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Items: 1 to 50 of 127

1.

Gelatinase B/matrix metalloproteinase-9 and other neutrophil proteases switch off interleukin-2 activity.

Rybakin V, Stas M, Ugarte-Berzal E, Noppen S, Vandooren J, Van Aelst I, Liekens S, Proost P, Opdenakker G.

Biochem J. 2019 Aug 9;476(15):2191-2208. doi: 10.1042/BCJ20180382.

PMID:
31262730
2.

Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity.

Gondim ACS, Roberta da Silva S, Mathys L, Noppen S, Liekens S, Holanda Sampaio A, Nagano CS, Renata Costa Rocha C, Nascimento KS, Cavada BS, Sadler PJ, Balzarini J.

Medchemcomm. 2019 Jan 14;10(3):390-398. doi: 10.1039/c8md00508g. eCollection 2019 Mar 1.

PMID:
30996857
3.

Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the αT5 loop.

Bueno O, Gargantilla M, Estévez-Gallego J, Martins S, Díaz JF, Camarasa MJ, Liekens S, Pérez-Pérez MJ, Priego EM.

Eur J Med Chem. 2019 Jun 1;171:195-208. doi: 10.1016/j.ejmech.2019.03.045. Epub 2019 Mar 21.

PMID:
30921759
4.

Influenza virus entry via the GM3 ganglioside-mediated platelet-derived growth factor receptor β signalling pathway.

Vrijens P, Noppen S, Boogaerts T, Vanstreels E, Ronca R, Chiodelli P, Laporte M, Vanderlinden E, Liekens S, Stevaert A, Naesens L.

J Gen Virol. 2019 Apr;100(4):583-601. doi: 10.1099/jgv.0.001235. Epub 2019 Feb 14.

PMID:
30762518
5.

CCL20, a direct-acting pro-angiogenic chemokine induced by hepatitis C virus (HCV): Potential role in HCV-related liver cancer.

Benkheil M, Van Haele M, Roskams T, Laporte M, Noppen S, Abbasi K, Delang L, Neyts J, Liekens S.

Exp Cell Res. 2018 Nov 15;372(2):168-177. doi: 10.1016/j.yexcr.2018.09.023. Epub 2018 Oct 2.

PMID:
30287142
6.

Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation in vivo and Anti-HIV-1 Activity.

Janssens R, Boff D, Ruytinx P, Mortier A, Vanheule V, Larsen O, Daugvilaite V, Rosenkilde MM, Noppen S, Liekens S, Schols D, De Meester I, Opdenakker G, Struyf S, Teixeira MM, Amaral FA, Proost P.

Front Immunol. 2018 Aug 28;9:1933. doi: 10.3389/fimmu.2018.01933. eCollection 2018.

7.

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis.

Eelen G, Dubois C, Cantelmo AR, Goveia J, Brüning U, DeRan M, Jarugumilli G, van Rijssel J, Saladino G, Comitani F, Zecchin A, Rocha S, Chen R, Huang H, Vandekeere S, Kalucka J, Lange C, Morales-Rodriguez F, Cruys B, Treps L, Ramer L, Vinckier S, Brepoels K, Wyns S, Souffreau J, Schoonjans L, Lamers WH, Wu Y, Haustraete J, Hofkens J, Liekens S, Cubbon R, Ghesquière B, Dewerchin M, Gervasio FL, Li X, van Buul JD, Wu X, Carmeliet P.

Nature. 2018 Sep;561(7721):63-69. doi: 10.1038/s41586-018-0466-7. Epub 2018 Aug 29.

8.

Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3',4',5'-trimethoxyphenyl)-3-(2'-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach.

Preti D, Romagnoli R, Rondanin R, Cacciari B, Hamel E, Balzarini J, Liekens S, Schols D, Estévez-Sarmiento F, Quintana J, Estévez F.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1225-1238. doi: 10.1080/14756366.2018.1493473.

9.

Synthesis of a 3'-C-ethynyl-β-d-ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides.

Hulpia F, Noppen S, Schols D, Andrei G, Snoeck R, Liekens S, Vervaeke P, Van Calenbergh S.

Eur J Med Chem. 2018 Sep 5;157:248-267. doi: 10.1016/j.ejmech.2018.07.062. Epub 2018 Jul 29.

PMID:
30098481
10.

HCV-induced EGFR-ERK signaling promotes a pro-inflammatory and pro-angiogenic signature contributing to liver cancer pathogenesis.

Benkheil M, Paeshuyse J, Neyts J, Van Haele M, Roskams T, Liekens S.

Biochem Pharmacol. 2018 Sep;155:305-315. doi: 10.1016/j.bcp.2018.07.011. Epub 2018 Jul 21.

PMID:
30012461
11.

Synthesis, molecular modeling and biological evaluation of potent analogs of 2-methoxyestradiol.

Al-Kazaale N, Tran PT, Haidari F, Solum EJ, Liekens S, Vervaeke P, Sylte I, Cheng JJ, Vik A, Hansen TV.

Steroids. 2018 Aug;136:47-55. doi: 10.1016/j.steroids.2018.05.002. Epub 2018 May 18.

PMID:
29772242
12.

High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design.

Bueno O, Estévez Gallego J, Martins S, Prota AE, Gago F, Gómez-SanJuan A, Camarasa MJ, Barasoain I, Steinmetz MO, Díaz JF, Pérez-Pérez MJ, Liekens S, Priego EM.

Sci Rep. 2018 Mar 9;8(1):4242. doi: 10.1038/s41598-018-22382-x.

13.

Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activity.

Bueno O, Tobajas G, Quesada E, Estévez-Gallego J, Noppen S, Camarasa MJ, Díaz JF, Liekens S, Priego EM, Pérez-Pérez MJ.

Eur J Med Chem. 2018 Mar 25;148:337-348. doi: 10.1016/j.ejmech.2018.02.019. Epub 2018 Feb 10.

PMID:
29471122
14.

2-Amino-3-methylcarboxy-5-heptyl-thiophene (TJ191) is a selective anti-cancer small molecule that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells.

El-Gazzar A, Noppen S, Thomas J, Dehaen W, Balzarini J, Liekens S.

Oncotarget. 2017 Dec 15;9(5):6259-6269. doi: 10.18632/oncotarget.23501. eCollection 2018 Jan 19.

15.

Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents.

Conesa-Milián L, Falomir E, Murga J, Carda M, Meyen E, Liekens S, Alberto Marco J.

Eur J Med Chem. 2018 Mar 10;147:183-193. doi: 10.1016/j.ejmech.2018.01.058. Epub 2018 Feb 9.

PMID:
29432949
16.

New findings on the d(TGGGAG) sequence: Surprising anti-HIV-1 activity.

Romanucci V, Zarrelli A, Liekens S, Noppen S, Pannecouque C, Di Fabio G.

Eur J Med Chem. 2018 Feb 10;145:425-430. doi: 10.1016/j.ejmech.2018.01.005. Epub 2018 Jan 5.

PMID:
29335208
17.

Modulation of BACE1 Activity by Chemically Modified Aptamers.

Gasse C, Zaarour M, Noppen S, Abramov M, Marlière P, Liekens S, De Strooper B, Herdewijn P.

Chembiochem. 2018 Apr 4;19(7):754-763. doi: 10.1002/cbic.201700461. Epub 2018 Feb 19.

PMID:
29327496
18.

An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein.

Delbart F, Brams M, Gruss F, Noppen S, Peigneur S, Boland S, Chaltin P, Brandao-Neto J, von Delft F, Touw WG, Joosten RP, Liekens S, Tytgat J, Ulens C.

J Biol Chem. 2018 Feb 16;293(7):2534-2545. doi: 10.1074/jbc.M117.815316. Epub 2017 Dec 13.

19.

2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition.

Romagnoli R, Kimatrai Salvador M, Schiaffino Ortega S, Baraldi PG, Oliva P, Baraldi S, Lopez-Cara LC, Brancale A, Ferla S, Hamel E, Balzarini J, Liekens S, Mattiuzzo E, Basso G, Viola G.

Eur J Med Chem. 2018 Jan 1;143:683-698. doi: 10.1016/j.ejmech.2017.11.096.

20.

Relative distribution and biological characterization of CXCL4L1 isoforms in platelets from healthy donors.

Ruytinx P, Janssens R, Berghmans N, Gouwy M, Ronsse I, Liekens S, Proost P, Van Damme J, Struyf S.

Biochem Pharmacol. 2017 Dec 1;145:123-131. doi: 10.1016/j.bcp.2017.08.020. Epub 2017 Aug 30.

PMID:
28859966
21.

Tumor angiogenesis revisited: Regulators and clinical implications.

Ronca R, Benkheil M, Mitola S, Struyf S, Liekens S.

Med Res Rev. 2017 Nov;37(6):1231-1274. doi: 10.1002/med.21452. Epub 2017 Jun 23. Review.

PMID:
28643862
22.

Regioselective monoalkylation of 17β-estradiol for the synthesis of cytotoxic estrogens.

Gansbeke KV, Solum EJ, Liekens S, Vik A, Hansen TV.

Steroids. 2017 Aug;124:54-59. doi: 10.1016/j.steroids.2017.06.001. Epub 2017 Jun 15.

PMID:
28624547
23.

Synthesis and anticancer activity of novel aza-artemisinin derivatives.

Jana S, Iram S, Thomas J, Liekens S, Dehaen W.

Bioorg Med Chem. 2017 Jul 15;25(14):3671-3676. doi: 10.1016/j.bmc.2017.04.041. Epub 2017 Apr 30.

PMID:
28529044
24.

A new four-component reaction involving the Michael addition and the Gewald reaction, leading to diverse biologically active 2-aminothiophenes.

Thomas J, Jana S, Sonawane M, Fiey B, Balzarini J, Liekens S, Dehaen W.

Org Biomol Chem. 2017 May 10;15(18):3892-3900. doi: 10.1039/c7ob00707h.

PMID:
28443928
25.

A Multitarget Approach toward the Development of 8-Substituted Purines for Photoprotection and Prevention of UV-Related Damage.

Djuidje EN, Dissette V, Bino A, Benetti S, Balzarini J, Liekens S, Manfredini S, Vertuani S, Baldisserotto A.

ChemMedChem. 2017 May 22;12(10):760-769. doi: 10.1002/cmdc.201700137. Epub 2017 May 3.

PMID:
28417557
26.

Guanine α-carboxy nucleoside phosphonate (G-α-CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses.

Balzarini J, Menni M, Das K, van Berckelaer L, Ford A, Maguire NM, Liekens S, Boehmer PE, Arnold E, Götte M, Maguire AR.

Biochem Pharmacol. 2017 Jul 15;136:51-61. doi: 10.1016/j.bcp.2017.04.001. Epub 2017 Apr 6.

27.

Pronounced anti-proliferative activity and tumor cell selectivity of 5-alkyl-2-amino-3-methylcarboxylate thiophenes.

Thomas J, Jecic A, Vanstreels E, van Berckelaer L, Romagnoli R, Dehaen W, Liekens S, Balzarini J.

Eur J Med Chem. 2017 May 26;132:219-235. doi: 10.1016/j.ejmech.2017.03.044. Epub 2017 Mar 23.

28.

Truncation of CXCL12 by CD26 reduces its CXC chemokine receptor 4- and atypical chemokine receptor 3-dependent activity on endothelial cells and lymphocytes.

Janssens R, Mortier A, Boff D, Ruytinx P, Gouwy M, Vantilt B, Larsen O, Daugvilaite V, Rosenkilde MM, Parmentier M, Noppen S, Liekens S, Van Damme J, Struyf S, Teixeira MM, Amaral FA, Proost P.

Biochem Pharmacol. 2017 May 15;132:92-101. doi: 10.1016/j.bcp.2017.03.009. Epub 2017 Mar 18.

PMID:
28322746
29.

Antiviral and Cytostatic Evaluation of 5-(1-Halo-2-sulfonylvinyl)- and 5-(2-Furyl)uracil Nucleosides.

Wen Z, Suzol SH, Peng J, Liang Y, Snoeck R, Andrei G, Liekens S, Wnuk SF.

Arch Pharm (Weinheim). 2017 Apr;350(3-4). doi: 10.1002/ardp.201700023. Epub 2017 Mar 17.

PMID:
28304114
30.

Structure-activity relationship studies on a Trp dendrimer with dual activities against HIV and enterovirus A71. Modifications on the amino acid.

Martínez-Gualda B, Sun L, Rivero-Buceta E, Flores A, Quesada E, Balzarini J, Noppen S, Liekens S, Schols D, Neyts J, Leyssen P, Mirabelli C, Camarasa MJ, San-Félix A.

Antiviral Res. 2017 Mar;139:32-40. doi: 10.1016/j.antiviral.2016.12.010. Epub 2016 Dec 23.

31.

High mannose-specific lectin Msl mediates key interactions of the vaginal Lactobacillus plantarum isolate CMPG5300.

Malik S, Petrova MI, Imholz NC, Verhoeven TL, Noppen S, Van Damme EJ, Liekens S, Balzarini J, Schols D, Vanderleyden J, Lebeer S.

Sci Rep. 2016 Nov 17;6:37339. doi: 10.1038/srep37339.

32.

Bioluminescent avian pathogenic Escherichia coli for monitoring colibacillosis in experimentally infected chickens.

Oosterik LH, Tuntufye HN, Tsonos J, Luyten T, Noppen S, Liekens S, Lavigne R, Butaye P, Goddeeris BM.

Vet J. 2016 Oct;216:87-92. doi: 10.1016/j.tvjl.2016.07.011. Epub 2016 Jul 20.

PMID:
27687932
33.

Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models.

Castillo-Acosta VM, Ruiz-Pérez LM, Etxebarria J, Reichardt NC, Navarro M, Igarashi Y, Liekens S, Balzarini J, González-Pacanowska D.

PLoS Pathog. 2016 Sep 23;12(9):e1005851. doi: 10.1371/journal.ppat.1005851. eCollection 2016 Sep.

34.

A single-step acid catalyzed reaction for rapid assembly of NH-1,2,3-triazoles.

Thomas J, Jana S, Liekens S, Dehaen W.

Chem Commun (Camb). 2016 Jul 28;52(59):9236-9. doi: 10.1039/c6cc03744e. Epub 2016 Jun 29.

PMID:
27353974
35.

Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth.

Pérez-Pérez MJ, Priego EM, Bueno O, Martins MS, Canela MD, Liekens S.

J Med Chem. 2016 Oct 13;59(19):8685-8711. Epub 2016 Jun 27.

36.

[Medication counselling and support with individual medication preparation for trail elderly living at home-preliminary results].

Liekens S, Zwaenepoel L, Van de Putte M.

J Pharm Belg. 2016 Jun;(2):10-17. Review. French.

PMID:
30281226
37.

Antivascular and antitumor properties of the tubulin-binding chalcone TUB091.

Canela MD, Noppen S, Bueno O, Prota AE, Bargsten K, Sáez-Calvo G, Jimeno ML, Benkheil M, Ribatti D, Velázquez S, Camarasa MJ, Díaz JF, Steinmetz MO, Priego EM, Pérez-Pérez MJ, Liekens S.

Oncotarget. 2017 Feb 28;8(9):14325-14342. doi: 10.18632/oncotarget.9527.

38.

Metal-Free Route for the Synthesis of 4-Acyl-1,2,3-Triazoles from Readily Available Building Blocks.

Thomas J, Goyvaerts V, Liekens S, Dehaen W.

Chemistry. 2016 Jul 11;22(29):9966-70. doi: 10.1002/chem.201601928. Epub 2016 Jun 10.

PMID:
27172985
39.

Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones.

Onnis V, Demurtas M, Deplano A, Balboni G, Baldisserotto A, Manfredini S, Pacifico S, Liekens S, Balzarini J.

Molecules. 2016 Apr 30;21(5). pii: E579. doi: 10.3390/molecules21050579.

40.

The Cellular Thioredoxin-1/Thioredoxin Reductase-1 Driven Oxidoreduction Represents a Chemotherapeutic Target for HIV-1 Entry Inhibition.

Reiser K, Mathys L, Curbo S, Pannecouque C, Noppen S, Liekens S, Engman L, Lundberg M, Balzarini J, Karlsson A.

PLoS One. 2016 Jan 27;11(1):e0147773. doi: 10.1371/journal.pone.0147773. eCollection 2016.

41.

Screening Platform toward New Anti-HIV Aptamers Set on Molecular Docking and Fluorescence Quenching Techniques.

Oliviero G, Stornaiuolo M, D'Atri V, Nici F, Yousif AM, D'Errico S, Piccialli G, Mayol L, Novellino E, Marinelli L, Grieco P, Carotenuto A, Noppen S, Liekens S, Balzarini J, Borbone N.

Anal Chem. 2016 Feb 16;88(4):2327-34. doi: 10.1021/acs.analchem.5b04268. Epub 2016 Feb 5.

PMID:
26810800
42.

A general metal-free route towards the synthesis of 1,2,3-triazoles from readily available primary amines and ketones.

Thomas J, Jana S, John J, Liekens S, Dehaen W.

Chem Commun (Camb). 2016 Feb 18;52(14):2885-8. doi: 10.1039/c5cc08347h.

PMID:
26744743
43.

Basic chemokine-derived glycosaminoglycan binding peptides exert antiviral properties against dengue virus serotype 2, herpes simplex virus-1 and respiratory syncytial virus.

Vanheule V, Vervaeke P, Mortier A, Noppen S, Gouwy M, Snoeck R, Andrei G, Van Damme J, Liekens S, Proost P.

Biochem Pharmacol. 2016 Jan 15;100:73-85. doi: 10.1016/j.bcp.2015.11.001. Epub 2015 Nov 10.

PMID:
26551597
44.

Anti-HIV-1 activity of a tripodal receptor that recognizes mannose oligomers.

Rivero-Buceta E, Carrero P, Casanova E, Doyagüez EG, Madrona A, Quesada E, Peréz-Pérez MJ, Mateos R, Bravo L, Mathys L, Noppen S, Kiselev E, Marchand C, Pommier Y, Liekens S, Balzarini J, Camarasa MJ, San-Félix A.

Eur J Med Chem. 2015 Dec 1;106:132-43. doi: 10.1016/j.ejmech.2015.10.027. Epub 2015 Oct 21.

PMID:
26540494
45.

Tryptophan dendrimers that inhibit HIV replication, prevent virus entry and bind to the HIV envelope glycoproteins gp120 and gp41.

Rivero-Buceta E, Doyagüez EG, Colomer I, Quesada E, Mathys L, Noppen S, Liekens S, Camarasa MJ, Pérez-Pérez MJ, Balzarini J, San-Félix A.

Eur J Med Chem. 2015 Dec 1;106:34-43. doi: 10.1016/j.ejmech.2015.10.031. Epub 2015 Oct 21.

PMID:
26513643
46.

Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α-Carboxy Nucleoside Phosphonates.

John J, Kim Y, Bennett N, Das K, Liekens S, Naesens L, Arnold E, Maguire AR, Götte M, Dehaen W, Balzarini J.

J Med Chem. 2015 Oct 22;58(20):8110-27. doi: 10.1021/acs.jmedchem.5b01180. Epub 2015 Oct 9.

47.

Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs.

Vande Voorde J, Vervaeke P, Liekens S, Balzarini J.

FEBS Open Bio. 2015 Aug 3;5:634-9. doi: 10.1016/j.fob.2015.07.007. eCollection 2015.

48.

Design, synthesis and antiproliferative activity of novel heterobivalent hybrids based on imidazo[2,1-b][1,3,4]thiadiazole and imidazo[2,1-b][1,3]thiazole scaffolds.

Romagnoli R, Baraldi PG, Prencipe F, Balzarini J, Liekens S, Estévez F.

Eur J Med Chem. 2015 Aug 28;101:205-17. doi: 10.1016/j.ejmech.2015.06.042. Epub 2015 Jun 25.

PMID:
26141911
49.

Antiviral Activity of Synthetic Aminopyrrolic Carbohydrate Binding Agents: Targeting the Glycans of Viral gp120 to Inhibit HIV Entry.

Francesconi O, Nativi C, Gabrielli G, De Simone I, Noppen S, Balzarini J, Liekens S, Roelens S.

Chemistry. 2015 Jul 6;21(28):10089-93. doi: 10.1002/chem.201501030. Epub 2015 Jun 1.

PMID:
26033383
50.

Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics.

Balzarini J, Das K, Bernatchez JA, Martinez SE, Ngure M, Keane S, Ford A, Maguire N, Mullins N, John J, Kim Y, Dehaen W, Vande Voorde J, Liekens S, Naesens L, Götte M, Maguire AR, Arnold E.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3475-80. doi: 10.1073/pnas.1420233112. Epub 2015 Mar 2.

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