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Items: 1 to 50 of 64

1.

Substrate specificity of thioredoxins and glutaredoxins - towards a functional classification.

Gellert M, Hossain MF, Berens FJF, Bruhn LW, Urbainsky C, Liebscher V, Lillig CH.

Heliyon. 2019 Dec 17;5(12):e02943. doi: 10.1016/j.heliyon.2019.e02943. eCollection 2019 Dec.

2.

Redox-mediated kick-start of mitochondrial energy metabolism drives resource-efficient seed germination.

Nietzel T, Mostertz J, Ruberti C, Née G, Fuchs P, Wagner S, Moseler A, Müller-Schüssele SJ, Benamar A, Poschet G, Büttner M, Møller IM, Lillig CH, Macherel D, Wirtz M, Hell R, Finkemeier I, Meyer AJ, Hochgräfe F, Schwarzländer M.

Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):741-751. doi: 10.1073/pnas.1910501117. Epub 2019 Dec 23.

PMID:
31871212
3.

Thioredoxin 1 Plays a Protective Role in Retinas Exposed to Perinatal Hypoxia-Ischemia.

Holubiec MI, Galeano P, Romero JI, Hanschmann EM, Lillig CH, Capani F.

Neuroscience. 2020 Jan 15;425:235-250. doi: 10.1016/j.neuroscience.2019.11.011. Epub 2019 Nov 27.

PMID:
31785355
4.

Nucleoredoxin-Dependent Targets and Processes in Neuronal Cells.

Urbainsky C, Nölker R, Imber M, Lübken A, Mostertz J, Hochgräfe F, Godoy JR, Hanschmann EM, Lillig CH.

Oxid Med Cell Longev. 2018 Nov 21;2018:4829872. doi: 10.1155/2018/4829872. eCollection 2018.

5.

Effects of cytotoxic cis- and trans-diammine monochlorido platinum(II) complexes on selenium-dependent redox enzymes and DNA.

Lemmerhirt H, Behnisch S, Bodtke A, Lillig CH, Pazderova L, Kasparkova J, Brabec V, Bednarski PJ.

J Inorg Biochem. 2018 Jan;178:94-105. doi: 10.1016/j.jinorgbio.2017.10.011. Epub 2017 Oct 26.

PMID:
29125948
6.

Molecular dynamics simulations and in vitro analysis of the CRMP2 thiol switch.

Möller D, Gellert M, Langel W, Lillig CH.

Mol Biosyst. 2017 Aug 22;13(9):1744-1753. doi: 10.1039/c7mb00160f.

PMID:
28726921
7.

Neuronal Damage Induced by Perinatal Asphyxia Is Attenuated by Postinjury Glutaredoxin-2 Administration.

Romero JI, Holubiec MI, Tornatore TL, Rivière S, Hanschmann EM, Kölliker-Frers RA, Tau J, Blanco E, Galeano P, Rodríguez de Fonseca F, Lillig CH, Capani F.

Oxid Med Cell Longev. 2017;2017:4162465. doi: 10.1155/2017/4162465. Epub 2017 Jun 15.

8.

The amino terminal subdomain of glycoprotein Gc of Schmallenberg virus: disulfide bonding and structural determinants of neutralization.

Roman-Sosa G, Karger A, Kraatz F, Aebischer A, Wernike K, Maksimov P, Lillig CH, Reimann I, Brocchi E, Keller M, Beer M.

J Gen Virol. 2017 Jun;98(6):1259-1273. doi: 10.1099/jgv.0.000810. Epub 2017 Jun 22.

PMID:
28640745
9.

Iron-sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia.

Lepka K, Volbracht K, Bill E, Schneider R, Rios N, Hildebrandt T, Ingwersen J, Prozorovski T, Lillig CH, van Horssen J, Steinman L, Hartung HP, Radi R, Holmgren A, Aktas O, Berndt C.

Glia. 2017 Sep;65(9):1521-1534. doi: 10.1002/glia.23178. Epub 2017 Jun 15.

PMID:
28618115
10.

Glutathione, Glutaredoxins, and Iron.

Berndt C, Lillig CH.

Antioxid Redox Signal. 2017 Nov 20;27(15):1235-1251. doi: 10.1089/ars.2017.7132. Epub 2017 Jun 26. Review.

PMID:
28537421
11.

The specificity of thioredoxins and glutaredoxins is determined by electrostatic and geometric complementarity.

Berndt C, Schwenn JD, Lillig CH.

Chem Sci. 2015 Dec 1;6(12):7049-7058. doi: 10.1039/c5sc01501d. Epub 2015 Sep 9.

12.

Redoxins in peripheral neurons after sciatic nerve injury.

Valek L, Kanngießer M, Häussler A, Agarwal N, Lillig CH, Tegeder I.

Free Radic Biol Med. 2015 Dec;89:581-92. doi: 10.1016/j.freeradbiomed.2015.09.008. Epub 2015 Oct 9.

PMID:
26456799
13.

Cold Atmospheric Plasma Treatment Induces Anti-Proliferative Effects in Prostate Cancer Cells by Redox and Apoptotic Signaling Pathways.

Weiss M, Gümbel D, Hanschmann EM, Mandelkow R, Gelbrich N, Zimmermann U, Walther R, Ekkernkamp A, Sckell A, Kramer A, Burchardt M, Lillig CH, Stope MB.

PLoS One. 2015 Jul 1;10(7):e0130350. doi: 10.1371/journal.pone.0130350. eCollection 2015.

14.

Redox proteomics of the inflammatory secretome identifies a common set of redoxins and other glutathionylated proteins released in inflammation, influenza virus infection and oxidative stress.

Checconi P, Salzano S, Bowler L, Mullen L, Mengozzi M, Hanschmann EM, Lillig CH, Sgarbanti R, Panella S, Nencioni L, Palamara AT, Ghezzi P.

PLoS One. 2015 May 18;10(5):e0127086. doi: 10.1371/journal.pone.0127086. eCollection 2015.

15.

Redox regulation of differentiation and de-differentiation.

Berndt C, Lillig CH.

Biochim Biophys Acta. 2015 Aug;1850(8):1467-8. doi: 10.1016/j.bbagen.2015.03.004. Epub 2015 Mar 17. No abstract available.

PMID:
25791023
16.

Thioredoxin 1 and glutaredoxin 2 contribute to maintain the phenotype and integrity of neurons following perinatal asphyxia.

Romero JI, Hanschmann EM, Gellert M, Eitner S, Holubiec MI, Blanco-Calvo E, Lillig CH, Capani F.

Biochim Biophys Acta. 2015 Jun;1850(6):1274-85. doi: 10.1016/j.bbagen.2015.02.015. Epub 2015 Feb 28.

PMID:
25735211
17.

Cysteine Oxidation Targets Peroxiredoxins 1 and 2 for Exosomal Release through a Novel Mechanism of Redox-Dependent Secretion.

Mullen L, Hanschmann EM, Lillig CH, Herzenberg LA, Ghezzi P.

Mol Med. 2015 Feb 13;21:98-108. doi: 10.2119/molmed.2015.00033.

18.

Enzymatic control of cysteinyl thiol switches in proteins.

Deponte M, Lillig CH.

Biol Chem. 2015 May;396(5):401-13. doi: 10.1515/hsz-2014-0280. Review.

PMID:
25581754
19.

Redox regulation of cytoskeletal dynamics during differentiation and de-differentiation.

Gellert M, Hanschmann EM, Lepka K, Berndt C, Lillig CH.

Biochim Biophys Acta. 2015 Aug;1850(8):1575-87. doi: 10.1016/j.bbagen.2014.10.030. Epub 2014 Nov 8. Review.

PMID:
25450486
20.

Redox regulation by glutathione needs enzymes.

Berndt C, Lillig CH, Flohé L.

Front Pharmacol. 2014 Jul 17;5:168. doi: 10.3389/fphar.2014.00168. eCollection 2014. No abstract available.

21.

Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal.

Salzano S, Checconi P, Hanschmann EM, Lillig CH, Bowler LD, Chan P, Vaudry D, Mengozzi M, Coppo L, Sacre S, Atkuri KR, Sahaf B, Herzenberg LA, Herzenberg LA, Mullen L, Ghezzi P.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12157-62. doi: 10.1073/pnas.1401712111. Epub 2014 Aug 5.

22.

Shortened isoforms of the androgen receptor are regulated by the cytoprotective heat-shock protein HSPB1 and the tumor-suppressive microRNA miR-1 in prostate cancer cells.

Stope MB, Bradl J, Peters S, Streitbörger A, Weiss M, Zimmermann U, Walther R, Lillig CH, Burchardt M.

Anticancer Res. 2013 Nov;33(11):4921-6.

PMID:
24222130
23.

Dual role of astrocytes in perinatal asphyxia injury and neuroprotection.

Romero J, Muñiz J, Logica Tornatore T, Holubiec M, González J, Barreto GE, Guelman L, Lillig CH, Blanco E, Capani F.

Neurosci Lett. 2014 Apr 17;565:42-6. doi: 10.1016/j.neulet.2013.10.046. Epub 2013 Oct 27. Review.

PMID:
24172702
24.

Molecular architecture of Streptococcus pneumoniae surface thioredoxin-fold lipoproteins crucial for extracellular oxidative stress resistance and maintenance of virulence.

Saleh M, Bartual SG, Abdullah MR, Jensch I, Asmat TM, Petruschka L, Pribyl T, Gellert M, Lillig CH, Antelmann H, Hermoso JA, Hammerschmidt S.

EMBO Mol Med. 2013 Dec;5(12):1852-70. doi: 10.1002/emmm.201202435. Epub 2013 Oct 18.

25.

Identification of a dithiol-disulfide switch in collapsin response mediator protein 2 (CRMP2) that is toggled in a model of neuronal differentiation.

Gellert M, Venz S, Mitlöhner J, Cott C, Hanschmann EM, Lillig CH.

J Biol Chem. 2013 Dec 6;288(49):35117-25. doi: 10.1074/jbc.M113.521443. Epub 2013 Oct 16.

26.

Identification of potential protein dithiol-disulfide substrates of mammalian Grx2.

Schütte LD, Baumeister S, Weis B, Hudemann C, Hanschmann EM, Lillig CH.

Biochim Biophys Acta. 2013 Nov;1830(11):4999-5005. doi: 10.1016/j.bbagen.2013.07.009. Epub 2013 Jul 18.

PMID:
23872354
27.

Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation.

Haunhorst P, Hanschmann EM, Bräutigam L, Stehling O, Hoffmann B, Mühlenhoff U, Lill R, Berndt C, Lillig CH.

Mol Biol Cell. 2013 Jun;24(12):1895-903. doi: 10.1091/mbc.E12-09-0648. Epub 2013 Apr 24.

28.

Cellular functions of glutathione.

Lillig CH, Berndt C.

Biochim Biophys Acta. 2013 May;1830(5):3137-8. doi: 10.1016/j.bbagen.2013.02.019. No abstract available.

PMID:
23540438
29.

Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling.

Hanschmann EM, Godoy JR, Berndt C, Hudemann C, Lillig CH.

Antioxid Redox Signal. 2013 Nov 1;19(13):1539-605. doi: 10.1089/ars.2012.4599. Epub 2013 Mar 28. Review.

30.

Glutaredoxins in thiol/disulfide exchange.

Lillig CH, Berndt C.

Antioxid Redox Signal. 2013 May 1;18(13):1654-65. doi: 10.1089/ars.2012.5007. Epub 2012 Dec 21. Review.

PMID:
23231445
31.

Oxidative Stress and Microcirculatory Flow Abnormalities in the Ventricles during Atrial Fibrillation.

Goette A, Bukowska A, Lillig CH, Lendeckel U.

Front Physiol. 2012 Jul 5;3:236. doi: 10.3389/fphys.2012.00236. eCollection 2012.

32.

Vertebrate-specific glutaredoxin is essential for brain development.

Bräutigam L, Schütte LD, Godoy JR, Prozorovski T, Gellert M, Hauptmann G, Holmgren A, Lillig CH, Berndt C.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20532-7. doi: 10.1073/pnas.1110085108. Epub 2011 Dec 2.

33.

Segment-specific overexpression of redoxins after renal ischemia and reperfusion: protective roles of glutaredoxin 2, peroxiredoxin 3, and peroxiredoxin 6.

Godoy JR, Oesteritz S, Hanschmann EM, Ockenga W, Ackermann W, Lillig CH.

Free Radic Biol Med. 2011 Jul 15;51(2):552-61. doi: 10.1016/j.freeradbiomed.2011.04.036. Epub 2011 Apr 29.

PMID:
21586322
34.

The multidomain thioredoxin-monothiol glutaredoxins represent a distinct functional group.

Hoffmann B, Uzarska MA, Berndt C, Godoy JR, Haunhorst P, Lillig CH, Lill R, Mühlenhoff U.

Antioxid Redox Signal. 2011 Jul 1;15(1):19-30. doi: 10.1089/ars.2010.3811. Epub 2011 Apr 20.

PMID:
21299470
35.

Both thioredoxin 2 and glutaredoxin 2 contribute to the reduction of the mitochondrial 2-Cys peroxiredoxin Prx3.

Hanschmann EM, Lönn ME, Schütte LD, Funke M, Godoy JR, Eitner S, Hudemann C, Lillig CH.

J Biol Chem. 2010 Dec 24;285(52):40699-705. doi: 10.1074/jbc.M110.185827. Epub 2010 Oct 7.

36.

Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster.

Mühlenhoff U, Molik S, Godoy JR, Uzarska MA, Richter N, Seubert A, Zhang Y, Stubbe J, Pierrel F, Herrero E, Lillig CH, Lill R.

Cell Metab. 2010 Oct 6;12(4):373-385. doi: 10.1016/j.cmet.2010.08.001. Erratum in: Cell Metab. 2014 Oct 7;20(4):696.

37.

Redox atlas of the mouse. Immunohistochemical detection of glutaredoxin-, peroxiredoxin-, and thioredoxin-family proteins in various tissues of the laboratory mouse.

Godoy JR, Funke M, Ackermann W, Haunhorst P, Oesteritz S, Capani F, Elsässer HP, Lillig CH.

Biochim Biophys Acta. 2011 Jan;1810(1):2-92. doi: 10.1016/j.bbagen.2010.05.006. Epub 2010 Jun 1.

PMID:
20682242
38.

Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system.

Aon-Bertolino ML, Romero JI, Galeano P, Holubiec M, Badorrey MS, Saraceno GE, Hanschmann EM, Lillig CH, Capani F.

Biochim Biophys Acta. 2011 Jan;1810(1):93-110. doi: 10.1016/j.bbagen.2010.06.011. Epub 2010 Jul 8.

PMID:
20620191
39.

Characterization of the human monothiol glutaredoxin 3 (PICOT) as iron-sulfur protein.

Haunhorst P, Berndt C, Eitner S, Godoy JR, Lillig CH.

Biochem Biophys Res Commun. 2010 Apr 2;394(2):372-6. doi: 10.1016/j.bbrc.2010.03.016. Epub 2010 Mar 10.

PMID:
20226171
40.

Lights on iron-sulfur clusters.

Lillig CH, Lill R.

Chem Biol. 2009 Dec 24;16(12):1213-4. doi: 10.1016/j.chembiol.2009.12.005.

41.

Special issue on selenoprotein expression and function.

Lillig CH, Arnér E.

Biochim Biophys Acta. 2009 Nov;1790(11):1387-8. doi: 10.1016/j.bbagen.2009.10.001. No abstract available.

PMID:
19835757
42.

Identification, expression pattern, and characterization of mouse glutaredoxin 2 isoforms.

Hudemann C, Lönn ME, Godoy JR, Zahedi Avval F, Capani F, Holmgren A, Lillig CH.

Antioxid Redox Signal. 2009 Jan;11(1):1-14. doi: 10.1089/ars.2008.2068.

PMID:
18707224
43.

Glutaredoxin systems.

Lillig CH, Berndt C, Holmgren A.

Biochim Biophys Acta. 2008 Nov;1780(11):1304-17. doi: 10.1016/j.bbagen.2008.06.003. Epub 2008 Jun 18. Review.

PMID:
18621099
44.

Saccharomyces cerevisiae Grx6 and Grx7 are monothiol glutaredoxins associated with the early secretory pathway.

Izquierdo A, Casas C, Mühlenhoff U, Lillig CH, Herrero E.

Eukaryot Cell. 2008 Aug;7(8):1415-26. doi: 10.1128/EC.00133-08. Epub 2008 May 23.

45.

Thioredoxins and glutaredoxins as facilitators of protein folding.

Berndt C, Lillig CH, Holmgren A.

Biochim Biophys Acta. 2008 Apr;1783(4):641-50. doi: 10.1016/j.bbamcr.2008.02.003. Epub 2008 Feb 19. Review.

46.

Expression pattern of human glutaredoxin 2 isoforms: identification and characterization of two testis/cancer cell-specific isoforms.

Lönn ME, Hudemann C, Berndt C, Cherkasov V, Capani F, Holmgren A, Lillig CH.

Antioxid Redox Signal. 2008 Mar;10(3):547-57.

PMID:
18092940
47.

Oxidation and S-nitrosylation of cysteines in human cytosolic and mitochondrial glutaredoxins: effects on structure and activity.

Hashemy SI, Johansson C, Berndt C, Lillig CH, Holmgren A.

J Biol Chem. 2007 May 11;282(19):14428-36. Epub 2007 Mar 13.

48.

The reducing activity of glutaredoxin 3 toward cytoplasmic substrate proteins is restricted by methionine 43.

Porat A, Lillig CH, Johansson C, Fernandes AP, Nilsson L, Holmgren A, Beckwith J.

Biochemistry. 2007 Mar 20;46(11):3366-77. Epub 2007 Feb 17.

49.

Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in the cardiovascular system.

Berndt C, Lillig CH, Holmgren A.

Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1227-36. Epub 2006 Dec 15. Review.

50.

How does iron-sulfur cluster coordination regulate the activity of human glutaredoxin 2?

Berndt C, Hudemann C, Hanschmann EM, Axelsson R, Holmgren A, Lillig CH.

Antioxid Redox Signal. 2007 Jan;9(1):151-7.

PMID:
17115894

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