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Items: 41

1.

A high-content cytokine screen identifies myostatin propeptide as a positive regulator of primitive chronic myeloid leukemia cells.

von Palffy S, Landberg N, Sandén C, Zacharaki D, Shah M, Nakamichi N, Hansen N, Askmyr M, Lilljebjörn H, Rissler M, Karlsson C, Scheding S, Richter J, Eaves CJ, Bhatia R, Järås M, Fioretos T.

Haematologica. 2019 Oct 3. pii: haematol.2019.220434. doi: 10.3324/haematol.2019.220434. [Epub ahead of print]

2.

PAX5 is part of a functional transcription factor network targeted in lymphoid leukemia.

Okuyama K, Strid T, Kuruvilla J, Somasundaram R, Cristobal S, Smith E, Prasad M, Fioretos T, Lilljebjörn H, Soneji S, Lang S, Ungerbäck J, Sigvardsson M.

PLoS Genet. 2019 Aug 5;15(8):e1008280. doi: 10.1371/journal.pgen.1008280. eCollection 2019 Aug.

3.

FLT3N676K drives acute myeloid leukemia in a xenograft model of KMT2A-MLLT3 leukemogenesis.

Hyrenius-Wittsten A, Pilheden M, Falqués-Costa A, Eriksson M, Sturesson H, Schneider P, Wander P, Garcia-Ruiz C, Liu J, Ågerstam H, Hultquist A, Lilljebjörn H, Stam RW, Järås M, Hagström-Andersson AK.

Leukemia. 2019 Sep;33(9):2310-2314. doi: 10.1038/s41375-019-0465-1. Epub 2019 Apr 5. No abstract available.

4.

Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia.

Yang M, Vesterlund M, Siavelis I, Moura-Castro LH, Castor A, Fioretos T, Jafari R, Lilljebjörn H, Odom DT, Olsson L, Ravi N, Woodward EL, Harewood L, Lehtiö J, Paulsson K.

Nat Commun. 2019 Apr 3;10(1):1519. doi: 10.1038/s41467-019-09469-3.

5.

Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells.

Chapellier M, Peña-Martínez P, Ramakrishnan R, Eriksson M, Talkhoncheh MS, Orsmark-Pietras C, Lilljebjörn H, Högberg C, Hagström-Andersson A, Fioretos T, Larsson J, Järås M.

Haematologica. 2019 Oct;104(10):2006-2016. doi: 10.3324/haematol.2018.192062. Epub 2019 Feb 28.

6.

Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases.

Li JF, Dai YT, Lilljebjörn H, Shen SH, Cui BW, Bai L, Liu YF, Qian MX, Kubota Y, Kiyoi H, Matsumura I, Miyazaki Y, Olsson L, Tan AM, Ariffin H, Chen J, Takita J, Yasuda T, Mano H, Johansson B, Yang JJ, Yeoh AE, Hayakawa F, Chen Z, Pui CH, Fioretos T, Chen SJ, Huang JY.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11711-E11720. doi: 10.1073/pnas.1814397115. Epub 2018 Nov 28.

7.

Whole-exome sequencing exploration of acquired uniparental disomies in B-cell precursor acute lymphoblastic leukemia.

Lundin-Ström KB, Biloglav A, Lilljebjörn H, Rissler M, Fioretos T, Hansson M, Behrendtz M, Castor A, Olsson L, Johansson B.

Leukemia. 2018 Sep;32(9):2058-2062. doi: 10.1038/s41375-018-0191-0. Epub 2018 Jul 2. No abstract available.

8.

Mutation, methylation, and gene expression profiles in dup(1q)-positive pediatric B-cell precursor acute lymphoblastic leukemia.

Gunnarsson R, Dilorenzo S, Lundin-Ström KB, Olsson L, Biloglav A, Lilljebjörn H, Rissler M, Wahlberg P, Lundmark A, Castor A, Behrendtz M, Fioretos T, Paulsson K, Isaksson A, Johansson B.

Leukemia. 2018 Oct;32(10):2117-2125. doi: 10.1038/s41375-018-0092-2. Epub 2018 Mar 12.

9.

CD36 defines primitive chronic myeloid leukemia cells less responsive to imatinib but vulnerable to antibody-based therapeutic targeting.

Landberg N, von Palffy S, Askmyr M, Lilljebjörn H, Sandén C, Rissler M, Mustjoki S, Hjorth-Hansen H, Richter J, Ågerstam H, Järås M, Fioretos T.

Haematologica. 2018 Mar;103(3):447-455. doi: 10.3324/haematol.2017.169946. Epub 2017 Dec 28.

10.

Isolated myelosarcoma is characterized by recurrent NFE2 mutations and concurrent preleukemic clones in the bone marrow.

Lazarevic V, Orsmark-Pietras C, Lilljebjörn H, Pettersson L, Rissler M, Lübking A, Ehinger M, Juliusson G, Fioretos T.

Blood. 2018 Feb 1;131(5):577-581. doi: 10.1182/blood-2017-07-793620. Epub 2017 Nov 30. No abstract available.

PMID:
29191917
11.

New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia.

Lilljebjörn H, Fioretos T.

Blood. 2017 Sep 21;130(12):1395-1401. doi: 10.1182/blood-2017-05-742643. Epub 2017 Aug 4. Review.

PMID:
28778863
12.

Clonal conversion of B lymphoid leukemia reveals cross-lineage transfer of malignant states.

Somasundaram R, Åhsberg J, Okuyama K, Ungerbäck J, Lilljebjörn H, Fioretos T, Strid T, Sigvardsson M.

Genes Dev. 2016 Nov 15;30(22):2486-2499. Epub 2016 Dec 2.

13.

IL1RAP antibodies block IL-1-induced expansion of candidate CML stem cells and mediate cell killing in xenograft models.

Ågerstam H, Hansen N, von Palffy S, Sandén C, Reckzeh K, Karlsson C, Lilljebjörn H, Landberg N, Askmyr M, Högberg C, Rissler M, Porkka K, Wadenvik H, Mustjoki S, Richter J, Järås M, Fioretos T.

Blood. 2016 Dec 8;128(23):2683-2693. Epub 2016 Sep 12.

PMID:
27621309
14.

Distinct global binding patterns of the Wilms tumor gene 1 (WT1) -KTS and +KTS isoforms in leukemic cells.

Ullmark T, Järvstråt L, Sandén C, Montano G, Jernmark-Nilsson H, Lilljebjörn H, Lennartsson A, Fioretos T, Drott K, Vidovic K, Nilsson B, Gullberg U.

Haematologica. 2017 Feb;102(2):336-345. doi: 10.3324/haematol.2016.149815. Epub 2016 Sep 9.

15.

Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia.

Lilljebjörn H, Henningsson R, Hyrenius-Wittsten A, Olsson L, Orsmark-Pietras C, von Palffy S, Askmyr M, Rissler M, Schrappe M, Cario G, Castor A, Pronk CJ, Behrendtz M, Mitelman F, Johansson B, Paulsson K, Andersson AK, Fontes M, Fioretos T.

Nat Commun. 2016 Jun 6;7:11790. doi: 10.1038/ncomms11790.

16.

Genomic profiling and directed ex vivo drug analysis of an unclassifiable myelodysplastic/myeloproliferative neoplasm progressing into acute myeloid leukemia.

Hyrenius-Wittsten A, Sturesson H, Bidgoli M, Jonson T, Ehinger M, Lilljebjörn H, Scheding S, Andersson AK.

Genes Chromosomes Cancer. 2016 Nov;55(11):847-54. doi: 10.1002/gcc.22384. Epub 2016 Jul 4.

PMID:
27240832
17.

The genomic landscape of high hyperdiploid childhood acute lymphoblastic leukemia.

Paulsson K, Lilljebjörn H, Biloglav A, Olsson L, Rissler M, Castor A, Barbany G, Fogelstrand L, Nordgren A, Sjögren H, Fioretos T, Johansson B.

Nat Genet. 2015 Jun;47(6):672-6. doi: 10.1038/ng.3301. Epub 2015 May 11.

PMID:
25961940
18.

Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency.

Prasad MA, Ungerbäck J, Åhsberg J, Somasundaram R, Strid T, Larsson M, Månsson R, De Paepe A, Lilljebjörn H, Fioretos T, Hagman J, Sigvardsson M.

Blood. 2015 Jun 25;125(26):4052-9. doi: 10.1182/blood-2014-12-617282. Epub 2015 Apr 2.

19.

Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer.

Mengelbier LH, Karlsson J, Lindgren D, Valind A, Lilljebjörn H, Jansson C, Bexell D, Braekeveldt N, Ameur A, Jonson T, Kultima HG, Isaksson A, Asmundsson J, Versteeg R, Rissler M, Fioretos T, Sandstedt B, Börjesson A, Backman T, Pal N, Øra I, Mayrhofer M, Gisselsson D.

Nat Commun. 2015 Jan 27;6:6125. doi: 10.1038/ncomms7125.

PMID:
25625758
20.

Modeling chronic myeloid leukemia in immunodeficient mice reveals expansion of aberrant mast cells and accumulation of pre-B cells.

Askmyr M, Ågerstam H, Lilljebjörn H, Hansen N, Karlsson C, von Palffy S, Landberg N, Högberg C, Lassen C, Rissler M, Richter J, Ehinger M, Järås M, Fioretos T.

Blood Cancer J. 2014 Dec 12;4:e269. doi: 10.1038/bcj.2014.89.

21.

Activation of human telomerase reverse transcriptase through gene fusion in clear cell sarcoma of the kidney.

Karlsson J, Lilljebjörn H, Holmquist Mengelbier L, Valind A, Rissler M, Øra I, Fioretos T, Gisselsson D.

Cancer Lett. 2015 Feb 28;357(2):498-501. doi: 10.1016/j.canlet.2014.11.057. Epub 2014 Dec 3.

PMID:
25481751
22.

Fusions involving protein kinase C and membrane-associated proteins in benign fibrous histiocytoma.

Płaszczyca A, Nilsson J, Magnusson L, Brosjö O, Larsson O, Vult von Steyern F, Domanski HA, Lilljebjörn H, Fioretos T, Tayebwa J, Mandahl N, Nord KH, Mertens F.

Int J Biochem Cell Biol. 2014 Aug;53:475-81. doi: 10.1016/j.biocel.2014.03.027. Epub 2014 Apr 8.

PMID:
24721208
23.

GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma.

Nord KH, Lilljebjörn H, Vezzi F, Nilsson J, Magnusson L, Tayebwa J, de Jong D, Bovée JV, Hogendoorn PC, Szuhai K.

Nat Genet. 2014 May;46(5):474-7. doi: 10.1038/ng.2927. Epub 2014 Mar 23.

PMID:
24658000
24.

A glioma classification scheme based on coexpression modules of EGFR and PDGFRA.

Sun Y, Zhang W, Chen D, Lv Y, Zheng J, Lilljebjörn H, Ran L, Bao Z, Soneson C, Sjögren HO, Salford LG, Ji J, French PJ, Fioretos T, Jiang T, Fan X.

Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3538-43. doi: 10.1073/pnas.1313814111. Epub 2014 Feb 18.

25.

A novel SERPINE1-FOSB fusion gene results in transcriptional up-regulation of FOSB in pseudomyogenic haemangioendothelioma.

Walther C, Tayebwa J, Lilljebjörn H, Magnusson L, Nilsson J, von Steyern FV, Øra I, Domanski HA, Fioretos T, Nord KH, Fletcher CD, Mertens F.

J Pathol. 2014 Apr;232(5):534-40. doi: 10.1002/path.4322. Epub 2014 Jan 29.

PMID:
24374978
26.

RNA-seq identifies clinically relevant fusion genes in leukemia including a novel MEF2D/CSF1R fusion responsive to imatinib.

Lilljebjörn H, Ågerstam H, Orsmark-Pietras C, Rissler M, Ehrencrona H, Nilsson L, Richter J, Fioretos T.

Leukemia. 2014 Apr;28(4):977-9. doi: 10.1038/leu.2013.324. Epub 2013 Nov 4. No abstract available.

PMID:
24186003
27.

SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function.

Hansen N, Ågerstam H, Wahlestedt M, Landberg N, Askmyr M, Ehinger M, Rissler M, Lilljebjörn H, Johnels P, Ishiko J, Melo JV, Alexander WS, Bryder D, Järås M, Fioretos T.

Leukemia. 2013 Jan;27(1):130-5. doi: 10.1038/leu.2012.169. Epub 2012 Jun 22.

28.

Whole-exome sequencing of pediatric acute lymphoblastic leukemia.

Lilljebjörn H, Rissler M, Lassen C, Heldrup J, Behrendtz M, Mitelman F, Johansson B, Fioretos T.

Leukemia. 2012 Jul;26(7):1602-7. doi: 10.1038/leu.2011.333. Epub 2011 Nov 18.

PMID:
22094584
29.

Myeloid malignancies with acquired trisomy 21 as the sole cytogenetic change are clinically highly variable and display a heterogeneous pattern of copy number alterations and mutations.

Larsson N, Lilljebjörn H, Lassen C, Johansson B, Fioretos T.

Eur J Haematol. 2012 Feb;88(2):136-43. doi: 10.1111/j.1600-0609.2011.01710.x. Epub 2011 Nov 17.

PMID:
21933280
30.

Genetic landscape of high hyperdiploid childhood acute lymphoblastic leukemia.

Paulsson K, Forestier E, Lilljebjörn H, Heldrup J, Behrendtz M, Young BD, Johansson B.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21719-24. doi: 10.1073/pnas.1006981107. Epub 2010 Nov 22.

31.

Concomitant deletions of tumor suppressor genes MEN1 and AIP are essential for the pathogenesis of the brown fat tumor hibernoma.

Nord KH, Magnusson L, Isaksson M, Nilsson J, Lilljebjörn H, Domanski HA, Kindblom LG, Mandahl N, Mertens F.

Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21122-7. doi: 10.1073/pnas.1013512107. Epub 2010 Nov 15.

32.

The correlation pattern of acquired copy number changes in 164 ETV6/RUNX1-positive childhood acute lymphoblastic leukemias.

Lilljebjörn H, Soneson C, Andersson A, Heldrup J, Behrendtz M, Kawamata N, Ogawa S, Koeffler HP, Mitelman F, Johansson B, Fontes M, Fioretos T.

Hum Mol Genet. 2010 Aug 15;19(16):3150-8. doi: 10.1093/hmg/ddq224. Epub 2010 May 31.

33.

Genetic analysis of dasatinib-treated chronic myeloid leukemia rapidly developing into acute myeloid leukemia with monosomy 7 in Philadelphia-negative cells.

Larsson N, Billström R, Lilljebjörn H, Lassen C, Richter J, Ekblom M, Fioretos T.

Cancer Genet Cytogenet. 2010 Jun;199(2):89-95. doi: 10.1016/j.cancergencyto.2010.02.005.

PMID:
20471511
34.

Integrative analysis of gene expression and copy number alterations using canonical correlation analysis.

Soneson C, Lilljebjörn H, Fioretos T, Fontes M.

BMC Bioinformatics. 2010 Apr 15;11:191. doi: 10.1186/1471-2105-11-191.

35.

Relapsed childhood high hyperdiploid acute lymphoblastic leukemia: presence of preleukemic ancestral clones and the secondary nature of microdeletions and RTK-RAS mutations.

Davidsson J, Paulsson K, Lindgren D, Lilljebjörn H, Chaplin T, Forestier E, Andersen MK, Nordgren A, Rosenquist R, Fioretos T, Young BD, Johansson B.

Leukemia. 2010 May;24(5):924-31. doi: 10.1038/leu.2010.39. Epub 2010 Mar 18.

PMID:
20237506
36.

The DNA methylome of pediatric acute lymphoblastic leukemia.

Davidsson J, Lilljebjörn H, Andersson A, Veerla S, Heldrup J, Behrendtz M, Fioretos T, Johansson B.

Hum Mol Genet. 2009 Nov 1;18(21):4054-65. doi: 10.1093/hmg/ddp354. Epub 2009 Aug 13.

PMID:
19679565
37.

BRAF mutations are very rare in B- and T-cell pediatric acute lymphoblastic leukemias.

Davidsson J, Lilljebjörn H, Panagopoulos I, Fioretos T, Johansson B.

Leukemia. 2008 Aug;22(8):1619-21. doi: 10.1038/leu.2008.14. Epub 2008 Feb 14. No abstract available.

PMID:
18273045
38.

FLT3 mutations in a 10 year consecutive series of 177 childhood acute leukemias and their impact on global gene expression patterns.

Andersson A, Paulsson K, Lilljebjörn H, Lassen C, Strömbeck B, Heldrup J, Behrendtz M, Johansson B, Fioretos T.

Genes Chromosomes Cancer. 2008 Jan;47(1):64-70.

PMID:
17943971
39.
40.

Fusion gene-mediated truncation of RUNX1 as a potential mechanism underlying disease progression in the 8p11 myeloproliferative syndrome.

Agerstam H, Lilljebjörn H, Lassen C, Swedin A, Richter J, Vandenberghe P, Johansson B, Fioretos T.

Genes Chromosomes Cancer. 2007 Jul;46(7):635-43.

PMID:
17394134
41.

MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia.

Panagopoulos I, Lilljebjörn H, Strömbeck B, Hjorth L, Olofsson T, Johansson B.

Haematologica. 2006 Sep;91(9):1287-8.

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