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Items: 17

1.

Mechanisms Underlying the Dual Effect of Polyunsaturated Fatty Acid Analogs on Kv7.1.

Liin SI, Yazdi S, Ramentol R, Barro-Soria R, Larsson HP.

Cell Rep. 2018 Sep 11;24(11):2908-2918. doi: 10.1016/j.celrep.2018.08.031.

2.

ω-6 and ω-9 polyunsaturated fatty acids with double bonds near the carboxyl head have the highest affinity and largest effects on the cardiac IK s potassium channel.

Bohannon BM, Perez ME, Liin SI, Larsson HP.

Acta Physiol (Oxf). 2019 Feb;225(2):e13186. doi: 10.1111/apha.13186. Epub 2018 Oct 17.

3.

KCNE1 tunes the sensitivity of KV7.1 to polyunsaturated fatty acids by moving turret residues close to the binding site.

Larsson JE, Larsson HP, Liin SI.

Elife. 2018 Jul 17;7. pii: e37257. doi: 10.7554/eLife.37257.

4.

Biaryl sulfonamide motifs up- or down-regulate ion channel activity by activating voltage sensors.

Liin SI, Lund PE, Larsson JE, Brask J, Wallner B, Elinder F.

J Gen Physiol. 2018 Aug 6;150(8):1215-1230. doi: 10.1085/jgp.201711942. Epub 2018 Jul 12.

5.

KCNE1 and KCNE3 modulate KCNQ1 channels by affecting different gating transitions.

Barro-Soria R, Ramentol R, Liin SI, Perez ME, Kass RS, Larsson HP.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7367-E7376. doi: 10.1073/pnas.1710335114. Epub 2017 Aug 14.

6.

Using fluorescence to understand β subunit-NaV channel interactions.

Barro-Soria R, Liin SI, Larsson HP.

J Gen Physiol. 2017 Jul 18. pii: jgp.201711843. doi: 10.1085/jgp.201711843. [Epub ahead of print] No abstract available.

7.

Actions and Mechanisms of Polyunsaturated Fatty Acids on Voltage-Gated Ion Channels.

Elinder F, Liin SI.

Front Physiol. 2017 Feb 6;8:43. doi: 10.3389/fphys.2017.00043. eCollection 2017. Review.

8.

Specificity of M-channel activators: binding or effect?

Barro-Soria R, Liin SI, Larsson HP.

J Physiol. 2017 Feb 1;595(3):605-606. doi: 10.1113/JP273250. No abstract available.

9.

Fatty acid analogue N-arachidonoyl taurine restores function of IKs channels with diverse long QT mutations.

Liin SI, Larsson JE, Barro-Soria R, Bentzen BH, Larsson HP.

Elife. 2016 Sep 30;5. pii: e20272. doi: 10.7554/eLife.20272.

10.

Reciprocal voltage sensor-to-pore coupling leads to potassium channel C-type inactivation.

Conti L, Renhorn J, Gabrielsson A, Turesson F, Liin SI, Lindahl E, Elinder F.

Sci Rep. 2016 Jun 9;6:27562. doi: 10.1038/srep27562.

11.

Polyunsaturated fatty acids are potent openers of human M-channels expressed in Xenopus laevis oocytes.

Liin SI, Karlsson U, Bentzen BH, Schmitt N, Elinder F.

Acta Physiol (Oxf). 2016 Sep;218(1):28-37. doi: 10.1111/apha.12663. Epub 2016 Mar 23.

12.

Electronic polymers in lipid membranes.

Johansson PK, Jullesson D, Elfwing A, Liin SI, Musumeci C, Zeglio E, Elinder F, Solin N, Inganäs O.

Sci Rep. 2015 Jun 10;5:11242. doi: 10.1038/srep11242.

13.

Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channel.

Liin SI, Silverå Ejneby M, Barro-Soria R, Skarsfeldt MA, Larsson JE, Starck Härlin F, Parkkari T, Bentzen BH, Schmitt N, Larsson HP, Elinder F.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5714-9. doi: 10.1073/pnas.1503488112. Epub 2015 Apr 21.

14.

The KCNQ1 channel - remarkable flexibility in gating allows for functional versatility.

Liin SI, Barro-Soria R, Larsson HP.

J Physiol. 2015 Jun 15;593(12):2605-15. doi: 10.1113/jphysiol.2014.287607. Epub 2015 Mar 18. Review.

15.

KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps.

Barro-Soria R, Rebolledo S, Liin SI, Perez ME, Sampson KJ, Kass RS, Larsson HP.

Nat Commun. 2014 Apr 28;5:3750. doi: 10.1038/ncomms4750.

16.

Drug-induced ion channel opening tuned by the voltage sensor charge profile.

Ottosson NE, Liin SI, Elinder F.

J Gen Physiol. 2014 Feb;143(2):173-82. doi: 10.1085/jgp.201311087. Epub 2014 Jan 13.

17.

The conserved phenylalanine in the K+ channel voltage-sensor domain creates a barrier with unidirectional effects.

Schwaiger CS, Liin SI, Elinder F, Lindahl E.

Biophys J. 2013 Jan 8;104(1):75-84. doi: 10.1016/j.bpj.2012.11.3827. Epub 2013 Jan 8.

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