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Items: 44


Transcriptional and genomic parallels between the monoxenous parasite Herpetomonas muscarum and Leishmania.

Sloan MA, Brooks K, Otto TD, Sanders MJ, Cotton JA, Ligoxygakis P.

PLoS Genet. 2019 Nov 11;15(11):e1008452. doi: 10.1371/journal.pgen.1008452. eCollection 2019 Nov.


Accessibility to Peptidoglycan Is Important for the Recognition of Gram-Positive Bacteria in Drosophila.

Vaz F, Kounatidis I, Covas G, Parton RM, Harkiolaki M, Davis I, Filipe SR, Ligoxygakis P.

Cell Rep. 2019 May 21;27(8):2480-2492.e6. doi: 10.1016/j.celrep.2019.04.103.


Intestinal NF-κB and STAT signalling is important for uptake and clearance in a Drosophila-Herpetomonas interaction model.

Wang L, Sloan MA, Ligoxygakis P.

PLoS Genet. 2019 Mar 1;15(3):e1007931. doi: 10.1371/journal.pgen.1007931. eCollection 2019 Mar.


Convergence of longevity and immunity: lessons from animal models.

Xia J, Gravato-Nobre M, Ligoxygakis P.

Biogerontology. 2019 Jun;20(3):271-278. doi: 10.1007/s10522-019-09801-w. Epub 2019 Feb 22. Review.


A Host-Pathogen Interaction Screen Identifies ada2 as a Mediator of Candida glabrata Defenses Against Reactive Oxygen Species.

Kounatidis I, Ames L, Mistry R, Ho HL, Haynes K, Ligoxygakis P.

G3 (Bethesda). 2018 May 4;8(5):1637-1647. doi: 10.1534/g3.118.200182.


Functional analysis of the C. elegans cyld-1 gene reveals extensive similarity with its human homolog.

Hadweh P, Chaitoglou I, Gravato-Nobre MJ, Ligoxygakis P, Mosialos G, Hatzivassiliou E.

PLoS One. 2018 Feb 2;13(2):e0191864. doi: 10.1371/journal.pone.0191864. eCollection 2018.


Immunity: Insect Immune Memory Goes Viral.

Ligoxygakis P.

Curr Biol. 2017 Nov 20;27(22):R1218-R1220. doi: 10.1016/j.cub.2017.10.020.


MicroRNAs That Contribute to Coordinating the Immune Response in Drosophila melanogaster.

Atilano ML, Glittenberg M, Monteiro A, Copley RR, Ligoxygakis P.

Genetics. 2017 Sep;207(1):163-178. doi: 10.1534/genetics.116.196584. Epub 2017 Jul 13.


NF-κB Immunity in the Brain Determines Fly Lifespan in Healthy Aging and Age-Related Neurodegeneration.

Kounatidis I, Chtarbanova S, Cao Y, Hayne M, Jayanth D, Ganetzky B, Ligoxygakis P.

Cell Rep. 2017 Apr 25;19(4):836-848. doi: 10.1016/j.celrep.2017.04.007.


Interaction Between Familial Transmission and a Constitutively Active Immune System Shapes Gut Microbiota in Drosophila melanogaster.

Mistry R, Kounatidis I, Ligoxygakis P.

Genetics. 2017 Jun;206(2):889-904. doi: 10.1534/genetics.116.190215. Epub 2017 Apr 16.


Exploring interactions between pathogens and the Drosophila gut.

Mistry R, Kounatidis I, Ligoxygakis P.

Dev Comp Immunol. 2016 Nov;64:3-10. doi: 10.1016/j.dci.2016.01.016. Epub 2016 Feb 11. Review.


Staphylococcus aureus Survives with a Minimal Peptidoglycan Synthesis Machine but Sacrifices Virulence and Antibiotic Resistance.

Reed P, Atilano ML, Alves R, Hoiczyk E, Sher X, Reichmann NT, Pereira PM, Roemer T, Filipe SR, Pereira-Leal JB, Ligoxygakis P, Pinho MG.

PLoS Pathog. 2015 May 7;11(5):e1004891. doi: 10.1371/journal.ppat.1004891. eCollection 2015 May.


Innate immunity. A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus.

Hepburn L, Prajsnar TK, Klapholz C, Moreno P, Loynes CA, Ogryzko NV, Brown K, Schiebler M, Hegyi K, Antrobus R, Hammond KL, Connolly J, Ochoa B, Bryant C, Otto M, Surewaard B, Seneviratne SL, Grogono DM, Cachat J, Ny T, Kaser A, Török ME, Peacock SJ, Holden M, Blundell T, Wang L, Ligoxygakis P, Minichiello L, Woods CG, Foster SJ, Renshaw SA, Floto RA.

Science. 2014 Oct 31;346(6209):641-646. doi: 10.1126/science.1258705.


Bacterial autolysins trim cell surface peptidoglycan to prevent detection by the Drosophila innate immune system.

Atilano ML, Pereira PM, Vaz F, Catalão MJ, Reed P, Grilo IR, Sobral RG, Ligoxygakis P, Pinho MG, Filipe SR.

Elife. 2014 Apr 1;3:e02277. doi: 10.7554/eLife.02277.


Loss of Trabid, a new negative regulator of the drosophila immune-deficiency pathway at the level of TAK1, reduces life span.

Fernando MD, Kounatidis I, Ligoxygakis P.

PLoS Genet. 2014 Feb 20;10(2):e1004117. doi: 10.1371/journal.pgen.1004117. eCollection 2014 Feb.


Drosophila as a model to study the role of blood cells in inflammation, innate immunity and cancer.

Wang L, Kounatidis I, Ligoxygakis P.

Front Cell Infect Microbiol. 2014 Jan 9;3:113. doi: 10.3389/fcimb.2013.00113. Review.


Genetics of immune recognition and response in Drosophila host defense.

Ligoxygakis P.

Adv Genet. 2013;83:71-97. doi: 10.1016/B978-0-12-407675-4.00002-X. Review.


Drosophila as a model system to unravel the layers of innate immunity to infection.

Kounatidis I, Ligoxygakis P.

Open Biol. 2012 May;2(5):120075. doi: 10.1098/rsob.120075. Review.


Wall teichoic acids of Staphylococcus aureus limit recognition by the drosophila peptidoglycan recognition protein-SA to promote pathogenicity.

Atilano ML, Yates J, Glittenberg M, Filipe SR, Ligoxygakis P.

PLoS Pathog. 2011 Dec;7(12):e1002421. doi: 10.1371/journal.ppat.1002421. Epub 2011 Dec 1.


Pathogen and host factors are needed to provoke a systemic host response to gastrointestinal infection of Drosophila larvae by Candida albicans.

Glittenberg MT, Kounatidis I, Christensen D, Kostov M, Kimber S, Roberts I, Ligoxygakis P.

Dis Model Mech. 2011 Jul;4(4):515-25. doi: 10.1242/dmm.006627. Epub 2011 May 2.


Wild-type Drosophila melanogaster as an alternative model system for investigating the pathogenicity of Candida albicans.

Glittenberg MT, Silas S, MacCallum DM, Gow NA, Ligoxygakis P.

Dis Model Mech. 2011 Jul;4(4):504-14. doi: 10.1242/dmm.006619. Epub 2011 May 2.


Toll-dependent antimicrobial responses in Drosophila larval fat body require Spätzle secreted by haemocytes.

Shia AK, Glittenberg M, Thompson G, Weber AN, Reichhart JM, Ligoxygakis P.

J Cell Sci. 2009 Dec 15;122(Pt 24):4505-15. doi: 10.1242/jcs.049155. Epub 2009 Nov 24.


Short-term starvation of immune deficient Drosophila improves survival to gram-negative bacterial infections.

Brown AE, Baumbach J, Cook PE, Ligoxygakis P.

PLoS One. 2009;4(2):e4490. doi: 10.1371/journal.pone.0004490. Epub 2009 Feb 16.


CYLD: a multifunctional deubiquitinase.

Glittenberg M, Ligoxygakis P.

Fly (Austin). 2007 Nov-Dec;1(6):330-2. Epub 2007 Nov 10. Review.


Peptidoglycan recognition protein-SD provides versatility of receptor formation in Drosophila immunity.

Wang L, Gilbert RJ, Atilano ML, Filipe SR, Gay NJ, Ligoxygakis P.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11881-6. doi: 10.1073/pnas.0710092105. Epub 2008 Aug 12.


Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes.

Waterhouse RM, Kriventseva EV, Meister S, Xi Z, Alvarez KS, Bartholomay LC, Barillas-Mury C, Bian G, Blandin S, Christensen BM, Dong Y, Jiang H, Kanost MR, Koutsos AC, Levashina EA, Li J, Ligoxygakis P, Maccallum RM, Mayhew GF, Mendes A, Michel K, Osta MA, Paskewitz S, Shin SW, Vlachou D, Wang L, Wei W, Zheng L, Zou Z, Severson DW, Raikhel AS, Kafatos FC, Dimopoulos G, Zdobnov EM, Christophides GK.

Science. 2007 Jun 22;316(5832):1738-43.


A Drosophila ortholog of the human cylindromatosis tumor suppressor gene regulates triglyceride content and antibacterial defense.

Tsichritzis T, Gaentzsch PC, Kosmidis S, Brown AE, Skoulakis EM, Ligoxygakis P, Mosialos G.

Development. 2007 Jul;134(14):2605-14. Epub 2007 Jun 6.


Sensing of Gram-positive bacteria in Drosophila: GNBP1 is needed to process and present peptidoglycan to PGRP-SA.

Wang L, Weber AN, Atilano ML, Filipe SR, Gay NJ, Ligoxygakis P.

EMBO J. 2006 Oct 18;25(20):5005-14. Epub 2006 Oct 5.


Pathogen recognition and signalling in the Drosophila innate immune response.

Wang L, Ligoxygakis P.

Immunobiology. 2006;211(4):251-61. Epub 2006 May 2. Review.


Prophenoloxidase activation is not required for survival to microbial infections in Drosophila.

Leclerc V, Pelte N, El Chamy L, Martinelli C, Ligoxygakis P, Hoffmann JA, Reichhart JM.

EMBO Rep. 2006 Feb;7(2):231-5.


Antimicrobial defences in Drosophila: the story so far.

Naitza S, Ligoxygakis P.

Mol Immunol. 2004 Feb;40(12):887-96. Review. Erratum in: Mol Immunol. 2004 Jul;41(5):563.


A serpin regulates dorsal-ventral axis formation in the Drosophila embryo.

Ligoxygakis P, Roth S, Reichhart JM.

Curr Biol. 2003 Dec 2;13(23):2097-102.


A serpin mutant links Toll activation to melanization in the host defence of Drosophila.

Ligoxygakis P, Pelte N, Ji C, Leclerc V, Duvic B, Belvin M, Jiang H, Hoffmann JA, Reichhart JM.

EMBO J. 2002 Dec 2;21(23):6330-7.


Splice-activated UAS hairpin vector gives complete RNAi knockout of single or double target transcripts in Drosophila melanogaster.

Reichhart JM, Ligoxygakis P, Naitza S, Woerfel G, Imler JL, Gubb D.

Genesis. 2002 Sep-Oct;34(1-2):160-4. No abstract available.


Activation of Drosophila Toll during fungal infection by a blood serine protease.

Ligoxygakis P, Pelte N, Hoffmann JA, Reichhart JM.

Science. 2002 Jul 5;297(5578):114-6.


Genetic diversity and conservation efforts.

Ligoxygakis P.

Trends Genet. 2001 Aug;17(8):442. No abstract available.


Copper transport meets development.

Ligoxygakis P.

Trends Genet. 2001 Aug;17(8):442. No abstract available.


Timing HIV infection.

Ligoxygakis P.

Trends Genet. 2001 Aug;17(8):441. No abstract available.


Specification of left-right asymmetry in the embryonic gut of Drosophila.

Ligoxygakis P, Strigini M, Averof M.

Development. 2001 Apr;128(7):1171-4.


A subset of notch functions during Drosophila eye development require Su(H) and the E(spl) gene complex.

Ligoxygakis P, Yu SY, Delidakis C, Baker NE.

Development. 1998 Aug;125(15):2893-900.


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