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Interleukin-6 improves infection identification when added to physician judgment during evaluation of potentially septic patients.

Henning DJ, Hall MK, Watsjold BK, Bhatraju PK, Kosamo S, Shapiro NI, Liles WC, Wurfel MM.

Am J Emerg Med. 2019 Jul 25:158361. doi: 10.1016/j.ajem.2019.158361. [Epub ahead of print]


Physician Judgment and Circulating Biomarkers Predict 28-Day Mortality in Emergency Department Patients.

Henning DJ, Bhatraju PK, Johnson NJ, Kosamo S, Shapiro NI, Zelnick LR, Liles WC, Wurfel MM.

Crit Care Med. 2019 Aug 1. doi: 10.1097/CCM.0000000000003899. [Epub ahead of print]


PPARα contributes to protection against metabolic and inflammatory derangements associated with acute kidney injury in experimental sepsis.

Iwaki T, Bennion BG, Stenson EK, Lynn JC, Otinga C, Djukovic D, Raftery D, Fei L, Wong HR, Liles WC, Standage SW.

Physiol Rep. 2019 May;7(10):e14078. doi: 10.14814/phy2.14078.


Biomarkers of endothelial activation/dysfunction distinguish sub-groups of Ugandan patients with sepsis and differing mortality risks.

Clark DV, Banura P, Bandeen-Roche K, Liles WC, Kain KC, Scheld WM, Moss WJ, Jacob ST.

JCI Insight. 2019 Apr 23;5. pii: 127623. doi: 10.1172/jci.insight.127623.


A Prediction Model for Severe AKI in Critically Ill Adults That Incorporates Clinical and Biomarker Data.

Bhatraju PK, Zelnick LR, Katz R, Mikacenic C, Kosamo S, Hahn WO, Dmyterko V, Kestenbaum B, Christiani DC, Liles WC, Himmelfarb J, Wurfel MM.

Clin J Am Soc Nephrol. 2019 Apr 5;14(4):506-514. doi: 10.2215/CJN.04100318. Epub 2019 Mar 27.


Higher Plasma Endothelial Markers in Adults with Cystic Fibrosis Compared with Healthy Age-matched Control Subjects.

Bhatraju PK, Hisert KB, Aitken ML, Goss CH, Liles WC, Altemeier WA.

Ann Am Thorac Soc. 2019 Jun;16(6):768-771. doi: 10.1513/AnnalsATS.201812-844RL. No abstract available.


Systemic Angiopoietin-1/2 Dysregulation in Pediatric Sepsis and Septic Shock.

Melendez E, Whitney JE, Norton JS, Silverman M, Harju-Baker S, Mikacenic C, Wurfel MM, Liles WC.

Int J Med Sci. 2019 Jan 1;16(2):318-323. doi: 10.7150/ijms.27731. eCollection 2019.


Von Willebrand Factor Adhesive Activity and ADAMTS13 Protease Activity in HIV-1-Infected Men.

Graham SM, Chen J, Le J, Ling M, Chung DW, Liles WC, López JA.

Int J Med Sci. 2019 Jan 1;16(2):276-284. doi: 10.7150/ijms.28110. eCollection 2019.


A Flow Cytometric Method for Isolating Cystic Fibrosis Airway Macrophages from Expectorated Sputum.

Hisert KB, Liles WC, Manicone AM.

Am J Respir Cell Mol Biol. 2019 Jul;61(1):42-50. doi: 10.1165/rcmb.2018-0236MA.


Neutrophil extracellular traps (NETs) are increased in the alveolar spaces of patients with ventilator-associated pneumonia.

Mikacenic C, Moore R, Dmyterko V, West TE, Altemeier WA, Liles WC, Lood C.

Crit Care. 2018 Dec 27;22(1):358. doi: 10.1186/s13054-018-2290-8.


Boiling Histotripsy Ablation of Renal Cell Carcinoma in the Eker Rat Promotes a Systemic Inflammatory Response.

Schade GR, Wang YN, D'Andrea S, Hwang JH, Liles WC, Khokhlova TD.

Ultrasound Med Biol. 2019 Jan;45(1):137-147. doi: 10.1016/j.ultrasmedbio.2018.09.006. Epub 2018 Oct 16.


Identification of Acute Kidney Injury Subphenotypes with Differing Molecular Signatures and Responses to Vasopressin Therapy.

Bhatraju PK, Zelnick LR, Herting J, Katz R, Mikacenic C, Kosamo S, Morrell ED, Robinson-Cohen C, Calfee CS, Christie JD, Liu KD, Matthay MA, Hahn WO, Dmyterko V, Slivinski NSJ, Russell JA, Walley KR, Christiani DC, Liles WC, Himmelfarb J, Wurfel MM.

Am J Respir Crit Care Med. 2019 Apr 1;199(7):863-872. doi: 10.1164/rccm.201807-1346OC.


Matrix metalloproteinase 28 is regulated by TRIF- and type I IFN-dependent signaling in macrophages.

Long ME, Gong KQ, Volk JS, Eddy WE, Chang MY, Frevert CW, Altemeier WA, Gale M Jr, Liles WC, Manicone AM.

Innate Immun. 2018 Aug;24(6):357-365. doi: 10.1177/1753425918791024. Epub 2018 Aug 1.


Inhaled nitric oxide and cognition in pediatric severe malaria: A randomized double-blind placebo controlled trial.

Bangirana P, Conroy AL, Opoka RO, Hawkes MT, Hermann L, Miller C, Namasopo S, Liles WC, John CC, Kain KC.

PLoS One. 2018 Jan 25;13(1):e0191550. doi: 10.1371/journal.pone.0191550. eCollection 2018.


cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses.

Hahn WO, Butler NS, Lindner SE, Akilesh HM, Sather DN, Kappe SH, Hamerman JA, Gale M Jr, Liles WC, Pepper M.

JCI Insight. 2018 Jan 25;3(2). pii: 94142. doi: 10.1172/jci.insight.94142. eCollection 2018 Jan 25.


Endothelial Activation and Blood-Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells.

Gust J, Hay KA, Hanafi LA, Li D, Myerson D, Gonzalez-Cuyar LF, Yeung C, Liles WC, Wurfel M, Lopez JA, Chen J, Chung D, Harju-Baker S, Özpolat T, Fink KR, Riddell SR, Maloney DG, Turtle CJ.

Cancer Discov. 2017 Dec;7(12):1404-1419. doi: 10.1158/2159-8290.CD-17-0698. Epub 2017 Oct 12.


Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor-modified T-cell therapy.

Hay KA, Hanafi LA, Li D, Gust J, Liles WC, Wurfel MM, López JA, Chen J, Chung D, Harju-Baker S, Cherian S, Chen X, Riddell SR, Maloney DG, Turtle CJ.

Blood. 2017 Nov 23;130(21):2295-2306. doi: 10.1182/blood-2017-06-793141. Epub 2017 Sep 18.


Pharmacologic inhibition of MEK1/2 reduces lung inflammation without impairing bacterial clearance in experimental Pseudomonas aeruginosa pneumonia.

Long ME, Gong KQ, Eddy WE, Liles WC, Manicone AM.

Pneumonia (Nathan). 2017 Sep 5;9:13. doi: 10.1186/s41479-017-0037-y. eCollection 2017.


Circulating levels of soluble Fas (sCD95) are associated with risk for development of a nonresolving acute kidney injury subphenotype.

Bhatraju PK, Robinson-Cohen C, Mikacenic C, Harju-Baker S, Dmyterko V, Slivinski NSJ, Liles WC, Himmelfarb J, Heckbert SR, Wurfel MM.

Crit Care. 2017 Aug 17;21(1):217. doi: 10.1186/s13054-017-1807-x.


Pentraxin 3 levels in bronchoalveolar lavage fluid of lung transplant recipients with invasive aspergillosis.

Kabbani D, Bhaskaran A, Singer LG, Bhimji A, Rotstein C, Keshavjee S, Liles WC, Husain S.

J Heart Lung Transplant. 2017 Sep;36(9):973-979. doi: 10.1016/j.healun.2017.04.007. Epub 2017 Apr 19.


A Two-Biomarker Model Predicts Mortality in the Critically Ill with Sepsis.

Mikacenic C, Price BL, Harju-Baker S, O'Mahony DS, Robinson-Cohen C, Radella F, Hahn WO, Katz R, Christiani DC, Himmelfarb J, Liles WC, Wurfel MM.

Am J Respir Crit Care Med. 2017 Oct 15;196(8):1004-1011. doi: 10.1164/rccm.201611-2307OC.


Lung pericyte-like cells are functional interstitial immune sentinel cells.

Hung CF, Mittelsteadt KL, Brauer R, McKinney BL, Hallstrand TS, Parks WC, Chen P, Schnapp LM, Liles WC, Duffield JS, Altemeier WA.

Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1;312(4):L556-L567. doi: 10.1152/ajplung.00349.2016. Epub 2017 Feb 10.


miR-155 Modifies Inflammation, Endothelial Activation and Blood-Brain Barrier Dysfunction in Cerebral Malaria.

Barker KR, Lu Z, Kim H, Zheng Y, Chen J, Conroy AL, Hawkes M, Cheng HS, Njock MS, Fish JE, Harlan JM, López JA, Liles WC, Kain KC.

Mol Med. 2017 Mar;23:24-33. doi: 10.2119/molmed.2016.00139. Epub 2017 Feb 2.


MEK1/2 Inhibition Promotes Macrophage Reparative Properties.

Long ME, Eddy WE, Gong KQ, Lovelace-Macon LL, McMahan RS, Charron J, Liles WC, Manicone AM.

J Immunol. 2017 Jan 15;198(2):862-872. doi: 10.4049/jimmunol.1601059. Epub 2016 Dec 21.


PPARα augments heart function and cardiac fatty acid oxidation in early experimental polymicrobial sepsis.

Standage SW, Bennion BG, Knowles TO, Ledee DR, Portman MA, McGuire JK, Liles WC, Olson AK.

Am J Physiol Heart Circ Physiol. 2017 Feb 1;312(2):H239-H249. doi: 10.1152/ajpheart.00457.2016. Epub 2016 Nov 23.


Seymour J. Klebanoff: Discoverer of WBC killing mechanisms.

Rosen H, Liles WC, Van Voorhis WC.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):12891-12892. Epub 2016 Nov 4. No abstract available.


Methemoglobin and nitric oxide therapy in Ugandan children hospitalized for febrile illness: results from a prospective cohort study and randomized double-blind placebo-controlled trial.

Conroy AL, Hawkes M, Hayford K, Hermann L, McDonald CR, Sharma S, Namasopo S, Opoka RO, John CC, Liles WC, Miller C, Kain KC.

BMC Pediatr. 2016 Nov 4;16(1):177.


Brain-derived Neurotrophic Factor Is Associated With Disease Severity and Clinical Outcome in Ugandan Children Admitted to Hospital With Severe Malaria.

McDonald CR, Conroy AL, Hawkes M, Elphinstone RE, Gamble JL, Hayford K, Namasopo S, Opoka RO, Liles WC, Kain KC.

Pediatr Infect Dis J. 2017 Feb;36(2):146-150. doi: 10.1097/INF.0000000000001382.


Ablation of Pericyte-Like Cells in Lungs by Oropharyngeal Aspiration of Diphtheria Toxin.

Hung CF, Chow YH, Liles WC, Altemeier WA, Schnapp LM.

Am J Respir Cell Mol Biol. 2017 Feb;56(2):160-167. doi: 10.1165/rcmb.2016-0083MA.


DJ-1/PARK7 Impairs Bacterial Clearance in Sepsis.

Amatullah H, Shan Y, Beauchamp BL, Gali PL, Gupta S, Maron-Gutierrez T, Speck ER, Fox-Robichaud AE, Tsang JL, Mei SH, Mak TW, Rocco PR, Semple JW, Zhang H, Hu P, Marshall JC, Stewart DJ, Harper ME, Liaw PC, Liles WC, Dos Santos CC; Canadian Critical Care Translational Biology Group.

Am J Respir Crit Care Med. 2017 Apr 1;195(7):889-905. doi: 10.1164/rccm.201604-0730OC.


Host Biomarkers Are Associated With Response to Therapy and Long-Term Mortality in Pediatric Severe Malaria.

Conroy AL, Hawkes M, McDonald CR, Kim H, Higgins SJ, Barker KR, Namasopo S, Opoka RO, John CC, Liles WC, Kain KC.

Open Forum Infect Dis. 2016 Jun 20;3(3):ofw134. eCollection 2016 Sep.


Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria.

Higgins SJ, Purcell LA, Silver KL, Tran V, Crowley V, Hawkes M, Conroy AL, Opoka RO, Hay JG, Quaggin SE, Thurston G, Liles WC, Kain KC.

Sci Transl Med. 2016 Sep 28;8(358):358ra128. doi: 10.1126/scitranslmed.aaf6812.


Alterations in Systemic Extracellular Heme and Hemopexin Are Associated With Adverse Clinical Outcomes in Ugandan Children With Severe Malaria.

Elphinstone RE, Conroy AL, Hawkes M, Hermann L, Namasopo S, Warren HS, John CC, Liles WC, Kain KC.

J Infect Dis. 2016 Oct 15;214(8):1268-75. doi: 10.1093/infdis/jiw357. Epub 2016 Aug 11.


Association of markers of endothelial dysregulation Ang1 and Ang2 with acute kidney injury in critically ill patients.

Robinson-Cohen C, Katz R, Price BL, Harju-Baker S, Mikacenic C, Himmelfarb J, Liles WC, Wurfel MM.

Crit Care. 2016 Jul 3;20(1):207. doi: 10.1186/s13054-016-1385-3.


Platelets in sepsis: beyond hemostasis.

Graham SM, Liles WC.

Blood. 2016 Jun 16;127(24):2947-9. doi: 10.1182/blood-2016-03-706168. No abstract available.


Acute Kidney Injury Is Common in Pediatric Severe Malaria and Is Associated With Increased Mortality.

Conroy AL, Hawkes M, Elphinstone RE, Morgan C, Hermann L, Barker KR, Namasopo S, Opoka RO, John CC, Liles WC, Kain KC.

Open Forum Infect Dis. 2016 Feb 26;3(2):ofw046. doi: 10.1093/ofid/ofw046. eCollection 2016 Mar.


Short Communication: Effect of Antiretroviral Therapy on Circulating Damage-Associated Molecular Pattern Molecules and CD4 Immune Reconstitution in HIV-Infected Individuals.

Drozd DR, Graham SM, Crane HM, Delaney JA, Kitahata MM, Liles WC.

AIDS Res Hum Retroviruses. 2016 Sep;32(9):876-8. doi: 10.1089/AID.2016.0059. Epub 2016 Jun 13.


CD47-SIRPα Interactions Regulate Macrophage Uptake of Plasmodium falciparum-Infected Erythrocytes and Clearance of Malaria In Vivo.

Ayi K, Lu Z, Serghides L, Ho JM, Finney C, Wang JCY, Liles WC, Kain KC.

Infect Immun. 2016 Jun 23;84(7):2002-2011. doi: 10.1128/IAI.01426-15. Print 2016 Jul.


Soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) Is Elevated in Bronchoalveolar Lavage Fluid of Patients with Acute Respiratory Distress Syndrome.

Attia EF, Jolley SE, Crothers K, Schnapp LM, Liles WC.

PLoS One. 2016 Feb 26;11(2):e0149687. doi: 10.1371/journal.pone.0149687. eCollection 2016.


Pretreatment with bone marrow-derived mesenchymal stromal cell-conditioned media confers pulmonary ischemic tolerance.

Hwang B, Liles WC, Waworuntu R, Mulligan MS.

J Thorac Cardiovasc Surg. 2016 Mar;151(3):841-849. doi: 10.1016/j.jtcvs.2015.11.043. Epub 2015 Nov 30.


Endothelial activation, haemostasis and thrombosis biomarkers in Ugandan children with severe malaria participating in a clinical trial.

Graham SM, Chen J, Chung DW, Barker KR, Conroy AL, Hawkes MT, Namasopo S, Kain KC, López JA, Liles WC.

Malar J. 2016 Feb 2;15:56. doi: 10.1186/s12936-016-1106-z.


Host derived biomarkers of inflammation, apoptosis, and endothelial activation are associated with clinical outcomes in patients with bacteremia and sepsis regardless of microbial etiology.

Hahn WO, Mikacenic C, Price BL, Harju-Baker S, Katz R, Himmelfarb J, Wurfel MM, Liles WC.

Virulence. 2016 May 18;7(4):387-94. doi: 10.1080/21505594.2016.1144003. Epub 2016 Jan 28. No abstract available.


Nonhematopoietic Peroxisome Proliferator-Activated Receptor-α Protects Against Cardiac Injury and Enhances Survival in Experimental Polymicrobial Sepsis.

Standage SW, Waworuntu RL, Delaney MA, Maskal SM, Bennion BG, Duffield JS, Parks WC, Liles WC, McGuire JK.

Crit Care Med. 2016 Aug;44(8):e594-603. doi: 10.1097/CCM.0000000000001585.


Virulence profile: W. Conrad Liles.

Liles WC.

Virulence. 2016 Apr 2;7(3):243-7. doi: 10.1080/21505594.2016.1139883. Epub 2016 Jan 11. No abstract available.


A common TLR1 polymorphism is associated with higher parasitaemia in a Southeast Asian population with Plasmodium falciparum malaria.

Hahn WO, Harju-Baker S, Erdman LK, Krudsood S, Kain KC, Wurfel MM, Liles WC.

Malar J. 2016 Jan 6;15:12. doi: 10.1186/s12936-015-1071-y.



Gharib SA, Mar D, Bomsztyk K, Denisenko O, Dhanireddy S, Liles WC, Altemeier WA.

Shock. 2016 Feb;45(2):148-56. doi: 10.1097/SHK.0000000000000507. Erratum in: Shock. 2016 Apr;45(4):469. Shock. 2016 Feb 12;:.


Inhaled nitric oxide as adjunctive therapy for severe malaria: a randomized controlled trial.

Hawkes MT, Conroy AL, Opoka RO, Hermann L, Thorpe KE, McDonald C, Kim H, Higgins S, Namasopo S, John C, Miller C, Liles WC, Kain KC.

Malar J. 2015 Oct 29;14:421. doi: 10.1186/s12936-015-0946-2.


Biomarkers of Endothelial Activation Are Associated with Poor Outcome in Critical Illness.

Mikacenic C, Hahn WO, Price BL, Harju-Baker S, Katz R, Kain KC, Himmelfarb J, Liles WC, Wurfel MM.

PLoS One. 2015 Oct 22;10(10):e0141251. doi: 10.1371/journal.pone.0141251. eCollection 2015.


Experimental Malaria in Pregnancy Induces Neurocognitive Injury in Uninfected Offspring via a C5a-C5a Receptor Dependent Pathway.

McDonald CR, Cahill LS, Ho KT, Yang J, Kim H, Silver KL, Ward PA, Mount HT, Liles WC, Sled JG, Kain KC.

PLoS Pathog. 2015 Sep 24;11(9):e1005140. doi: 10.1371/journal.ppat.1005140. eCollection 2015 Sep.


Effect of Intercurrent Infections and Vaccinations on Immune and Inflammatory Biomarkers Among Human Immunodeficiency Virus-Infected Adults on Suppressive Antiretroviral Therapy.

Tan DH, Szadkowski L, Raboud J, Yi TJ, Shannon B, Kaul R, Liles WC, Walmsley S.

Open Forum Infect Dis. 2015 Mar 9;2(2):ofv036. doi: 10.1093/ofid/ofv036. eCollection 2015 Apr.

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