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Items: 34


CRISPR/Cas9 mediated generation of an ovine model for infantile neuronal ceroid lipofuscinosis (CLN1 disease).

Eaton SL, Proudfoot C, Lillico SG, Skehel P, Kline RA, Hamer K, Rzechorzek NM, Clutton E, Gregson R, King T, O'Neill CA, Cooper JD, Thompson G, Whitelaw CB, Wishart TM.

Sci Rep. 2019 Jul 9;9(1):9891. doi: 10.1038/s41598-019-45859-9.


Pigs Lacking the Scavenger Receptor Cysteine-Rich Domain 5 of CD163 Are Resistant to Porcine Reproductive and Respiratory Syndrome Virus 1 Infection.

Burkard C, Opriessnig T, Mileham AJ, Stadejek T, Ait-Ali T, Lillico SG, Whitelaw CBA, Archibald AL.

J Virol. 2018 Jul 31;92(16). pii: e00415-18. doi: 10.1128/JVI.00415-18. Print 2018 Aug 15.


C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity.

Selvaraj BT, Livesey MR, Zhao C, Gregory JM, James OT, Cleary EM, Chouhan AK, Gane AB, Perkins EM, Dando O, Lillico SG, Lee YB, Nishimura AL, Poreci U, Thankamony S, Pray M, Vasistha NA, Magnani D, Borooah S, Burr K, Story D, McCampbell A, Shaw CE, Kind PC, Aitman TJ, Whitelaw CBA, Wilmut I, Smith C, Miles GB, Hardingham GE, Wyllie DJA, Chandran S.

Nat Commun. 2018 Jan 24;9(1):347. doi: 10.1038/s41467-017-02729-0.


CRISPR-Based Gene Drives for Pest Control.

McFarlane GR, Whitelaw CBA, Lillico SG.

Trends Biotechnol. 2018 Feb;36(2):130-133. doi: 10.1016/j.tibtech.2017.10.001. Review.


Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function.

Burkard C, Lillico SG, Reid E, Jackson B, Mileham AJ, Ait-Ali T, Whitelaw CB, Archibald AL.

PLoS Pathog. 2017 Feb 23;13(2):e1006206. doi: 10.1371/journal.ppat.1006206. eCollection 2017 Feb.


Generation of germline ablated male pigs by CRISPR/Cas9 editing of the NANOS2 gene.

Park KE, Kaucher AV, Powell A, Waqas MS, Sandmaier SE, Oatley MJ, Park CH, Tibary A, Donovan DM, Blomberg LA, Lillico SG, Whitelaw CB, Mileham A, Telugu BP, Oatley JM.

Sci Rep. 2017 Jan 10;7:40176. doi: 10.1038/srep40176.


Comparison of CRISPR/Cas9 and TALENs on editing an integrated EGFP gene in the genome of HEK293FT cells.

He Z, Proudfoot C, Whitelaw CB, Lillico SG.

Springerplus. 2016 Jun 21;5(1):814. doi: 10.1186/s40064-016-2536-3. eCollection 2016.


Mammalian interspecies substitution of immune modulatory alleles by genome editing.

Lillico SG, Proudfoot C, King TJ, Tan W, Zhang L, Mardjuki R, Paschon DE, Rebar EJ, Urnov FD, Mileham AJ, McLaren DG, Whitelaw CB.

Sci Rep. 2016 Feb 22;6:21645. doi: 10.1038/srep21645.


Genetically engineering milk.

Whitelaw CB, Joshi A, Kumar S, Lillico SG, Proudfoot C.

J Dairy Res. 2016 Feb;83(1):3-11. doi: 10.1017/S0022029916000017. Review.


Gene targeting, genome editing: from Dolly to editors.

Tan W, Proudfoot C, Lillico SG, Whitelaw CB.

Transgenic Res. 2016 Jun;25(3):273-87. doi: 10.1007/s11248-016-9932-x. Epub 2016 Feb 3. Review.


Comparison of surrogate reporter systems for enrichment of cells with mutations induced by genome editors.

He Z, Shi X, Liu M, Sun G, Proudfoot C, Whitelaw CB, Lillico SG, Chen Y.

J Biotechnol. 2016 Mar 10;221:49-54. doi: 10.1016/j.jbiotec.2016.01.009. Epub 2016 Jan 14.


Engineering large animal models of human disease.

Whitelaw CB, Sheets TP, Lillico SG, Telugu BP.

J Pathol. 2016 Jan;238(2):247-56. doi: 10.1002/path.4648. Epub 2015 Nov 28. Review.


Highly efficient targeted chromosome deletions using CRISPR/Cas9.

He Z, Proudfoot C, Mileham AJ, McLaren DG, Whitelaw CB, Lillico SG.

Biotechnol Bioeng. 2015 May;112(5):1060-4. doi: 10.1002/bit.25490. Epub 2014 Dec 23.


Genome edited sheep and cattle.

Proudfoot C, Carlson DF, Huddart R, Long CR, Pryor JH, King TJ, Lillico SG, Mileham AJ, McLaren DG, Whitelaw CB, Fahrenkrug SC.

Transgenic Res. 2015 Feb;24(1):147-53. doi: 10.1007/s11248-014-9832-x. Epub 2014 Sep 10.


Live pigs produced from genome edited zygotes.

Lillico SG, Proudfoot C, Carlson DF, Stverakova D, Neil C, Blain C, King TJ, Ritchie WA, Tan W, Mileham AJ, McLaren DG, Fahrenkrug SC, Whitelaw CB.

Sci Rep. 2013 Oct 10;3:2847. doi: 10.1038/srep02847.


Rapid cohort generation and analysis of disease spectrum of large animal model of cone dystrophy.

Kostic C, Lillico SG, Crippa SV, Grandchamp N, Pilet H, Philippe S, Lu Z, King TJ, Mallet J, Sarkis C, Arsenijevic Y, Whitelaw CB.

PLoS One. 2013 Aug 19;8(8):e71363. doi: 10.1371/journal.pone.0071363. eCollection 2013.


Stable conditional expression and effect of C/ebpβ-LIP in adipocytes using the pSLIK system.

Esteves CL, Kelly V, Bégay V, Lillico SG, Leutz A, Seckl JR, Chapman KE.

J Mol Endocrinol. 2013 Jun 4;51(1):91-8. doi: 10.1530/JME-13-0029. Print 2013.


Efficient TALEN-mediated gene knockout in livestock.

Carlson DF, Tan W, Lillico SG, Stverakova D, Proudfoot C, Christian M, Voytas DF, Long CR, Whitelaw CB, Fahrenkrug SC.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17382-7. doi: 10.1073/pnas.1211446109. Epub 2012 Oct 1.


USP18 restricts PRRSV growth through alteration of nuclear translocation of NF-κB p65 and p50 in MARC-145 cells.

Xu D, Lillico SG, Barnett MW, Whitelaw CB, Archibald AL, Ait-Ali T.

Virus Res. 2012 Oct;169(1):264-7. doi: 10.1016/j.virusres.2012.07.002. Epub 2012 Jul 13.


Ovine-induced pluripotent stem cells can contribute to chimeric lambs.

Sartori C, DiDomenico AI, Thomson AJ, Milne E, Lillico SG, Burdon TG, Whitelaw CB.

Cell Reprogram. 2012 Feb;14(1):8-19. doi: 10.1089/cell.2011.0050. Epub 2012 Jan 4.


Milk lacking α-casein leads to permanent reduction in body size in mice.

Kolb AF, Huber RC, Lillico SG, Carlisle A, Robinson CJ, Neil C, Petrie L, Sorensen DB, Olsson IA, Whitelaw CB.

PLoS One. 2011;6(7):e21775. doi: 10.1371/journal.pone.0021775. Epub 2011 Jul 18.


Species-specific variation in RELA underlies differences in NF-κB activity: a potential role in African swine fever pathogenesis.

Palgrave CJ, Gilmour L, Lowden CS, Lillico SG, Mellencamp MA, Whitelaw CB.

J Virol. 2011 Jun;85(12):6008-14. doi: 10.1128/JVI.00331-11. Epub 2011 Mar 30.


Evaluation of RNA-knockdown strategies for modulation of cytochrome P450 reductase activity in mouse hepatocytes.

Mackenzie NC, Lillico SG, Brown K, Wolf CR, Whitelaw CB.

J RNAi Gene Silencing. 2010 Nov 26;6(2):416-21.


Tissue-specific and expression of porcine growth hormone gene in BAC transgenic mice.

Tong J, Lillico SG, Bi MJ, Qing T, Liu XF, Wang Y, Zheng M, Wang M, Dai YP, Whitelaw CB, Li N.

Transgenic Res. 2011 Aug;20(4):933-8. doi: 10.1007/s11248-010-9454-x. Epub 2010 Nov 25.


Functional conservation between rodents and chicken of regulatory sequences driving skeletal muscle gene expression in transgenic chickens.

McGrew MJ, Sherman A, Lillico SG, Taylor L, Sang H.

BMC Dev Biol. 2010 Feb 25;10:26. doi: 10.1186/1471-213X-10-26.


p21(Waf1/Cip1) as a molecular sensor for BoHV-4 replication.

Capocefalo A, Franceschi V, Whitelaw CB, Vasey DB, Lillico SG, Cavirani S, Donofrio G.

J Virol Methods. 2009 Nov;161(2):308-11. doi: 10.1016/j.jviromet.2009.06.012. Epub 2009 Jun 18.


CMV enhancer-promoter is preferentially active in exocrine cells in vivo.

Vasey DB, Lillico SG, Sang HM, King TJ, Whitelaw CB.

Transgenic Res. 2009 Apr;18(2):309-14. doi: 10.1007/s11248-008-9235-y. Epub 2008 Dec 16.


Production of transgenic farm animals by viral vector-mediated gene transfer.

Whitelaw CB, Lillico SG, King T.

Reprod Domest Anim. 2008 Jul;43 Suppl 2:355-8. doi: 10.1111/j.1439-0531.2008.01184.x. Review.


Localised axial progenitor cell populations in the avian tail bud are not committed to a posterior Hox identity.

McGrew MJ, Sherman A, Lillico SG, Ellard FM, Radcliffe PA, Gilhooley HJ, Mitrophanous KA, Cambray N, Wilson V, Sang H.

Development. 2008 Jul;135(13):2289-99. doi: 10.1242/dev.022020. Epub 2008 May 28.


Oviduct-specific expression of two therapeutic proteins in transgenic hens.

Lillico SG, Sherman A, McGrew MJ, Robertson CD, Smith J, Haslam C, Barnard P, Radcliffe PA, Mitrophanous KA, Elliot EA, Sang HM.

Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1771-6. Epub 2007 Jan 26.


Trypanosoma brucei MOB1 is required for accurate and efficient cytokinesis but not for exit from mitosis.

Hammarton TC, Lillico SG, Welburn SC, Mottram JC.

Mol Microbiol. 2005 Apr;56(1):104-16.


Transgenic chickens as bioreactors for protein-based drugs.

Lillico SG, McGrew MJ, Sherman A, Sang HM.

Drug Discov Today. 2005 Feb 1;10(3):191-6. Review.


Efficient production of germline transgenic chickens using lentiviral vectors.

McGrew MJ, Sherman A, Ellard FM, Lillico SG, Gilhooley HJ, Kingsman AJ, Mitrophanous KA, Sang H.

EMBO Rep. 2004 Jul;5(7):728-33. Epub 2004 Jun 11.


Characterisation of the QM gene of Trypanosoma brucei.

Lillico SG, Mottram JC, Murphy NB, Welburn SC.

FEMS Microbiol Lett. 2002 Jun 4;211(2):123-8.

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