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Macrophage Coordination of the Interferon Lambda Immune Response.

Read SA, Wijaya R, Ramezani-Moghadam M, Tay E, Schibeci S, Liddle C, Lam VWT, Yuen L, Douglas MW, Booth D, George J, Ahlenstiel G.

Front Immunol. 2019 Nov 19;10:2674. doi: 10.3389/fimmu.2019.02674. eCollection 2019.


IFNL3 genotype is associated with pulmonary fibrosis in patients with systemic sclerosis.

Metwally M, Thabet K, Bayoumi A, Nikpour M, Stevens W, Sahhar J, Zochling J, Roddy J, Tymms K, Strickland G, Lester S, Rischmueller M, Ngian GS, Walker J, Hissaria P, Shaker O, Liddle C, Manolios N, Beretta L, Proudman S, George J, Eslam M.

Sci Rep. 2019 Oct 16;9(1):14834. doi: 10.1038/s41598-019-50709-9.


Lean NAFLD: A Distinct Entity Shaped by Differential Metabolic Adaptation.

Chen F, Esmaili S, Rogers GB, Bugianesi E, Petta S, Marchesini G, Bayoumi A, Metwally M, Azardaryany MK, Coulter S, Choo JM, Younes R, Rosso C, Liddle C, Adams LA, Craxì A, George J, Eslam M.

Hepatology. 2019 Aug 23. doi: 10.1002/hep.30908. [Epub ahead of print]


Altered cytochrome 2E1 and 3A P450-dependent drug metabolism in advanced ovarian cancer correlates to tumour-associated inflammation.

Trousil S, Lee P, Edwards RJ, Maslen L, Lozan-Kuehne JP, Ramaswami R, Aboagye EO, Clarke S, Liddle C, Sharma R.

Br J Pharmacol. 2019 Sep;176(18):3712-3722. doi: 10.1111/bph.14776. Epub 2019 Aug 5.


Tamoxifen-induced severe hot flashes and endoxifen levels: is dose reduction a safe and effective strategy?

Lee CI, Fox P, Balakrishnar B, Balleine RL, Gao B, Provan P, Coulter S, Liddle C, Hui R, Wong M, Gurney H, Wilcken N.

Breast. 2019 Aug;46:52-57. doi: 10.1016/j.breast.2019.05.009. Epub 2019 May 6.


FXR Regulates Intestinal Cancer Stem Cell Proliferation.

Fu T, Coulter S, Yoshihara E, Oh TG, Fang S, Cayabyab F, Zhu Q, Zhang T, Leblanc M, Liu S, He M, Waizenegger W, Gasser E, Schnabl B, Atkins AR, Yu RT, Knight R, Liddle C, Downes M, Evans RM.

Cell. 2019 Feb 21;176(5):1098-1112.e18. doi: 10.1016/j.cell.2019.01.036.


A variant in the MICA gene is associated with liver fibrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms.

Sharkawy RE, Bayoumi A, Metwally M, Mangia A, Berg T, Romero-Gomez M, Abate ML, Irving WL, Sheridan D, Dore GJ, Spengler U, Lampertico P, Bugianesi E, Weltman M, Mollison L, Cheng W, Riordan S, Santoro R, Gallego-Durán R, Fischer J, Nattermann J, D'Ambrosio R, McLeod D, Powell E, Latchoumanin O, Thabet K, Najim MAM, Douglas MW, Liddle C, Qiao L, George J, Eslam M; International Liver Disease Genetics Consortium (ILDGC).

Sci Rep. 2019 Feb 5;9(1):1439. doi: 10.1038/s41598-018-35736-2.


A polymorphism in the Irisin-encoding gene (FNDC5) associates with hepatic steatosis by differential miRNA binding to the 3'UTR.

Metwally M, Bayoumi A, Romero-Gomez M, Thabet K, John M, Adams LA, Huo X, Aller R, García-Monzón C, Teresa Arias-Loste M, Bugianesi E, Miele L, Gallego-Durán R, Fischer J, Berg T, Liddle C, Qiao L, George J, Eslam M.

J Hepatol. 2019 Mar;70(3):494-500. doi: 10.1016/j.jhep.2018.10.021. Epub 2018 Oct 31.


The latitude-dependent autoimmune disease risk genes ZMIZ1 and IRF8 regulate mononuclear phagocytic cell differentiation in response to vitamin D.

Parnell GP, Schibeci SD, Fewings NL, Afrasiabi A, Law SPL, Samaranayake S, Kh'ng JH, Fong YH, Brown DA, Liddle C, Stewart GJ, Booth DR.

Hum Mol Genet. 2019 Jan 15;28(2):269-278. doi: 10.1093/hmg/ddy324.


An overview of the principles of preoperative care.

Liddle C.

Nurs Stand. 2018 Aug 24. doi: 10.7748/ns.2018.e11170. [Epub ahead of print]


A STAT4 variant increases liver fibrosis risk in Caucasian patients with chronic hepatitis B.

El Sharkawy R, Thabet K, Lampertico P, Petta S, Mangia A, Berg T, Metwally M, Bayoumi A, Boonstra A, Brouwer WP, Smedile A, Abate ML, Loglio A, Douglas MW, Khan A, Santoro R, Fischer J, Leeming DJ, Liddle C, George J, Eslam M.

Aliment Pharmacol Ther. 2018 Sep;48(5):564-573. doi: 10.1111/apt.14866. Epub 2018 Jul 2.


Vitamin D Switches BAF Complexes to Protect β Cells.

Wei Z, Yoshihara E, He N, Hah N, Fan W, Pinto AFM, Huddy T, Wang Y, Ross B, Estepa G, Dai Y, Ding N, Sherman MH, Fang S, Zhao X, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM.

Cell. 2018 May 17;173(5):1135-1149.e15. doi: 10.1016/j.cell.2018.04.013. Epub 2018 May 10.


Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis.

Brandl K, Hartmann P, Jih LJ, Pizzo DP, Argemi J, Ventura-Cots M, Coulter S, Liddle C, Ling L, Rossi SJ, DePaoli AM, Loomba R, Mehal WZ, Fouts DE, Lucey MR, Bosques-Padilla F, Mathurin P, Louvet A, Garcia-Tsao G, Verna EC, Abraldes JG, Brown RS Jr, Vargas V, Altamirano J, Caballería J, Shawcross D, Stärkel P, Ho SB, Bataller R, Schnabl B.

J Hepatol. 2018 Aug;69(2):396-405. doi: 10.1016/j.jhep.2018.03.031. Epub 2018 Apr 12.


Aptamers as targeting ligands and therapeutic molecules for overcoming drug resistance in cancers.

Zhou G, Latchoumanin O, Hebbard L, Duan W, Liddle C, George J, Qiao L.

Adv Drug Deliv Rev. 2018 Sep;134:107-121. doi: 10.1016/j.addr.2018.04.005. Epub 2018 Apr 6. Review.


ERRγ Preserves Brown Fat Innate Thermogenic Activity.

Ahmadian M, Liu S, Reilly SM, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, Saltiel AR, Downes M, Evans RM.

Cell Rep. 2018 Mar 13;22(11):2849-2859. doi: 10.1016/j.celrep.2018.02.061.


ERRγ Promotes Angiogenesis, Mitochondrial Biogenesis, and Oxidative Remodeling in PGC1α/β-Deficient Muscle.

Fan W, He N, Lin CS, Wei Z, Hah N, Waizenegger W, He MX, Liddle C, Yu RT, Atkins AR, Downes M, Evans RM.

Cell Rep. 2018 Mar 6;22(10):2521-2529. doi: 10.1016/j.celrep.2018.02.047.


Cellular Reorganization Plays a Vital Role in Acupuncture Analgesia.

Liddle CE, Harris RE.

Med Acupunct. 2018 Feb 1;30(1):15-20. doi: 10.1089/acu.2017.1258. Review.


Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy.

Saison-Ridinger M, DelGiorno KE, Zhang T, Kraus A, French R, Jaquish D, Tsui C, Erikson G, Spike BT, Shokhirev MN, Liddle C, Yu RT, Downes M, Evans RM, Saghatelian A, Lowy AM, Wahl GM.

PLoS One. 2017 Dec 6;12(12):e0189051. doi: 10.1371/journal.pone.0189051. eCollection 2017.


Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice.

Hartmann P, Hochrath K, Horvath A, Chen P, Seebauer CT, Llorente C, Wang L, Alnouti Y, Fouts DE, Stärkel P, Loomba R, Coulter S, Liddle C, Yu RT, Ling L, Rossi SJ, DePaoli AM, Downes M, Evans RM, Brenner DA, Schnabl B.

Hepatology. 2018 Jun;67(6):2150-2166. doi: 10.1002/hep.29676. Epub 2018 Apr 16.


Aptamer-Based Therapeutic Approaches to Target Cancer Stem Cells.

Zhou G, Latchoumanin O, Bagdesar M, Hebbard L, Duan W, Liddle C, George J, Qiao L.

Theranostics. 2017 Sep 13;7(16):3948-3961. doi: 10.7150/thno.20725. eCollection 2017. Review.


Circadian clock cryptochrome proteins regulate autoimmunity.

Cao Q, Zhao X, Bai J, Gery S, Sun H, Lin DC, Chen Q, Chen Z, Mack L, Yang H, Deng R, Shi X, Chong LW, Cho H, Xie J, Li QZ, Müschen M, Atkins AR, Liddle C, Yu RT, Alkan S, Said JW, Zheng Y, Downes M, Evans RM, Koeffler HP.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12548-12553. doi: 10.1073/pnas.1619119114. Epub 2017 Nov 6.


Metabolic control of regulatory T cell (Treg) survival and function by Lkb1.

He N, Fan W, Henriquez B, Yu RT, Atkins AR, Liddle C, Zheng Y, Downes M, Evans RM.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12542-12547. doi: 10.1073/pnas.1715363114. Epub 2017 Nov 6.


NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection.

Wang J, He N, Zhang N, Quan D, Zhang S, Zhang C, Yu RT, Atkins AR, Zhu R, Yang C, Cui Y, Liddle C, Downes M, Xiao H, Zheng Y, Auwerx J, Evans RM, Leng Q.

Nat Commun. 2017 Oct 16;8(1):959. doi: 10.1038/s41467-017-00931-8.


Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes.

Oral EA, Reilly SM, Gomez AV, Meral R, Butz L, Ajluni N, Chenevert TL, Korytnaya E, Neidert AH, Hench R, Rus D, Horowitz JF, Poirier B, Zhao P, Lehmann K, Jain M, Yu R, Liddle C, Ahmadian M, Downes M, Evans RM, Saltiel AR.

Cell Metab. 2017 Jul 5;26(1):157-170.e7. doi: 10.1016/j.cmet.2017.06.006.


Dose individualization of sunitinib in metastatic renal cell cancer: toxicity-adjusted dose or therapeutic drug monitoring.

Sabanathan D, Zhang A, Fox P, Coulter S, Gebski V, Balakrishnar B, Chan M, Liddle C, Gurney H.

Cancer Chemother Pharmacol. 2017 Aug;80(2):385-393. doi: 10.1007/s00280-017-3362-1. Epub 2017 Jun 30.


PPARδ Promotes Running Endurance by Preserving Glucose.

Fan W, Waizenegger W, Lin CS, Sorrentino V, He MX, Wall CE, Li H, Liddle C, Yu RT, Atkins AR, Auwerx J, Downes M, Evans RM.

Cell Metab. 2017 May 2;25(5):1186-1193.e4. doi: 10.1016/j.cmet.2017.04.006.


IFN-λ3, not IFN-λ4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis.

Eslam M, McLeod D, Kelaeng KS, Mangia A, Berg T, Thabet K, Irving WL, Dore GJ, Sheridan D, Grønbæk H, Abate ML, Hartmann R, Bugianesi E, Spengler U, Rojas A, Booth DR, Weltman M, Mollison L, Cheng W, Riordan S, Mahajan H, Fischer J, Nattermann J, Douglas MW, Liddle C, Powell E, Romero-Gomez M, George J; International Liver Disease Genetics Consortium (ILDGC).

Nat Genet. 2017 May;49(5):795-800. doi: 10.1038/ng.3836. Epub 2017 Apr 10.


The membrane-bound O-acyltransferase domain-containing 7 variant rs641738 increases inflammation and fibrosis in chronic hepatitis B.

Thabet K, Chan HLY, Petta S, Mangia A, Berg T, Boonstra A, Brouwer WP, Abate ML, Wong VW, Nazmy M, Fischer J, Liddle C, George J, Eslam M.

Hepatology. 2017 Jun;65(6):1840-1850. doi: 10.1002/hep.29064. Epub 2017 Apr 28.


Stromal cues regulate the pancreatic cancer epigenome and metabolome.

Sherman MH, Yu RT, Tseng TW, Sousa CM, Liu S, Truitt ML, He N, Ding N, Liddle C, Atkins AR, Leblanc M, Collisson EA, Asara JM, Kimmelman AC, Downes M, Evans RM.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1129-1134. doi: 10.1073/pnas.1620164114. Epub 2017 Jan 17.


Thyroid transcription factor FOXE1 interacts with ETS factor ELK1 to co-regulate TERT.

Bullock M, Lim G, Li C, Choi IH, Kochhar S, Liddle C, Zhang L, Clifton-Bligh RJ.

Oncotarget. 2016 Dec 27;7(52):85948-85962. doi: 10.18632/oncotarget.13288.


MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C.

Thabet K, Asimakopoulos A, Shojaei M, Romero-Gomez M, Mangia A, Irving WL, Berg T, Dore GJ, Grønbæk H, Sheridan D, Abate ML, Bugianesi E, Weltman M, Mollison L, Cheng W, Riordan S, Fischer J, Spengler U, Nattermann J, Wahid A, Rojas A, White R, Douglas MW, McLeod D, Powell E, Liddle C, van der Poorten D, George J, Eslam M; International Liver Disease Genetics Consortium.

Nat Commun. 2016 Sep 15;7:12757. doi: 10.1038/ncomms12757.


A critical evaluation of the fish early-life stage toxicity test for engineered nanomaterials: experimental modifications and recommendations.

Shaw BJ, Liddle CC, Windeatt KM, Handy RD.

Arch Toxicol. 2016 Sep;90(9):2077-2107. doi: 10.1007/s00204-016-1734-7. Epub 2016 Jun 18. Review.


IFNL3/4 genotype is associated with altered immune cell populations in peripheral blood in chronic hepatitis C infection.

O'Connor KS, Read SA, Wang M, Schibeci S, Eslam M, Ong A, Weltman MD, Douglas MW, Mazzola A, Craxì A, Petta S, Stewart GJ, Liddle C, George J, Ahlenstiel G, Booth DR.

Genes Immun. 2016 Sep;17(6):328-34. doi: 10.1038/gene.2016.27. Epub 2016 Jun 16.


Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation.

Zhao X, Hirota T, Han X, Cho H, Chong LW, Lamia K, Liu S, Atkins AR, Banayo E, Liddle C, Yu RT, Yates JR 3rd, Kay SA, Downes M, Evans RM.

Cell. 2016 Jun 16;165(7):1644-1657. doi: 10.1016/j.cell.2016.05.012. Epub 2016 May 26.


Overcoming treatment resistance in cancer: Current understanding and tactics.

Wu G, Wilson G, George J, Liddle C, Hebbard L, Qiao L.

Cancer Lett. 2017 Feb 28;387:69-76. doi: 10.1016/j.canlet.2016.04.018. Epub 2016 Apr 14. Review.


ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells.

Yoshihara E, Wei Z, Lin CS, Fang S, Ahmadian M, Kida Y, Tseng T, Dai Y, Yu RT, Liddle C, Atkins AR, Downes M, Evans RM.

Cell Metab. 2016 Apr 12;23(4):622-34. doi: 10.1016/j.cmet.2016.03.005.


Cistromic and genetic evidence that the vitamin D receptor mediates susceptibility to latitude-dependent autoimmune diseases.

Booth DR, Ding N, Parnell GP, Shahijanian F, Coulter S, Schibeci SD, Atkins AR, Stewart GJ, Evans RM, Downes M, Liddle C.

Genes Immun. 2016 Jun;17(4):213-9. doi: 10.1038/gene.2016.12. Epub 2016 Mar 17.


Aptamers: A promising chemical antibody for cancer therapy.

Zhou G, Wilson G, Hebbard L, Duan W, Liddle C, George J, Qiao L.

Oncotarget. 2016 Mar 22;7(12):13446-63. doi: 10.18632/oncotarget.7178. Review.


Dose Escalation of Tamoxifen in Patients with Low Endoxifen Level: Evidence for Therapeutic Drug Monitoring-The TADE Study.

Fox P, Balleine RL, Lee C, Gao B, Balakrishnar B, Menzies AM, Yeap SH, Ali SS, Gebski V, Provan P, Coulter S, Liddle C, Hui R, Kefford R, Lynch J, Wong M, Wilcken N, Gurney H.

Clin Cancer Res. 2016 Jul 1;22(13):3164-71. doi: 10.1158/1078-0432.CCR-15-1470. Epub 2016 Feb 4.


Diverse impacts of the rs58542926 E167K variant in TM6SF2 on viral and metabolic liver disease phenotypes.

Eslam M, Mangia A, Berg T, Chan HL, Irving WL, Dore GJ, Abate ML, Bugianesi E, Adams LA, Najim MA, Miele L, Weltman M, Mollison L, Cheng W, Riordan S, Fischer J, Romero-Gomez M, Spengler U, Nattermann J, Rahme A, Sheridan D, Booth DR, McLeod D, Powell E, Liddle C, Douglas MW, van der Poorten D, George J; International Liver Disease Genetics Consortium.

Hepatology. 2016 Jul;64(1):34-46. doi: 10.1002/hep.28475. Epub 2016 Mar 30.


BRD4 is a novel therapeutic target for liver fibrosis.

Ding N, Hah N, Yu RT, Sherman MH, Benner C, Leblanc M, He M, Liddle C, Downes M, Evans RM.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15713-8. doi: 10.1073/pnas.1522163112. Epub 2015 Dec 7.


FibroGENE: A gene-based model for staging liver fibrosis.

Eslam M, Hashem AM, Romero-Gomez M, Berg T, Dore GJ, Mangia A, Chan HLY, Irving WL, Sheridan D, Abate ML, Adams LA, Weltman M, Bugianesi E, Spengler U, Shaker O, Fischer J, Mollison L, Cheng W, Nattermann J, Riordan S, Miele L, Kelaeng KS, Ampuero J, Ahlenstiel G, McLeod D, Powell E, Liddle C, Douglas MW, Booth DR, George J; International Liver Disease Genetics Consortium (ILDGC).

J Hepatol. 2016 Feb;64(2):390-398. doi: 10.1016/j.jhep.2015.11.008. Epub 2015 Dec 1.


Depletion of fat-resident Treg cells prevents age-associated insulin resistance.

Bapat SP, Myoung Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, LeBlanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM, Zheng Y.

Nature. 2015 Dec 3;528(7580):137-41. doi: 10.1038/nature16151. Epub 2015 Nov 18.


Antimicrobials in Cirrhotic Patients After Upper Gastrointestinal Hemorrhage: One Size No Longer Fits All.

Watts MR, Gupta V, Liddle C.

Clin Gastroenterol Hepatol. 2016 Feb;14(2):324-5. doi: 10.1016/j.cgh.2015.07.040. Epub 2015 Aug 3. No abstract available.


Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic Cancer.

Arensman MD, Nguyen P, Kershaw KM, Lay AR, Ostertag-Hill CA, Sherman MH, Downes M, Liddle C, Evans RM, Dawson DW.

Mol Cancer Res. 2015 Nov;13(11):1509-19. doi: 10.1158/1541-7786.MCR-15-0204. Epub 2015 Jul 29.


High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice.

Wall CE, Whyte J, Suh JM, Fan W, Collins B, Liddle C, Yu RT, Atkins AR, Naviaux JC, Li K, Bright AT, Alaynick WA, Downes M, Naviaux RK, Evans RM.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8714-9. doi: 10.1073/pnas.1509930112. Epub 2015 Jun 29.


Coherence analysis discriminates between retroviral integration patterns in CD34(+) cells transduced under differing clinical trial conditions.

Hallwirth CV, Garg G, Peters TJ, Kramer BA, Malani NV, Hyman J, Ruan X, Ginn SL, Hetherington NA, Veeravalli L, Shahab A, Ranganathan S, Wei CL, Liddle C, Thrasher AJ, Bushman FD, Buckley MJ, Alexander IE.

Mol Ther Methods Clin Dev. 2015 Apr 29;2:15015. doi: 10.1038/mtm.2015.15. eCollection 2015.


ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency.

Kida YS, Kawamura T, Wei Z, Sogo T, Jacinto S, Shigeno A, Kushige H, Yoshihara E, Liddle C, Ecker JR, Yu RT, Atkins AR, Downes M, Evans RM.

Cell Stem Cell. 2015 May 7;16(5):547-55. doi: 10.1016/j.stem.2015.03.001. Epub 2015 Apr 9.


Dependence of hippocampal function on ERRγ-regulated mitochondrial metabolism.

Pei L, Mu Y, Leblanc M, Alaynick W, Barish GD, Pankratz M, Tseng TW, Kaufman S, Liddle C, Yu RT, Downes M, Pfaff SL, Auwerx J, Gage FH, Evans RM.

Cell Metab. 2015 Apr 7;21(4):628-36. doi: 10.1016/j.cmet.2015.03.004.


Hepatocyte-specific deletion of ARNT (aryl hydrocarbon Receptor Nuclear Translocator) results in altered fibrotic gene expression in the thioacetamide model of liver injury.

Scott C, Cha K, Rao R, Liddle C, George J, Gunton JE.

PLoS One. 2015 Mar 26;10(3):e0121650. doi: 10.1371/journal.pone.0121650. eCollection 2015.

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