay MY, Swaminathan K, Cornvik TC, Lim SP, Shi PY, Lescar J, Vasudevan SG, Luo D.

PLoS Pathog. 2015 Mar 16;11(3):e1004682. doi: 10.1371/journal.ppat.1004682. eCollection 2015 Mar.

33.

Obesity and the challenges of noninvasive imaging for the detection of coronary artery disease.

Lim SP, Arasaratnam P, Chow BJ, Beanlands RS, Hessian RC.

Can J Cardiol. 2015 Feb;31(2):223-6. doi: 10.1016/j.cjca.2014.12.003. Epub 2014 Dec 9. Review.

PMID:
25661558
34.

Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign.

Smith TM, Lim SP, Yue K, Busby SA, Arora R, Seh CC, Wright SK, Nutiu R, Niyomrattanakit P, Wan KF, Beer D, Shi PY, Benson TE.

J Biomol Screen. 2015 Jan;20(1):153-63. doi: 10.1177/1087057114551141. Epub 2014 Sep 24.

PMID:
25252731
35.

Myocardial viability: it is still alive.

Lim SP, Mc Ardle BA, Beanlands RS, Hessian RC.

Semin Nucl Med. 2014 Sep;44(5):358-74. doi: 10.1053/j.semnuclmed.2014.07.003. Review.

PMID:
25234080
36.

Aortic periannular abscess invading into the central fibrous body, mitral valve, and tricuspid valve.

Oh HK, Kim NY, Kang MW, Kang SK, Yu JH, Lim SP, Choi JS, Na MH.

Korean J Thorac Cardiovasc Surg. 2014 Jun;47(3):283-6. doi: 10.5090/kjtcs.2014.47.3.283. Epub 2014 Jun 5.

38.

Pemphigoid nodularis mimicking nodular prurigo in an immune-suppressed patient with rheumatoid arthritis.

Kwong HL, Lim SP.

Acta Derm Venereol. 2015 Feb;95(2):237-8. doi: 10.2340/00015555-1904. No abstract available.

39.

Cube Kohonen self-organizing map (CKSOM) model with new equations in organizing unstructured data.

Lim SP, Haron H.

IEEE Trans Neural Netw Learn Syst. 2013 Sep;24(9):1414-24. doi: 10.1109/TNNLS.2013.2259259.

PMID:
24808578
40.

Development and validation of two subject-specific finite element models of human head against three cadaveric experiments.

Tse KM, Tan LB, Lee SJ, Lim SP, Lee HP.

Int J Numer Method Biomed Eng. 2014 Mar;30(3):397-415. doi: 10.1002/cnm.2609. Epub 2013 Nov 5.

PMID:
24574171
41.

Polymerases of hepatitis C viruses and flaviviruses: structural and mechanistic insights and drug development.

Caillet-Saguy C, Lim SP, Shi PY, Lescar J, Bressanelli S.

Antiviral Res. 2014 May;105:8-16. doi: 10.1016/j.antiviral.2014.02.006. Epub 2014 Feb 19. Review.

PMID:
24561230
42.

Flavivirus RNA methylation.

Dong H, Fink K, Züst R, Lim SP, Qin CF, Shi PY.

J Gen Virol. 2014 Apr;95(Pt 4):763-78. doi: 10.1099/vir.0.062208-0. Epub 2014 Jan 31. Review.

PMID:
24486628
43.

Autopsy-proven Acute Hemorrhagic Leukoencephalitis in an Elderly Patient.

dos Santos MP, Martin J, Woulfe J, Lim SP, Chakraborty S.

Can J Neurol Sci. 2014 Jan;41(1):99-102. No abstract available.

PMID:
24384347
44.

Nafamostat mesilate: can it be used as a conduit preserving agent in coronary artery bypass surgery?

Yoon YS, Oh H, Kim Y, Lim SP, Kim CS, Kang MW.

Korean J Thorac Cardiovasc Surg. 2013 Dec;46(6):413-25. doi: 10.5090/kjtcs.2013.46.6.413. Epub 2013 Dec 6.

45.

Conventional and complex modal analyses of a finite element model of human head and neck.

Tse KM, Tan LB, Lim SP, Lee HP.

Comput Methods Biomech Biomed Engin. 2015 Jul;18(9):961-973. Epub 2013 Dec 13.

PMID:
24328395
46.

West Nile virus drug discovery.

Lim SP, Shi PY.

Viruses. 2013 Dec 3;5(12):2977-3006. doi: 10.3390/v5122977. Review.

47.

Activation of peripheral blood mononuclear cells by dengue virus infection depotentiates balapiravir.

Chen YL, Abdul Ghafar N, Karuna R, Fu Y, Lim SP, Schul W, Gu F, Herve M, Yokohama F, Wang G, Cerny D, Fink K, Blasco F, Shi PY.

J Virol. 2014 Feb;88(3):1740-7. doi: 10.1128/JVI.02841-13. Epub 2013 Nov 20.

48.

Ten years of dengue drug discovery: progress and prospects.

Lim SP, Wang QY, Noble CG, Chen YL, Dong H, Zou B, Yokokawa F, Nilar S, Smith P, Beer D, Lescar J, Shi PY.

Antiviral Res. 2013 Nov;100(2):500-19. doi: 10.1016/j.antiviral.2013.09.013. Epub 2013 Sep 27. Review.

PMID:
24076358
49.

A crystal structure of the dengue virus non-structural protein 5 (NS5) polymerase delineates interdomain amino acid residues that enhance its thermostability and de novo initiation activities.

Lim SP, Koh JH, Seh CC, Liew CW, Davidson AD, Chua LS, Chandrasekaran R, Cornvik TC, Shi PY, Lescar J.

J Biol Chem. 2013 Oct 25;288(43):31105-14. doi: 10.1074/jbc.M113.508606. Epub 2013 Sep 11.

50.

Comparative studies of perceived vibration strength for commercial mobile phones.

Lee HP, Lim SP.

Appl Ergon. 2014 May;45(3):807-10. doi: 10.1016/j.apergo.2013.07.006. Epub 2013 Jul 25.

PMID:
23891505

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