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Items: 1 to 50 of 108

1.

Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition.

Augert A, Eastwood E, Ibrahim AH, Wu N, Grunblatt E, Basom R, Liggitt D, Eaton KD, Martins R, Poirier JT, Rudin CM, Milletti F, Cheng WY, Mack F, MacPherson D.

Sci Signal. 2019 Feb 5;12(567). pii: eaau2922. doi: 10.1126/scisignal.aau2922.

PMID:
30723171
2.

Host Nitric Oxide Disrupts Microbial Cell-to-Cell Communication to Inhibit Staphylococcal Virulence.

Urbano R, Karlinsey JE, Libby SJ, Doulias PT, Ischiropoulos H, Warheit-Niemi HI, Liggitt DH, Horswill AR, Fang FC.

Cell Host Microbe. 2018 May 9;23(5):594-606.e7. doi: 10.1016/j.chom.2018.04.001.

PMID:
29706505
3.

Testing drug combinations to slow aging.

Ladiges W, Liggitt D.

Pathobiol Aging Age Relat Dis. 2017 Nov 23;8(1):1407203. doi: 10.1080/20010001.2017.1407203. eCollection 2018. No abstract available.

4.

Tomographic magnetic particle imaging of cancer targeted nanoparticles.

Arami H, Teeman E, Troksa A, Bradshaw H, Saatchi K, Tomitaka A, Gambhir SS, Häfeli UO, Liggitt D, Krishnan KM.

Nanoscale. 2017 Dec 7;9(47):18723-18730. doi: 10.1039/c7nr05502a.

5.

The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.

Gorman JA, Hundhausen C, Errett JS, Stone AE, Allenspach EJ, Ge Y, Arkatkar T, Clough C, Dai X, Khim S, Pestal K, Liggitt D, Cerosaletti K, Stetson DB, James RG, Oukka M, Concannon P, Gale M Jr, Buckner JH, Rawlings DJ.

Nat Immunol. 2017 Jul;18(7):744-752. doi: 10.1038/ni.3766. Epub 2017 May 29.

6.

Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector.

Singh S, Khan I, Khim S, Seymour B, Sommer K, Wielgosz M, Norgaard Z, Kiem HP, Adair J, Liggitt D, Nienhuis A, Rawlings DJ.

Mol Ther Methods Clin Dev. 2016 Dec 18;4:1-16. doi: 10.1016/j.omtm.2016.11.001. eCollection 2017 Mar 17.

7.

A New Preclinical Paradigm for Testing Anti-Aging Therapeutics.

Ladiges W, Snyder JM, Wilkinson E, Imai DM, Snider T, Ge X, Ciol M, Pettan-Brewer C, Pillai SPS, Morton J, Quarles E, Rabinovitch P, Niedernhofer L, Liggitt D.

J Gerontol A Biol Sci Med Sci. 2017 Jun 1;72(6):760-762. doi: 10.1093/gerona/glx019.

8.
9.

Response to paper by Singh et al. "Hyperinsulinemia adversely affects lung structure and function".

Wolff RK, Brain JD, Patton JS, Liggitt D.

Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1;311(1):L180-2. doi: 10.1152/ajplung.00187.2016. No abstract available.

10.

ST-11: A New Brain-Penetrant Microtubule-Destabilizing Agent with Therapeutic Potential for Glioblastoma Multiforme.

Cherry AE, Haas BR, Naydenov AV, Fung S, Xu C, Swinney K, Wagenbach M, Freeling J, Canton DA, Coy J, Horne EA, Rickman B, Vicente JJ, Scott JD, Ho RJ, Liggitt D, Wordeman L, Stella N.

Mol Cancer Ther. 2016 Sep;15(9):2018-29. doi: 10.1158/1535-7163.MCT-15-0800. Epub 2016 Jun 20.

11.

Neuropathological assessment and validation of mouse models for Alzheimer's disease: applying NIA-AA guidelines.

Keene CD, Darvas M, Kraemer B, Liggitt D, Sigurdson C, Ladiges W.

Pathobiol Aging Age Relat Dis. 2016 Jun 16;6:32397. doi: 10.3402/pba.v6.32397. eCollection 2016.

12.

In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles.

Arami H, Khandhar A, Liggitt D, Krishnan KM.

Chem Soc Rev. 2015 Dec 7;44(23):8576-607. doi: 10.1039/c5cs00541h. Epub 2015 Sep 21. Review.

13.

The Geropathology Research Network: An Interdisciplinary Approach for Integrating Pathology Into Research on Aging.

Ladiges W, Ikeno Y, Niedernhofer L, McIndoe RA, Ciol MA, Ritchey J, Liggitt D.

J Gerontol A Biol Sci Med Sci. 2016 Apr;71(4):431-4. doi: 10.1093/gerona/glv079. Epub 2015 Aug 4.

14.

A streptococcal lipid toxin induces membrane permeabilization and pyroptosis leading to fetal injury.

Whidbey C, Vornhagen J, Gendrin C, Boldenow E, Samson JM, Doering K, Ngo L, Ezekwe EA Jr, Gundlach JH, Elovitz MA, Liggitt D, Duncan JA, Adams Waldorf KM, Rajagopal L.

EMBO Mol Med. 2015 Apr;7(4):488-505. doi: 10.15252/emmm.201404883.

15.

Hepatocellular heme oxygenase-1: a potential mechanism of erythropoietin-mediated protection after liver ischemia-reperfusion injury.

Riehle KJ, Hoagland V, Benz W, Campbell JS, Liggitt DH, Langdale LA.

Shock. 2014 Nov;42(5):424-31. doi: 10.1097/SHK.0000000000000231.

16.

Preclinical safety and effectiveness studies of ultrasonic propulsion of kidney stones.

Harper JD, Dunmire B, Wang YN, Simon JC, Liggitt D, Paun M, Cunitz BW, Starr F, Bailey MR, Penniston KL, Lee FC, Hsi RS, Sorensen MD.

Urology. 2014 Aug;84(2):484-9. doi: 10.1016/j.urology.2014.04.041. Epub 2014 Jun 26.

17.

Focused ultrasound to displace renal calculi: threshold for tissue injury.

Wang YN, Simon JC, Cunitz BW, Starr FL, Paun M, Liggitt DH, Evan AP, McAteer JA, Liu Z, Dunmire B, Bailey MR.

J Ther Ultrasound. 2014 Mar 31;2:5. doi: 10.1186/2050-5736-2-5. eCollection 2014.

18.

Cytokine-regulated neutrophil recruitment is required for brain but not spinal cord inflammation during experimental autoimmune encephalomyelitis.

Simmons SB, Liggitt D, Goverman JM.

J Immunol. 2014 Jul 15;193(2):555-63. doi: 10.4049/jimmunol.1400807. Epub 2014 Jun 9.

19.

CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer.

Kemp CJ, Moore JM, Moser R, Bernard B, Teater M, Smith LE, Rabaia NA, Gurley KE, Guinney J, Busch SE, Shaknovich R, Lobanenkov VV, Liggitt D, Shmulevich I, Melnick A, Filippova GN.

Cell Rep. 2014 May 22;7(4):1020-9. doi: 10.1016/j.celrep.2014.04.004. Epub 2014 May 1.

20.

Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation.

Jackson SW, Scharping NE, Kolhatkar NS, Khim S, Schwartz MA, Li QZ, Hudkins KL, Alpers CE, Liggitt D, Rawlings DJ.

J Immunol. 2014 May 15;192(10):4525-32. doi: 10.4049/jimmunol.1400098. Epub 2014 Apr 7.

21.

Relapsing-remitting central nervous system autoimmunity mediated by GFAP-specific CD8 T cells.

Sasaki K, Bean A, Shah S, Schutten E, Huseby PG, Peters B, Shen ZT, Vanguri V, Liggitt D, Huseby ES.

J Immunol. 2014 Apr 1;192(7):3029-42. doi: 10.4049/jimmunol.1302911. Epub 2014 Mar 3.

22.

Pathology is a critical aspect of preclinical aging studies.

Ladiges W, Ikeno Y, Liggitt D, Treuting PM.

Pathobiol Aging Age Relat Dis. 2013 Aug 20;3. doi: 10.3402/pba.v3i0.22451. eCollection 2013.

23.

3aBAb5. Ultrasound intensity to propel stones from the kidney is below the threshold for renal injury.

Wang YN, Simon JC, Cunitz B, Starr F, Paun M, Liggitt D, Evan A, McAteer J, Williams J, Liu Z, Kaczkowski P, Hsi R, Sorensen M, Harper J, Bailey MR.

Proc Meet Acoust. 2013 Jun;19(1). pii: 075066.

24.

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.

Dai X, James RG, Habib T, Singh S, Jackson S, Khim S, Moon RT, Liggitt D, Wolf-Yadlin A, Buckner JH, Rawlings DJ.

J Clin Invest. 2013 May;123(5):2024-36. doi: 10.1172/JCI66963. Epub 2013 Apr 24.

25.

Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells.

Bermejo DA, Jackson SW, Gorosito-Serran M, Acosta-Rodriguez EV, Amezcua-Vesely MC, Sather BD, Singh AK, Khim S, Mucci J, Liggitt D, Campetella O, Oukka M, Gruppi A, Rawlings DJ.

Nat Immunol. 2013 May;14(5):514-22. doi: 10.1038/ni.2569. Epub 2013 Apr 7.

26.

Increased ribonuclease expression reduces inflammation and prolongs survival in TLR7 transgenic mice.

Sun X, Wiedeman A, Agrawal N, Teal TH, Tanaka L, Hudkins KL, Alpers CE, Bolland S, Buechler MB, Hamerman JA, Ledbetter JA, Liggitt D, Elkon KB.

J Immunol. 2013 Mar 15;190(6):2536-43. doi: 10.4049/jimmunol.1202689. Epub 2013 Feb 4.

27.

Inhalation of nebulized perfluorochemical enhances recombinant adenovirus and adeno-associated virus-mediated gene expression in lung epithelium.

Beckett T, Bonneau L, Howard A, Blanchard J, Borda J, Weiner DJ, Wang L, Gao GP, Kolls JK, Bohm R, Liggitt D, Weiss DJ.

Hum Gene Ther Methods. 2012 Apr;23(2):98-110. doi: 10.1089/hgtb.2012.014. Epub 2012 May 8.

28.

WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity.

Becker-Herman S, Meyer-Bahlburg A, Schwartz MA, Jackson SW, Hudkins KL, Liu C, Sather BD, Khim S, Liggitt D, Song W, Silverman GJ, Alpers CE, Rawlings DJ.

J Exp Med. 2011 Sep 26;208(10):2033-42. doi: 10.1084/jem.20110200. Epub 2011 Aug 29.

29.

Plasma proteome profiles associated with inflammation, angiogenesis, and cancer.

Kelly-Spratt KS, Pitteri SJ, Gurley KE, Liggitt D, Chin A, Kennedy J, Wong CH, Zhang Q, Buson TB, Wang H, Hanash SM, Kemp CJ.

PLoS One. 2011 May 12;6(5):e19721. doi: 10.1371/journal.pone.0019721.

30.

Vascular endothelial platelet endothelial cell adhesion molecule 1 (PECAM-1) regulates advanced metastatic progression.

DeLisser H, Liu Y, Desprez PY, Thor A, Briasouli P, Handumrongkul C, Wilfong J, Yount G, Nosrati M, Fong S, Shtivelman E, Fehrenbach M, Cao G, Moore DH, Nayak S, Liggitt D, Kashani-Sabet M, Debs R.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18616-21. doi: 10.1073/pnas.1004654107. Epub 2010 Oct 6. Erratum in: Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3821. Nyack, Shruti [corrected to Nayak, Shruti].

31.

A phase I study of concurrent chemotherapy (paclitaxel and carboplatin) and thoracic radiotherapy with swallowed manganese superoxide dismutase plasmid liposome protection in patients with locally advanced stage III non-small-cell lung cancer.

Tarhini AA, Belani CP, Luketich JD, Argiris A, Ramalingam SS, Gooding W, Pennathur A, Petro D, Kane K, Liggitt D, Championsmith T, Zhang X, Epperly MW, Greenberger JS.

Hum Gene Ther. 2011 Mar;22(3):336-42. doi: 10.1089/hum.2010.078. Epub 2011 Feb 2.

32.

A non-coding cationic lipid DNA complex produces lasting anti-leukemic effects.

Keasey N, Herse Z, Chang S, Liggitt DH, Lay M, Fairman J, Claxton DF.

Cancer Biol Ther. 2010 Sep 15;10(6):625-31. Epub 2010 Sep 13.

33.

G alpha q-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity.

Misra RS, Shi G, Moreno-Garcia ME, Thankappan A, Tighe M, Mousseau B, Kusser K, Becker-Herman S, Hudkins KL, Dunn R, Kehry MR, Migone TS, Marshak-Rothstein A, Simon M, Randall TD, Alpers CE, Liggitt D, Rawlings DJ, Lund FE.

J Exp Med. 2010 Aug 2;207(8):1775-89. doi: 10.1084/jem.20092735. Epub 2010 Jul 12.

34.

B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.

Kerns HM, Ryu BY, Stirling BV, Sather BD, Astrakhan A, Humblet-Baron S, Liggitt D, Rawlings DJ.

Blood. 2010 Mar 18;115(11):2146-55. doi: 10.1182/blood-2009-09-241869. Epub 2010 Jan 21.

35.

Evaluation of vascular delivery methodologies to enhance rAAV6-mediated gene transfer to canine striated musculature.

Gregorevic P, Schultz BR, Allen JM, Halldorson JB, Blankinship MJ, Meznarich NA, Kuhr CS, Doremus C, Finn E, Liggitt D, Chamberlain JS.

Mol Ther. 2009 Aug;17(8):1427-33. doi: 10.1038/mt.2009.116. Epub 2009 May 26.

36.

A Bayesian integration model of high-throughput proteomics and metabolomics data for improved early detection of microbial infections.

Webb-Robertson BJ, McCue LA, Beagley N, McDermott JE, Wunschel DS, Varnum SM, Hu JZ, Isern NG, Buchko GW, Mcateer K, Pounds JG, Skerrett SJ, Liggitt D, Frevert CW.

Pac Symp Biocomput. 2009:451-63.

37.

Suppressor of cytokine signaling expression with increasing severity of murine hepatic ischemia-reperfusion injury.

Langdale LA, Hoagland V, Benz W, Riehle KJ, Campbell JS, Liggitt DH, Fausto N.

J Hepatol. 2008 Aug;49(2):198-206. doi: 10.1016/j.jhep.2008.03.014. Epub 2008 May 8.

38.

Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells.

Stromnes IM, Cerretti LM, Liggitt D, Harris RA, Goverman JM.

Nat Med. 2008 Mar;14(3):337-42. doi: 10.1038/nm1715. Epub 2008 Feb 17.

39.

Regulatory T cells maintain long-term tolerance to myelin basic protein by inducing a novel, dynamic state of T cell tolerance.

Cabbage SE, Huseby ES, Sather BD, Brabb T, Liggitt D, Goverman J.

J Immunol. 2007 Jan 15;178(2):887-96.

40.

Mechanical ventilation interacts with endotoxemia to induce extrapulmonary organ dysfunction.

O'Mahony DS, Liles WC, Altemeier WA, Dhanireddy S, Frevert CW, Liggitt D, Martin TR, Matute-Bello G.

Crit Care. 2006;10(5):R136.

42.

Systemic co-administration of depsipeptide selectively targets transfection enhancement to specific tissues and cell types.

Liu Y, Liggitt D, Fong S, Debs RJ.

Gene Ther. 2006 Dec;13(24):1724-30. Epub 2006 Aug 3.

PMID:
16886001
43.

An adult dog with cyclic neutropenia treated by lentivirus- mediated delivery of granulocyte colony-stimulating factor.

Yanay O, Brzezinski M, Christensen J, Liggitt D, Dale DC, Osborne WR.

Hum Gene Ther. 2006 Apr;17(4):464-9.

PMID:
16610934
44.

Liposome-DNA complexes infused intravenously inhibit tumor angiogenesis and elicit antitumor activity in dogs with soft tissue sarcoma.

Kamstock D, Guth A, Elmslie R, Kurzman I, Liggitt D, Coro L, Fairman J, Dow S.

Cancer Gene Ther. 2006 Mar;13(3):306-17.

PMID:
16138118
45.

Phase I study of liposome-DNA complexes encoding the interleukin-2 gene in dogs with osteosarcoma lung metastases.

Dow S, Elmslie R, Kurzman I, MacEwen G, Pericle F, Liggitt D.

Hum Gene Ther. 2005 Aug;16(8):937-46.

PMID:
16076252
46.
47.

Interleukin-7 improves reconstitution of antiviral CD4 T cells.

Lu H, Zhao Z, Kalina T, Gillespy T 3rd, Liggitt D, Andrews RG, Maloney DG, Kiem HP, Storek J.

Clin Immunol. 2005 Jan;114(1):30-41.

PMID:
15596407
48.
49.

Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors.

Hsieh CS, Liang Y, Tyznik AJ, Self SG, Liggitt D, Rudensky AY.

Immunity. 2004 Aug;21(2):267-77.

50.

Radiation-induced glioblastoma multiforme in two adult baboons (Papio cynocephalus anubis).

Schielke JE, Kiem HP, Liggitt D, Bielefeldt-Ohmann H.

Comp Med. 2004 Jun;54(3):327-32.

PMID:
15253281

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