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Items: 25


Charting the transcriptional landscape of cells of renin lineage following podocyte depletion.

McClelland AD, Lichtnekert J, Eng DG, Pippin JW, Gross KW, Gharib SA, Shankland SJ.

PLoS One. 2017 Dec 12;12(12):e0189084. doi: 10.1371/journal.pone.0189084. eCollection 2017.


The Immune System in Tissue Environments Regaining Homeostasis after Injury: Is "Inflammation" Always Inflammation?

Kulkarni OP, Lichtnekert J, Anders HJ, Mulay SR.

Mediators Inflamm. 2016;2016:2856213. doi: 10.1155/2016/2856213. Epub 2016 Aug 11. Review.


Reducing mTOR augments parietal epithelial cell density in a model of acute podocyte depletion and in aged kidneys.

McNicholas BA, Eng DG, Lichtnekert J, Rabinowitz PS, Pippin JW, Shankland SJ.

Am J Physiol Renal Physiol. 2016 Sep 1;311(3):F626-39. doi: 10.1152/ajprenal.00196.2016. Epub 2016 Jul 20.


Renin-Angiotensin-Aldosterone System Inhibition Increases Podocyte Derivation from Cells of Renin Lineage.

Lichtnekert J, Kaverina NV, Eng DG, Gross KW, Kutz JN, Pippin JW, Shankland SJ.

J Am Soc Nephrol. 2016 Dec;27(12):3611-3627. Epub 2016 Apr 14.


Changes in glomerular parietal epithelial cells in mouse kidneys with advanced age.

Roeder SS, Stefanska A, Eng DG, Kaverina N, Sunseri MW, McNicholas BA, Rabinovitch P, Engel FB, Daniel C, Amann K, Lichtnekert J, Pippin JW, Shankland SJ.

Am J Physiol Renal Physiol. 2015 Jul 15;309(2):F164-78. doi: 10.1152/ajprenal.00144.2015. Epub 2015 May 27.


ACE-inhibition increases podocyte number in experimental glomerular disease independent of proliferation.

Zhang J, Yanez D, Floege A, Lichtnekert J, Krofft RD, Liu ZH, Pippin JW, Shankland SJ.

J Renin Angiotensin Aldosterone Syst. 2015 Jun;16(2):234-48. doi: 10.1177/1470320314543910. Epub 2014 Aug 20.


Hyaluronan is not a ligand but a regulator of toll-like receptor signaling in mesangial cells: role of extracellular matrix in innate immunity.

Ebid R, Lichtnekert J, Anders HJ.

ISRN Nephrol. 2014 Jan 21;2014:714081. doi: 10.1155/2014/714081. eCollection 2014.


The NLRP3/ASC inflammasome promotes T-cell-dependent immune complex glomerulonephritis by canonical and noncanonical mechanisms.

Andersen K, Eltrich N, Lichtnekert J, Anders HJ, Vielhauer V.

Kidney Int. 2014 Nov;86(5):965-78. doi: 10.1038/ki.2014.161. Epub 2014 May 7.


Focal adhesion kinase regulates the activity of the osmosensitive transcription factor TonEBP/NFAT5 under hypertonic conditions.

Neuhofer W, Küper C, Lichtnekert J, Holzapfel K, Rupanagudi KV, Fraek ML, Bartels H, Beck FX.

Front Physiol. 2014 Apr 4;5:123. doi: 10.3389/fphys.2014.00123. eCollection 2014.


Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming.

Rupanagudi KV, Kulkarni OP, Lichtnekert J, Darisipudi MN, Mulay SR, Schott B, Gruner S, Haap W, Hartmann G, Anders HJ.

Ann Rheum Dis. 2015 Feb;74(2):452-63. doi: 10.1136/annrheumdis-2013-203717. Epub 2013 Dec 3.


Resident renal mononuclear phagocytes comprise five discrete populations with distinct phenotypes and functions.

Kawakami T, Lichtnekert J, Thompson LJ, Karna P, Bouabe H, Hohl TM, Heinecke JW, Ziegler SF, Nelson PJ, Duffield JS.

J Immunol. 2013 Sep 15;191(6):3358-72. doi: 10.4049/jimmunol.1300342. Epub 2013 Aug 16.


Changes in macrophage phenotype as the immune response evolves.

Lichtnekert J, Kawakami T, Parks WC, Duffield JS.

Curr Opin Pharmacol. 2013 Aug;13(4):555-64. doi: 10.1016/j.coph.2013.05.013. Epub 2013 Jun 7. Review.


Histones from dying renal cells aggravate kidney injury via TLR2 and TLR4.

Allam R, Scherbaum CR, Darisipudi MN, Mulay SR, Hägele H, Lichtnekert J, Hagemann JH, Rupanagudi KV, Ryu M, Schwarzenberger C, Hohenstein B, Hugo C, Uhl B, Reichel CA, Krombach F, Monestier M, Liapis H, Moreth K, Schaefer L, Anders HJ.

J Am Soc Nephrol. 2012 Aug;23(8):1375-88. doi: 10.1681/ASN.2011111077. Epub 2012 Jun 7.


Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1.

Lichtnekert J, Kulkarni OP, Mulay SR, Rupanagudi KV, Ryu M, Allam R, Vielhauer V, Muruve D, Lindenmeyer MT, Cohen CD, Anders HJ.

PLoS One. 2011;6(10):e26778. doi: 10.1371/journal.pone.0026778. Epub 2011 Oct 27.


Mdm2 promotes systemic lupus erythematosus and lupus nephritis.

Allam R, Sayyed SG, Kulkarni OP, Lichtnekert J, Anders HJ.

J Am Soc Nephrol. 2011 Nov;22(11):2016-27. doi: 10.1681/ASN.2011010045. Epub 2011 Sep 23.


Activated protein C attenuates systemic lupus erythematosus and lupus nephritis in MRL-Fas(lpr) mice.

Lichtnekert J, Rupanagudi KV, Kulkarni OP, Darisipudi MN, Allam R, Anders HJ.

J Immunol. 2011 Sep 15;187(6):3413-21. doi: 10.4049/jimmunol.1101125. Epub 2011 Aug 17.


An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes.

Sayyed SG, Ryu M, Kulkarni OP, Schmid H, Lichtnekert J, Grüner S, Green L, Mattei P, Hartmann G, Anders HJ.

Kidney Int. 2011 Jul;80(1):68-78. doi: 10.1038/ki.2011.102. Epub 2011 Apr 20.


Cutting edge: cyclic polypeptide and aminoglycoside antibiotics trigger IL-1β secretion by activating the NLRP3 inflammasome.

Allam R, Darisipudi MN, Rupanagudi KV, Lichtnekert J, Tschopp J, Anders HJ.

J Immunol. 2011 Mar 1;186(5):2714-8. doi: 10.4049/jimmunol.1002657. Epub 2011 Jan 28.


Interferon-alpha and -beta in kidney inflammation.

Anders HJ, Lichtnekert J, Allam R.

Kidney Int. 2010 May;77(10):848-54. doi: 10.1038/ki.2010.71. Epub 2010 Mar 17. Review.


Renal failure increases cardiac histone h3 acetylation, dimethylation, and phosphorylation and the induction of cardiomyopathy-related genes in type 2 diabetes.

Gaikwad AB, Sayyed SG, Lichtnekert J, Tikoo K, Anders HJ.

Am J Pathol. 2010 Mar;176(3):1079-83. doi: 10.2353/ajpath.2010.090528. Epub 2010 Jan 14.


Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation, H3K4 dimethylation and phosphorylation at serine 10.

Sayyed SG, Gaikwad AB, Lichtnekert J, Kulkarni O, Eulberg D, Klussmann S, Tikoo K, Anders HJ.

Nephrol Dial Transplant. 2010 Jun;25(6):1811-7. doi: 10.1093/ndt/gfp730. Epub 2010 Jan 12.


Viral RNA induces type I interferon-dependent cytokine release and cell death in mesangial cells via melanoma-differentiation-associated gene-5: Implications for viral infection-associated glomerulonephritis.

Flür K, Allam R, Zecher D, Kulkarni OP, Lichtnekert J, Schwarz M, Beutler B, Vielhauer V, Anders HJ.

Am J Pathol. 2009 Nov;175(5):2014-22. doi: 10.2353/ajpath.2009.080585. Epub 2009 Oct 22.


Viral RNA and DNA trigger common antiviral responses in mesangial cells.

Allam R, Lichtnekert J, Moll AG, Taubitz A, Vielhauer V, Anders HJ.

J Am Soc Nephrol. 2009 Sep;20(9):1986-96. doi: 10.1681/ASN.2008101067. Epub 2009 Aug 27.


Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif.

Lichtnekert J, Vielhauer V, Zecher D, Kulkarni OP, Clauss S, Segerer S, Hornung V, Mayadas TN, Beutler B, Akira S, Anders HJ.

Am J Physiol Renal Physiol. 2009 Apr;296(4):F867-74. doi: 10.1152/ajprenal.90213.2008. Epub 2009 Jan 21.


Coactivation of Toll-like receptor-3 and -7 in immune complex glomerulonephritis.

Patole PS, Pawar RD, Lichtnekert J, Lech M, Kulkarni OP, Ramanjaneyulu A, Segerer S, Anders HJ.

J Autoimmun. 2007 Aug;29(1):52-9. Epub 2007 Jun 4.


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