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Items: 1 to 50 of 83

1.

Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis.

Sperling R, Salloway S, Brooks DJ, Tampieri D, Barakos J, Fox NC, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Lieberburg I, Arrighi HM, Morris KA, Lu Y, Liu E, Gregg KM, Brashear HR, Kinney GG, Black R, Grundman M.

Lancet Neurol. 2012 Mar;11(3):241-9. doi: 10.1016/S1474-4422(12)70015-7. Epub 2012 Feb 3.

2.

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease.

Salloway S, Sperling R, Gilman S, Fox NC, Blennow K, Raskind M, Sabbagh M, Honig LS, Doody R, van Dyck CH, Mulnard R, Barakos J, Gregg KM, Liu E, Lieberburg I, Schenk D, Black R, Grundman M; Bapineuzumab 201 Clinical Trial Investigators.

Neurology. 2009 Dec 15;73(24):2061-70. doi: 10.1212/WNL.0b013e3181c67808. Epub 2009 Nov 18.

3.

Lethality of Alzheimer disease and its impact on nursing home placement.

Arrighi HM, Neumann PJ, Lieberburg IM, Townsend RJ.

Alzheimer Dis Assoc Disord. 2010 Jan-Mar;24(1):90-5. doi: 10.1097/WAD.0b013e31819fe7d1.

PMID:
19568155
4.

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain.

Dovey HF, John V, Anderson JP, Chen LZ, de Saint Andrieu P, Fang LY, Freedman SB, Folmer B, Goldbach E, Holsztynska EJ, Hu KL, Johnson-Wood KL, Kennedy SL, Kholodenko D, Knops JE, Latimer LH, Lee M, Liao Z, Lieberburg IM, Motter RN, Mutter LC, Nietz J, Quinn KP, Sacchi KL, Seubert PA, Shopp GM, Thorsett ED, Tung JS, Wu J, Yang S, Yin CT, Schenk DB, May PC, Altstiel LD, Bender MH, Boggs LN, Britton TC, Clemens JC, Czilli DL, Dieckman-McGinty DK, Droste JJ, Fuson KS, Gitter BD, Hyslop PA, Johnstone EM, Li WY, Little SP, Mabry TE, Miller FD, Audia JE.

J Neurochem. 2001 Jan;76(1):173-81.

5.

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease.

Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Lieberburg I, Motter R, Nguyen M, Soriano F, Vasquez N, Weiss K, Welch B, Seubert P, Schenk D, Yednock T.

Nat Med. 2000 Aug;6(8):916-9.

PMID:
10932230
6.

beta-peptide immunization: a possible new treatment for Alzheimer disease.

Schenk DB, Seubert P, Lieberburg I, Wallace J.

Arch Neurol. 2000 Jul;57(7):934-6. Review. No abstract available.

PMID:
10891974
7.

Purification and cloning of amyloid precursor protein beta-secretase from human brain.

Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, Schenk D, Seubert P, Suomensaari SM, Wang S, Walker D, Zhao J, McConlogue L, John V.

Nature. 1999 Dec 2;402(6761):537-40.

PMID:
10591214
8.

Cellular mechanisms of beta-amyloid production and secretion.

Sinha S, Lieberburg I.

Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11049-53. Review.

9.

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse.

Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Liao Z, Lieberburg I, Motter R, Mutter L, Soriano F, Shopp G, Vasquez N, Vandevert C, Walker S, Wogulis M, Yednock T, Games D, Seubert P.

Nature. 1999 Jul 8;400(6740):173-7.

PMID:
10408445
10.

High cerebrospinal fluid tau and low amyloid beta42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype.

Galasko D, Chang L, Motter R, Clark CM, Kaye J, Knopman D, Thomas R, Kholodenko D, Schenk D, Lieberburg I, Miller B, Green R, Basherad R, Kertiles L, Boss MA, Seubert P.

Arch Neurol. 1998 Jul;55(7):937-45.

PMID:
9678311
11.

Estrogen therapy in postmenopausal women: effects on cognitive function and dementia.

Yaffe K, Sawaya G, Lieberburg I, Grady D.

JAMA. 1998 Mar 4;279(9):688-95.

PMID:
9496988
12.

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease.

Johnson-Wood K, Lee M, Motter R, Hu K, Gordon G, Barbour R, Khan K, Gordon M, Tan H, Games D, Lieberburg I, Schenk D, Seubert P, McConlogue L.

Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1550-5.

13.

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice.

Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesque G, Johnson-Wood K, Lee M, Seubert P, Davis A, Kholodenko D, Motter R, Sherrington R, Perry B, Yao H, Strome R, Lieberburg I, Rommens J, Kim S, Schenk D, Fraser P, St George Hyslop P, Selkoe DJ.

Nat Med. 1997 Jan;3(1):67-72.

PMID:
8986743
14.

The effect of apolipoprotein E genotype on biochemical markers of Alzheimer's disease.

Schenk D, Lieberburg I, Motter R, Seubert P.

Ann N Y Acad Sci. 1996 Dec 16;802:92-100. No abstract available.

PMID:
8993488
15.

Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes.

Zhao J, Paganini L, Mucke L, Gordon M, Refolo L, Carman M, Sinha S, Oltersdorf T, Lieberburg I, McConlogue L.

J Biol Chem. 1996 Dec 6;271(49):31407-11.

16.
17.

Amyloid beta-peptide in cerebrospinal fluid in individuals with the Swedish Alzheimer amyloid precursor protein mutation.

Lannfelt L, Basun H, Vigo-Pelfrey C, Wahlund LO, Winblad B, Lieberburg I, Schenk D.

Neurosci Lett. 1995 Oct 27;199(3):203-6.

PMID:
8577398
18.

Therapeutic approaches related to amyloid-beta peptide and Alzheimer's disease.

Schenk DB, Rydel RE, May P, Little S, Panetta J, Lieberburg I, Sinha S.

J Med Chem. 1995 Oct 13;38(21):4141-54. Review. No abstract available.

PMID:
7473539
19.

Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau.

Seubert P, Mawal-Dewan M, Barbour R, Jakes R, Goedert M, Johnson GV, Litersky JM, Schenk D, Lieberburg I, Trojanowski JQ, et al.

J Biol Chem. 1995 Aug 11;270(32):18917-22.

20.

Chronic elevation of secreted amyloid precursor protein in subcortically lesioned rats, and its exacerbation in aged rats.

Wallace WC, Lieberburg I, Schenk D, Vigo-Pelfrey C, Davis KL, Haroutunian V.

J Neurosci. 1995 Jul;15(7 Pt 1):4896-905.

21.

Elevation of microtubule-associated protein tau in the cerebrospinal fluid of patients with Alzheimer's disease.

Vigo-Pelfrey C, Seubert P, Barbour R, Blomquist C, Lee M, Lee D, Coria F, Chang L, Miller B, Lieberburg I, et al.

Neurology. 1995 Apr;45(4):788-93.

PMID:
7723971
22.

Cerebrospinal fluid levels of amyloid beta-protein in Alzheimer's disease: inverse correlation with severity of dementia and effect of apolipoprotein E genotype.

Nitsch RM, Rebeck GW, Deng M, Richardson UI, Tennis M, Schenk DB, Vigo-Pelfrey C, Lieberburg I, Wurtman RJ, Hyman BT, et al.

Ann Neurol. 1995 Apr;37(4):512-8.

PMID:
7717688
23.

Channel formation in planar lipid bilayers by a neurotoxic fragment of the beta-amyloid peptide.

Mirzabekov T, Lin MC, Yuan WL, Marshall PJ, Carman M, Tomaselli K, Lieberburg I, Kagan BL.

Biochem Biophys Res Commun. 1994 Jul 29;202(2):1142-8.

PMID:
7519420
24.

Identification of secreted beta-amyloid precursor protein binding sites on intact human fibroblasts.

Johnson-Wood KL, Henriksson T, Seubert P, Oltersdorf T, Lieberburg I, Schenk DB.

Biochem Biophys Res Commun. 1994 May 16;200(3):1685-92.

PMID:
8185626
25.

Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro.

Simmons LK, May PC, Tomaselli KJ, Rydel RE, Fuson KS, Brigham EF, Wright S, Lieberburg I, Becker GW, Brems DN, et al.

Mol Pharmacol. 1994 Mar;45(3):373-9.

PMID:
8145724
26.

Future directions for research on Alzheimer's disease.

Lieberburg I.

Neurobiol Aging. 1994;15 Suppl 2:S117-9. Review. No abstract available.

PMID:
7700434
27.

Serine phosphorylation of the secreted extracellular domain of APP.

Knops J, Gandy S, Greengard P, Lieberburg I, Sinha S.

Biochem Biophys Res Commun. 1993 Dec 15;197(2):380-5.

PMID:
8267571
28.

Regulated cleavage of Alzheimer beta-amyloid precursor protein in the absence of the cytoplasmic tail.

da Cruz e Silva OA, Iverfeldt K, Oltersdorf T, Sinha S, Lieberburg I, Ramabhadran TV, Suzuki T, Sisodia SS, Gandy S, Greengard P.

Neuroscience. 1993 Dec;57(4):873-7.

PMID:
8309547
29.

Characterization of beta-amyloid peptide from human cerebrospinal fluid.

Vigo-Pelfrey C, Lee D, Keim P, Lieberburg I, Schenk DB.

J Neurochem. 1993 Nov;61(5):1965-8.

PMID:
8229004
30.

beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease.

Mattson MP, Barger SW, Cheng B, Lieberburg I, Smith-Swintosky VL, Rydel RE.

Trends Neurosci. 1993 Oct;16(10):409-14. Review.

PMID:
7504356
31.

Cells with a familial Alzheimer's disease mutation produce authentic beta-peptide.

Dovey HF, Suomensaari-Chrysler S, Lieberburg I, Sinha S, Keim PS.

Neuroreport. 1993 Aug;4(8):1039-42.

PMID:
8241460
32.

Altered calcium signaling and neuronal injury: stroke and Alzheimer's disease as examples.

Mattson MP, Rydel RE, Lieberburg I, Smith-Swintosky VL.

Ann N Y Acad Sci. 1993 May 28;679:1-21. Review.

PMID:
8512177
33.

Development of lipophilic anticancer agents for the treatment of brain tumors by the esterification of water-soluble chlorambucil.

Genka S, Deutsch J, Shetty UH, Stahle PL, John V, Lieberburg IM, Ali-Osman F, Rapoport SI, Greig NH.

Clin Exp Metastasis. 1993 Mar;11(2):131-40.

PMID:
8444006
34.

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein.

Mattson MP, Cheng B, Culwell AR, Esch FS, Lieberburg I, Rydel RE.

Neuron. 1993 Feb;10(2):243-54.

PMID:
8094963
35.

Microinjection of synthetic amyloid beta-protein in monkey cerebral cortex fails to produce acute neurotoxicity.

Podlisny MB, Stephenson DT, Frosch MP, Tolan DR, Lieberburg I, Clemens JA, Selkoe DJ.

Am J Pathol. 1993 Jan;142(1):17-24.

36.

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.

Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ.

Nature. 1992 Dec 17;360(6405):672-4.

PMID:
1465129
37.

Beta/A4 domain of APP: antigenic differences between cell lines.

Wolozin B, Zheng B, Loren D, Lesch KP, Lebovics RS, Lieberburg I, Sunderland T.

J Neurosci Res. 1992 Oct;33(2):189-95.

PMID:
1453487
38.

Amyloid beta-peptide is produced by cultured cells during normal metabolism.

Haass C, Schlossmacher MG, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL, Lieberburg I, Koo EH, Schenk D, Teplow DB, et al.

Nature. 1992 Sep 24;359(6393):322-5.

PMID:
1383826
39.

Lack of Alzheimer pathology after beta-amyloid protein injections in rat brain.

Games D, Khan KM, Soriano FG, Keim PS, Davis DL, Bryant K, Lieberburg I.

Neurobiol Aging. 1992 Sep-Oct;13(5):569-76.

PMID:
1461344
40.

Synthetic amyloid beta-protein fails to produce specific neurotoxicity in monkey cerebral cortex.

Podlisny MB, Stephenson DT, Frosch MP, Lieberburg I, Clemens JA, Selkoe DJ.

Neurobiol Aging. 1992 Sep-Oct;13(5):561-7.

PMID:
1281288
42.

Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes.

Schlossmacher MG, Ostaszewski BL, Hecker LI, Celi A, Haass C, Chin D, Lieberburg I, Furie BC, Furie B, Selkoe DJ.

Neurobiol Aging. 1992 May-Jun;13(3):421-34.

PMID:
1625772
43.

Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels.

Tamaoka A, Kalaria RN, Lieberburg I, Selkoe DJ.

Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1345-9.

44.

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity.

Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE.

J Neurosci. 1992 Feb;12(2):376-89.

45.

The beta-amyloid precursor protein is not processed by the regulated secretory pathway.

Overly CC, Fritz LC, Lieberburg I, McConlogue L.

Biochem Biophys Res Commun. 1991 Dec 16;181(2):513-9.

PMID:
1661581
46.

DNA diagnosis for hereditary cerebral hemorrhage with amyloidosis (Dutch type)

Bakker E, van Broeckhoven C, Haan J, Voorhoeve E, van Hul W, Levy E, Lieberburg I, Carman MD, van Ommen GJ, Frangione B, et al.

Am J Hum Genet. 1991 Sep;49(3):518-21.

47.

Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells.

Anderson JP, Esch FS, Keim PS, Sambamurti K, Lieberburg I, Robakis NK.

Neurosci Lett. 1991 Jul 8;128(1):126-8.

PMID:
1922940
48.

A possible mechanism of action of the neurotoxic agent iminodipropionitrile (IDPN): a selective aggregation of the medium and heavy neurofilament polypeptides (NF-M and NF-H)

Anderson JP, Carroll Z, Smulowitz M, Lieberburg I.

Brain Res. 1991 May 3;547(2):353-7. Erratum in: Brain Res 1991 Oct 11;561(2):357.

PMID:
1884214
49.

Isolation of baculovirus-derived secreted and full-length beta-amyloid precursor protein.

Knops J, Johnson-Wood K, Schenk DB, Sinha S, Lieberburg I, McConlogue L.

J Biol Chem. 1991 Apr 15;266(11):7285-90.

50.

The protease inhibitory properties of the Alzheimer's beta-amyloid precursor protein.

Sinha S, Dovey HF, Seubert P, Ward PJ, Blacher RW, Blaber M, Bradshaw RA, Arici M, Mobley WC, Lieberburg I.

J Biol Chem. 1990 Jun 5;265(16):8983-5.

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