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Redesigning the Aspergillus nidulans xylanase regulatory pathway to enhance cellulase production with xylose as the carbon and inducer source.

Ballmann P, Lightfoot J, Müller M, Dröge S, Prade R.

Microb Cell Fact. 2019 Nov 7;18(1):193. doi: 10.1186/s12934-019-1243-5.


CRISPR/Cas9-Mediated Gene Replacement in the Fungal Keratitis Pathogen Fusarium solani var. petroliphilum.

Lightfoot JD, Fuller KK.

Microorganisms. 2019 Oct 16;7(10). pii: E457. doi: 10.3390/microorganisms7100457.


Cilia drive developmental plasticity and are essential for efficient prey detection in predatory nematodes.

Moreno E, Lightfoot JW, Lenuzzi M, Sommer RJ.

Proc Biol Sci. 2019 Oct 9;286(1912):20191089. doi: 10.1098/rspb.2019.1089. Epub 2019 Oct 2.


Case report of severe bronchial web-like stenoses after 'surviving the unsurvivable'.

Crowhurst T, Lightfoot J, Yeo A, Reddi B, Nguyen P, Whitford H, Holmes-Liew CL.

BMC Pulm Med. 2019 Jul 2;19(1):119. doi: 10.1186/s12890-019-0873-z.


The Physiology of Auto Racing.

Reid MB, Lightfoot JT.

Med Sci Sports Exerc. 2019 Dec;51(12):2548-2562. doi: 10.1249/MSS.0000000000002070.


Alleles associated with physical activity levels are estimated to be older than anatomically modern humans.

Letsinger AC, Granados JZ, Little SE, Lightfoot JT.

PLoS One. 2019 Apr 29;14(4):e0216155. doi: 10.1371/journal.pone.0216155. eCollection 2019.


Small peptide-mediated self-recognition prevents cannibalism in predatory nematodes.

Lightfoot JW, Wilecki M, Rödelsperger C, Moreno E, Susoy V, Witte H, Sommer RJ.

Science. 2019 Apr 5;364(6435):86-89. doi: 10.1126/science.aav9856.


Genomic Characterization of Candidate Division LCP-89 Reveals an Atypical Cell Wall Structure, Microcompartment Production, and Dual Respiratory and Fermentative Capacities.

Youssef NH, Farag IF, Hahn CR, Jarett J, Becraft E, Eloe-Fadrosh E, Lightfoot J, Bourgeois A, Cole T, Ferrante S, Truelock M, Marsh W, Jamaleddine M, Ricketts S, Simpson R, McFadden A, Hoff W, Ravin NV, Sievert S, Stepanauskas R, Woyke T, Elshahed M.

Appl Environ Microbiol. 2019 May 2;85(10). pii: e00110-19. doi: 10.1128/AEM.00110-19. Print 2019 May 15.


Multivariate analysis as a method to understand variability in a complex excipient, and its contribution to formulation performance.

Tobyn M, Ferreira AP, Lightfoot J, Martin EB, Ghimire M, Vesey C, Kasuboski-Freeman A, Rajabi-Siahboomi A.

Pharm Dev Technol. 2018 Dec;23(10):1146-1155. doi: 10.1080/10837450.2018.1534862. Epub 2018 Nov 14.


Inter-individual variation in adaptations to endurance and resistance exercise training: genetic approaches towards understanding a complex phenotype.

Vellers HL, Kleeberger SR, Lightfoot JT.

Mamm Genome. 2018 Feb;29(1-2):48-62. doi: 10.1007/s00335-017-9732-5. Epub 2018 Jan 22. Review.


Regulation of hyperoxia-induced social behaviour in Pristionchus pacificus nematodes requires a novel cilia-mediated environmental input.

Moreno E, Sieriebriennikov B, Witte H, Rödelsperger C, Lightfoot JW, Sommer RJ.

Sci Rep. 2017 Dec 14;7(1):17550. doi: 10.1038/s41598-017-18019-0.


Biological/Genetic Regulation of Physical Activity Level: Consensus from GenBioPAC.

Lightfoot JT, DE Geus EJC, Booth FW, Bray MS, DEN Hoed M, Kaprio J, Kelly SA, Pomp D, Saul MC, Thomis MA, Garland T Jr, Bouchard C.

Med Sci Sports Exerc. 2018 Apr;50(4):863-873. doi: 10.1249/MSS.0000000000001499. Review.


High Fat High Sugar Diet Reduces Voluntary Wheel Running in Mice Independent of Sex Hormone Involvement.

Vellers HL, Letsinger AC, Walker NR, Granados JZ, Lightfoot JT.

Front Physiol. 2017 Aug 25;8:628. doi: 10.3389/fphys.2017.00628. eCollection 2017.


Hand and Wrist Injuries in Elite Boxing: A Longitudinal Prospective Study (2005-2012) of the Great Britain Olympic Boxing Squad.

Loosemore M, Lightfoot J, Gatt I, Hayton M, Beardsley C.

Hand (N Y). 2017 Mar;12(2):181-187. doi: 10.1177/1558944716642756. Epub 2016 Jul 8.


N-terminal acetylation promotes synaptonemal complex assembly in C. elegans.

Gao J, Barroso C, Zhang P, Kim HM, Li S, Labrador L, Lightfoot J, Gerashchenko MV, Labunskyy VM, Dong MQ, Martinez-Perez E, Colaiácovo MP.

Genes Dev. 2016 Nov 1;30(21):2404-2416. Epub 2016 Nov 14.


Assaying Predatory Feeding Behaviors in Pristionchus and Other Nematodes.

Lightfoot JW, Wilecki M, Okumura M, Sommer RJ.

J Vis Exp. 2016 Sep 4;(115). doi: 10.3791/54404.


The McArdle's Mouse Model: Providing Important Insight into Skeletal Muscle Regulation.

Lightfoot JT.

Med Sci Sports Exerc. 2016 Aug;48(8):1447. doi: 10.1249/MSS.0000000000000960. No abstract available.


Comparative transcriptomics of the nematode gut identifies global shifts in feeding mode and pathogen susceptibility.

Lightfoot JW, Chauhan VM, Aylott JW, Rödelsperger C.

BMC Res Notes. 2016 Mar 5;9:142. doi: 10.1186/s13104-016-1886-9.


Environmental Endocrine Disruptor Affects Voluntary Physical Activity in Mice.

Schmitt EE, Vellers HL, Porter WW, Lightfoot JT.

Med Sci Sports Exerc. 2016 Jul;48(7):1251-8. doi: 10.1249/MSS.0000000000000908.


Germline organization in Strongyloides nematodes reveals alternative differentiation and regulation mechanisms.

Kulkarni A, Lightfoot JW, Streit A.

Chromosoma. 2016 Sep;125(4):725-45. doi: 10.1007/s00412-015-0562-5. Epub 2015 Dec 12.


Comparison of Neurocognitive Testing and the Measurement of Marinobufagenin in Mild Traumatic Brain Injury: A Preliminary Report.

Oliver J, Abbas K, Lightfoot JT, Baskin K, Collins B, Wier D, Bramhall JP, Huang J, Puschett JB.

J Exp Neurosci. 2015 Jul 27;9:67-72. doi: 10.4137/JEN.S27921. eCollection 2015.


Boxing injury epidemiology in the Great Britain team: a 5-year surveillance study of medically diagnosed injury incidence and outcome.

Loosemore M, Lightfoot J, Palmer-Green D, Gatt I, Bilzon J, Beardsley C.

Br J Sports Med. 2015 Sep;49(17):1100-7. doi: 10.1136/bjsports-2015-094755. Epub 2015 Jul 17.


Heart Rate Response of Professional Musicians When Playing Music.

Vellers HL, Irwin C, Lightfoot JT.

Med Probl Perform Art. 2015 Jun;30(2):100-5. doi: 10.21091/mppa.2015.2017.


Differential protein expression in the nucleus accumbens of high and low active mice.

Ferguson DP, Dangott LJ, Vellers HL, Schmitt EE, Lightfoot JT.

Behav Brain Res. 2015 Sep 15;291:283-288. doi: 10.1016/j.bbr.2015.05.035. Epub 2015 May 23.


Predatory feeding behaviour in Pristionchus nematodes is dependent on phenotypic plasticity and induced by serotonin.

Wilecki M, Lightfoot JW, Susoy V, Sommer RJ.

J Exp Biol. 2015 May;218(Pt 9):1306-13. doi: 10.1242/jeb.118620. Epub 2015 Mar 12.


The fidelity of synaptonemal complex assembly is regulated by a signaling mechanism that controls early meiotic progression.

Silva N, Ferrandiz N, Barroso C, Tognetti S, Lightfoot J, Telecan O, Encheva V, Faull P, Hanni S, Furger A, Snijders AP, Speck C, Martinez-Perez E.

Dev Cell. 2014 Nov 24;31(4):503-11. doi: 10.1016/j.devcel.2014.10.001. Epub 2014 Nov 6.


Optimizing the physical conditioning of the NASCAR sprint cup pit crew athlete.

Ferguson DP, Davis AM, Lightfoot JT.

J Strength Cond Res. 2015 Mar;29(3):567-77. doi: 10.1519/JSC.0000000000000659.


An intronic microRNA links Rb/E2F and EGFR signaling.

Truscott M, Islam AB, Lightfoot J, López-Bigas N, Frolov MV.

PLoS Genet. 2014 Jul 24;10(7):e1004493. doi: 10.1371/journal.pgen.1004493. eCollection 2014 Jul.


Genetics of regular exercise and sedentary behaviors.

de Geus EJ, Bartels M, Kaprio J, Lightfoot JT, Thomis M.

Twin Res Hum Genet. 2014 Aug;17(4):262-71. doi: 10.1017/thg.2014.42. Review.


Lessons learned from vivo-morpholinos: How to avoid vivo-morpholino toxicity.

Ferguson DP, Dangott LJ, Lightfoot JT.

Biotechniques. 2014 May 1;56(5):251-6. doi: 10.2144/000114167. eCollection 2014 May.


Differential gene expression in high- and low-active inbred mice.

Dawes M, Moore-Harrison T, Hamilton AT, Ceaser T, Kochan KJ, Riggs PK, Lightfoot JT.

Biomed Res Int. 2014;2014:361048. doi: 10.1155/2014/361048. Epub 2014 Jan 16.


Differential skeletal muscle proteome of high- and low-active mice.

Ferguson DP, Dangott LJ, Schmitt EE, Vellers HL, Lightfoot JT.

J Appl Physiol (1985). 2014 Apr 15;116(8):1057-67. doi: 10.1152/japplphysiol.00911.2013. Epub 2014 Feb 6.


Exercise biology and medicine: innovative research to improve global health.

Bamman MM, Cooper DM, Booth FW, Chin ER, Neufer PD, Trappe S, Lightfoot JT, Kraus WE, Joyner MJ.

Mayo Clin Proc. 2014 Feb;89(2):148-53. doi: 10.1016/j.mayocp.2013.11.013. No abstract available.


Why control activity? Evolutionary selection pressures affecting the development of physical activity genetic and biological regulation.

Lightfoot JT.

Biomed Res Int. 2013;2013:821678. doi: 10.1155/2013/821678. Epub 2013 Dec 24. Review.


Chromosome movements promoted by the mitochondrial protein SPD-3 are required for homology search during Caenorhabditis elegans meiosis.

Labrador L, Barroso C, Lightfoot J, Müller-Reichert T, Flibotte S, Taylor J, Moerman DG, Villeneuve AM, Martinez-Perez E.

PLoS Genet. 2013 May;9(5):e1003497. doi: 10.1371/journal.pgen.1003497. Epub 2013 May 9.


Vivo-morpholinos induced transient knockdown of physical activity related proteins.

Ferguson DP, Schmitt EE, Lightfoot JT.

PLoS One. 2013 Apr 22;8(4):e61472. doi: 10.1371/journal.pone.0061472. Print 2013.


Effects of Supraphysiological Doses of Sex Steroids on Wheel Running Activity in Mice.

Bowen RS, Knab AM, Hamilton AT, McCall JR, Moore-Harrison TL, Lightfoot JT.

J Steroids Horm Sci. 2012 Nov 1;3(2):110.


Parents' understanding of and compliance with fasting instruction for pediatric day case surgery.

Cantellow S, Lightfoot J, Bould H, Beringer R.

Paediatr Anaesth. 2012 Sep;22(9):897-900. doi: 10.1111/j.1460-9592.2012.03903.x. Epub 2012 Jun 25.


Novel use of a disposable digital pressure transducer to increase the safety of pericardiocentesis.

Visweswaran GK, Lightfoot J, Gilchrist IC.

Catheter Cardiovasc Interv. 2013 Jan 1;81(1):E68-71. doi: 10.1002/ccd.24336. Epub 2012 May 2.


Pharmacological manipulation of the dopaminergic system affects wheel-running activity in differentially active mice.

Knab AM, Bowen RS, Hamilton AT, Lightfoot JT.

J Biol Regul Homeost Agents. 2012 Jan-Mar;26(1):119-29.


Effects of Aromatase Inhibition on the Physical Activity Levels of Male Mice.

Bowen RS, Ferguson DP, Lightfoot JT.

J Steroids Horm Sci. 2011 Nov 25;1(1):1-7.


Incidence and causes for syringe driver site reactions in palliative care: A prospective hospice-based study.

Mitchell K, Pickard J, Herbert A, Lightfoot J, Roberts D.

Palliat Med. 2012 Dec;26(8):979-85. doi: 10.1177/0269216311428096. Epub 2011 Nov 14.


Loading of meiotic cohesin by SCC-2 is required for early processing of DSBs and for the DNA damage checkpoint.

Lightfoot J, Testori S, Barroso C, Martinez-Perez E.

Curr Biol. 2011 Sep 13;21(17):1421-30. doi: 10.1016/j.cub.2011.07.007.


Epistatic interactions of genes influence within-individual variation of physical activity traits in mice.

Leamy LJ, Pomp D, Lightfoot JT.

Genetica. 2011 Jun;139(6):813-21. doi: 10.1007/s10709-011-9586-9. Epub 2011 Jun 11.


Heart rate and core temperature responses of elite pit crews during automobile races.

Ferguson DP, Bowen RS, Lightfoot JT.

J Strength Cond Res. 2011 Aug;25(8):2075-83. doi: 10.1519/JSC.0b013e3181f5676d.


Pharmacologic treatment of panic disorder.

Stein M, Steckler T, Lightfoot JD, Hay E, Goddard AW.

Curr Top Behav Neurosci. 2010;2:469-85. Review.


Current understanding of the genetic basis for physical activity.

Lightfoot JT.

J Nutr. 2011 Mar;141(3):526-30. doi: 10.3945/jn.110.127290. Epub 2011 Jan 26.


Sex hormone effects on physical activity levels: why doesn't Jane run as much as Dick?

Bowen RS, Turner MJ, Lightfoot JT.

Sports Med. 2011 Jan 1;41(1):73-86. doi: 10.2165/11536860-000000000-00000. Review.


Driven to be inactive? The genetics of physical activity.

Moore-Harrison T, Lightfoot JT.

Prog Mol Biol Transl Sci. 2010;94:271-90. doi: 10.1016/S1877-1173(10)94010-6. Review.


Preclinical toxicity and toxicokinetics of GTI-2040, a phosphorothioate oligonucleotide targeting ribonucleotide reductase R2.

Ferdinandi ES, Vassilakos A, Lee Y, Lightfoot J, Fitsialos D, Wright JA, Young AH.

Cancer Chemother Pharmacol. 2011 Jul;68(1):193-205. doi: 10.1007/s00280-010-1473-z. Epub 2010 Oct 1.


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