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Sleep fragmentation, microglial aging, and cognitive impairment in adults with and without Alzheimer's dementia.

Kaneshwaran K, Olah M, Tasaki S, Yu L, Bradshaw EM, Schneider JA, Buchman AS, Bennett DA, De Jager PL, Lim ASP.

Sci Adv. 2019 Dec 11;5(12):eaax7331. doi: 10.1126/sciadv.aax7331. eCollection 2019 Dec.


Utility of incorporating next-generation sequencing (NGS) in an Asian non-small cell lung cancer (NSCLC) population: Incremental yield of actionable alterations and cost-effectiveness analysis.

Tan AC, Lai GGY, Tan GS, Poon SY, Doble B, Lim TH, Aung ZW, Takano A, Tan WL, Ang MK, Tan BS, Devanand A, Too CW, Gogna A, Ong BH, Koh TPT, Kanesvaran R, Ng QS, Jain A, Rajasekaran T, Lim AST, Lim WT, Toh CK, Tan EH, Lim TKH, Tan DSW.

Lung Cancer. 2020 Jan;139:207-215. doi: 10.1016/j.lungcan.2019.11.022. Epub 2019 Nov 26.


Small Polar Hits against S. aureus: Screening, Initial Hit Optimization, and Metabolomic Studies.

Lim AST, Vincent IM, Barrett MP, Gilbert IH.

ACS Omega. 2019 Nov 4;4(21):19199-19215. doi: 10.1021/acsomega.9b02507. eCollection 2019 Nov 19.


More random motor activity fluctuations predict incident frailty, disability, and mortality.

Li P, Lim ASP, Gao L, Hu C, Yu L, Bennett DA, Buchman AS, Hu K.

Sci Transl Med. 2019 Oct 30;11(516). pii: eaax1977. doi: 10.1126/scitranslmed.aax1977.


Facilitators and barriers of human papillomavirus vaccine uptake in young females 18-26 years old in Singapore: A qualitative study.

Lim ASE, Lim RBT.

Vaccine. 2019 Sep 24;37(41):6030-6038. doi: 10.1016/j.vaccine.2019.08.053. Epub 2019 Aug 28.


Actigraphic measures of sleep on the wards after ICU discharge.

Wilcox ME, Rubenfeld GD, Walczak KD, Black SE, McAndrews MP, Lim AS.

J Crit Care. 2019 Dec;54:163-169. doi: 10.1016/j.jcrc.2019.08.006. Epub 2019 Aug 16.


Effects of light and temperature on the growth of Takayama helix (Dinophyceae): mixotrophy as a survival strategy against photoinhibition.

Ok JH, Jeong HJ, Lim AS, You JH, Kang HC, Kim SJ, Lee SY.

J Phycol. 2019 Oct;55(5):1181-1195. doi: 10.1111/jpy.12907. Epub 2019 Sep 9.


Taurolidine-citrate lock solution for the prevention of central line-associated bloodstream infection in paediatric haematology-oncology and gastrointestinal failure patients with high baseline central-line associated bloodstream infection rates.

Chong CY, Ong RY, Seah VX, Tan NW, Chan MY, Soh SY, Ong C, Lim AS, Thoon KC.

J Paediatr Child Health. 2020 Jan;56(1):123-129. doi: 10.1111/jpc.14506. Epub 2019 May 30.


Chromosomal microarray analysis is superior in identifying cryptic aberrations in patients with acute lymphoblastic leukemia at diagnosis/relapse as a single assay.

Chen C, Heng EYH, Lim AST, Lau LC, Lim TH, Wong GC, Tien SL.

Int J Lab Hematol. 2019 Aug;41(4):561-571. doi: 10.1111/ijlh.13052. Epub 2019 May 21.


Effects of lipids on the water sorption, glass transition and structural strength of carbohydrate-protein systems.

Maidannyk VA, Lim ASL, Auty MAE, Roos YH.

Food Res Int. 2019 Feb;116:1212-1222. doi: 10.1016/j.foodres.2018.10.008. Epub 2018 Oct 3.


Clonal MET Amplification as a Determinant of Tyrosine Kinase Inhibitor Resistance in Epidermal Growth Factor Receptor-Mutant Non-Small-Cell Lung Cancer.

Lai GGY, Lim TH, Lim J, Liew PJR, Kwang XL, Nahar R, Aung ZW, Takano A, Lee YY, Lau DPX, Tan GS, Tan SH, Tan WL, Ang MK, Toh CK, Tan BS, Devanand A, Too CW, Gogna A, Ong BH, Koh TPT, Kanesvaran R, Ng QS, Jain A, Rajasekaran T, Yuan J, Lim TKH, Lim AST, Hillmer AM, Lim WT, Iyer NG, Tam WL, Zhai W, Tan EH, Tan DSW.

J Clin Oncol. 2019 Apr 10;37(11):876-884. doi: 10.1200/JCO.18.00177. Epub 2019 Jan 24.


Gonyaulax whaseongensis sp. nov. (Gonyaulacales, Dinophyceae), a new phototrophic species from Korean coastal waters.

Lim AS, Jeong HJ, Kwon JE, Lee SY, Kim JH.

J Phycol. 2018 Dec;54(6):923-928. doi: 10.1111/jpy.12792. Epub 2018 Oct 22.


Seasonal plasticity of cognition and related biological measures in adults with and without Alzheimer disease: Analysis of multiple cohorts.

Lim ASP, Gaiteri C, Yu L, Sohail S, Swardfager W, Tasaki S, Schneider JA, Paquet C, Stuss DT, Masellis M, Black SE, Hugon J, Buchman AS, Barnes LL, Bennett DA, De Jager PL.

PLoS Med. 2018 Sep 4;15(9):e1002647. doi: 10.1371/journal.pmed.1002647. eCollection 2018 Sep.


HER2 positive rates are enriched amongst colorectal cancer brain metastases: a study amongst 1920 consecutive patients.

Tan RYC, Camat MD, Ng M, Lim TH, Lim AST, Lim KH, Tan IBH.

Ann Oncol. 2018 Jul 1;29(7):1598-1603. doi: 10.1093/annonc/mdy156. No abstract available.


A comparative study of quality of life, functional and bone outcomes in osteogenesis imperfecta with bisphosphonate therapy initiated in childhood or adulthood.

Feehan AG, Zacharin MR, Lim AS, Simm PJ.

Bone. 2018 Aug;113:137-143. doi: 10.1016/j.bone.2018.05.021. Epub 2018 May 19.


Fractal regulation and incident Alzheimer's disease in elderly individuals.

Li P, Yu L, Lim ASP, Buchman AS, Scheer FAJL, Shea SA, Schneider JA, Bennett DA, Hu K.

Alzheimers Dement. 2018 Sep;14(9):1114-1125. doi: 10.1016/j.jalz.2018.03.010. Epub 2018 May 4.


Feeding by the heterotrophic nanoflagellate Katablepharis remigera on algal prey and its nationwide distribution in Korea.

Ok JH, Jeong HJ, Lim AS, Lee SY, Kim SJ.

Harmful Algae. 2018 Apr;74:30-45. doi: 10.1016/j.hal.2018.03.011. Epub 2018 Apr 12.


Feeding by the harmful phototrophic dinoflagellate Takayama tasmanica (Family Kareniaceae).

Lim AS, Jeong HJ, Ok JH, Kim SJ.

Harmful Algae. 2018 Apr;74:19-29. doi: 10.1016/j.hal.2018.03.009. Epub 2018 Apr 6.


TFE3-Expressing Epithelioid Rich Perivascular Epithelioid Cell Neoplasm (PEComa) of the Bladder with Unusual Benign Course.

Chen XF, Yeong J, Chang KTE, Lim AST, Kuick CH, Lim TH, Sudhanshi J, Selvarajan S, Gan VHL, Khor LY.

Ann Clin Lab Sci. 2018 Jan;48(1):110-115.


Sleep on the ward in intensive care unit survivors: a case series of polysomnography.

Wilcox ME, Lim AS, Pinto R, Black SE, McAndrews MP, Rubenfeld GD.

Intern Med J. 2018 Jul;48(7):795-802. doi: 10.1111/imj.13791.


Actigraphy Detects Greater Intra-Individual Variability During Gait in Non-Manifesting LRRK2 Mutation Carriers.

van den Heuvel L, Lim AS, Visanji NP, Huang J, Ghate T, Mestre TA, AlDakheel A, Connolly BS, Gasca-Salas C, Kern DS, Jain J, Slow EJ, Pondal M, Faust-Socher A, Rogaeva E, Tomlinson G, Lang AE, Marras C.

J Parkinsons Dis. 2018;8(1):131-139. doi: 10.3233/JPD-171151.


Establishment of the nasal microbiota in the first 18 months of life: Correlation with early-onset rhinitis and wheezing.

Ta LDH, Yap GC, Tay CJX, Lim ASM, Huang CH, Chu CW, De Sessions PF, Shek LP, Goh A, Van Bever HPS, Teoh OH, Soh JY, Thomas B, Ramamurthy MB, Goh DYT, Lay C, Soh SE, Chan YH, Saw SM, Kwek K, Chong YS, Godfrey KM, Hibberd ML, Lee BW.

J Allergy Clin Immunol. 2018 Jul;142(1):86-95. doi: 10.1016/j.jaci.2018.01.032. Epub 2018 Feb 13.


Ex Vivo Expansion of CD34+ CD90+ CD49f+ Hematopoietic Stem and Progenitor Cells from Non-Enriched Umbilical Cord Blood with Azole Compounds.

Bari S, Zhong Q, Fan X, Poon Z, Lim AST, Lim TH, Dighe N, Li S, Chiu GNC, Chai CLL, Hwang WYK.

Stem Cells Transl Med. 2018 May;7(5):376-393. doi: 10.1002/sctm.17-0251. Epub 2018 Feb 2.


Sleep fragmentation and Parkinson's disease pathology in older adults without Parkinson's disease.

Sohail S, Yu L, Schneider JA, Bennett DA, Buchman AS, Lim ASP.

Mov Disord. 2017 Dec;32(12):1729-1737. doi: 10.1002/mds.27200. Epub 2017 Oct 30.


Chromosome 1q21.3 amplification is a trackable biomarker and actionable target for breast cancer recurrence.

Goh JY, Feng M, Wang W, Oguz G, Yatim SMJM, Lee PL, Bao Y, Lim TH, Wang P, Tam WL, Kodahl AR, Lyng MB, Sarma S, Lin SY, Lezhava A, Yap YS, Lim AST, Hoon DSB, Ditzel HJ, Lee SC, Tan EY, Yu Q.

Nat Med. 2017 Nov;23(11):1319-1330. doi: 10.1038/nm.4405. Epub 2017 Sep 25.


Interactions between the mixotrophic dinoflagellate Takayama helix and common heterotrophic protists.

Ok JH, Jeong HJ, Lim AS, Lee KH.

Harmful Algae. 2017 Sep;68:178-191. doi: 10.1016/j.hal.2017.08.006. Epub 2017 Aug 29.


Association Between Quantitative Gait and Balance Measures and Total Daily Physical Activity in Community-Dwelling Older Adults.

Dawe RJ, Leurgans SE, Yang J, Bennett JM, Hausdorff JM, Lim AS, Gaiteri C, Bennett DA, Buchman AS.

J Gerontol A Biol Sci Med Sci. 2018 Apr 17;73(5):636-642. doi: 10.1093/gerona/glx167.


Restless legs syndrome after high-risk TIA and minor stroke: association with reduced quality of life.

Boulos MI, Wan A, Black SE, Lim AS, Swartz RH, Murray BJ.

Sleep Med. 2017 Sep;37:135-140. doi: 10.1016/j.sleep.2017.05.020. Epub 2017 Jun 30.


Clear cell sarcomas of the kidney are characterised by BCOR gene abnormalities, including exon 15 internal tandem duplications and BCOR-CCNB3 gene fusion.

Wong MK, Ng CCY, Kuick CH, Aw SJ, Rajasegaran V, Lim JQ, Sudhanshi J, Loh E, Yin M, Ma J, Zhang Z, Iyer P, Loh AHP, Lian DWQ, Wang S, Goh SGH, Lim TH, Lim AST, Ng T, Goytain A, Loh AHL, Tan PH, Teh BT, Chang KTE.

Histopathology. 2018 Jan;72(2):320-329. doi: 10.1111/his.13366. Epub 2017 Oct 30.


Impact of a Carbapenem Antimicrobial Stewardship Program on Patient Outcomes.

Seah VXF, Ong RYL, Lim ASY, Chong CY, Tan NWH, Thoon KC.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00736-17. doi: 10.1128/AAC.00736-17. Print 2017 Sep.


A study protocol for an observational cohort investigating COGnitive outcomes and WELLness in survivors of critical illness: the COGWELL study.

Wilcox ME, Lim AS, McAndrews MP, Wennberg RA, Pinto RL, Black SE, Walczak KD, Friedrich JO, Taglione MS, Rubenfeld GD.

BMJ Open. 2017 Jul 13;7(7):e015600. doi: 10.1136/bmjopen-2016-015600.


Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma.

Jusakul A, Cutcutache I, Yong CH, Lim JQ, Huang MN, Padmanabhan N, Nellore V, Kongpetch S, Ng AWT, Ng LM, Choo SP, Myint SS, Thanan R, Nagarajan S, Lim WK, Ng CCY, Boot A, Liu M, Ong CK, Rajasegaran V, Lie S, Lim AST, Lim TH, Tan J, Loh JL, McPherson JR, Khuntikeo N, Bhudhisawasdi V, Yongvanit P, Wongkham S, Totoki Y, Nakamura H, Arai Y, Yamasaki S, Chow PK, Chung AYF, Ooi LLPJ, Lim KH, Dima S, Duda DG, Popescu I, Broet P, Hsieh SY, Yu MC, Scarpa A, Lai J, Luo DX, Carvalho AL, Vettore AL, Rhee H, Park YN, Alexandrov LB, Gordân R, Rozen SG, Shibata T, Pairojkul C, Teh BT, Tan P.

Cancer Discov. 2017 Oct;7(10):1116-1135. doi: 10.1158/2159-8290.CD-17-0368. Epub 2017 Jun 30.


Reply to: "Periodic Limb Movements During Sleep and White Matter MRI Hyperintensity in Minor Stroke or TIA".

Boulos MI, Muir RT, Gao F, Lim AS, Swartz RH, Black SE, Walters AS, Murray BJ.

Sleep. 2017 May 1;40(5). doi: 10.1093/sleep/zsx060. No abstract available.


Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer's disease.

Lim AS, Klein HU, Yu L, Chibnik LB, Ali S, Xu J, Bennett DA, De Jager PL.

Nat Commun. 2017 Apr 3;8:14931. doi: 10.1038/ncomms14931.


Validation of a smartphone-based EEG among people with epilepsy: A prospective study.

McKenzie ED, Lim AS, Leung EC, Cole AJ, Lam AD, Eloyan A, Nirola DK, Tshering L, Thibert R, Garcia RZ, Bui E, Deki S, Lee L, Clark SJ, Cohen JM, Mantia J, Brizzi KT, Sorets TR, Wahlster S, Borzello M, Stopczynski A, Cash SS, Mateen FJ.

Sci Rep. 2017 Apr 3;7:45567. doi: 10.1038/srep45567.


Improved real-time PCR method for quantification of the abundance of all known ribotypes of the ichthyotoxic dinoflagellate Cochlodinium polykrikoides by comparing 4 different preparation methods.

Lee SY, Jeong HJ, Seong KA, Lim AS, Kim JH, Lee KH, Lee MJ, Jang SH.

Harmful Algae. 2017 Mar;63:23-31. doi: 10.1016/j.hal.2017.01.006. Epub 2017 Jan 27.


Removal of two pathogenic scuticociliates Miamiensis avidus and Miamiensis sp. using cells or culture filtrates of the dinoflagellate Alexandrium andersonii.

Kim JH, Jeong HJ, Lim AS, Kwon JE, Lee KH, Park KH, Kim HS.

Harmful Algae. 2017 Mar;63:133-145. doi: 10.1016/j.hal.2017.02.002. Epub 2017 Feb 27.


Control of ichthyotoxic Cochlodinium polykrikoides using the mixotrophic dinoflagellate Alexandrium pohangense: A potential effective sustainable method.

Lim AS, Jeong HJ, Kim JH, Lee SY.

Harmful Algae. 2017 Mar;63:109-118. doi: 10.1016/j.hal.2017.02.001. Epub 2017 Feb 17.


Developing a Framework for Objective Structured Clinical Examinations Using the Nominal Group Technique.

Hussainy SY, Crum MF, White PJ, Larson I, Malone DT, Manallack DT, Nicolazzo JA, McDowell J, Lim AS, Kirkpatrick CM.

Am J Pharm Educ. 2016 Nov 25;80(9):158. doi: 10.5688/ajpe809158.


Mixotrophy in the phototrophic dinoflagellate Takayama helix (family Kareniaceae): Predator of diverse toxic and harmful dinoflagellates.

Jeong HJ, Ok JH, Lim AS, Kwon JE, Kim SJ, Lee SY.

Harmful Algae. 2016 Dec;60:92-106. doi: 10.1016/j.hal.2016.10.008. Epub 2016 Nov 13.


Killing potential protist predators as a survival strategy of the newly described dinoflagellate Alexandrium pohangense.

Kim JH, Jeong HJ, Lim AS, Rho JR, Lee SB.

Harmful Algae. 2016 May;55:41-55. doi: 10.1016/j.hal.2016.01.009. Epub 2016 Feb 15.


Fluorescence In Situ Hybridization on Tissue Sections.

Lim AS, Lim TH.

Methods Mol Biol. 2017;1541:119-125.


Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1.

Cronin P, McCarthy MJ, Lim ASP, Salmon DP, Galasko D, Masliah E, De Jager PL, Bennett DA, Desplats P.

Alzheimers Dement. 2017 Jun;13(6):689-700. doi: 10.1016/j.jalz.2016.10.003. Epub 2016 Nov 22.


Self-Reported Sleep in Older African Americans and White Americans.

Turner AD, Lim AS, Leurgans SE, Bennett DA, Buchman AS, Barnes LL.

Ethn Dis. 2016 Oct 20;26(4):521-528.


Incident parkinsonism in older adults without Parkinson disease.

Buchman AS, Leurgans SE, Yu L, Wilson RS, Lim AS, James BD, Shulman JM, Bennett DA.

Neurology. 2016 Sep 6;87(10):1036-44. doi: 10.1212/WNL.0000000000003059. Epub 2016 Aug 3.


Medication prescribing and patient-reported outcome measures in people with epilepsy in Bhutan.

McKenzie ED, Nirola DK, Deki S, Tshering L, Patenaude B, Clark SJ, Cash SS, Thibert R, Zepeda R, Leung EC, Lam AD, Lim AS, Mantia J, Cohen J, Cole AJ, Mateen FJ.

Epilepsy Behav. 2016 Jun;59:122-7. doi: 10.1016/j.yebeh.2016.03.035. Epub 2016 Apr 28.


Response to Letter Regarding Article, "Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People".

Lim AS, Bennett DA, Buchman AS.

Stroke. 2016 Jun;47(6):e175. doi: 10.1161/STROKEAHA.116.013342. Epub 2016 Apr 26. No abstract available.


Concordance of anaplastic lymphoma kinase (ALK) gene rearrangements between circulating tumor cells and tumor in non-small cell lung cancer.

Tan CL, Lim TH, Lim TKh, Tan DS, Chua YW, Ang MK, Pang B, Lim CT, Takano A, Lim AS, Leong MC, Lim WT.

Oncotarget. 2016 Apr 26;7(17):23251-62. doi: 10.18632/oncotarget.8136.


Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People.

Lim AS, Yu L, Schneider JA, Bennett DA, Buchman AS.

Stroke. 2016 Feb;47(2):516-8. doi: 10.1161/STROKEAHA.115.011608. Epub 2016 Jan 14.

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