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Items: 1 to 50 of 453

1.

A three-dimensional dementia model reveals spontaneous cell cycle re-entry and a senescence-associated secretory phenotype.

Porterfield V, Khan SS, Foff EP, Koseoglu MM, Blanco IK, Jayaraman S, Lien E, McConnell MJ, Bloom GS, Lazo JS, Sharlow ER.

Neurobiol Aging. 2020 Feb 19. pii: S0197-4580(20)30038-5. doi: 10.1016/j.neurobiolaging.2020.02.011. [Epub ahead of print]

PMID:
32184029
2.

Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling.

Shahini N, Schjalm C, Nilsson PH, Holt MF, Øgaard JDS, Lien E, Ahmed MS, Attramadal H, Aukrust P, Yndestad A, Mollnes TE, Louwe MC.

Biochem Biophys Res Commun. 2020 Mar 19;523(4):867-873. doi: 10.1016/j.bbrc.2020.01.018. Epub 2020 Jan 16.

PMID:
31955888
3.

Gasdermins and their role in immunity and inflammation.

Orning P, Lien E, Fitzgerald KA.

J Exp Med. 2019 Nov 4;216(11):2453-2465. doi: 10.1084/jem.20190545. Epub 2019 Sep 23. Review.

PMID:
31548300
4.

A framework for examining how diet impacts tumour metabolism.

Lien EC, Vander Heiden MG.

Nat Rev Cancer. 2019 Nov;19(11):651-661. doi: 10.1038/s41568-019-0198-5. Epub 2019 Sep 17. Review.

PMID:
31530936
5.

NLRP3 Inflammasome Promotes Myocardial Remodeling During Diet-Induced Obesity.

Sokolova M, Sjaastad I, Louwe MC, Alfsnes K, Aronsen JM, Zhang L, Haugstad SB, Bendiksen BA, Øgaard J, Bliksøen M, Lien E, Berge RK, Aukrust P, Ranheim T, Yndestad A.

Front Immunol. 2019 Jul 16;10:1621. doi: 10.3389/fimmu.2019.01621. eCollection 2019.

6.

Drug monitoring of tamoxifen metabolites predicts vaginal dryness and verifies a low discontinuation rate from the Norwegian Prescription Database.

Helland T, Hagen KB, Haugstøyl ME, Kvaløy JT, Lunde S, Lode K, Lind RA, Gripsrud BH, Jonsdottir K, Gjerde J, Bifulco E, Hustad S, Jonassen J, Aas T, Lende TH, Lien EA, Janssen EAM, Søiland H, Mellgren G.

Breast Cancer Res Treat. 2019 Aug;177(1):185-195. doi: 10.1007/s10549-019-05294-w. Epub 2019 May 29.

PMID:
31144152
7.

Putting the K+ in K+aloric Restriction.

Lien EC, Lau AN, Vander Heiden MG.

Immunity. 2019 May 21;50(5):1129-1131. doi: 10.1016/j.immuni.2019.04.016.

PMID:
31117009
8.

Streptolysin O Induces the Ubiquitination and Degradation of Pro-IL-1β.

Hancz D, Westerlund E, Valfridsson C, Aemero GM, Bastiat-Sempe B, Orning P, Lien E, Wessels MR, Persson JJ.

J Innate Immun. 2019;11(6):457-468. doi: 10.1159/000496403. Epub 2019 Mar 19.

9.

Incidence and mortality of moderate and severe traumatic brain injury in children: A ten year population-based cohort study in Norway.

Olsen M, Vik A, Lund Nilsen TI, Uleberg O, Moen KG, Fredriksli O, Lien E, Finnanger TG, Skandsen T.

Eur J Paediatr Neurol. 2019 May;23(3):500-506. doi: 10.1016/j.ejpn.2019.01.009. Epub 2019 Mar 4.

10.

STRmix™ collaborative exercise on DNA mixture interpretation.

Bright JA, Cheng K, Kerr Z, McGovern C, Kelly H, Moretti TR, Smith MA, Bieber FR, Budowle B, Coble MD, Alghafri R, Allen PS, Barber A, Beamer V, Buettner C, Russell M, Gehrig C, Hicks T, Charak J, Cheong-Wing K, Ciecko A, Davis CT, Donley M, Pedersen N, Gartside B, Granger D, Greer-Ritzheimer M, Reisinger E, Kennedy J, Grammer E, Kaplan M, Hansen D, Larsen HJ, Laureano A, Li C, Lien E, Lindberg E, Kelly C, Mallinder B, Malsom S, Yacovone-Margetts A, McWhorter A, Prajapati SM, Powell T, Shutler G, Stevenson K, Stonehouse AR, Smith L, Murakami J, Halsing E, Wright D, Clark L, Taylor DA, Buckleton J.

Forensic Sci Int Genet. 2019 May;40:1-8. doi: 10.1016/j.fsigen.2019.01.006. Epub 2019 Jan 15.

PMID:
30665115
11.

TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling.

Jung YS, Jun S, Kim MJ, Lee SH, Suh HN, Lien EM, Jung HY, Lee S, Zhang J, Yang JI, Ji H, Wu JY, Wang W, Miller RK, Chen J, McCrea PD, Kopetz S, Park JI.

Nat Cell Biol. 2018 Dec;20(12):1421-1433. doi: 10.1038/s41556-018-0219-8. Epub 2018 Oct 29.

12.

Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin.

Jung YS, Wang W, Jun S, Zhang J, Srivastava M, Kim MJ, Lien EM, Shang J, Chen J, McCrea PD, Zhang S, Park JI.

Nat Cell Biol. 2018 Nov;20(11):1303-1314. doi: 10.1038/s41556-018-0215-z. Epub 2018 Oct 22.

13.

Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.

Orning P, Weng D, Starheim K, Ratner D, Best Z, Lee B, Brooks A, Xia S, Wu H, Kelliher MA, Berger SB, Gough PJ, Bertin J, Proulx MM, Goguen JD, Kayagaki N, Fitzgerald KA, Lien E.

Science. 2018 Nov 30;362(6418):1064-1069. doi: 10.1126/science.aau2818. Epub 2018 Oct 25.

14.

Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth.

Cox AG, Tsomides A, Yimlamai D, Hwang KL, Miesfeld J, Galli GG, Fowl BH, Fort M, Ma KY, Sullivan MR, Hosios AM, Snay E, Yuan M, Brown KK, Lien EC, Chhangawala S, Steinhauser ML, Asara JM, Houvras Y, Link B, Vander Heiden MG, Camargo FD, Goessling W.

EMBO J. 2018 Nov 15;37(22). pii: e100294. doi: 10.15252/embj.2018100294. Epub 2018 Oct 22.

15.

A Sugar Rush for Innate Immunity.

Orning P, Flo TH, Lien E.

Cell Host Microbe. 2018 Oct 10;24(4):461-463. doi: 10.1016/j.chom.2018.09.017.

16.

A Walk in Nature. Sesquiterpene Lactones as Multi-Target Agents Involved in Inflammatory Pathways.

Coricello A, Adams JD, Lien E, Nguyen C, Perri F, Williams TJ, Aiello F.

Curr Med Chem. 2018 Jul 18. doi: 10.2174/0929867325666180719111123. [Epub ahead of print]

PMID:
30027844
17.

NLRP3 inflammasome mediates oxidative stress-induced pancreatic islet dysfunction.

Sokolova M, Sahraoui A, Høyem M, Øgaard J, Lien E, Aukrust P, Yndestad A, Ranheim T, Scholz H.

Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E912-E923. doi: 10.1152/ajpendo.00461.2017. Epub 2018 Jul 17.

18.

Altered exocrine function can drive adipose wasting in early pancreatic cancer.

Danai LV, Babic A, Rosenthal MH, Dennstedt EA, Muir A, Lien EC, Mayers JR, Tai K, Lau AN, Jones-Sali P, Prado CM, Petersen GM, Takahashi N, Sugimoto M, Yeh JJ, Lopez N, Bardeesy N, Fernandez-Del Castillo C, Liss AS, Koong AC, Bui J, Yuan C, Welch MW, Brais LK, Kulke MH, Dennis C, Clish CB, Wolpin BM, Vander Heiden MG.

Nature. 2018 Jun;558(7711):600-604. doi: 10.1038/s41586-018-0235-7. Epub 2018 Jun 20.

19.

Growth, stool consistency and bone mineral content in healthy term infants fed sn-2-palmitate-enriched starter infant formula: A randomized, double-blind, multicentre clinical trial.

Béghin L, Marchandise X, Lien E, Bricout M, Bernet JP, Lienhardt JF, Jeannerot F, Menet V, Requillart JC, Marx J, De Groot N, Jaeger J, Steenhout P, Turck D.

Clin Nutr. 2019 Jun;38(3):1023-1030. doi: 10.1016/j.clnu.2018.05.015. Epub 2018 Jun 1.

20.

PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis.

Kim MJ, Xia B, Suh HN, Lee SH, Jun S, Lien EM, Zhang J, Chen K, Park JI.

Dev Cell. 2018 Mar 12;44(5):582-596.e4. doi: 10.1016/j.devcel.2018.02.010.

21.

DHA and ARA addition to infant formula: Current status and future research directions.

Lien EL, Richard C, Hoffman DR.

Prostaglandins Leukot Essent Fatty Acids. 2018 Jan;128:26-40. doi: 10.1016/j.plefa.2017.09.005. Epub 2017 Sep 15. Review.

PMID:
29413359
22.

Internal validation of STRmix™ - A multi laboratory response to PCAST.

Bright JA, Richards R, Kruijver M, Kelly H, McGovern C, Magee A, McWhorter A, Ciecko A, Peck B, Baumgartner C, Buettner C, McWilliams S, McKenna C, Gallacher C, Mallinder B, Wright D, Johnson D, Catella D, Lien E, O'Connor C, Duncan G, Bundy J, Echard J, Lowe J, Stewart J, Corrado K, Gentile S, Kaplan M, Hassler M, McDonald N, Hulme P, Oefelein RH, Montpetit S, Strong M, Noël S, Malsom S, Myers S, Welti S, Moretti T, McMahon T, Grill T, Kalafut T, Greer-Ritzheimer M, Beamer V, Taylor DA, Buckleton JS.

Forensic Sci Int Genet. 2018 May;34:11-24. doi: 10.1016/j.fsigen.2018.01.003. Epub 2018 Jan 8.

PMID:
29367014
23.

Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT.

Lien EC, Ghisolfi L, Geck RC, Asara JM, Toker A.

Sci Signal. 2017 Dec 19;10(510). pii: eaao6604. doi: 10.1126/scisignal.aao6604.

24.

Quiescence Exit of Tert+ Stem Cells by Wnt/β-Catenin Is Indispensable for Intestinal Regeneration.

Suh HN, Kim MJ, Jung YS, Lien EM, Jun S, Park JI.

Cell Rep. 2017 Nov 28;21(9):2571-2584. doi: 10.1016/j.celrep.2017.10.118.

25.

Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients.

Helland T, Henne N, Bifulco E, Naume B, Borgen E, Kristensen VN, Kvaløy JT, Lash TL, Alnæs GIG, van Schaik RH, Janssen EAM, Hustad S, Lien EA, Mellgren G, Søiland H.

Breast Cancer Res. 2017 Nov 28;19(1):125. doi: 10.1186/s13058-017-0916-4.

26.

PI3K signaling in cancer: beyond AKT.

Lien EC, Dibble CC, Toker A.

Curr Opin Cell Biol. 2017 Apr;45:62-71. doi: 10.1016/j.ceb.2017.02.007. Epub 2017 Mar 24. Review.

27.

[Juvenile-onset muscular diseases].

Aden P, Annexstad EJ, Lien E, Tajsic JM, Mjellem N, Rasmussen M.

Tidsskr Nor Laegeforen. 2017 Jan 24;137(2):108-111. doi: 10.4045/tidsskr.16.0623. eCollection 2017 Jan. Review. Norwegian.

28.

The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis.

Shimizu K, Fukushima H, Ogura K, Lien EC, Nihira NT, Zhang J, North BJ, Guo A, Nagashima K, Nakagawa T, Hoshikawa S, Watahiki A, Okabe K, Yamada A, Toker A, Asara JM, Fukumoto S, Nakayama KI, Nakayama K, Inuzuka H, Wei W.

Sci Signal. 2017 Jan 3;10(460). pii: eaah4117. doi: 10.1126/scisignal.aah4117.

29.

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation.

Ratner D, Orning MP, Proulx MK, Wang D, Gavrilin MA, Wewers MD, Alnemri ES, Johnson PF, Lee B, Mecsas J, Kayagaki N, Goguen JD, Lien E.

PLoS Pathog. 2016 Dec 2;12(12):e1006035. doi: 10.1371/journal.ppat.1006035. eCollection 2016 Dec.

30.

Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts.

Sokolova M, Vinge LE, Alfsnes K, Olsen MB, Eide L, Kaasbøll OJ, Attramadal H, Torp MK, Fosshaug LE, Rashidi A, Lien E, Finsen AV, Sandanger Ø, Aukrust P, Ranheim T, Yndestad A.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Feb;1862(2):234-245. doi: 10.1016/j.bbalip.2016.11.003. Epub 2016 Nov 12.

PMID:
27845246
31.

Bacterial secretion systems and regulation of inflammasome activation.

Ratner D, Orning MP, Lien E.

J Leukoc Biol. 2017 Jan;101(1):165-181. doi: 10.1189/jlb.4MR0716-330R. Epub 2016 Nov 3. Review.

32.

Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis.

Cox AG, Tsomides A, Kim AJ, Saunders D, Hwang KL, Evason KJ, Heidel J, Brown KK, Yuan M, Lien EC, Lee BC, Nissim S, Dickinson B, Chhangawala S, Chang CJ, Asara JM, Houvras Y, Gladyshev VN, Goessling W.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5562-71. doi: 10.1073/pnas.1600204113. Epub 2016 Sep 1.

33.

Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer.

Lien EC, Lyssiotis CA, Cantley LC.

Recent Results Cancer Res. 2016;207:39-72. doi: 10.1007/978-3-319-42118-6_3. Review.

PMID:
27557534
34.

A pooled analysis of CYP2D6 genotype in breast cancer prevention trials of low-dose tamoxifen.

Johansson H, Gandini S, Serrano D, Gjerde J, Lattanzi M, Macis D, Guerrieri-Gonzaga A, Aristarco V, Mellgren G, Lien E, DeCensi A, Bonanni B.

Breast Cancer Res Treat. 2016 Aug;159(1):97-108. doi: 10.1007/s10549-016-3932-7. Epub 2016 Aug 2.

PMID:
27484880
35.

Manipulation of interleukin-1β and interleukin-18 production by Yersinia pestis effectors YopJ and YopM and redundant impact on virulence.

Ratner D, Orning MP, Starheim KK, Marty-Roix R, Proulx MK, Goguen JD, Lien E.

J Biol Chem. 2016 Jul 29;291(31):16417. doi: 10.1074/jbc.A115.697698. No abstract available.

36.

Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth.

Cox AG, Hwang KL, Brown KK, Evason K, Beltz S, Tsomides A, O'Connor K, Galli GG, Yimlamai D, Chhangawala S, Yuan M, Lien EC, Wucherpfennig J, Nissim S, Minami A, Cohen DE, Camargo FD, Asara JM, Houvras Y, Stainier DYR, Goessling W.

Nat Cell Biol. 2016 Aug;18(8):886-896. doi: 10.1038/ncb3389. Epub 2016 Jul 18.

37.

Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion.

Juvekar A, Hu H, Yadegarynia S, Lyssiotis CA, Ullas S, Lien EC, Bellinger G, Son J, Hok RC, Seth P, Daly MB, Kim B, Scully R, Asara JM, Cantley LC, Wulf GM.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4338-47. doi: 10.1073/pnas.1522223113. Epub 2016 Jul 8.

38.

Heteromeles Arbutifolia, a Traditional Treatment for Alzheimer's Disease, Phytochemistry and Safety.

Wang X, Dubois R, Young C, Lien EJ, Adams JD.

Medicines (Basel). 2016 Jul 7;3(3). pii: E17. doi: 10.3390/medicines3030017.

39.

A second patient with a De Novo GABRB1 mutation and epileptic encephalopathy.

Lien E, Våtevik AK, Østern R, Haukanes BI, Houge G.

Ann Neurol. 2016 Aug;80(2):311-2. doi: 10.1002/ana.24699. Epub 2016 Jun 28. No abstract available.

PMID:
27273810
40.

Defects in early cell recruitment contribute to the increased susceptibility to respiratory Klebsiella pneumoniae infection in diabetic mice.

Martinez N, Ketheesan N, Martens GW, West K, Lien E, Kornfeld H.

Microbes Infect. 2016 Oct;18(10):649-655. doi: 10.1016/j.micinf.2016.05.007. Epub 2016 May 30.

PMID:
27256462
41.

Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt.

Zhang J, Xu K, Liu P, Geng Y, Wang B, Gan W, Guo J, Wu F, Chin YR, Berrios C, Lien EC, Toker A, DeCaprio JA, Sicinski P, Wei W.

Mol Cell. 2016 Jun 16;62(6):929-942. doi: 10.1016/j.molcel.2016.04.023. Epub 2016 May 26.

42.

ADCK3 mutations with epilepsy, stroke-like episodes and ataxia: a POLG mimic?

Hikmat O, Tzoulis C, Knappskog PM, Johansson S, Boman H, Sztromwasser P, Lien E, Brodtkorb E, Ghezzi D, Bindoff LA.

Eur J Neurol. 2016 Jul;23(7):1188-94. doi: 10.1111/ene.13003. Epub 2016 Apr 23.

PMID:
27106809
43.

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer.

Lien EC, Lyssiotis CA, Juvekar A, Hu H, Asara JM, Cantley LC, Toker A.

Nat Cell Biol. 2016 May;18(5):572-8. doi: 10.1038/ncb3341. Epub 2016 Apr 18.

44.

LIG4 mediates Wnt signalling-induced radioresistance.

Jun S, Jung YS, Suh HN, Wang W, Kim MJ, Oh YS, Lien EM, Shen X, Matsumoto Y, McCrea PD, Li L, Chen J, Park JI.

Nat Commun. 2016 Mar 24;7:10994. doi: 10.1038/ncomms10994.

45.

Oncogenic AKT1(E17K) mutation induces mammary hyperplasia but prevents HER2-driven tumorigenesis.

Mancini ML, Lien EC, Toker A.

Oncotarget. 2016 Apr 5;7(14):17301-13. doi: 10.18632/oncotarget.8191.

46.

Manipulation of Interleukin-1β and Interleukin-18 Production by Yersinia pestis Effectors YopJ and YopM and Redundant Impact on Virulence.

Ratner D, Orning MP, Starheim KK, Marty-Roix R, Proulx MK, Goguen JD, Lien E.

J Biol Chem. 2016 May 6;291(19):9894-905. doi: 10.1074/jbc.M115.697698. Epub 2016 Feb 16. Erratum in: J Biol Chem. 2016 Jul 29;291(31):16417.

47.

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton.

Hu H, Juvekar A, Lyssiotis CA, Lien EC, Albeck JG, Oh D, Varma G, Hung YP, Ullas S, Lauring J, Seth P, Lundquist MR, Tolan DR, Grant AK, Needleman DJ, Asara JM, Cantley LC, Wulf GM.

Cell. 2016 Jan 28;164(3):433-46. doi: 10.1016/j.cell.2015.12.042.

48.

Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants.

Marty-Roix R, Vladimer GI, Pouliot K, Weng D, Buglione-Corbett R, West K, MacMicking JD, Chee JD, Wang S, Lu S, Lien E.

J Biol Chem. 2016 Jan 15;291(3):1123-36. doi: 10.1074/jbc.M115.683011. Epub 2015 Nov 10.

49.

Mammalian Lipopolysaccharide Receptors Incorporated into the Retroviral Envelope Augment Virus Transmission.

Wilks J, Lien E, Jacobson AN, Fischbach MA, Qureshi N, Chervonsky AV, Golovkina TV.

Cell Host Microbe. 2015 Oct 14;18(4):456-62. doi: 10.1016/j.chom.2015.09.005.

50.

Early Upregulation of NLRP3 in the Brain of Neonatal Mice Exposed to Hypoxia-Ischemia: No Early Neuroprotective Effects of NLRP3 Deficiency.

Ystgaard MB, Sejersted Y, Løberg EM, Lien E, Yndestad A, Saugstad OD.

Neonatology. 2015;108(3):211-9. doi: 10.1159/000437247. Epub 2015 Aug 13.

PMID:
26279061

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