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Preface to Special Issue on 'Cytochrome P450 Variation in Pharmacogenomics'.

Rettie AE, Liggett SB.

J Pers Med. 2018 Jul 4;8(3). pii: E23. doi: 10.3390/jpm8030023. No abstract available.


Pepducins as a potential treatment strategy for asthma and COPD.

Panettieri RA, Pera T, Liggett SB, Benovic JL, Penn RB.

Curr Opin Pharmacol. 2018 Jun;40:120-125. doi: 10.1016/j.coph.2018.04.008. Epub 2018 May 2. Review.


Genetic Vulnerability of GPCRs: A Call to Action.

Liggett SB.

Trends Biochem Sci. 2018 Apr;43(4):227-229. doi: 10.1016/j.tibs.2018.02.006.


A Genome-Wide Association Study of Idiopathic Dilated Cardiomyopathy in African Americans.

Xu H, Dorn GW 2nd, Shetty A, Parihar A, Dave T, Robinson SW, Gottlieb SS, Donahue MP, Tomaselli GF, Kraus WE, Mitchell BD, Liggett SB.

J Pers Med. 2018 Feb 26;8(1). pii: E11. doi: 10.3390/jpm8010011.


A CREB-mediated increase in miRNA let-7f during prolonged β-agonist exposure: a novel mechanism of β2-adrenergic receptor down-regulation in airway smooth muscle.

Kim D, Cho S, Woo JA, Liggett SB.

FASEB J. 2018 Jul;32(7):3680-3688. doi: 10.1096/fj.201701278R. Epub 2018 Feb 13.


Taste and smell GPCRs in the lung: Evidence for a previously unrecognized widespread chemosensory system.

An SS, Liggett SB.

Cell Signal. 2018 Jan;41:82-88. doi: 10.1016/j.cellsig.2017.02.002. Epub 2017 Feb 4. Review.


Coupling of Airway Smooth Muscle Bitter Taste Receptors to Intracellular Signaling and Relaxation Is via Gαi1,2,3.

Kim D, Woo JA, Geffken E, An SS, Liggett SB.

Am J Respir Cell Mol Biol. 2017 Jun;56(6):762-771. doi: 10.1165/rcmb.2016-0373OC.


Defining an olfactory receptor function in airway smooth muscle cells.

Aisenberg WH, Huang J, Zhu W, Rajkumar P, Cruz R, Santhanam L, Natarajan N, Yong HM, De Santiago B, Oh JJ, Yoon AR, Panettieri RA, Homann O, Sullivan JK, Liggett SB, Pluznick JL, An SS.

Sci Rep. 2016 Dec 1;6:38231. doi: 10.1038/srep38231.


Inhibition of PI3K promotes dilation of human small airways in a rho kinase-dependent manner.

Koziol-White CJ, Yoo EJ, Cao G, Zhang J, Papanikolaou E, Pushkarsky I, Andrews A, Himes BE, Damoiseaux RD, Liggett SB, Di Carlo D, Kurten RC, Panettieri RA Jr.

Br J Pharmacol. 2016 Sep;173(18):2726-38. doi: 10.1111/bph.13542. Epub 2016 Aug 3.


β2-Adrenergic Receptors Chaperone Trapped Bitter Taste Receptor 14 to the Cell Surface as a Heterodimer and Exert Unidirectional Desensitization of Taste Receptor Function.

Kim D, Pauer SH, Yong HM, An SS, Liggett SB.

J Biol Chem. 2016 Aug 19;291(34):17616-28. doi: 10.1074/jbc.M116.722736. Epub 2016 Jun 24.


An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma.

An SS, Mitzner W, Tang WY, Ahn K, Yoon AR, Huang J, Kilic O, Yong HM, Fahey JW, Kumar S, Biswal S, Holgate ST, Panettieri RA Jr, Solway J, Liggett SB.

J Allergy Clin Immunol. 2016 Jul;138(1):294-297.e4. doi: 10.1016/j.jaci.2015.12.1315. Epub 2016 Feb 28. No abstract available.


Pleiotropic Effects of Bitter Taste Receptors on [Ca2+]i Mobilization, Hyperpolarization, and Relaxation of Human Airway Smooth Muscle Cells.

Camoretti-Mercado B, Pauer SH, Yong HM, Smith DC, Deshpande DA, An SS, Liggett SB.

PLoS One. 2015 Jun 29;10(6):e0131582. doi: 10.1371/journal.pone.0131582. eCollection 2015.


Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association.

Fox CS, Hall JL, Arnett DK, Ashley EA, Delles C, Engler MB, Freeman MW, Johnson JA, Lanfear DE, Liggett SB, Lusis AJ, Loscalzo J, MacRae CA, Musunuru K, Newby LK, O'Donnell CJ, Rich SS, Terzic A; American Heart Association Council on Functional Genomics and Translational Biology, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, Council on Quality of Care and Outcomes Research, and Council on Epidemiology and Prevention.

Circulation. 2015 May 12;131(19):1715-36. doi: 10.1161/CIR.0000000000000211. Epub 2015 Apr 16.


Race, common genetic variation, and therapeutic response disparities in heart failure.

Taylor MR, Sun AY, Davis G, Fiuzat M, Liggett SB, Bristow MR.

JACC Heart Fail. 2014 Dec;2(6):561-72. doi: 10.1016/j.jchf.2014.06.010. Epub 2014 Oct 22. Review.


Targeted transgenesis identifies Gαs as the bottleneck in β2-adrenergic receptor cell signaling and physiological function in airway smooth muscle.

Wang WC, Pauer SH, Smith DC, Dixon MA, Disimile DJ, Panebra A, An SS, Camoretti-Mercado B, Liggett SB.

Am J Physiol Lung Cell Mol Physiol. 2014 Nov 15;307(10):L775-80. doi: 10.1152/ajplung.00209.2014. Epub 2014 Sep 26.


Bitter taste receptors in the wrong place: novel airway smooth muscle targets for treating asthma.

Liggett SB.

Trans Am Clin Climatol Assoc. 2014;125:64-74; discussion 74-5.


Polymorphisms in human heat shock factor-1 and analysis of potential biological consequences.

Bridges TM, Scheraga RG, Tulapurkar ME, Suffredini D, Liggett SB, Ramarathnam A, Potla R, Singh IS, Hasday JD.

Cell Stress Chaperones. 2015 Jan;20(1):47-59. doi: 10.1007/s12192-014-0524-5. Epub 2014 Jul 16.


Genome sequences of rhinovirus C isolates from wisconsin pediatric respiratory studies.

Liggett SB, Bochkov YA, Pappas T, Lemanske RF Jr, Gern JE, Sengamalay N, Zhao X, Su Q, Fraser CM, Palmenberg AC.

Genome Announc. 2014 Mar 27;2(2). pii: e00203-14. doi: 10.1128/genomeA.00203-14.


Genome sequences of rhinovirus B isolates from wisconsin pediatric respiratory studies.

Liggett SB, Bochkov YA, Pappas T, Lemanske RF Jr, Gern JE, Sengamalay N, Zhao X, Su Q, Fraser CM, Palmenberg AC.

Genome Announc. 2014 Mar 27;2(2). pii: e00202-14. doi: 10.1128/genomeA.00202-14.


Genome sequences of rhinovirus a isolates from wisconsin pediatric respiratory studies.

Liggett SB, Bochkov YA, Pappas T, Lemanske RF Jr, Gern JE, Sengamalay N, Zhao X, Su Q, Fraser CM, Palmenberg AC.

Genome Announc. 2014 Mar 27;2(2). pii: e00200-14. doi: 10.1128/genomeA.00200-14.


Bitter taste receptor function in asthmatic and nonasthmatic human airway smooth muscle cells.

Robinett KS, Koziol-White CJ, Akoluk A, An SS, Panettieri RA Jr, Liggett SB.

Am J Respir Cell Mol Biol. 2014 Apr;50(4):678-83. doi: 10.1165/rcmb.2013-0439RC.


Prevention of atrial fibrillation by bucindolol is dependent on the beta₁389 Arg/Gly adrenergic receptor polymorphism.

Aleong RG, Sauer WH, Davis G, Murphy GA, Port JD, Anand IS, Fiuzat M, O'Connor CM, Abraham WT, Liggett SB, Bristow MR.

JACC Heart Fail. 2013 Aug;1(4):338-344. doi: 10.1016/j.jchf.2013.04.002.


Bitter taste receptors on airway smooth muscle as targets for novel bronchodilators.

Liggett SB.

Expert Opin Ther Targets. 2013 Jun;17(6):721-31. doi: 10.1517/14728222.2013.782395. Epub 2013 Apr 12. Review.


Adrenergic receptor polymorphisms and prevention of ventricular arrhythmias with bucindolol in patients with chronic heart failure.

Aleong RG, Sauer WH, Robertson AD, Liggett SB, Bristow MR.

Circ Arrhythm Electrophysiol. 2013 Feb;6(1):137-43. doi: 10.1161/CIRCEP.111.969618. Epub 2012 Dec 30.


Combinatorial pharmacogenetic interactions of bucindolol and β1, α2C adrenergic receptor polymorphisms.

O'Connor CM, Fiuzat M, Carson PE, Anand IS, Plehn JF, Gottlieb SS, Silver MA, Lindenfeld J, Miller AB, White M, Walsh R, Nelson P, Medway A, Davis G, Robertson AD, Port JD, Carr J, Murphy GA, Lazzeroni LC, Abraham WT, Liggett SB, Bristow MR.

PLoS One. 2012;7(10):e44324. doi: 10.1371/journal.pone.0044324. Epub 2012 Oct 10.


Extraoral bitter taste receptors as mediators of off-target drug effects.

Clark AA, Liggett SB, Munger SD.

FASEB J. 2012 Dec;26(12):4827-31. doi: 10.1096/fj.12-215087. Epub 2012 Sep 10.


G protein receptor kinase 4 polymorphisms: β-blocker pharmacogenetics and treatment-related outcomes in hypertension.

Vandell AG, Lobmeyer MT, Gawronski BE, Langaee TY, Gong Y, Gums JG, Beitelshees AL, Turner ST, Chapman AB, Cooper-DeHoff RM, Bailey KR, Boerwinkle E, Pepine CJ, Liggett SB, Johnson JA.

Hypertension. 2012 Oct;60(4):957-64. doi: 10.1161/HYPERTENSIONAHA.112.198721. Epub 2012 Sep 4.


TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis.

An SS, Wang WC, Koziol-White CJ, Ahn K, Lee DY, Kurten RC, Panettieri RA Jr, Liggett SB.

Am J Physiol Lung Cell Mol Physiol. 2012 Aug 15;303(4):L304-11. doi: 10.1152/ajplung.00126.2012. Epub 2012 Jun 8.


Reply to: Activation of BK channels may not be required for bitter tastant-induced bronchodilation.

An SS, Robinett KS, Deshpande DA, Wang WC, Liggett SB.

Nat Med. 2012 May 4;18(5):650-1. doi: 10.1038/nm.2734. No abstract available.


A polymorphism in the thyroid hormone receptor gene is associated with bronchodilator response in asthmatics.

Duan QL, Du R, Lasky-Su J, Klanderman BJ, Partch AB, Peters SP, Irvin CG, Hanrahan JP, Lima JJ, Blake KV, Liggett SB, Litonjua AA, Tantisira KG.

Pharmacogenomics J. 2013 Apr;13(2):130-6. doi: 10.1038/tpj.2011.56. Epub 2012 Jan 3.


Temporal analysis of mRNA and miRNA expression in transgenic mice overexpressing Arg- and Gly389 polymorphic variants of the β1-adrenergic receptor.

Dockstader K, Nunley K, Karimpour-Fard A, Medway A, Nelson P, Port JD, Liggett SB, Bristow MR, Sucharov CC.

Physiol Genomics. 2011 Dec 5;43(23):1294-306. doi: 10.1152/physiolgenomics.00067.2011. Epub 2011 Sep 27.


Genetic variation, β-blockers, and perioperative myocardial infarction.

Nagele P, Liggett SB.

Anesthesiology. 2011 Dec;115(6):1316-27. doi: 10.1097/ALN.0b013e3182315eb2. Review.


Phosphorylation barcoding as a mechanism of directing GPCR signaling.

Liggett SB.

Sci Signal. 2011 Aug 9;4(185):pe36. doi: 10.1126/scisignal.2002331. Review.


Bronchodilator activity of bitter tastants in human tissue.

Deshpande DA, Robinett KS, Wang WC, Sham JS, An SS, Liggett SB.

Nat Med. 2011 Jul 7;17(7):776-8. doi: 10.1038/nm0711-776b. No abstract available.


Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors.

Robinett KS, Deshpande DA, Malone MM, Liggett SB.

Am J Respir Cell Mol Biol. 2011 Nov;45(5):1069-74. doi: 10.1165/rcmb.2011-0061OC. Epub 2011 Jun 3.


β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D.

Trian T, Burgess JK, Niimi K, Moir LM, Ge Q, Berger P, Liggett SB, Black JL, Oliver BG.

PLoS One. 2011;6(5):e20000. doi: 10.1371/journal.pone.0020000. Epub 2011 May 17.


Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C.

Bochkov YA, Palmenberg AC, Lee WM, Rathe JA, Amineva SP, Sun X, Pasic TR, Jarjour NN, Liggett SB, Gern JE.

Nat Med. 2011 May;17(5):627-32. doi: 10.1038/nm.2358. Epub 2011 Apr 10.


MicroRNA let-7 establishes expression of beta2-adrenergic receptors and dynamically down-regulates agonist-promoted down-regulation.

Wang WC, Juan AH, Panebra A, Liggett SB.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6246-51. doi: 10.1073/pnas.1101439108. Epub 2011 Mar 29.


Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.

Parsa A, Chang YP, Kelly RJ, Corretti MC, Ryan KA, Robinson SW, Gottlieb SS, Kardia SL, Shuldiner AR, Liggett SB.

Clin Transl Sci. 2011 Feb;4(1):17-23. doi: 10.1111/j.1752-8062.2010.00251.x.


Cardiovascular pharmacogenomics of adrenergic receptor signaling: clinical implications and future directions.

Johnson JA, Liggett SB.

Clin Pharmacol Ther. 2011 Mar;89(3):366-78. doi: 10.1038/clpt.2010.315. Epub 2011 Feb 2. Review.


Paradoxical attenuation of β2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase.

Wang WC, Schillinger RM, Malone MM, Liggett SB.

Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L472-8. doi: 10.1152/ajplung.00273.2010. Epub 2010 Dec 3.


Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction.

Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB.

Nat Med. 2010 Nov;16(11):1299-304. doi: 10.1038/nm.2237. Epub 2010 Oct 24.


Regulatory haplotypes in ARG1 are associated with altered bronchodilator response.

Duan QL, Gaume BR, Hawkins GA, Himes BE, Bleecker ER, Klanderman B, Irvin CG, Peters SP, Meyers DA, Hanrahan JP, Lima JJ, Litonjua AA, Tantisira KG, Liggett SB.

Am J Respir Crit Care Med. 2011 Feb 15;183(4):449-54. doi: 10.1164/rccm.201005-0758OC. Epub 2010 Sep 17.


Striated muscle tropomyosin isoforms differentially regulate cardiac performance and myofilament calcium sensitivity.

Jagatheesan G, Rajan S, Ahmed RP, Petrashevskaya N, Boivin G, Arteaga GM, Tae HJ, Liggett SB, Solaro RJ, Wieczorek DF.

J Muscle Res Cell Motil. 2010 Sep;31(3):227-39. doi: 10.1007/s10974-010-9228-3. Epub 2010 Aug 28.


Common ADRB2 haplotypes derived from 26 polymorphic sites direct beta2-adrenergic receptor expression and regulation phenotypes.

Panebra A, Wang WC, Malone MM, Pitter DR, Weiss ST, Hawkins GA, Liggett SB.

PLoS One. 2010 Jul 29;5(7):e11819. doi: 10.1371/journal.pone.0011819.


Analysis of the complete genome sequences of human rhinovirus.

Palmenberg AC, Rathe JA, Liggett SB.

J Allergy Clin Immunol. 2010 Jun;125(6):1190-9; quiz 1200-1. doi: 10.1016/j.jaci.2010.04.010. Epub 2010 May 14. Review.


alpha2A-adrenergic receptors in the genetics, pathogenesis, and treatment of type 2 diabetes.

Liggett SB.

Sci Transl Med. 2009 Dec 23;1(12):12ps15. doi: 10.1126/scitranslmed.3000606. Review.


Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform.

Rajan S, Jagatheesan G, Karam CN, Alves ML, Bodi I, Schwartz A, Bulcao CF, D'Souza KM, Akhter SA, Boivin GP, Dube DK, Petrashevskaya N, Herr AB, Hullin R, Liggett SB, Wolska BM, Solaro RJ, Wieczorek DF.

Circulation. 2010 Jan 26;121(3):410-8. doi: 10.1161/CIRCULATIONAHA.109.889725. Epub 2010 Jan 11.


Pharmacogenomics of beta1-adrenergic receptor polymorphisms in heart failure.

Liggett SB.

Heart Fail Clin. 2010 Jan;6(1):27-33. doi: 10.1016/j.hfc.2009.08.011. Review.


Full-genome sequence and analysis of a novel human rhinovirus strain within a divergent HRV-A clade.

Rathe JA, Liu X, Tallon LJ, Gern JE, Liggett SB.

Arch Virol. 2010;155(1):83-7. doi: 10.1007/s00705-009-0549-8. Epub 2009 Nov 20.

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