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Items: 31

1.

The CSF-1 receptor fashions the intestinal stem cell niche.

Akcora D, Huynh D, Lightowler S, Germann M, Robine S, de May JR, Pollard JW, Stanley ER, Malaterre J, Ramsay RG.

Stem Cell Res. 2013 Mar;10(2):203-12. doi: 10.1016/j.scr.2012.12.001. Epub 2012 Dec 9.

2.

Enhanced lithium-induced brain recovery following cranial irradiation is not impeded by inflammation.

Malaterre J, McPherson CS, Denoyer D, Lai E, Hagekyriakou J, Lightowler S, Shudo K, Ernst M, Ashley DM, Short JL, Wheeler G, Ramsay RG.

Stem Cells Transl Med. 2012 Jun;1(6):469-79. doi: 10.5966/sctm.2011-0046. Epub 2012 May 30.

3.

The tumor suppressor Apc controls planar cell polarities central to gut homeostasis.

Bellis J, Duluc I, Romagnolo B, Perret C, Faux MC, Dujardin D, Formstone C, Lightowler S, Ramsay RG, Freund JN, De Mey JR.

J Cell Biol. 2012 Aug 6;198(3):331-41. doi: 10.1083/jcb.201204086. Epub 2012 Jul 30.

4.

Fatty acid amide hydrolase inhibitors. 3: tetra-substituted azetidine ureas with in vivo activity.

Roughley SD, Browne H, Macias AT, Benwell K, Brooks T, D'Alessandro J, Daniels Z, Dugdale S, Francis G, Gibbons B, Hart T, Haymes T, Kennett G, Lightowler S, Matassova N, Mansell H, Merrett A, Misra A, Padfield A, Parsons R, Pratt R, Robertson A, Simmonite H, Tan K, Walls SB, Wong M.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):901-6. doi: 10.1016/j.bmcl.2011.12.032. Epub 2011 Dec 13.

PMID:
22209458
5.

Myb controls intestinal stem cell genes and self-renewal.

Cheasley D, Pereira L, Lightowler S, Vincan E, Malaterre J, Ramsay RG.

Stem Cells. 2011 Dec;29(12):2042-50. doi: 10.1002/stem.761.

6.

Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor.

Bedford ST, Benwell KR, Brooks T, Chen I, Comer M, Dugdale S, Haymes T, Jordan AM, Kennett GA, Knight AR, Klenke B, LeStrat L, Merrett A, Misra A, Lightowler S, Padfield A, Poullennec K, Reece M, Simmonite H, Wong M, Yule IA.

Bioorg Med Chem Lett. 2009 Oct 15;19(20):5945-9. doi: 10.1016/j.bmcl.2009.08.040. Epub 2009 Aug 14.

PMID:
19733067
7.

Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.

Hart T, Macias AT, Benwell K, Brooks T, D'Alessandro J, Dokurno P, Francis G, Gibbons B, Haymes T, Kennett G, Lightowler S, Mansell H, Matassova N, Misra A, Padfield A, Parsons R, Pratt R, Robertson A, Walls S, Wong M, Roughley S.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4241-4. doi: 10.1016/j.bmcl.2009.05.097. Epub 2009 May 29.

PMID:
19515560
8.

Colony stimulating factor-1 dependence of paneth cell development in the mouse small intestine.

Huynh D, Dai XM, Nandi S, Lightowler S, Trivett M, Chan CK, Bertoncello I, Ramsay RG, Stanley ER.

Gastroenterology. 2009 Jul;137(1):136-44, 144.e1-3. doi: 10.1053/j.gastro.2009.03.004. Epub 2009 Mar 18.

9.

Antagonists of the human A(2A) adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo[4,5-d]pyrimidines.

Gillespie RJ, Bamford SJ, Botting R, Comer M, Denny S, Gaur S, Griffin M, Jordan AM, Knight AR, Lerpiniere J, Leonardi S, Lightowler S, McAteer S, Merrett A, Misra A, Padfield A, Reece M, Saadi M, Selwood DL, Stratton GC, Surry D, Todd R, Tong X, Ruston V, Upton R, Weiss SM.

J Med Chem. 2009 Jan 8;52(1):33-47. doi: 10.1021/jm800961g.

PMID:
19072055
10.

c-Myb is required for neural progenitor cell proliferation and maintenance of the neural stem cell niche in adult brain.

Malaterre J, Mantamadiotis T, Dworkin S, Lightowler S, Yang Q, Ransome MI, Turnley AM, Nichols NR, Emambokus NR, Frampton J, Ramsay RG.

Stem Cells. 2008 Jan;26(1):173-81. Epub 2007 Sep 27.

11.

Colony-stimulating factor-1 promotes clonogenic growth of normal murine colonic crypt epithelial cells in vitro.

Ramsay RG, Micallef SJ, Williams B, Lightowler S, Vincan E, Heath JK, Mantamadiotis T, Bertoncello I.

J Interferon Cytokine Res. 2004 Jul;24(7):416-27.

PMID:
15296653
12.

c-myb Heterozygous mice are hypersensitive to 5-fluorouracil and ionizing radiation.

Ramsay RG, Micallef S, Lightowler S, Mucenski ML, Mantamadiotis T, Bertoncello I.

Mol Cancer Res. 2004 Jun;2(6):354-61.

13.

The muscarinic receptor agonist xanomeline has an antipsychotic-like profile in the rat.

Stanhope KJ, Mirza NR, Bickerdike MJ, Bright JL, Harrington NR, Hesselink MB, Kennett GA, Lightowler S, Sheardown MJ, Syed R, Upton RL, Wadsworth G, Weiss SM, Wyatt A.

J Pharmacol Exp Ther. 2001 Nov;299(2):782-92.

PMID:
11602695
14.

SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety.

Wood MD, Reavill C, Trail B, Wilson A, Stean T, Kennett GA, Lightowler S, Blackburn TP, Thomas D, Gager TL, Riley G, Holland V, Bromidge SM, Forbes IT, Middlemiss DN.

Neuropharmacology. 2001 Aug;41(2):186-99.

PMID:
11489455
15.

1-[2-[(Heteroarylmethoxy)aryl]carbamoyl]indolines are selective and orally active 5-HT2C receptor inverse agonists.

Bromidge SM, Davies S, Duckworth DM, Forbes IT, Jones GE, Jones J, King FD, Blackburn TP, Holland V, Kennett GA, Lightowler S, Middlemiss DN, Riley GJ, Trail B, Wood MD.

Bioorg Med Chem Lett. 2000 Aug 21;10(16):1867-70.

PMID:
10969987
16.

1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents.

Bromidge SM, Dabbs S, Davies S, Duckworth DM, Forbes IT, Jones GE, Jones J, King FD, Saunders DV, Blackburn TP, Holland V, Kennett GA, Lightowler S, Middlemiss DN, Riley GJ, Trail B, Wood MD.

Bioorg Med Chem Lett. 2000 Aug 21;10(16):1863-6.

PMID:
10969986
17.

Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent.

Bromidge SM, Dabbs S, Davies DT, Davies S, Duckworth DM, Forbes IT, Gaster LM, Ham P, Jones GE, King FD, Mulholland KR, Saunders DV, Wyman PA, Blaney FE, Clarke SE, Blackburn TP, Holland V, Kennett GA, Lightowler S, Middlemiss DN, Trail B, Riley GJ, Wood MD.

J Med Chem. 2000 Mar 23;43(6):1123-34.

PMID:
10737744
18.

Measurement of anxiety in transgenic mice.

Weiss SM, Lightowler S, Stanhope KJ, Kennett GA, Dourish CT.

Rev Neurosci. 2000;11(1):59-74. Review.

PMID:
10716656
19.

Effects of RO 60 0175, a 5-HT(2C) receptor agonist, in three animal models of anxiety.

Kennett G, Lightowler S, Trail B, Bright F, Bromidge S.

Eur J Pharmacol. 2000 Jan 10;387(2):197-204.

PMID:
10650160
20.

Activation of 5-HT2B receptors in the medial amygdala causes anxiolysis in the social interaction test in the rat.

Duxon MS, Kennett GA, Lightowler S, Blackburn TP, Fone KC.

Neuropharmacology. 1997 Apr-May;36(4-5):601-8.

PMID:
9225285
21.

An investigation of the mechanism responsible for fluoxetine-induced hypophagia in rats.

Lightowler S, Wood M, Brown T, Glen A, Blackburn T, Tulloch I, Kennett G.

Eur J Pharmacol. 1996 Jan 25;296(2):137-43.

PMID:
8838449
22.

Effect of chronic administration of selective 5-hydroxytryptamine and noradrenaline uptake inhibitors on a putative index of 5-HT2C/2B receptor function.

Kennett GA, Lightowler S, de Biasi V, Stevens NC, Wood MD, Tulloch IF, Blackburn TP.

Neuropharmacology. 1994 Dec;33(12):1581-8.

PMID:
7760981
23.

Anxiolytic-like effect of paroxetine in a rat social interaction test.

Lightowler S, Kennett GA, Williamson IJ, Blackburn TP, Tulloch IF.

Pharmacol Biochem Behav. 1994 Oct;49(2):281-5.

PMID:
7824539
24.

Low-frequency oscillatory activities intrinsic to rat and cat thalamocortical cells.

Leresche N, Lightowler S, Soltesz I, Jassik-Gerschenfeld D, Crunelli V.

J Physiol. 1991 Sep;441:155-74.

25.

Two inward currents and the transformation of low-frequency oscillations of rat and cat thalamocortical cells.

Soltesz I, Lightowler S, Leresche N, Jassik-Gerschenfeld D, Pollard CE, Crunelli V.

J Physiol. 1991 Sep;441:175-97.

26.

Postnatal development of the T calcium current in cat thalamocortical cells.

Pirchio M, Lightowler S, Crunelli V.

Neuroscience. 1990;38(1):39-45.

PMID:
2255399
27.
28.

Optic tract stimulation evokes GABAA but not GABAB IPSPs in the rat ventral lateral geniculate nucleus.

Soltesz I, Lightowler S, Leresche N, Crunelli V.

Brain Res. 1989 Feb 6;479(1):49-55.

PMID:
2924152
30.

Total hip replacement using the Charnley prosthesis in inflammatory joint disease.

Harris J, Lightowler SD, Todd RC.

Ann Rheum Dis. 1972 Nov;31(6):537-8. No abstract available.

31.

Ortho fibrindex as a source of thrombim.

Lightowler SA, Maris J.

J Clin Pathol. 1972 Sep;25(9):835. No abstract available.

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