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Items: 1 to 50 of 98

1.

Development and Clinical Translation of Approved Gene Therapy Products for Genetic Disorders.

Shahryari A, Saghaeian Jazi M, Mohammadi S, Razavi Nikoo H, Nazari Z, Hosseini ES, Burtscher I, Mowla SJ, Lickert H.

Front Genet. 2019 Sep 25;10:868. doi: 10.3389/fgene.2019.00868. eCollection 2019. Review.

2.

Endocardium differentiation through Sox17 expression in endocardium precursor cells regulates heart development in mice.

Saba R, Kitajima K, Rainbow L, Engert S, Uemura M, Ishida H, Kokkinopoulos I, Shintani Y, Miyagawa S, Kanai Y, Kanai-Azuma M, Koopman P, Meno C, Kenny J, Lickert H, Saga Y, Suzuki K, Sawa Y, Yashiro K.

Sci Rep. 2019 Aug 16;9(1):11953. doi: 10.1038/s41598-019-48321-y.

3.

Generation of a human induced pluripotent stem cell line (HMGUi002-A) from a healthy male individual.

Wang X, Malinowski AR, Beckenbauer J, Siehler J, Blöchinger A, Meitinger T, Häring HU, Staiger H, Burtscher I, Lickert H.

Stem Cell Res. 2019 Aug;39:101531. doi: 10.1016/j.scr.2019.101531. Epub 2019 Aug 7.

4.

Wnt signaling: implications in endoderm development and pancreas organogenesis.

Scheibner K, Bakhti M, Bastidas-Ponce A, Lickert H.

Curr Opin Cell Biol. 2019 Aug 1;61:48-55. doi: 10.1016/j.ceb.2019.07.002. [Epub ahead of print] Review.

PMID:
31377680
5.

Pre-marked chromatin and transcription factor co-binding shape the pioneering activity of Foxa2.

Cernilogar FM, Hasenöder S, Wang Z, Scheibner K, Burtscher I, Sterr M, Smialowski P, Groh S, Evenroed IM, Gilfillan GD, Lickert H, Schotta G.

Nucleic Acids Res. 2019 Sep 26;47(17):9069-9086. doi: 10.1093/nar/gkz627.

6.

Concepts and limitations for learning developmental trajectories from single cell genomics.

Tritschler S, Büttner M, Fischer DS, Lange M, Bergen V, Lickert H, Theis FJ.

Development. 2019 Jun 27;146(12). pii: dev170506. doi: 10.1242/dev.170506. Review.

PMID:
31249007
7.

Comprehensive single cell mRNA profiling reveals a detailed roadmap for pancreatic endocrinogenesis.

Bastidas-Ponce A, Tritschler S, Dony L, Scheibner K, Tarquis-Medina M, Salinno C, Schirge S, Burtscher I, Böttcher A, Theis FJ, Lickert H, Bakhti M.

Development. 2019 Jun 17;146(12). pii: dev173849. doi: 10.1242/dev.173849.

PMID:
31160421
8.

A map of β-cell differentiation pathways supports cell therapies for diabetes.

Theis FJ, Lickert H.

Nature. 2019 May;569(7756):342-343. doi: 10.1038/d41586-019-01211-9. No abstract available.

PMID:
31076731
9.

Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition.

Modic M, Grosch M, Rot G, Schirge S, Lepko T, Yamazaki T, Lee FCY, Rusha E, Shaposhnikov D, Palo M, Merl-Pham J, Cacchiarelli D, Rogelj B, Hauck SM, von Mering C, Meissner A, Lickert H, Hirose T, Ule J, Drukker M.

Mol Cell. 2019 Jun 6;74(5):951-965.e13. doi: 10.1016/j.molcel.2019.03.041. Epub 2019 Apr 29.

10.

Sorting Out Fate Determination.

Bakhti M, Bastidas-Ponce A, Lickert H.

Dev Cell. 2019 Apr 8;49(1):1-3. doi: 10.1016/j.devcel.2019.03.020.

PMID:
30965032
11.

Inferring population dynamics from single-cell RNA-sequencing time series data.

Fischer DS, Fiedler AK, Kernfeld EM, Genga RMJ, Bastidas-Ponce A, Bakhti M, Lickert H, Hasenauer J, Maehr R, Theis FJ.

Nat Biotechnol. 2019 Apr;37(4):461-468. doi: 10.1038/s41587-019-0088-0. Epub 2019 Apr 1.

PMID:
30936567
12.

Point mutations in the PDX1 transactivation domain impair human β-cell development and function.

Wang X, Sterr M, Ansarullah, Burtscher I, Böttcher A, Beckenbauer J, Siehler J, Meitinger T, Häring HU, Staiger H, Cernilogar FM, Schotta G, Irmler M, Beckers J, Wright CVE, Bakhti M, Lickert H.

Mol Metab. 2019 Jun;24:80-97. doi: 10.1016/j.molmet.2019.03.006. Epub 2019 Mar 20.

13.

EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology.

Brennecke P, Rasina D, Aubi O, Herzog K, Landskron J, Cautain B, Vicente F, Quintana J, Mestres J, Stechmann B, Ellinger B, Brea J, Kolanowski JL, Pilarski R, Orzaez M, Pineda-Lucena A, Laraia L, Nami F, Zielenkiewicz P, Paruch K, Hansen E, von Kries JP, Neuenschwander M, Specker E, Bartunek P, Simova S, Leśnikowski Z, Krauss S, Lehtiö L, Bilitewski U, Brönstrup M, Taskén K, Jirgensons A, Lickert H, Clausen MH, Andersen JH, Vicent MJ, Genilloud O, Martinez A, Nazaré M, Fecke W, Gribbon P.

SLAS Discov. 2019 Mar;24(3):398-413. doi: 10.1177/2472555218816276. Epub 2019 Jan 7.

PMID:
30616481
14.

Modelling the endocrine pancreas in health and disease.

Bakhti M, Böttcher A, Lickert H.

Nat Rev Endocrinol. 2019 Mar;15(3):155-171. doi: 10.1038/s41574-018-0132-z. Review.

PMID:
30504925
15.

Dual embryonic origin of the mammalian enteric nervous system.

Brokhman I, Xu J, Coles BLK, Razavi R, Engert S, Lickert H, Babona-Pilipos R, Morshead CM, Sibley E, Chen C, van der Kooy D.

Dev Biol. 2019 Jan 15;445(2):256-270. doi: 10.1016/j.ydbio.2018.11.014. Epub 2018 Nov 22.

16.

Night Shift Work Affects Urine Metabolite Profiles of Nurses with Early Chronotype.

Rotter M, Brandmaier S, Covic M, Burek K, Hertel J, Troll M, Bader E, Adam J, Prehn C, Rathkolb B, Hrabe de Angelis M, Grabe HJ, Daniel H, Kantermann T, Harth V, Illig T, Pallapies D, Behrens T, Brüning T, Adamski J, Lickert H, Rabstein S, Wang-Sattler R.

Metabolites. 2018 Aug 21;8(3). pii: E45. doi: 10.3390/metabo8030045.

17.

Neurog3-dependent pancreas dysgenesis causes ectopic pancreas in Hes1 mutant mice.

Jørgensen MC, de Lichtenberg KH, Collin CA, Klinck R, Ekberg JH, Engelstoft MS, Lickert H, Serup P.

Development. 2018 Sep 3;145(17). pii: dev163568. doi: 10.1242/dev.163568.

18.

Maintenance of hematopoietic stem and progenitor cells in fetal intra-aortic hematopoietic clusters by the Sox17-Notch1-Hes1 axis.

Saito K, Nobuhisa I, Harada K, Takahashi S, Anani M, Lickert H, Kanai-Azuma M, Kanai Y, Taga T.

Exp Cell Res. 2018 Apr 1;365(1):145-155. doi: 10.1016/j.yexcr.2018.02.014. Epub 2018 Feb 16.

PMID:
29458175
19.

Neural tube closure depends on expression of Grainyhead-like 3 in multiple tissues.

De Castro SCP, Hirst CS, Savery D, Rolo A, Lickert H, Andersen B, Copp AJ, Greene NDE.

Dev Biol. 2018 Mar 15;435(2):130-137. doi: 10.1016/j.ydbio.2018.01.016. Epub 2018 Feb 2.

20.

Genome-wide analysis of PDX1 target genes in human pancreatic progenitors.

Wang X, Sterr M, Burtscher I, Chen S, Hieronimus A, Machicao F, Staiger H, Häring HU, Lederer G, Meitinger T, Cernilogar FM, Schotta G, Irmler M, Beckers J, Hrabě de Angelis M, Ray M, Wright CVE, Bakhti M, Lickert H.

Mol Metab. 2018 Mar;9:57-68. doi: 10.1016/j.molmet.2018.01.011. Epub 2018 Jan 31.

21.

Animal models of obesity and diabetes mellitus.

Kleinert M, Clemmensen C, Hofmann SM, Moore MC, Renner S, Woods SC, Huypens P, Beckers J, de Angelis MH, Schürmann A, Bakhti M, Klingenspor M, Heiman M, Cherrington AD, Ristow M, Lickert H, Wolf E, Havel PJ, Müller TD, Tschöp MH.

Nat Rev Endocrinol. 2018 Mar;14(3):140-162. doi: 10.1038/nrendo.2017.161. Epub 2018 Jan 19. Review.

22.

Erratum. Direct Substrate Delivery Into Mitochondrial Fission-Deficient Pancreatic Islets Rescues Insulin Secretion. Diabetes 2017;66:1247-1257.

Kabra UD, Pfuhlmann K, Migliorini A, Keipert S, Lamp D, Korsgren O, Gegg M, Woods SC, Pfluger PT, Lickert H, Affourtit C, Tschöp MH, Jastroch M.

Diabetes. 2017 Dec;66(12):3144. doi: 10.2337/db17-er12d. Epub 2017 Oct 12. No abstract available.

23.

Islet biology.

Lickert H, Kaestner KH.

Mol Metab. 2017 Jun 13;6(9):vi. doi: 10.1016/j.molmet.2017.06.005. eCollection 2017 Sep. No abstract available.

24.

Systematic single-cell analysis provides new insights into heterogeneity and plasticity of the pancreas.

Tritschler S, Theis FJ, Lickert H, Böttcher A.

Mol Metab. 2017 Jul 20;6(9):974-990. doi: 10.1016/j.molmet.2017.06.021. eCollection 2017 Sep. Review.

25.

A novel Cre-inducible knock-in ARL13B-tRFP fusion cilium reporter.

Schmitz F, Burtscher I, Stauber M, Gossler A, Lickert H.

Genesis. 2017 Nov;55(11). doi: 10.1002/dvg.23073. Epub 2017 Oct 13.

PMID:
28948682
26.

Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity.

Quarta C, Clemmensen C, Zhu Z, Yang B, Joseph SS, Lutter D, Yi CX, Graf E, García-Cáceres C, Legutko B, Fischer K, Brommage R, Zizzari P, Franklin BS, Krueger M, Koch M, Vettorazzi S, Li P, Hofmann SM, Bakhti M, Bastidas-Ponce A, Lickert H, Strom TM, Gailus-Durner V, Bechmann I, Perez-Tilve D, Tuckermann J, Hrabě de Angelis M, Sandoval D, Cota D, Latz E, Seeley RJ, Müller TD, DiMarchi RD, Finan B, Tschöp MH.

Cell Metab. 2017 Oct 3;26(4):620-632.e6. doi: 10.1016/j.cmet.2017.08.023. Epub 2017 Sep 21.

27.

Netrin-1 Derived from the Ventricular Zone, but not the Floor Plate, Directs Hindbrain Commissural Axons to the Ventral Midline.

Yamauchi K, Yamazaki M, Abe M, Sakimura K, Lickert H, Kawasaki T, Murakami F, Hirata T.

Sci Rep. 2017 Sep 20;7(1):11992. doi: 10.1038/s41598-017-12269-8.

28.

Cellular and molecular mechanisms coordinating pancreas development.

Bastidas-Ponce A, Scheibner K, Lickert H, Bakhti M.

Development. 2017 Aug 15;144(16):2873-2888. doi: 10.1242/dev.140756. Review.

29.

Engineering Skin with Skinny Genes.

Böttcher A, Lickert H, Tschöp M.

Cell Stem Cell. 2017 Aug 3;21(2):153-155. doi: 10.1016/j.stem.2017.07.013.

30.

A high-content small molecule screen identifies novel inducers of definitive endoderm.

Korostylev A, Mahaddalkar PU, Keminer O, Hadian K, Schorpp K, Gribbon P, Lickert H.

Mol Metab. 2017 May 4;6(7):640-650. doi: 10.1016/j.molmet.2017.04.009. eCollection 2017 Jul.

31.

Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells.

Bastidas-Ponce A, Roscioni SS, Burtscher I, Bader E, Sterr M, Bakhti M, Lickert H.

Mol Metab. 2017 Mar 25;6(6):524-534. doi: 10.1016/j.molmet.2017.03.007. eCollection 2017 Jun.

32.

Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes.

Hockman D, Burns AJ, Schlosser G, Gates KP, Jevans B, Mongera A, Fisher S, Unlu G, Knapik EW, Kaufman CK, Mosimann C, Zon LI, Lancman JJ, Dong PDS, Lickert H, Tucker AS, Baker CV.

Elife. 2017 Apr 7;6. pii: e21231. doi: 10.7554/eLife.21231.

33.

Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential.

Bardot E, Calderon D, Santoriello F, Han S, Cheung K, Jadhav B, Burtscher I, Artap S, Jain R, Epstein J, Lickert H, Gouon-Evans V, Sharp AJ, Dubois NC.

Nat Commun. 2017 Feb 14;8:14428. doi: 10.1038/ncomms14428.

34.

Direct Substrate Delivery Into Mitochondrial Fission-Deficient Pancreatic Islets Rescues Insulin Secretion.

Kabra UD, Pfuhlmann K, Migliorini A, Keipert S, Lamp D, Korsgren O, Gegg M, Woods SC, Pfluger PT, Lickert H, Affourtit C, Tschöp MH, Jastroch M.

Diabetes. 2017 May;66(5):1247-1257. doi: 10.2337/db16-1088. Epub 2017 Feb 7. Erratum in: Diabetes. 2017 Dec;66(12 ):3144.

35.

Stability of targeted metabolite profiles of urine samples under different storage conditions.

Rotter M, Brandmaier S, Prehn C, Adam J, Rabstein S, Gawrych K, Brüning T, Illig T, Lickert H, Adamski J, Wang-Sattler R.

Metabolomics. 2017;13(1):4. Epub 2016 Nov 28.

36.

Generation of a human induced pluripotent stem cell (iPSC) line from a patient with family history of diabetes carrying a C18R mutation in the PDX1 gene.

Wang X, Chen S, Burtscher I, Sterr M, Hieronimus A, Machicao F, Staiger H, Häring HU, Lederer G, Meitinger T, Lickert H.

Stem Cell Res. 2016 Sep;17(2):292-295. doi: 10.1016/j.scr.2016.08.005. Epub 2016 Aug 6.

37.

Generation of a human induced pluripotent stem cell (iPSC) line from a patient carrying a P33T mutation in the PDX1 gene.

Wang X, Chen S, Burtscher I, Sterr M, Hieronimus A, Machicao F, Staiger H, Häring HU, Lederer G, Meitinger T, Lickert H.

Stem Cell Res. 2016 Sep;17(2):273-276. doi: 10.1016/j.scr.2016.08.004. Epub 2016 Aug 5.

38.

Impact of islet architecture on β-cell heterogeneity, plasticity and function.

Roscioni SS, Migliorini A, Gegg M, Lickert H.

Nat Rev Endocrinol. 2016 Dec;12(12):695-709. doi: 10.1038/nrendo.2016.147. Epub 2016 Sep 2. Review.

PMID:
27585958
39.

Targeting insulin-producing beta cells for regenerative therapy.

Migliorini A, Roscioni SS, Lickert H.

Diabetologia. 2016 Sep;59(9):1838-42. doi: 10.1007/s00125-016-3949-9. Epub 2016 Jul 13. Review.

PMID:
27412250
40.

Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios.

Hoppe PS, Schwarzfischer M, Loeffler D, Kokkaliaris KD, Hilsenbeck O, Moritz N, Endele M, Filipczyk A, Gambardella A, Ahmed N, Etzrodt M, Coutu DL, Rieger MA, Marr C, Strasser MK, Schauberger B, Burtscher I, Ermakova O, Bürger A, Lickert H, Nerlov C, Theis FJ, Schroeder T.

Nature. 2016 Jul 14;535(7611):299-302. doi: 10.1038/nature18320.

PMID:
27411635
41.

Identification of proliferative and mature β-cells in the islets of Langerhans.

Bader E, Migliorini A, Gegg M, Moruzzi N, Gerdes J, Roscioni SS, Bakhti M, Brandl E, Irmler M, Beckers J, Aichler M, Feuchtinger A, Leitzinger C, Zischka H, Wang-Sattler R, Jastroch M, Tschöp M, Machicao F, Staiger H, Häring HU, Chmelova H, Chouinard JA, Oskolkov N, Korsgren O, Speier S, Lickert H.

Nature. 2016 Jul 21;535(7612):430-4. Epub 2016 Jul 11.

PMID:
27398620
42.

Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.

Jung B, Messias AC, Schorpp K, Geerlof A, Schneider G, Saur D, Hadian K, Sattler M, Wanker EE, Hasenöder S, Lickert H.

Sci Rep. 2016 Mar 2;6:22540. doi: 10.1038/srep22540.

43.

Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation.

Jung B, Padula D, Burtscher I, Landerer C, Lutter D, Theis F, Messias AC, Geerlof A, Sattler M, Kremmer E, Boldt K, Ueffing M, Lickert H.

PLoS One. 2016 Feb 22;11(2):e0149477. doi: 10.1371/journal.pone.0149477. eCollection 2016.

44.

The global gene expression profile of the secondary transition during pancreatic development.

Willmann SJ, Mueller NS, Engert S, Sterr M, Burtscher I, Raducanu A, Irmler M, Beckers J, Sass S, Theis FJ, Lickert H.

Mech Dev. 2016 Feb;139:51-64. doi: 10.1016/j.mod.2015.11.004. Epub 2015 Nov 28.

45.

Homology arms of targeting vectors for gene insertions and CRISPR/Cas9 technology: size does not matter; quality control of targeted clones does.

Petrezselyova S, Kinsky S, Truban D, Sedlacek R, Burtscher I, Lickert H.

Cell Mol Biol Lett. 2015 Dec;20(5):773-87. doi: 10.1515/cmble-2015-0047.

PMID:
26540224
46.

Revising the embryonic origin of thyroid C cells in mice and humans.

Johansson E, Andersson L, Örnros J, Carlsson T, Ingeson-Carlsson C, Liang S, Dahlberg J, Jansson S, Parrillo L, Zoppoli P, Barila GO, Altschuler DL, Padula D, Lickert H, Fagman H, Nilsson M.

Development. 2015 Oct 15;142(20):3519-28. doi: 10.1242/dev.126581. Epub 2015 Sep 22.

47.

SimiRa: A tool to identify coregulation between microRNAs and RNA-binding proteins.

Preusse M, Marr C, Saunders S, Maticzka D, Lickert H, Backofen R, Theis F.

RNA Biol. 2015;12(9):998-1009. doi: 10.1080/15476286.2015.1068496.

48.

Repurposing an Osteoporosis Drug for β Cell Regeneration in Diabetic Patients.

Schmitz F, Roscioni S, Lickert H.

Cell Metab. 2015 Jul 7;22(1):58-9. doi: 10.1016/j.cmet.2015.05.024. Epub 2015 Jun 18.

49.

Beyond association: A functional role for Tcf7l2 in β-cell development.

Migliorini A, Lickert H.

Mol Metab. 2015 Mar 17;4(5):365-6. doi: 10.1016/j.molmet.2015.03.002. eCollection 2015 May. No abstract available.

50.

Endoderm generates endothelial cells during liver development.

Goldman O, Han S, Hamou W, Jodon de Villeroche V, Uzan G, Lickert H, Gouon-Evans V.

Stem Cell Reports. 2014 Oct 14;3(4):556-65. doi: 10.1016/j.stemcr.2014.08.009. Epub 2014 Sep 18.

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