Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 56

1.

Sex-specific metabolic functions of adipose Lipocalin-2.

Chella Krishnan K, Sabir S, Shum M, Meng Y, Acín-Pérez R, Lang JM, Floyd RR, Vergnes L, Seldin MM, Fuqua BK, Jayasekera DW, Nand SK, Anum DC, Pan C, Stiles L, Péterfy M, Reue K, Liesa M, Lusis AJ.

Mol Metab. 2019 Dec;30:30-47. doi: 10.1016/j.molmet.2019.09.009. Epub 2019 Sep 27.

2.

Mitochondrial Proton Leak Regulated by Cyclophilin D elevates Insulin Secretion in Islets at Non-Stimulatory Glucose Levels.

Taddeo EP, Alsabeeh N, Baghdasarian S, Wikstrom JD, Ritou E, Sereda S, Erion K, Li J, Stiles L, Abdulla M, Swanson Z, Wilhelm J, Bellin MD, Kibbey RG, Liesa M, Shirihai O.

Diabetes. 2019 Nov 18. pii: db190379. doi: 10.2337/db19-0379. [Epub ahead of print]

PMID:
31740442
3.

Author Correction: LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.

Kottakis F, Nicolay BN, Roumane A, Karnik R, Gu H, Nagle JM, Boukhali M, Hayward MC, Li YY, Chen T, Liesa M, Hammerman PS, Wong KK, Hayes DN, Shirihai OS, Dyson NJ, Haas W, Meissner A, Bardeesy N.

Nature. 2019 Nov;575(7783):E5. doi: 10.1038/s41586-019-1696-z.

PMID:
31695192
4.

Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent.

Wolf DM, Segawa M, Kondadi AK, Anand R, Bailey ST, Reichert AS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS.

EMBO J. 2019 Nov 15;38(22):e101056. doi: 10.15252/embj.2018101056. Epub 2019 Oct 14.

5.

To Fis or not to Fuse? This is the question!

Liesa M, Van der Bliek A, Shirihai OS.

EMBO J. 2019 Apr 15;38(8). pii: e101839. doi: 10.15252/embj.2019101839. Epub 2019 Apr 1. No abstract available.

PMID:
30936092
6.

Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization.

Benador IY, Veliova M, Liesa M, Shirihai OS.

Cell Metab. 2019 Apr 2;29(4):827-835. doi: 10.1016/j.cmet.2019.02.011. Epub 2019 Mar 21. Review.

PMID:
30905670
7.

Nanoparticle-mediated lysosomal reacidification restores mitochondrial turnover and function in β cells under lipotoxicity.

Assali EA, Shlomo D, Zeng J, Taddeo EP, Trudeau KM, Erion KA, Colby AH, Grinstaff MW, Liesa M, Las G, Shirihai OS.

FASEB J. 2019 Mar;33(3):4154-4165. doi: 10.1096/fj.201801292R. Epub 2018 Dec 14.

PMID:
30550357
8.

Mechanisms of Mitochondria Assembly, Dynamics and Turnover in Health and Disease.

Chouchani ET, Liesa M, Trifunovic A.

J Mol Biol. 2018 Dec 7;430(24):4821-4822. doi: 10.1016/j.jmb.2018.11.009. Epub 2018 Nov 11. No abstract available.

PMID:
30428302
9.

Elamipretide Promotes Mitophagosome Formation and Prevents Its Reduction Induced by Nutrient Excess in INS1 β-cells.

Petcherski A, Trudeau KM, Wolf DM, Segawa M, Lee J, Taddeo EP, Deeney JT, Liesa M.

J Mol Biol. 2018 Dec 7;430(24):4823-4833. doi: 10.1016/j.jmb.2018.10.020. Epub 2018 Oct 30.

PMID:
30389435
10.

Individual islet respirometry reveals functional diversity within the islet population of mice and human donors.

Taddeo EP, Stiles L, Sereda S, Ritou E, Wolf DM, Abdullah M, Swanson Z, Wilhelm J, Bellin M, McDonald P, Caradonna K, Neilson A, Liesa M, Shirihai OS.

Mol Metab. 2018 Oct;16:150-159. doi: 10.1016/j.molmet.2018.07.003. Epub 2018 Jul 25.

11.

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis.

Divakaruni AS, Hsieh WY, Minarrieta L, Duong TN, Kim KKO, Desousa BR, Andreyev AY, Bowman CE, Caradonna K, Dranka BP, Ferrick DA, Liesa M, Stiles L, Rogers GW, Braas D, Ciaraldi TP, Wolfgang MJ, Sparwasser T, Berod L, Bensinger SJ, Murphy AN.

Cell Metab. 2018 Sep 4;28(3):490-503.e7. doi: 10.1016/j.cmet.2018.06.001. Epub 2018 Jun 28.

12.

Mitochondrial adaptation in obesity is a ClpPicated business.

Liesa M, Shirihai OS.

EMBO Rep. 2018 Jun;19(6). pii: e46295. doi: 10.15252/embr.201846295. Epub 2018 May 22. No abstract available.

13.

Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency.

Rodríguez-Nuevo A, Díaz-Ramos A, Noguera E, Díaz-Sáez F, Duran X, Muñoz JP, Romero M, Plana N, Sebastián D, Tezze C, Romanello V, Ribas F, Seco J, Planet E, Doctrow SR, González J, Borràs M, Liesa M, Palacín M, Vendrell J, Villarroya F, Sandri M, Shirihai O, Zorzano A.

EMBO J. 2018 May 15;37(10). pii: e96553. doi: 10.15252/embj.201796553. Epub 2018 Apr 9.

14.

Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion.

Benador IY, Veliova M, Mahdaviani K, Petcherski A, Wikstrom JD, Assali EA, Acín-Pérez R, Shum M, Oliveira MF, Cinti S, Sztalryd C, Barshop WD, Wohlschlegel JA, Corkey BE, Liesa M, Shirihai OS.

Cell Metab. 2018 Apr 3;27(4):869-885.e6. doi: 10.1016/j.cmet.2018.03.003.

15.

Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation.

Cardamone MD, Tanasa B, Cederquist CT, Huang J, Mahdaviani K, Li W, Rosenfeld MG, Liesa M, Perissi V.

Mol Cell. 2018 Mar 1;69(5):757-772.e7. doi: 10.1016/j.molcel.2018.01.037.

16.

Estrogen receptor α protects pancreatic β-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress.

Zhou Z, Ribas V, Rajbhandari P, Drew BG, Moore TM, Fluitt AH, Reddish BR, Whitney KA, Georgia S, Vergnes L, Reue K, Liesa M, Shirihai O, van der Bliek AM, Chi NW, Mahata SK, Tiano JP, Hewitt SC, Tontonoz P, Korach KS, Mauvais-Jarvis F, Hevener AL.

J Biol Chem. 2018 Mar 30;293(13):4735-4751. doi: 10.1074/jbc.M117.805069. Epub 2018 Jan 29.

17.

Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis.

Mahdaviani K, Benador IY, Su S, Gharakhanian RA, Stiles L, Trudeau KM, Cardamone M, Enríquez-Zarralanga V, Ritou E, Aprahamian T, Oliveira MF, Corkey BE, Perissi V, Liesa M, Shirihai OS.

EMBO Rep. 2017 Jul;18(7):1123-1138. doi: 10.15252/embr.201643827. Epub 2017 May 24.

18.

LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.

Kottakis F, Nicolay BN, Roumane A, Karnik R, Gu H, Nagle JM, Boukhali M, Hayward MC, Li YY, Chen T, Liesa M, Hammerman PS, Wong KK, Hayes DN, Shirihai OS, Dyson NJ, Haas W, Meissner A, Bardeesy N.

Nature. 2016 Nov 17;539(7629):390-395. doi: 10.1038/nature20132. Epub 2016 Oct 31. Erratum in: Nature. 2019 Nov;575(7783):E5.

19.

Mitochondrial Networking in T Cell Memory.

Liesa M, Shirihai OS.

Cell. 2016 Jun 30;166(1):9-10. doi: 10.1016/j.cell.2016.06.035.

20.

Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet-Induced Metabolic Heart Disease.

Sverdlov AL, Elezaby A, Qin F, Behring JB, Luptak I, Calamaras TD, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Bachschmid MM, Colucci WS.

J Am Heart Assoc. 2016 Jan 11;5(1). pii: e002555. doi: 10.1161/JAHA.115.002555.

21.

Diluted serum from calorie-restricted animals promotes mitochondrial β-cell adaptations and protect against glucolipotoxicity.

Cerqueira FM, Chausse B, Baranovski BM, Liesa M, Lewis EC, Shirihai OS, Kowaltowski AJ.

FEBS J. 2016 Mar;283(5):822-33. doi: 10.1111/febs.13632. Epub 2016 Feb 15.

22.

ATP Binding and Hydrolysis Properties of ABCB10 and Their Regulation by Glutathione.

Qiu W, Liesa M, Carpenter EP, Shirihai OS.

PLoS One. 2015 Jun 8;10(6):e0129772. doi: 10.1371/journal.pone.0129772. eCollection 2015.

23.

Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity.

Guan J, Mishra S, Qiu Y, Shi J, Trudeau K, Las G, Liesa M, Shirihai OS, Connors LH, Seldin DC, Falk RH, MacRae CA, Liao R.

EMBO Mol Med. 2015 May;7(5):688. doi: 10.15252/emmm.201505318. No abstract available.

24.

A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity.

Qiao S, Dennis M, Song X, Vadysirisack DD, Salunke D, Nash Z, Yang Z, Liesa M, Yoshioka J, Matsuzawa S, Shirihai OS, Lee RT, Reed JC, Ellisen LW.

Nat Commun. 2015 Apr 28;6:7014. doi: 10.1038/ncomms8014.

25.

Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells.

Wilson AA, Ying L, Liesa M, Segeritz CP, Mills JA, Shen SS, Jean J, Lonza GC, Liberti DC, Lang AH, Nazaire J, Gower AC, Müeller FJ, Mehta P, Ordóñez A, Lomas DA, Vallier L, Murphy GJ, Mostoslavsky G, Spira A, Shirihai OS, Ramirez MI, Gadue P, Kotton DN.

Stem Cell Reports. 2015 May 12;4(5):873-85. doi: 10.1016/j.stemcr.2015.02.021. Epub 2015 Apr 2.

26.

The extracellular redox state modulates mitochondrial function, gluconeogenesis, and glycogen synthesis in murine hepatocytes.

Nocito L, Kleckner AS, Yoo EJ, Jones Iv AR, Liesa M, Corkey BE.

PLoS One. 2015 Mar 27;10(3):e0122818. doi: 10.1371/journal.pone.0122818. eCollection 2015.

27.

Mitochondrial remodeling in mice with cardiomyocyte-specific lipid overload.

Elezaby A, Sverdlov AL, Tu VH, Soni K, Luptak I, Qin F, Liesa M, Shirihai OS, Rimer J, Schaffer JE, Colucci WS, Miller EJ.

J Mol Cell Cardiol. 2015 Feb;79:275-83. doi: 10.1016/j.yjmcc.2014.12.001. Epub 2014 Dec 9.

28.

Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity.

Guan J, Mishra S, Qiu Y, Shi J, Trudeau K, Las G, Liesa M, Shirihai OS, Connors LH, Seldin DC, Falk RH, MacRae CA, Liao R.

EMBO Mol Med. 2014 Nov;6(11):1493-507. doi: 10.15252/emmm.201404190. Erratum in: EMBO Mol Med. 2015 May;7(5):688.

29.

Conditional knockout of proximal tubule mitofusin 2 accelerates recovery and improves survival after renal ischemia.

Gall JM, Wang Z, Bonegio RG, Havasi A, Liesa M, Vemula P, Borkan SC.

J Am Soc Nephrol. 2015 May;26(5):1092-102. doi: 10.1681/ASN.2014010126. Epub 2014 Sep 8.

30.

High fat, high sucrose diet causes cardiac mitochondrial dysfunction due in part to oxidative post-translational modification of mitochondrial complex II.

Sverdlov AL, Elezaby A, Behring JB, Bachschmid MM, Luptak I, Tu VH, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Colucci WS.

J Mol Cell Cardiol. 2015 Jan;78:165-73. doi: 10.1016/j.yjmcc.2014.07.018. Epub 2014 Aug 7.

31.

Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure.

Wikstrom JD, Mahdaviani K, Liesa M, Sereda SB, Si Y, Las G, Twig G, Petrovic N, Zingaretti C, Graham A, Cinti S, Corkey BE, Cannon B, Nedergaard J, Shirihai OS.

EMBO J. 2014 Mar 3;33(5):418-36. doi: 10.1002/embj.201385014. Epub 2014 Jan 15.

32.

Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in Mammalian cells.

Kalghatgi S, Spina CS, Costello JC, Liesa M, Morones-Ramirez JR, Slomovic S, Molina A, Shirihai OS, Collins JJ.

Sci Transl Med. 2013 Jul 3;5(192):192ra85. doi: 10.1126/scitranslmed.3006055.

33.

ATP-binding cassette B10 regulates early steps of heme synthesis.

Bayeva M, Khechaduri A, Wu R, Burke MA, Wasserstrom JA, Singh N, Liesa M, Shirihai OS, Langer NB, Paw BH, Ardehali H.

Circ Res. 2013 Jul 19;113(3):279-87. doi: 10.1161/CIRCRESAHA.113.301552. Epub 2013 May 29.

34.

Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure.

Liesa M, Shirihai OS.

Cell Metab. 2013 Apr 2;17(4):491-506. doi: 10.1016/j.cmet.2013.03.002. Review.

35.

Testosterone plus low-intensity physical training in late life improves functional performance, skeletal muscle mitochondrial biogenesis, and mitochondrial quality control in male mice.

Guo W, Wong S, Li M, Liang W, Liesa M, Serra C, Jasuja R, Bartke A, Kirkland JL, Shirihai O, Bhasin S.

PLoS One. 2012;7(12):e51180. doi: 10.1371/journal.pone.0051180. Epub 2012 Dec 11.

36.

Mitochondrial ABC transporters function: the role of ABCB10 (ABC-me) as a novel player in cellular handling of reactive oxygen species.

Liesa M, Qiu W, Shirihai OS.

Biochim Biophys Acta. 2012 Oct;1823(10):1945-57. doi: 10.1016/j.bbamcr.2012.07.013. Epub 2012 Aug 3. Review.

37.

Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle.

Blättler SM, Verdeguer F, Liesa M, Cunningham JT, Vogel RO, Chim H, Liu H, Romanino K, Shirihai OS, Vazquez F, Rüegg MA, Shi Y, Puigserver P.

Mol Cell Biol. 2012 Aug;32(16):3333-46. doi: 10.1128/MCB.00337-12. Epub 2012 Jun 18.

38.

Glucocorticoid modulation of mitochondrial function in hepatoma cells requires the mitochondrial fission protein Drp1.

Hernández-Alvarez MI, Paz JC, Sebastián D, Muñoz JP, Liesa M, Segalés J, Palacín M, Zorzano A.

Antioxid Redox Signal. 2013 Aug 1;19(4):366-78. doi: 10.1089/ars.2011.4269. Epub 2012 Aug 6.

39.

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis.

Sebastián D, Hernández-Alvarez MI, Segalés J, Sorianello E, Muñoz JP, Sala D, Waget A, Liesa M, Paz JC, Gopalacharyulu P, Orešič M, Pich S, Burcelin R, Palacín M, Zorzano A.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5523-8. doi: 10.1073/pnas.1108220109. Epub 2012 Mar 16.

40.

Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer.

Hu J, Hwang SS, Liesa M, Gan B, Sahin E, Jaskelioff M, Ding Z, Ying H, Boutin AT, Zhang H, Johnson S, Ivanova E, Kost-Alimova M, Protopopov A, Wang YA, Shirihai OS, Chin L, DePinho RA.

Cell. 2012 Feb 17;148(4):651-63. doi: 10.1016/j.cell.2011.12.028.

41.

Role of mitofusin 2 in the renal stress response.

Gall JM, Wang Z, Liesa M, Molina A, Havasi A, Schwartz JH, Shirihai O, Borkan SC, Bonegio RG.

PLoS One. 2012;7(1):e31074. doi: 10.1371/journal.pone.0031074. Epub 2012 Jan 26.

42.

The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo.

Hyde BB, Liesa M, Elorza AA, Qiu W, Haigh SE, Richey L, Mikkola HK, Schlaeger TM, Shirihai OS.

Cell Death Differ. 2012 Jul;19(7):1117-26. doi: 10.1038/cdd.2011.195. Epub 2012 Jan 13.

43.

Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion.

Liesa M, Luptak I, Qin F, Hyde BB, Sahin E, Siwik DA, Zhu Z, Pimentel DR, Xu XJ, Ruderman NB, Huffman KD, Doctrow SR, Richey L, Colucci WS, Shirihai OS.

Circulation. 2011 Aug 16;124(7):806-13. doi: 10.1161/CIRCULATIONAHA.110.003418. Epub 2011 Jul 25.

44.

Pancreatic cancers require autophagy for tumor growth.

Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman AC.

Genes Dev. 2011 Apr 1;25(7):717-29. doi: 10.1101/gad.2016111. Epub 2011 Mar 15.

45.

Telomere dysfunction induces metabolic and mitochondrial compromise.

Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA.

Nature. 2011 Feb 17;470(7334):359-65. doi: 10.1038/nature09787. Epub 2011 Feb 9. Erratum in: Nature. 2011 Jul 14;475(7355):254.

46.

Biophysical properties of mitochondrial fusion events in pancreatic beta-cells and cardiac cells unravel potential control mechanisms of its selectivity.

Twig G, Liu X, Liesa M, Wikstrom JD, Molina AJ, Las G, Yaniv G, Hajnóczky G, Shirihai OS.

Am J Physiol Cell Physiol. 2010 Aug;299(2):C477-87. doi: 10.1152/ajpcell.00427.2009. Epub 2010 May 5.

47.

Mitochondrial fusion proteins: dual regulators of morphology and metabolism.

Zorzano A, Liesa M, Sebastián D, Segalés J, Palacín M.

Semin Cell Dev Biol. 2010 Aug;21(6):566-74. doi: 10.1016/j.semcdb.2010.01.002. Epub 2010 Jan 15. Review.

PMID:
20079867
48.

Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1{alpha}/Mitofusin-2 regulatory pathway in response to physical activity.

Hernández-Alvarez MI, Thabit H, Burns N, Shah S, Brema I, Hatunic M, Finucane F, Liesa M, Chiellini C, Naon D, Zorzano A, Nolan JJ.

Diabetes Care. 2010 Mar;33(3):645-51. doi: 10.2337/dc09-1305. Epub 2009 Dec 23.

49.

Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes.

Zorzano A, Liesa M, Palacín M.

Int J Biochem Cell Biol. 2009 Oct;41(10):1846-54. doi: 10.1016/j.biocel.2009.02.004. Epub 2009 Feb 20. Review.

PMID:
19703653
50.

Mitochondrial dynamics in mammalian health and disease.

Liesa M, Palacín M, Zorzano A.

Physiol Rev. 2009 Jul;89(3):799-845. doi: 10.1152/physrev.00030.2008. Review.

Supplemental Content

Support Center