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An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE).

Clouthier DL, Lien SC, Yang SYC, Nguyen LT, Manem VSK, Gray D, Ryczko M, Razak ARA, Lewin J, Lheureux S, Colombo I, Bedard PL, Cescon D, Spreafico A, Butler MO, Hansen AR, Jang RW, Ghai S, Weinreb I, Sotov V, Gadalla R, Noamani B, Guo M, Elston S, Giesler A, Hakgor S, Jiang H, McGaha T, Brooks DG, Haibe-Kains B, Pugh TJ, Ohashi PS, Siu LL.

J Immunother Cancer. 2019 Mar 13;7(1):72. doi: 10.1186/s40425-019-0541-0.


Temperature-Dependent HfO2/Si Interface Structural Evolution and its Mechanism.

Zhang XY, Hsu CH, Lien SY, Wu WY, Ou SL, Chen SY, Huang W, Zhu WZ, Xiong FB, Zhang S.

Nanoscale Res Lett. 2019 Mar 7;14(1):83. doi: 10.1186/s11671-019-2915-0.


The Chromosome-Level Genome Assembly of European Grayling Reveals Aspects of a Unique Genome Evolution Process Within Salmonids.

Sävilammi T, Primmer CR, Varadharajan S, Guyomard R, Guiguen Y, Sandve SR, Vøllestad LA, Papakostas S, Lien S.

G3 (Bethesda). 2019 Mar 4. pii: g3.200919.2018. doi: 10.1534/g3.118.200919. [Epub ahead of print]


Chromosome polymorphisms track trans-Atlantic divergence and secondary contact in Atlantic salmon.

Lehnert SJ, Bentzen P, Kess T, Lien S, Horne JB, Clément M, Bradbury IR.

Mol Ecol. 2019 Mar 2. doi: 10.1111/mec.15065. [Epub ahead of print]


Cumulin and FSH cooperate to regulate inhibin B and activin B production by human granulosa-lutein cells in vitro.

Richani D, Constance K, Lien S, Agapiou D, Stocker WA, Hedger MP, Ledger WL, Thompson JG, Robertson DM, Mottershead DG, Walton KL, Harrison CA, Gilchrist RB.

Endocrinology. 2019 Feb 8. doi: 10.1210/en.2018-01026. [Epub ahead of print]


Characterization of a male specific region containing a candidate sex determining gene in Atlantic cod.

Kirubakaran TG, Andersen Ø, De Rosa MC, Andersstuen T, Hallan K, Kent MP, Lien S.

Sci Rep. 2019 Jan 15;9(1):116. doi: 10.1038/s41598-018-36748-8.


Oxidative Stress and Nonalcoholic Fatty Liver Disease in Hemodialysis Patients.

Wu PJ, Chen JB, Lee WC, Ng HY, Lien SC, Tsai PY, Wu CH, Lee CT, Chiou TT.

Biomed Res Int. 2018 Nov 1;2018:3961748. doi: 10.1155/2018/3961748. eCollection 2018.


A genetic linkage map for the salmon louse (Lepeophtheirus salmonis): evidence for high male:female and inter-familial recombination rate differences.

Danzmann RG, Norman JD, Rondeau EB, Messmer AM, Kent MP, Lien S, Igboeli O, Fast MD, Koop BF.

Mol Genet Genomics. 2019 Apr;294(2):343-363. doi: 10.1007/s00438-018-1513-7. Epub 2018 Nov 20.


Development and Validation of 58K SNP-Array and High-Density Linkage Map in Nile Tilapia (O. niloticus).

Joshi R, Árnyasi M, Lien S, Gjøen HM, Alvarez AT, Kent M.

Front Genet. 2018 Oct 15;9:472. doi: 10.3389/fgene.2018.00472. eCollection 2018.


The Grayling Genome Reveals Selection on Gene Expression Regulation after Whole-Genome Duplication.

Varadharajan S, Sandve SR, Gillard GB, Tørresen OK, Mulugeta TD, Hvidsten TR, Lien S, Asbjørn Vøllestad L, Jentoft S, Nederbragt AJ, Jakobsen KS.

Genome Biol Evol. 2018 Oct 1;10(10):2785-2800. doi: 10.1093/gbe/evy201.


Signs of adaptation to trace metal contamination in a common urban bird.

Andrew SC, Taylor MP, Lundregan S, Lien S, Jensen H, Griffith SC.

Sci Total Environ. 2019 Feb 10;650(Pt 1):679-686. doi: 10.1016/j.scitotenv.2018.09.052. Epub 2018 Sep 5.


Inferences of genetic architecture of bill morphology in house sparrow using a high-density SNP array point to a polygenic basis.

Lundregan SL, Hagen IJ, Gohli J, Niskanen AK, Kemppainen P, Ringsby TH, Kvalnes T, Pärn H, Rønning B, Holand H, Ranke PS, Båtnes AS, Selvik LK, Lien S, Saether BE, Husby A, Jensen H.

Mol Ecol. 2018 Sep;27(17):3498-3514. doi: 10.1111/mec.14811. Epub 2018 Aug 11.


Vestibular Injury After Low-Intensity Blast Exposure.

Lien S, Dickman JD.

Front Neurol. 2018 May 14;9:297. doi: 10.3389/fneur.2018.00297. eCollection 2018.


Genome-wide association study reveals a QTL and strong candidate genes for umbilical hernia in pigs on SSC14.

Grindflek E, Hansen MHS, Lien S, van Son M.

BMC Genomics. 2018 May 29;19(1):412. doi: 10.1186/s12864-018-4812-9.


Arthroprotective Effects of Cf-02 Sharing Structural Similarity with Quercetin.

Liu FC, Lu JW, Chien CY, Huang HS, Lee CC, Lien SB, Lin LC, Chen LW, Ho YJ, Shen MC, Ho LJ, Lai JH.

Int J Mol Sci. 2018 May 14;19(5). pii: E1453. doi: 10.3390/ijms19051453.


A New Single Nucleotide Polymorphism Database for Rainbow Trout Generated Through Whole Genome Resequencing.

Gao G, Nome T, Pearse DE, Moen T, Naish KA, Thorgaard GH, Lien S, Palti Y.

Front Genet. 2018 Apr 24;9:147. doi: 10.3389/fgene.2018.00147. eCollection 2018.


A 200K SNP chip reveals a novel Pacific salmon louse genotype linked to differential efficacy of emamectin benzoate.

Messmer AM, Leong JS, Rondeau EB, Mueller A, Despins CA, Minkley DR, Kent MP, Lien S, Boyce B, Morrison D, Fast MD, Norman JD, Danzmann RG, Koop BF.

Mar Genomics. 2018 Jul;40:45-57. doi: 10.1016/j.margen.2018.03.005. Epub 2018 Apr 16.



Kirubakaran TG, Grove H, Kent MP, Sandve SR, Baranski M, Nome T, De Rosa MC, Righino B, Johansen T, Otterå H, Sonesson A, Lien SR, Andersen Ø.

Mol Ecol. 2018 Mar;27(6):1520. doi: 10.1111/mec.14530. No abstract available.


Evolution of Sex Determination Loci in Atlantic Salmon.

Kijas J, McWilliam S, Naval Sanchez M, Kube P, King H, Evans B, Nome T, Lien S, Verbyla K.

Sci Rep. 2018 Apr 4;8(1):5664. doi: 10.1038/s41598-018-23984-1.


Prospective analysis of bleeding events in left ventricular assist device patients.

Sherazi S, Kouides P, Francis C, Lowenstein CJ, Refaai M, Conley G, Johnson BA, Muchnik E, Lien S, Massey HT, Alexis JD.

Int J Artif Organs. 2018 May;41(5):269-276. doi: 10.1177/0391398818762353. Epub 2018 Mar 22.


Chondroprotective Effects and Mechanisms of Dextromethorphan: Repurposing Antitussive Medication for Osteoarthritis Treatment.

Chen LW, Liu FC, Hung LF, Huang CY, Lien SB, Lin LC, Lai JH, Ho LJ.

Int J Mol Sci. 2018 Mar 12;19(3). pii: E825. doi: 10.3390/ijms19030825.


Functional outcomes and quality of life after a 6-month early intervention program for oral cancer survivors: a single-arm clinical trial.

Chen YH, Liang WA, Hsu CY, Guo SL, Lien SH, Tseng HJ, Chao YH.

PeerJ. 2018 Feb 21;6:e4419. doi: 10.7717/peerj.4419. eCollection 2018.


Life-stage-associated remodelling of lipid metabolism regulation in Atlantic salmon.

Gillard G, Harvey TN, Gjuvsland A, Jin Y, Thomassen M, Lien S, Leaver M, Torgersen JS, Hvidsten TR, Vik JO, Sandve SR.

Mol Ecol. 2018 Mar;27(5):1200-1213. doi: 10.1111/mec.14533. Epub 2018 Mar 12.


Unravelling genetic variation underlying de novo-synthesis of bovine milk fatty acids.

Knutsen TM, Olsen HG, Tafintseva V, Svendsen M, Kohler A, Kent MP, Lien S.

Sci Rep. 2018 Feb 1;8(1):2179. doi: 10.1038/s41598-018-20476-0.


Ancient chromosomal rearrangement associated with local adaptation of a postglacially colonized population of Atlantic Cod in the northwest Atlantic.

Sinclair-Waters M, Bradbury IR, Morris CJ, Lien S, Kent MP, Bentzen P.

Mol Ecol. 2018 Jan;27(2):339-351. doi: 10.1111/mec.14442. Epub 2017 Dec 27.


Mapping of quantitative trait loci associated with size, shape, and parr mark traits using first- and second-generation backcrosses between European and North American Atlantic salmon (Salmo salar).

Pedersen S, Liu L, Glebe B, Leadbeater S, Lien S, Boulding EG.

Genome. 2018 Jan;61(1):33-42. doi: 10.1139/gen-2017-0026. Epub 2017 Oct 16.


Exploiting whole genome sequence data to fine map and characterize candidate genes within a quantitative trait loci region affecting androstenone on porcine chromosome 5.

van Son M, Agarwal R, Kent MP, Grove H, Grindflek E, Lien S.

Anim Genet. 2017 Dec;48(6):653-659. doi: 10.1111/age.12615. Epub 2017 Oct 16.


Fine mapping of a QTL affecting levels of skatole on pig chromosome 7.

van Son M, Kent MP, Grove H, Agarwal R, Hamland H, Lien S, Grindflek E.

BMC Genet. 2017 Oct 11;18(1):85. doi: 10.1186/s12863-017-0549-8.


Simultaneous Stiles-Bunnell Tendon Transfer Enhances Intrinsic Function of Second-Toe Transplantations.

Lin YT, Loh CYY, Lien SH, Lin CH, Wei FC.

Plast Reconstr Surg. 2017 Dec;140(6):1229-1234. doi: 10.1097/PRS.0000000000003861.


Low Cost Local Contact Opening by Using Polystyrene Spheres Spin-Coating Method for PERC Solar Cells.

Hsu CH, Yang CH, Wang YH, Huang CW, Lien SY, Kung CY, Lou JC.

Materials (Basel). 2016 Jul 8;9(7). pii: E549. doi: 10.3390/ma9070549.


Thin-Film Coated Plastic Wrap for Food Packaging.

Wu HY, Liu TX, Hsu CH, Cho YS, Xu ZJ, Liao SC, Zeng BH, Jiang YL, Lien SY.

Materials (Basel). 2017 Jul 18;10(7). pii: E821. doi: 10.3390/ma10070821.


Genetic differences between wild and hatchery-bred brown trout (Salmo trutta L.) in single nucleotide polymorphisms linked to selective traits.

Linløkken AN, Haugen TO, Kent MP, Lien S.

Ecol Evol. 2017 May 30;7(13):4963-4972. doi: 10.1002/ece3.3070. eCollection 2017 Jul.


Functional Annotation of All Salmonid Genomes (FAASG): an international initiative supporting future salmonid research, conservation and aquaculture.

Macqueen DJ, Primmer CR, Houston RD, Nowak BF, Bernatchez L, Bergseth S, Davidson WS, Gallardo-Escárate C, Goldammer T, Guiguen Y, Iturra P, Kijas JW, Koop BF, Lien S, Maass A, Martin SAM, McGinnity P, Montecino M, Naish KA, Nichols KM, Ólafsson K, Omholt SW, Palti Y, Plastow GS, Rexroad CE Rd, Rise ML, Ritchie RJ, Sandve SR, Schulte PM, Tello A, Vidal R, Vik JO, Wargelius A, Yáñez JM; FAASG Consortium.

BMC Genomics. 2017 Jun 27;18(1):484. doi: 10.1186/s12864-017-3862-8.


SalmoBase: an integrated molecular data resource for Salmonid species.

Samy JKA, Mulugeta TD, Nome T, Sandve SR, Grammes F, Kent MP, Lien S, Våge DI.

BMC Genomics. 2017 Jun 26;18(1):482. doi: 10.1186/s12864-017-3877-1.


The genomic mosaicism of hybrid speciation.

Elgvin TO, Trier CN, Tørresen OK, Hagen IJ, Lien S, Nederbragt AJ, Ravinet M, Jensen H, Sætre GP.

Sci Adv. 2017 Jun 14;3(6):e1602996. doi: 10.1126/sciadv.1602996. eCollection 2017 Jun.


Lineage-specific rediploidization is a mechanism to explain time-lags between genome duplication and evolutionary diversification.

Robertson FM, Gundappa MK, Grammes F, Hvidsten TR, Redmond AK, Lien S, Martin SAM, Holland PWH, Sandve SR, Macqueen DJ.

Genome Biol. 2017 Jun 14;18(1):111. doi: 10.1186/s13059-017-1241-z.


Physiological concentrations of soluble uric acid are chondroprotective and anti-inflammatory.

Lai JH, Luo SF, Hung LF, Huang CY, Lien SB, Lin LC, Liu FC, Yen BL, Ho LJ.

Sci Rep. 2017 May 24;7(1):2359. doi: 10.1038/s41598-017-02640-0.


Genome-wide association study confirm major QTL for backfat fatty acid composition on SSC14 in Duroc pigs.

van Son M, Enger EG, Grove H, Ros-Freixedes R, Kent MP, Lien S, Grindflek E.

BMC Genomics. 2017 May 11;18(1):369. doi: 10.1186/s12864-017-3752-0.


Sex difference determined the role of sex hormone-binding globulin in obese children during short-term weight reduction program.

Wang FM, Lin CM, Lien SH, Wu LW, Huang CF, Chu DM.

Medicine (Baltimore). 2017 May;96(19):e6834. doi: 10.1097/MD.0000000000006834.


Surface Passivation of Silicon Using HfO2 Thin Films Deposited by Remote Plasma Atomic Layer Deposition System.

Zhang XY, Hsu CH, Lien SY, Chen SY, Huang W, Yang CH, Kung CY, Zhu WZ, Xiong FB, Meng XG.

Nanoscale Res Lett. 2017 Dec;12(1):324. doi: 10.1186/s11671-017-2098-5. Epub 2017 May 4.


Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer.

Butler MS, Roshan-Moniri M, Hsing M, Lau D, Kim A, Yen P, Mroczek M, Nouri M, Lien S, Axerio-Cilies P, Dalal K, Yau C, Ghaidi F, Guo Y, Yamazaki T, Lawn S, Gleave ME, Gregory-Evans CY, McIntosh LP, Cox ME, Rennie PS, Cherkasov A.

Oncotarget. 2017 Jun 27;8(26):42438-42454. doi: 10.18632/oncotarget.17124.


A genome scan for selection signatures comparing farmed Atlantic salmon with two wild populations: Testing colocalization among outlier markers, candidate genes, and quantitative trait loci for production traits.

Liu L, Ang KP, Elliott JA, Kent MP, Lien S, MacDonald D, Boulding EG.

Evol Appl. 2016 Dec 29;10(3):276-296. doi: 10.1111/eva.12450. eCollection 2017 Mar.


Genome-wide association mapping for milk fat composition and fine mapping of a QTL for de novo synthesis of milk fatty acids on bovine chromosome 13.

Olsen HG, Knutsen TM, Kohler A, Svendsen M, Gidskehaug L, Grove H, Nome T, Sodeland M, Sundsaasen KK, Kent MP, Martens H, Lien S.

Genet Sel Evol. 2017 Feb 13;49(1):20. doi: 10.1186/s12711-017-0294-5.


An improved genome assembly uncovers prolific tandem repeats in Atlantic cod.

Tørresen OK, Star B, Jentoft S, Reinar WB, Grove H, Miller JR, Walenz BP, Knight J, Ekholm JM, Peluso P, Edvardsen RB, Tooming-Klunderud A, Skage M, Lien S, Jakobsen KS, Nederbragt AJ.

BMC Genomics. 2017 Jan 18;18(1):95. doi: 10.1186/s12864-016-3448-x.


Customizing Extensor Reconstruction in Vascularized Toe Joint Transfers to Finger Proximal Interphalangeal Joints: A Strategic Approach for Correcting Extensor Lag.

Loh CY, Hsu CC, Lin CH, Chen SH, Lien SH, Lin CH, Wei FC, Lin YT.

Plast Reconstr Surg. 2017 Apr;139(4):915-922. doi: 10.1097/PRS.0000000000003153.


Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations.

Lien SA, Young L, Gau BS, K Shiao SP.

Oncotarget. 2017 Jan 17;8(3):4387-4398. doi: 10.18632/oncotarget.13876.


Controlling for P-value inflation in allele frequency change in experimental evolution and artificial selection experiments.

Kemppainen P, Rønning B, Kvalnes T, Hagen IJ, Ringsby TH, Billing AM, Pärn H, Lien S, Husby A, Saether BE, Jensen H.

Mol Ecol Resour. 2017 Jul;17(4):770-782. doi: 10.1111/1755-0998.12631. Epub 2016 Nov 25.


Fine mapping of a QTL on bovine chromosome 6 using imputed full sequence data suggests a key role for the group-specific component (GC) gene in clinical mastitis and milk production.

Olsen HG, Knutsen TM, Lewandowska-Sabat AM, Grove H, Nome T, Svendsen M, Arnyasi M, Sodeland M, Sundsaasen KK, Dahl SR, Heringstad B, Hansen HH, Olsaker I, Kent MP, Lien S.

Genet Sel Evol. 2016 Oct 19;48(1):79.


Endoscopy-assisted subfascial anterior transposition of the ulnar nerve for the treatment of cubital tunnel syndrome.

Wong JK, Hsu CC, Lin CH, Lien SH, Lin YT.

J Plast Reconstr Aesthet Surg. 2016 Dec;69(12):1704-1710. doi: 10.1016/j.bjps.2016.09.004. Epub 2016 Sep 16.


Single nucleotide polymorphisms to discriminate different classes of hybrid between wild Atlantic salmon and aquaculture escapees.

Pritchard VL, Erkinaro J, Kent MP, Niemelä E, Orell P, Lien S, Primmer CR.

Evol Appl. 2016 Aug 18;9(8):1017-31. doi: 10.1111/eva.12407. eCollection 2016 Sep.

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