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Items: 1 to 50 of 111

1.

The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion.

Scortegagna M, Berthon A, Settas N, Giannakou A, Garcia G, Li JL, James B, Liddington RC, Vilches-Moure JG, Stratakis CA, Ronai ZA.

JCI Insight. 2017 Dec 7;2(23). pii: 97128. doi: 10.1172/jci.insight.97128. [Epub ahead of print]

2.

Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα.

Chen L, Aleshin AE, Alitongbieke G, Zhou Y, Zhang X, Ye X, Hu M, Ren G, Chen Z, Ma Y, Zhang D, Liu S, Gao W, Cai L, Wu L, Zeng Z, Jiang F, Liu J, Zhou H, Cadwell G, Liddington RC, Su Y, Zhang XK.

Nat Commun. 2017 Jul 17;8:16066. doi: 10.1038/ncomms16066.

3.

Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.

Stanford SM, Aleshin AE, Zhang V, Ardecky RJ, Hedrick MP, Zou J, Ganji SR, Bliss MR, Yamamoto F, Bobkov AA, Kiselar J, Liu Y, Cadwell GW, Khare S, Yu J, Barquilla A, Chung TDY, Mustelin T, Schenk S, Bankston LA, Liddington RC, Pinkerton AB, Bottini N.

Nat Chem Biol. 2017 Jun;13(6):624-632. doi: 10.1038/nchembio.2344. Epub 2017 Mar 27.

4.

Definition of a Novel Feed-Forward Mechanism for Glycolysis-HIF1α Signaling in Hypoxic Tumors Highlights Aldolase A as a Therapeutic Target.

Grandjean G, de Jong PR, James B, Koh MY, Lemos R, Kingston J, Aleshin A, Bankston LA, Miller CP, Cho EJ, Edupuganti R, Devkota A, Stancu G, Liddington RC, Dalby K, Powis G.

Cancer Res. 2016 Jul 15;76(14):4259-4269. doi: 10.1158/0008-5472.CAN-16-0401. Epub 2016 Jun 3.

5.

Fibulin-1 purification from human plasma using affinity chromatography on Factor H-Sepharose.

DiScipio RG, Liddington RC, Schraufstatter IU.

Protein Expr Purif. 2016 May;121:118-24. doi: 10.1016/j.pep.2016.01.013. Epub 2016 Jan 28.

6.

Structural basis of protein-protein interactions.

Liddington RC.

Methods Mol Biol. 2015;1278:3-22. doi: 10.1007/978-1-4939-2425-7_1.

PMID:
25859940
7.

Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models.

Choi MS, Nakamura T, Cho SJ, Han X, Holland EA, Qu J, Petsko GA, Yates JR 3rd, Liddington RC, Lipton SA.

J Neurosci. 2014 Nov 5;34(45):15123-31. doi: 10.1523/JNEUROSCI.4751-13.2014.

8.

Effects of human anti-spike protein receptor binding domain antibodies on severe acute respiratory syndrome coronavirus neutralization escape and fitness.

Sui J, Deming M, Rockx B, Liddington RC, Zhu QK, Baric RS, Marasco WA.

J Virol. 2014 Dec;88(23):13769-80. doi: 10.1128/JVI.02232-14. Epub 2014 Sep 17.

9.

Structural aspects of integrins.

Liddington RC.

Adv Exp Med Biol. 2014;819:111-26. doi: 10.1007/978-94-017-9153-3_8. Review.

PMID:
25023171
10.

Molecular signatures of hemagglutinin stem-directed heterosubtypic human neutralizing antibodies against influenza A viruses.

Avnir Y, Tallarico AS, Zhu Q, Bennett AS, Connelly G, Sheehan J, Sui J, Fahmy A, Huang CY, Cadwell G, Bankston LA, McGuire AT, Stamatatos L, Wagner G, Liddington RC, Marasco WA.

PLoS Pathog. 2014 May 1;10(5):e1004103. doi: 10.1371/journal.ppat.1004103. eCollection 2014 May.

11.

Sulindac-derived RXRα modulators inhibit cancer cell growth by binding to a novel site.

Chen L, Wang ZG, Aleshin AE, Chen F, Chen J, Jiang F, Alitongbieke G, Zeng Z, Ma Y, Huang M, Zhou H, Cadwell G, Zheng JF, Huang PQ, Liddington RC, Zhang XK, Su Y.

Chem Biol. 2014 May 22;21(5):596-607. doi: 10.1016/j.chembiol.2014.02.017. Epub 2014 Apr 3.

12.

Structural and functional diversity of metalloproteinases encoded by the Bacteroides fragilis pathogenicity island.

Shiryaev SA, Aleshin AE, Muranaka N, Kukreja M, Routenberg DA, Remacle AG, Liddington RC, Cieplak P, Kozlov IA, Strongin AY.

FEBS J. 2014 Jun;281(11):2487-502. doi: 10.1111/febs.12804. Epub 2014 Apr 22.

13.

Structure-based design of covalent Siah inhibitors.

Stebbins JL, Santelli E, Feng Y, De SK, Purves A, Motamedchaboki K, Wu B, Ronai ZA, Liddington RC, Pellecchia M.

Chem Biol. 2013 Aug 22;20(8):973-82. doi: 10.1016/j.chembiol.2013.06.008. Epub 2013 Jul 25.

14.

Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation.

Gerlic M, Faustin B, Postigo A, Yu EC, Proell M, Gombosuren N, Krajewska M, Flynn R, Croft M, Way M, Satterthwait A, Liddington RC, Salek-Ardakani S, Matsuzawa S, Reed JC.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):7808-13. doi: 10.1073/pnas.1215995110. Epub 2013 Apr 19.

15.

Identification and structural characterization of a broadly neutralizing antibody targeting a novel conserved epitope on the influenza virus H5N1 hemagglutinin.

Du L, Jin L, Zhao G, Sun S, Li J, Yu H, Li Y, Zheng BJ, Liddington RC, Zhou Y, Jiang S.

J Virol. 2013 Feb;87(4):2215-25. doi: 10.1128/JVI.02344-12. Epub 2012 Dec 5.

16.

Activity, specificity, and probe design for the smallpox virus protease K7L.

Aleshin AE, Drag M, Gombosuren N, Wei G, Mikolajczyk J, Satterthwait AC, Strongin AY, Liddington RC, Salvesen GS.

J Biol Chem. 2012 Nov 16;287(47):39470-9. doi: 10.1074/jbc.M112.388678. Epub 2012 Sep 25.

17.

αE-catenin is an autoinhibited molecule that coactivates vinculin.

Choi HJ, Pokutta S, Cadwell GW, Bobkov AA, Bankston LA, Liddington RC, Weis WI.

Proc Natl Acad Sci U S A. 2012 May 29;109(22):8576-81. doi: 10.1073/pnas.1203906109. Epub 2012 May 14.

18.

Crystal structure of C5b-6 suggests structural basis for priming assembly of the membrane attack complex.

Aleshin AE, DiScipio RG, Stec B, Liddington RC.

J Biol Chem. 2012 Jun 1;287(23):19642-52. doi: 10.1074/jbc.M112.361121. Epub 2012 Apr 12.

19.

Structure of complement C6 suggests a mechanism for initiation and unidirectional, sequential assembly of membrane attack complex (MAC).

Aleshin AE, Schraufstatter IU, Stec B, Bankston LA, Liddington RC, DiScipio RG.

J Biol Chem. 2012 Mar 23;287(13):10210-22. doi: 10.1074/jbc.M111.327809. Epub 2012 Jan 20.

20.

Fine epitope mapping of monoclonal antibodies against hemagglutinin of a highly pathogenic H5N1 influenza virus using yeast surface display.

Han T, Sui J, Bennett AS, Liddington RC, Donis RO, Zhu Q, Marasco WA.

Biochem Biophys Res Commun. 2011 Jun 3;409(2):253-9. doi: 10.1016/j.bbrc.2011.04.139. Epub 2011 May 5.

21.

Wide prevalence of heterosubtypic broadly neutralizing human anti-influenza A antibodies.

Sui J, Sheehan J, Hwang WC, Bankston LA, Burchett SK, Huang CY, Liddington RC, Beigel JH, Marasco WA.

Clin Infect Dis. 2011 Apr 15;52(8):1003-9. doi: 10.1093/cid/cir121.

22.

Structural insights into inhibition of Bacillus anthracis sporulation by a novel class of non-heme globin sensor domains.

Stranzl GR, Santelli E, Bankston LA, La Clair C, Bobkov A, Schwarzenbacher R, Godzik A, Perego M, Grynberg M, Liddington RC.

J Biol Chem. 2011 Mar 11;286(10):8448-58. doi: 10.1074/jbc.M110.207126. Epub 2011 Jan 7.

23.

Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention.

Cheltsov AV, Aoyagi M, Aleshin A, Yu EC, Gilliland T, Zhai D, Bobkov AA, Reed JC, Liddington RC, Abagyan R.

J Med Chem. 2010 May 27;53(10):3899-906. doi: 10.1021/jm901446n.

24.

Selective and potent furin inhibitors protect cells from anthrax without significant toxicity.

Remacle AG, Gawlik K, Golubkov VS, Cadwell GW, Liddington RC, Cieplak P, Millis SZ, Desjardins R, Routhier S, Yuan XW, Neugebauer WA, Day R, Strongin AY.

Int J Biochem Cell Biol. 2010 Jun;42(6):987-95. doi: 10.1016/j.biocel.2010.02.013. Epub 2010 Mar 1.

25.

Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs).

Premkumar L, Bobkov AA, Patel M, Jaroszewski L, Bankston LA, Stec B, Vuori K, Côté JF, Liddington RC.

J Biol Chem. 2010 Apr 23;285(17):13211-22. doi: 10.1074/jbc.M110.102517. Epub 2010 Feb 18.

26.

Crystal and solution structures of a prokaryotic M16B peptidase: an open and shut case.

Aleshin AE, Gramatikova S, Hura GL, Bobkov A, Strongin AY, Stec B, Tainer JA, Liddington RC, Smith JW.

Structure. 2009 Nov 11;17(11):1465-75. doi: 10.1016/j.str.2009.09.009.

27.

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses.

Sui J, Hwang WC, Perez S, Wei G, Aird D, Chen LM, Santelli E, Stec B, Cadwell G, Ali M, Wan H, Murakami A, Yammanuru A, Han T, Cox NJ, Bankston LA, Donis RO, Liddington RC, Marasco WA.

Nat Struct Mol Biol. 2009 Mar;16(3):265-73. doi: 10.1038/nsmb.1566. Epub 2009 Feb 22.

28.

Structural determinants of integrin binding to the talin rod.

Gingras AR, Ziegler WH, Bobkov AA, Joyce MG, Fasci D, Himmel M, Rothemund S, Ritter A, Grossmann JG, Patel B, Bate N, Goult BT, Emsley J, Barsukov IL, Roberts GC, Liddington RC, Ginsberg MH, Critchley DR.

J Biol Chem. 2009 Mar 27;284(13):8866-76. doi: 10.1074/jbc.M805937200. Epub 2009 Jan 27.

29.

Substrate cleavage analysis of furin and related proprotein convertases. A comparative study.

Remacle AG, Shiryaev SA, Oh ES, Cieplak P, Srinivasan A, Wei G, Liddington RC, Ratnikov BI, Parent A, Desjardins R, Day R, Smith JW, Lebl M, Strongin AY.

J Biol Chem. 2008 Jul 25;283(30):20897-906. doi: 10.1074/jbc.M803762200. Epub 2008 May 27.

30.

The two-component NS2B-NS3 proteinase represses DNA unwinding activity of the West Nile virus NS3 helicase.

Chernov AV, Shiryaev SA, Aleshin AE, Ratnikov BI, Smith JW, Liddington RC, Strongin AY.

J Biol Chem. 2008 Jun 20;283(25):17270-8. doi: 10.1074/jbc.M801719200. Epub 2008 Apr 28.

31.

Structure-based mutagenesis identifies important novel determinants of the NS2B cofactor of the West Nile virus two-component NS2B-NS3 proteinase.

Radichev I, Shiryaev SA, Aleshin AE, Ratnikov BI, Smith JW, Liddington RC, Strongin AY.

J Gen Virol. 2008 Mar;89(Pt 3):636-41. doi: 10.1099/vir.0.83359-0.

PMID:
18272753
32.

Modifying murine von Willebrand factor A1 domain for in vivo assessment of human platelet therapies.

Chen J, Tan K, Zhou H, Lo HF, Tronik-Le Roux D, Liddington RC, Diacovo TG.

Nat Biotechnol. 2008 Jan;26(1):114-9. Epub 2007 Dec 16.

PMID:
18084279
33.

Complement C3d conjugation to anthrax protective antigen promotes a rapid, sustained, and protective antibody response.

Kolla RV, Chintalapati S, Sabet M, Santelli E, Liddington RC, David M, Fierer J, Guiney D, Rickert RC.

PLoS One. 2007 Oct 17;2(10):e1044.

34.

The PTB domain of tensin: NMR solution structure and phosphoinositides binding studies.

Leone M, Yu EC, Liddington RC, Pasquale EB, Pellecchia M.

Biopolymers. 2008 Jan;89(1):86-92.

PMID:
17922498
35.

Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens.

Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R, Fugere M, Day R, Sabet M, Pellecchia M, Liddington RC, Smith JW, Mustelin T, Guiney DG, Lebl M, Strongin AY.

J Biol Chem. 2007 Jul 20;282(29):20847-53. Epub 2007 May 30.

36.

Structure of the PTB domain of tensin1 and a model for its recruitment to fibrillar adhesions.

McCleverty CJ, Lin DC, Liddington RC.

Protein Sci. 2007 Jun;16(6):1223-9. Epub 2007 May 1.

37.

Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold.

Aleshin AE, Shiryaev SA, Strongin AY, Liddington RC.

Protein Sci. 2007 May;16(5):795-806. Epub 2007 Mar 30.

38.

The crystal structure of Bacillus subtilis YycI reveals a common fold for two members of an unusual class of sensor histidine kinase regulatory proteins.

Santelli E, Liddington RC, Mohan MA, Hoch JA, Szurmant H.

J Bacteriol. 2007 Apr;189(8):3290-5. Epub 2007 Feb 16.

39.

Switching the substrate specificity of the two-component NS2B-NS3 flavivirus proteinase by structure-based mutagenesis.

Shiryaev SA, Ratnikov BI, Aleshin AE, Kozlov IA, Nelson NA, Lebl M, Smith JW, Liddington RC, Strongin AY.

J Virol. 2007 May;81(9):4501-9. Epub 2007 Feb 14.

40.

Minor capsid proteins of simian virus 40 are dispensable for nucleocapsid assembly and cell entry but are required for nuclear entry of the viral genome.

Nakanishi A, Itoh N, Li PP, Handa H, Liddington RC, Kasamatsu H.

J Virol. 2007 Apr;81(8):3778-85. Epub 2007 Jan 31.

41.

Selection of anthrax toxin protective antigen variants that discriminate between the cellular receptors TEM8 and CMG2 and achieve targeting of tumor cells.

Chen KH, Liu S, Bankston LA, Liddington RC, Leppla SH.

J Biol Chem. 2007 Mar 30;282(13):9834-45. Epub 2007 Jan 24.

42.

Structural basis of integrin activation by talin.

Wegener KL, Partridge AW, Han J, Pickford AR, Liddington RC, Ginsberg MH, Campbell ID.

Cell. 2007 Jan 12;128(1):171-82.

43.

Expression and purification of a two-component flaviviral proteinase resistant to autocleavage at the NS2B-NS3 junction region.

Shiryaev SA, Aleshin AE, Ratnikov BI, Smith JW, Liddington RC, Strongin AY.

Protein Expr Purif. 2007 Apr;52(2):334-9. Epub 2006 Dec 1.

44.

Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein.

Aoyagi M, Zhai D, Jin C, Aleshin AE, Stec B, Reed JC, Liddington RC.

Protein Sci. 2007 Jan;16(1):118-24. Epub 2006 Nov 22.

45.

Structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80R.

Hwang WC, Lin Y, Santelli E, Sui J, Jaroszewski L, Stec B, Farzan M, Marasco WA, Liddington RC.

J Biol Chem. 2006 Nov 10;281(45):34610-6. Epub 2006 Sep 5.

46.

The structure and regulation of vinculin.

Ziegler WH, Liddington RC, Critchley DR.

Trends Cell Biol. 2006 Sep;16(9):453-60. Epub 2006 Aug 8. Review.

PMID:
16893648
47.

A structural rationale for SV40 Vp1 temperature-sensitive mutants and their complementation.

Kasamatsu H, Woo J, Nakamura A, Müller P, Tevethia MJ, Liddington RC.

Protein Sci. 2006 Sep;15(9):2207-13. Epub 2006 Aug 1.

48.

Role of vinculin in regulating focal adhesion turnover.

Saunders RM, Holt MR, Jennings L, Sutton DH, Barsukov IL, Bobkov A, Liddington RC, Adamson EA, Dunn GA, Critchley DR.

Eur J Cell Biol. 2006 Jun;85(6):487-500. Epub 2006 Apr 3.

PMID:
16584805
49.

Structure of the alpha-actinin-vinculin head domain complex determined by cryo-electron microscopy.

Kelly DF, Taylor DW, Bakolitsa C, Bobkov AA, Bankston L, Liddington RC, Taylor KA.

J Mol Biol. 2006 Mar 24;357(2):562-73. Epub 2006 Jan 18.

PMID:
16430917
50.

The activity of the vinculin binding sites in talin is influenced by the stability of the helical bundles that make up the talin rod.

Patel B, Gingras AR, Bobkov AA, Fujimoto LM, Zhang M, Liddington RC, Mazzeo D, Emsley J, Roberts GC, Barsukov IL, Critchley DR.

J Biol Chem. 2006 Mar 17;281(11):7458-67. Epub 2006 Jan 9.

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