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Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity.

Sim JPL, Ziyin W, Basil AH, Lin S, Chen Z, Zhang C, Zeng L, Cai Y, Lim KL.

Neuromolecular Med. 2019 Oct 29. doi: 10.1007/s12017-019-08577-z. [Epub ahead of print]


Physiological and pathological roles of LRRK2 in the nuclear envelope integrity.

Shani V, Safory H, Szargel R, Wang N, Cohen T, Elghani FA, Hamza H, Savyon M, Radzishevsky I, Shaulov L, Rott R, Lim KL, Ross CA, Bandopadhyay R, Zhang H, Engelender S.

Hum Mol Genet. 2019 Oct 18. pii: ddz245. doi: 10.1093/hmg/ddz245. [Epub ahead of print]


Apoptosis and metastasis inhibitory potential of pineapple vinegar against mouse mammary gland cells in vitro and in vivo.

Mohamad NE, Abu N, Yeap SK, Lim KL, Romli MF, Sharifuddin SA, Long K, Alitheen NB.

Nutr Metab (Lond). 2019 Jul 26;16:49. doi: 10.1186/s12986-019-0380-5. eCollection 2019.


Visualization of Intra-neuronal Motor Protein Transport through Upconversion Microscopy.

Zeng X, Chen S, Weitemier A, Han S, Blasiak A, Prasad A, Zheng K, Yi Z, Luo B, Yang IH, Thakor N, Chai C, Lim KL, McHugh TJ, All AH, Liu X.

Angew Chem Int Ed Engl. 2019 Jul 1;58(27):9262-9268. doi: 10.1002/anie.201904208. Epub 2019 May 28. Review.


Mitochondria-Targeted Two-Photon Fluorescent Photosensitizers for Cancer Cell Apoptosis via Spatial Selectability.

Ni Y, Zhang H, Chai C, Peng B, Zhao A, Zhang J, Li L, Zhang C, Ma B, Bai H, Lim KL, Huang W.

Adv Healthc Mater. 2019 Jul;8(14):e1900212. doi: 10.1002/adhm.201900212. Epub 2019 May 13.


In vitro and in vivo antitumour effects of coconut water vinegar on 4T1 breast cancer cells.

Mohamad NE, Yeap SK, Abu N, Lim KL, Zamberi NR, Nordin N, Sharifuddin SA, Long K, Alitheen NB.

Food Nutr Res. 2019 Jan 10;63. doi: 10.29219/fnr.v63.1616. eCollection 2019.


Structure-Based Specific Detection and Inhibition of Monoamine Oxidases and Their Applications in Central Nervous System Diseases.

Shi R, Wu Q, Xin C, Yu H, Lim KL, Li X, Shi Z, Zhang CW, Qian L, Li L, Huang W.

Chembiochem. 2019 Jun 14;20(12):1487-1497. doi: 10.1002/cbic.201800813. Epub 2019 Apr 8. Review.


AMP Kinase Activation is Selectively Disrupted in the Ventral Midbrain of Mice Deficient in Parkin or PINK1 Expression.

Hang L, Thundyil J, Goh GWY, Lim KL.

Neuromolecular Med. 2019 Mar;21(1):25-32. doi: 10.1007/s12017-018-8517-7. Epub 2018 Nov 8.


Vascular Bed Molecular Profiling by Differential Systemic Decellularization In Vivo.

Serra A, Gallart-Palau X, Park JE, Lim GGY, Lim KL, Ho HH, Tam JP, Sze SK.

Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):2396-2409. doi: 10.1161/ATVBAHA.118.311552.


Polydopamine Dots-Based Fluorescent Nanoswitch Assay for Reversible Recognition of Glutamic Acid and Al3+ in Human Serum and Living Cell.

Ci Q, Liu J, Qin X, Han L, Li H, Yu H, Lim KL, Zhang CW, Li L, Huang W.

ACS Appl Mater Interfaces. 2018 Oct 24;10(42):35760-35769. doi: 10.1021/acsami.8b12087. Epub 2018 Oct 11.


The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson's Disease.

Weng M, Xie X, Liu C, Lim KL, Zhang CW, Li L.

Parkinsons Dis. 2018 Sep 2;2018:9163040. doi: 10.1155/2018/9163040. eCollection 2018. Review.


Natural Molecules From Chinese Herbs Protecting Against Parkinson's Disease via Anti-oxidative Stress.

Ding Y, Xin C, Zhang CW, Lim KL, Zhang H, Fu Z, Li L, Huang W.

Front Aging Neurosci. 2018 Aug 28;10:246. doi: 10.3389/fnagi.2018.00246. eCollection 2018.


S-Nitrosylation of Divalent Metal Transporter 1 Enhances Iron Uptake to Mediate Loss of Dopaminergic Neurons and Motoric Deficit.

Liu C, Zhang CW, Lo SQ, Ang ST, Chew KCM, Yu D, Chai BH, Tan B, Tsang F, Tai YK, Tan BWQ, Liang MC, Tan HT, Tang JY, Lai MKP, Chua JJE, Chung MCM, Khanna S, Lim KL, Soong TW.

J Neurosci. 2018 Sep 26;38(39):8364-8377. doi: 10.1523/JNEUROSCI.3262-17.2018. Epub 2018 Aug 13.


Author Correction: PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy.

Wang L, Cho YL, Tang Y, Wang J, Park JE, Wu Y, Wang C, Tong Y, Chawla R, Zhang J, Shi Y, Deng S, Lu G, Wu Y, Tan HW, Pawijit P, Lim GG, Chan HY, Zhang J, Fang L, Yu H, Liou YC, Karthik M, Bay BH, Lim KL, Sze SK, Yap CT, Shen HM.

Cell Res. 2018 Aug;28(8):872-873. doi: 10.1038/s41422-018-0068-9.


Correction: Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria.

Xiao B, Deng X, Lim GG, Xie S, Zhou ZD, Lim KL, Tan EK.

Cell Death Dis. 2018 Jul 19;9(8):794. doi: 10.1038/s41419-018-0832-2.


Coconut water vinegar ameliorates recovery of acetaminophen induced liver damage in mice.

Mohamad NE, Yeap SK, Beh BK, Ky H, Lim KL, Ho WY, Sharifuddin SA, Long K, Alitheen NB.

BMC Complement Altern Med. 2018 Jun 25;18(1):195. doi: 10.1186/s12906-018-2199-4.


Sequential Application of Discrete Topographical Patterns Enhances Derivation of Functional Mesencephalic Dopaminergic Neurons from Human Induced Pluripotent Stem Cells.

Tan KKB, Lim WWM, Chai C, Kukumberg M, Lim KL, Goh ELK, Yim EKF.

Sci Rep. 2018 Jun 22;8(1):9567. doi: 10.1038/s41598-018-27653-1.


PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy.

Wang L, Cho YL, Tang Y, Wang J, Park JE, Wu Y, Wang C, Tong Y, Chawla R, Zhang J, Shi Y, Deng S, Lu G, Wu Y, Tan HW, Pawijit P, Lim GG, Chan HY, Zhang J, Fang L, Yu H, Liou YC, Karthik M, Bay BH, Lim KL, Sze SK, Yap CT, Shen HM.

Cell Res. 2018 Aug;28(8):787-802. doi: 10.1038/s41422-018-0056-0. Epub 2018 Jun 22. Erratum in: Cell Res. 2018 Jul 23;:.


Importance of Proactive Malaria Case Surveillance and Management in Malaysia.

Liew JWK, Mahpot RB, Dzul S, Abdul Razak HAB, Ahmad Shah Azizi NAB, Kamarudin MB, Russell B, Lim KL, de Silva JR, Lim BS, Jelip J, Mudin RNB, Lau YL.

Am J Trop Med Hyg. 2018 Jun;98(6):1709-1713. doi: 10.4269/ajtmh.17-1010.


Improved Bioavailability of Levodopa Using Floatable Spray-Coated Microcapsules for the Management of Parkinson's Disease.

Baek JS, Tee JK, Pang YY, Tan EY, Lim KL, Ho HK, Loo SCJ.

Neuromolecular Med. 2018 Jun;20(2):262-270. doi: 10.1007/s12017-018-8491-0. Epub 2018 Apr 25.


Discovery of indolylpiperazinylpyrimidines with dual-target profiles at adenosine A2A and dopamine D2 receptors for Parkinson's disease treatment.

Shao YM, Ma X, Paira P, Tan A, Herr DR, Lim KL, Ng CH, Venkatesan G, Klotz KN, Federico S, Spalluto G, Cheong SL, Chen YZ, Pastorin G.

PLoS One. 2018 Jan 5;13(1):e0188212. doi: 10.1371/journal.pone.0188212. eCollection 2018.


APP upregulation contributes to retinal ganglion cell degeneration via JNK3.

Liu C, Zhang CW, Zhou Y, Wong WQ, Lee LC, Ong WY, Yoon SO, Hong W, Fu XY, Soong TW, Koo EH, Stanton LW, Lim KL, Xiao ZC, Dawe GS.

Cell Death Differ. 2018 Mar;25(4):663-678. doi: 10.1038/s41418-017-0005-3. Epub 2017 Dec 13.


Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria.

Xiao B, Deng X, Lim GGY, Xie S, Zhou ZD, Lim KL, Tan EK.

Cell Death Dis. 2017 Oct 12;8(10):e3097. doi: 10.1038/cddis.2017.463. Erratum in: Cell Death Dis. 2018 Jul 19;9(8):794.


Mitochondrial homeostasis in Parkinson's disease - a triumvirate rule?

Ng CH, Hang L, Lim KL.

Neural Regen Res. 2017 Aug;12(8):1270-1272. doi: 10.4103/1673-5374.213546. No abstract available.


Synthesis and characterization of modified κ-carrageenan for enhanced proton conductivity as polymer electrolyte membrane.

Liew JWY, Loh KS, Ahmad A, Lim KL, Wan Daud WR.

PLoS One. 2017 Sep 28;12(9):e0185313. doi: 10.1371/journal.pone.0185313. eCollection 2017.


AF-6 Protects Against Dopaminergic Dysfunction and Mitochondrial Abnormalities in Drosophila Models of Parkinson's Disease.

Basil AH, Sim JPL, Lim GGY, Lin S, Chan HY, Engelender S, Lim KL.

Front Cell Neurosci. 2017 Aug 10;11:241. doi: 10.3389/fncel.2017.00241. eCollection 2017.


Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin.

Xiao B, Goh JY, Xiao L, Xian H, Lim KL, Liou YC.

J Biol Chem. 2017 Oct 6;292(40):16697-16708. doi: 10.1074/jbc.M117.787739. Epub 2017 Aug 28.


Static Magnetic Field Stimulation Enhances Oligodendrocyte Differentiation and Secretion of Neurotrophic Factors.

Prasad A, Teh DBL, Blasiak A, Chai C, Wu Y, Gharibani PM, Yang IH, Phan TT, Lim KL, Yang H, Liu X, All AH.

Sci Rep. 2017 Jul 27;7(1):6743. doi: 10.1038/s41598-017-06331-8.


Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.

Chen ZC, Zhang W, Chua LL, Chai C, Li R, Lin L, Cao Z, Angeles DC, Stanton LW, Peng JH, Zhou ZD, Lim KL, Zeng L, Tan EK.

Sci Signal. 2017 Jul 18;10(488). pii: eaam6790. doi: 10.1126/scisignal.aam6790.


Transgenic Mice Overexpressing the Divalent Metal Transporter 1 Exhibit Iron Accumulation and Enhanced Parkin Expression in the Brain.

Zhang CW, Tai YK, Chai BH, Chew KCM, Ang ET, Tsang F, Tan BWQ, Hong ETE, Asad ABA, Chuang KH, Lim KL, Soong TW.

Neuromolecular Med. 2017 Sep;19(2-3):375-386. doi: 10.1007/s12017-017-8451-0. Epub 2017 Jul 10.


Parkin-independent mitophagy-FKBP8 takes the stage.

Lim GG, Lim KL.

EMBO Rep. 2017 Jun;18(6):864-865. doi: 10.15252/embr.201744313. Epub 2017 May 17.


p62-Mediated mitochondrial clustering attenuates apoptosis induced by mitochondrial depolarization.

Xiao B, Deng X, Lim GGY, Zhou W, Saw WT, Zhou ZD, Lim KL, Tan EK.

Biochim Biophys Acta Mol Cell Res. 2017 Jul;1864(7):1308-1317. doi: 10.1016/j.bbamcr.2017.04.009. Epub 2017 Apr 19.


Genetic or pharmacological activation of the Drosophila PGC-1α ortholog spargel rescues the disease phenotypes of genetic models of Parkinson's disease.

Ng CH, Basil AH, Hang L, Tan R, Goh KL, O'Neill S, Zhang X, Yu F, Lim KL.

Neurobiol Aging. 2017 Jul;55:33-37. doi: 10.1016/j.neurobiolaging.2017.03.017. Epub 2017 Mar 18.


Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells.

Etti IC, Rasedee A, Hashim NM, Abdul AB, Kadir A, Yeap SK, Waziri P, Malami I, Lim KL, Etti CJ.

Drug Des Devel Ther. 2017 Mar 20;11:865-879. doi: 10.2147/DDDT.S124324. eCollection 2017.


Synthetic curcumin derivative DK1 possessed G2/M arrest and induced apoptosis through accumulation of intracellular ROS in MCF-7 breast cancer cells.

Ali NM, Yeap SK, Abu N, Lim KL, Ky H, Pauzi AZM, Ho WY, Tan SW, Alan-Ong HK, Zareen S, Alitheen NB, Akhtar MN.

Cancer Cell Int. 2017 Feb 21;17:30. doi: 10.1186/s12935-017-0400-3. eCollection 2017.


Combination of cisplatin and bromelain exerts synergistic cytotoxic effects against breast cancer cell line MDA-MB-231 in vitro.

Pauzi AZ, Yeap SK, Abu N, Lim KL, Omar AR, Aziz SA, Chow AL, Subramani T, Tan SG, Alitheen NB.

Chin Med. 2016 Nov 15;11:46. eCollection 2016.


Lipidomic Profiling of Lung Pleural Effusion Identifies Unique Metabotype for EGFR Mutants in Non-Small Cell Lung Cancer.

Ho YS, Yip LY, Basri N, Chong VS, Teo CC, Tan E, Lim KL, Tan GS, Yang X, Yeo SY, Koh MS, Devanand A, Takano A, Tan EH, Tan DS, Lim TK.

Sci Rep. 2016 Oct 14;6:35110. doi: 10.1038/srep35110.


Flavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line.

Ali NM, Akhtar MN, Ky H, Lim KL, Abu N, Zareen S, Ho WY, Alan-Ong HK, Tan SW, Alitheen NB, Ismail JB, Yeap SK, Kamarul T.

Drug Des Devel Ther. 2016 Jun 10;10:1897-907. doi: 10.2147/DDDT.S102164. eCollection 2016.


Intraparticle Energy Level Alignment of Semiconducting Polymer Nanoparticles to Amplify Chemiluminescence for Ultrasensitive In Vivo Imaging of Reactive Oxygen Species.

Zhen X, Zhang C, Xie C, Miao Q, Lim KL, Pu K.

ACS Nano. 2016 Jun 28;10(6):6400-9. doi: 10.1021/acsnano.6b02908. Epub 2016 Jun 16.


Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1.

Nucifora FC Jr, Nucifora LG, Ng CH, Arbez N, Guo Y, Roby E, Shani V, Engelender S, Wei D, Wang XF, Li T, Moore DJ, Pletnikova O, Troncoso JC, Sawa A, Dawson TM, Smith W, Lim KL, Ross CA.

Nat Commun. 2016 Jun 7;7:11792. doi: 10.1038/ncomms11792.


Two-Photon Enzymatic Probes Visualizing Sub-cellular/Deep-brain Caspase Activities in Neurodegenerative Models.

Qian L, Zhang CW, Mao Y, Li L, Gao N, Lim KL, Xu QH, Yao SQ.

Sci Rep. 2016 May 23;6:26385. doi: 10.1038/srep26385.


Drosophila expressing human SOD1 successfully recapitulates mitochondrial phenotypic features of familial amyotrophic lateral sclerosis.

Gallart-Palau X, Ng CH, Ribera J, Sze SK, Lim KL.

Neurosci Lett. 2016 Jun 15;624:47-52. doi: 10.1016/j.neulet.2016.05.006. Epub 2016 May 7.


Nutraceuticals in Parkinson's Disease.

Hang L, Basil AH, Lim KL.

Neuromolecular Med. 2016 Sep;18(3):306-21. doi: 10.1007/s12017-016-8398-6. Epub 2016 May 4. Review.


A Multi-Site Study of Norovirus Molecular Epidemiology in Australia and New Zealand, 2013-2014.

Lim KL, Hewitt J, Sitabkhan A, Eden JS, Lun J, Levy A, Merif J, Smith D, Rawlinson WD, White PA.

PLoS One. 2016 Apr 26;11(4):e0145254. doi: 10.1371/journal.pone.0145254. eCollection 2016.


Antioxidants inhibit neuronal toxicity in Parkinson's disease-linked LRRK2.

Angeles DC, Ho P, Dymock BW, Lim KL, Zhou ZD, Tan EK.

Ann Clin Transl Neurol. 2016 Mar 2;3(4):288-94. doi: 10.1002/acn3.282. eCollection 2016 Apr.


Reprogramming cancer cells: overview & current progress.

Lim KL, Teoh HK, Choong PF, Teh HX, Cheong SK, Kamarul T.

Expert Opin Biol Ther. 2016 Jul;16(7):941-51. doi: 10.1517/14712598.2016.1174211. Epub 2016 Apr 21. Review. Erratum in: Expert Opin Biol Ther. 2016 Jul;16(7):v.


Puromycin Analogues Capable of Multiplexed Imaging and Profiling of Protein Synthesis and Dynamics in Live Cells and Neurons.

Ge J, Zhang CW, Ng XW, Peng B, Pan S, Du S, Wang D, Li L, Lim KL, Wohland T, Yao SQ.

Angew Chem Int Ed Engl. 2016 Apr 11;55(16):4933-7. doi: 10.1002/anie.201511030. Epub 2016 Mar 11.


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